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Prabhakar V Grinstaff MW Alarcon J Knors C Solan AK Niklason LE 《Journal of biomedical materials research. Part A》2003,67(1):303-311
Techniques have been developed to culture bovine or porcine vascular cells on polyglycolic acid (PGA) scaffolds to form engineered vessels. Previously, it was shown that smooth muscle cells (SMCs) that were in close proximity to PGA remnants after 8 weeks of culture had lower expression of SMC markers of differentiation and were more mitotic compared with SMCs that were distant from polymer residuals. Modifications of PGA were explored as a means to minimize residual polymer fragments after culture. To hasten degradation, polymer was treated with heat, NaOH, or gamma-irradiation. Differential scanning calorimetry, mass and tensile strength degradation, and inherent viscosity were used to assess polymer characteristics. When polymer was maintained in aqueous conditions, tensile strength of treated PGA degraded to zero within 3 weeks for each treatment. Engineered vessel constructs cultured on NaOH and gamma-treated polymer displayed smooth muscle alpha-actin throughout the vessel wall. Scaffold treatment impacted graft morphology, cellular differentiation, and mechanical integrity. 相似文献
3.
Ricky K. Taira PhD David B. Johnson Vikas Bhushan Monica Rivera Clement Wong Lujia Huang Denise R. Aberle Melanie Greaves Jonathan G. Goldin 《Journal of digital imaging》1996,9(1):25-36
Current digital information systems in radiology are insufficient to accommodate the retrieval needs of academicians. Significant efforts are required in retrieving clinical cases for teaching and research. We describe a prototype system that supports intelligent case retrieval based on a combined specification of patient demographics, radiologic findings, and pathologic diagnoses. The documents for these cases can be distributed among multiple heterogeneous data bases. The system features automatic indexing of radiology and pathology reports, a comprehensive lexicon for thoracic radiology, an interface to a hospital information system, radiology information system, and picture archiving and communication systems, and a graphical user interface for query formulation and results visualization. The prototype system was developed within the domain of thoracic radiology involving patients with lung cancer. 相似文献
4.
Vikas S. Gupta Amir M. Khan Ashley H. Ebanks Pamela A. Lally Kevin P. Lally Matthew T. Harting 《Journal of pediatric surgery》2021,56(4):697-699
PurposeThere is a known association between Cornelia de Lange syndrome (CdLS) and congenital diaphragmatic hernia (CDH), with CDH being the cause of death in 5%–20% of CdLS cases. We aimed to identify and describe patients with CDLS and CDH. We hypothesized that CdLS would be associated with high-risk CDH and poor outcomes.MethodsCDH Study Group patients from 1995 to 2019 were included. Those with CdLS were reviewed retrospectively. Rates of repair and outcomes were compared between patients with and without CdLS.ResultsWe identified 9,251 CDH patients. Of those, 21 had confirmed CdLS. CdLS patients had a lower birth weight (2.2 ± 0.57 kg) than non-CdLS patients (2.9 ± 0.64 kg) (p < 0.001). 5-min Apgar scores were lower in CdLS patients (6, 4–7) than non-CdLS patients (7, 5–8) (p = 0.014). Only 33% of CdLS patients underwent diaphragmatic repair compared to 84.2% of non-CdLS patients (p < 0.001). Mortality was 76% for CdLS patients compared with 29% for non-CdLS patients (p < 0.001). Of the 7 CdLS patients who underwent repair, 5 survived to hospital discharge.ConclusionsInfants with CdLS and CDH have a poor prognosis. However, CdLS patients who undergo repair can survive to discharge; therefore, the concomitant diagnosis of CdLS and CDH is not necessarily a contraindication to repair. Early recognition of these anomalies can assist with counseling and prognostication.Type of studyRetrospective comparative studyLevel of evidenceIII 相似文献
5.
Verma AK Vohra A Maitra A Banerjee M Singh R Mittal SK Bharadwaj V Batra V Bhatia A Aggarwal P 《Indian journal of pediatrics》1995,62(6):725-729
Of 613 children evaluated in a village in Haryana 94 (15.3%) were observed to have chronic suppurative otitis media (CSOM).
