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排序方式: 共有427条查询结果,搜索用时 9 毫秒
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Arumugam Somasundaram Ramadoss Karthikeyan Vadivel Velmurugan Balasubramanian Dhandapani Muthu Raja 《Journal of ethnopharmacology》2010
Aim of study
In view of the use of rhizomes of Kyllinga nemoralis L., against hepatopathy in ethnomedicine the present study was aimed at evaluating the hepatoprotective activity of the rhizomes of Kyllinga nemoralis against carbon tetrachloride (CCl4)-induced hepatotoxicity in rats.Materials and methods
Hepatotoxicity was induced in male Wistar rats by carbon tetrachloride and olive oil (50%, v/v). i.p. ethanolic and petroleum ether extracts of Kyllinga nemoralis rhizomes were administered to the experimental rats (100 and 200 mg/kg, p.o. for seven days). The hepatoprotective effect of these extracts was evaluated by the assay of liver function biochemical parameters and histopathological studies of the liver compared with silymarin.Results
Both extracts showed significant hepatoprotection when compared to control, similar to standard silymarin. Histology of liver sections also revealed that the extracts protected liver from injury.Conclusions
The study identified a plant with potential hepatoprotective constituents which will be isolated and characterized in future. 相似文献74.
Shuo Deng PhD Muthu K. Shanmugam PhD Alan Prem Kumar PhD Celestial T. Yap PhD Gautam Sethi PhD Anupam Bishayee PhD 《Cancer》2019,125(8):1228-1246
Autophagy, also known as macroautophagy, is a tightly regulated process involved in the stress responses, such as starvation. It is a vacuolar, lysosomal pathway for the degradation of damaged proteins and organelles in eukaryotic cells. Autophagy also plays a key role in various tissue processes and immune responses and in the regulation of inflammation. Over the past decade, three levels of autophagy regulation have been identified in mammalian cells: 1) signaling, 2) autophagosome formation, and 3) autophagosome maturation and lysosomal degradation. Any deregulation of the autophagy processes can lead to the development of diverse chronic diseases, such as diabetes, obesity, cardiovascular disease, neurodegenerative disease, and malignancies. However, the potential role of autophagy in cancer is rather complex and has been associated with both the induction and the inhibition of neoplasia. Several synthetic autophagy modulators have been identified as promising candidates for cancer therapy. In addition, diverse phytochemicals derived from natural sources, such as curcumin, ursolic acid, resveratrol, thymoquinone, and γ-tocotrienol, also have attracted attention as promising autophagy modulators with minimal side effects. In this review, the authors discuss the importance of autophagy regulators and various natural compounds that induce and/or inhibit autophagy in the prevention and therapy of cancer. 相似文献
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Abrus agglutinin promotes irreparable DNA damage by triggering ROS generation followed by ATM‐p73 mediated apoptosis in oral squamous cell carcinoma 下载免费PDF全文
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Yeomans L Muthu D Lowery JJ Martinez HN Abrell L Lin G Strom K Knapp BI Bidlack JM Bilsky EJ Polt R 《Chemical biology & drug design》2011,78(5):749-756
Phosphorylation of l-serine-containing enkephalin analogs has been explored as an alternative to glycosylation in an effort to increase blood-brain barrier permeability and CNS bioavailability of peptide pharmacophores. Two enkephalin-based peptides were modified for these studies, a set related to DTLES, a mixed μ/δ-agonist, and one related to DAMGO, a highly selective μ-agonist. Each unglycosylated peptide was compared to its phosphate, its mono-benzylphosphate ester, and its β-d-glucoside. Binding was characterized in membrane preparations from Chinese hamster ovary cells expressing human μ, δ and κ-opiate receptors. Antinociception was measured in mice using the 55 °C tail-flick assay. To estimate bioavailability, the antinociceptive effect of each opioid agonist was evaluated after intracerebroventricular (i.c.v.) or intravenous administration (i.v.) of the peptides. Circular dichroism methods and high-field nuclear magnetic resonance were used in the presence and absence of sodium dodecylsulfate to understand how the presence of a membrane might influence the peptide conformations. 相似文献
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Nestin is considered to be a characteristic marker of multipotent proliferative precursors found in some embryonic and fetal tissues. Its expression might be a suitable diagnostic and prognostic indicator of malignancy and a potential marker of cancer stem cells in solid tumors. Unexpectedly, nestin protein was detected in mature CD138+CD38+ plasma cells of multiple myeloma patients and statistical analysis confirmed significant differences between myeloma patients and control group without hematological malignancy. Our results represent the first evidence of nestin expression in multiple myeloma. Further studies are required to elucidate the role of this protein in multiple myeloma. 相似文献
80.
Shankar EM Balakrishnan P Vignesh R Velu V Jayakumar P Solomon S 《Current infectious disease reports》2011,13(1):47-52
GB virus C (GBV-C), a member of the Flaviviridae family of viruses, recently received considerable attention largely owing
to its potential role in decelerating HIV-1 disease progression by interfering with HIV replication. With similar transmission
features, GBV-C is parenterally transmitted, similar to the serum hepatitis viruses and HIV-1, and replicates in hemopoietic
cells and T lymphocytes in particular, with no observable disease pathology. Progressive T-cell depletion and subsequent immune
abrogation being the cardinal features of HIV-1 infection, accumulating evidence indicates that GBV-C effectively overturns
HIV’s chances of exploiting the T-cell machinery and leads to enhanced survival rates of HIV-infected subjects. Much effort
has been devoted to understanding the beneficial role of GBV-C in HIV disease. This review discusses recently proposed mechanisms
underlying the pathophysiology of GBV-C coinfection in HIV disease. 相似文献