Fifty eight (61.7%) children had hearing impairment. CSOM contributed to 71.6% of the hearing impaired (58/81). On analysis
of association of CSOM with literacy and socio-economic status of mothers, and age, sex, and upper respiratory tract infections
(URI) in children positive correlation was observed only with URIs (P<0.001).
Literacy and socio-economic status of the mothers did not correlate significantly with knowledge about treatment seeking,
and ear cleaning practices, probably due to the narrow range of incomes and literacy levels. An intervention program consisting
of play, demonstrations, health charts and slogans, and aural cleaning and antibiotic drops was introduced. 相似文献
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Arti Kapil Sumeeta Gulati Vikas Goel Lalit Kumar Rakhee Krishnan V Kochupillai 《Medical oncology (Northwood, London, England)》1998,15(4):270-274
Acinetobacter baumannii is emerging as a major cause of nosocomial infections particularly in high risk patients. Being resistant to adverse environmental
conditions, it can stay for prolonged periods in the hospital environment. We report an outbreak in the medical oncology ward
where nine patients suspected of bacteraemia were blood culture positive forA. baumannii from the two samples each, one collected through the i.v. cannula and another through the peripheral venous puncture. The
bacteria was also isolated from the environmental sources from the various samples collected. The biotype, antibiogram, cellular
protein profiles on SDS-PAGE and the restriction enzyme analysis patterns of the patient isolates and the environmental isolates
were similar. This points to the environment as a source of infection. With reinforcement of proper barrier nursing and use
of disposable heparine ampoules it was possible to control the outbreak. 相似文献
8.
Vikas A. Gupta Shannon M. Matulis Benjamin G. Barwick R. Devin Bog Conrad W. Shebelut Mala Shanmugam Paola Neri Nizar J. Bahlis Madhav V. Dhodapkar Leonard T. Heffner Craig C. Hofmeister Nisha S. Joseph Sagar Lonial Jonathan L. Kaufman David L. Jaye Ajay K. Nooka Lawrence H. Boise 《Blood cancer journal》2022,12(8)
9.
A. Danielle Iuliano Joan M. Brunkard Tegan K. Boehmer Elisha Peterson Stacey Adjei Alison M. Binder Stacy Cobb Philip Graff Pauline Hidalgo Mark J. Panaggio Jeanette J. Rainey Preetika Rao Karl Soetebier Susan Wacaster ChinEn Ai Vikas Gupta Noelle-Angelique M. Molinari Matthew D. Ritchey 《MMWR. Morbidity and mortality weekly report》2022,71(4):146
10.
Bhakti Gajjar Sanjay Sharma Erum Khan Pranita Sharma Pawan Jain Vikas Goel Arvind Neral Jyotish Patel Mamta Parmar Kanika Sharma Vijay K. Sharma Arvind K. Sharma 《Medicine》2022,101(27)
India has the second highest number of cases of sickle cell disease (SCD) and affects the most socioeconomically disadvantaged communities living in a horizontal belt from Gujarat to Odisha state. Despite high prevalence, information about cerebral hemodynamics among children with SCD in India remains scarcely described.We performed transcranial Doppler (TCD) to assess cerebral hemodynamics among Indian children with SCD and evaluated their association with clinical and hematological parameters.Children aged 3-18years, diagnosed with SCD living in Raipur in Chhattisgarh and Ahmedabad in Gujarat state were recruited. TCD was performed to obtain flow velocities from middle cerebral (MCA), intracranial internal carotid (ICA) and basilar artery. Associations were evaluated between timed-average-mean-maximum velocities (TAMMV) and various clinical and hematological parameters.Our prospective study included 62 consecutive children with known SCD. Mean ± SD age of the study population was 9.8 ± 3.9 years and 31 (50%) were male. Mean ± SD hemoglobin was 8.64 ± 1.34 Gm/dL while the mean HbSS ± SD was 70.25 ± 15.27%. While 6 (9.6%) children had suffered from stroke during previous 2 years, 7 (11%) demonstrated abnormal TAMMV. Higher HbSS level along with history of iron chelation therapy, blood transfusion and/or stroke showed a trend towards having higher TAMMV.Stroke and cerebral hemodynamic alterations are common among Indian children with SCD. Larger studies with detailed neuroimaging and genetic evaluations are needed for better understanding, characterization, risk stratification as well as optimization of the timing of blood transfusion to reduce physical disabilities among Indian children with SCD. 相似文献