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11.
Sylvia Mitchell Veronica A. Bradley John L. Welch Peter G. Britton 《Brain injury : [BI]》1990,4(3):273-279
This study reports on the efficacy of a 'coma arousal procedure'. This procedure involved a programme of vigorous sensory stimulation administered to comatose patients by relatives using Comakits. An experimental group of 12 severely head-injured patients received the coma arousal procedure while a matched control group did not. Total duration of coma and weekly Glasgow Coma Scale Scores were recorded for the two groups. Results indicate that the total duration of coma was significantly shorter and that coma lightened more rapidly for the experimental group. 相似文献
12.
Veronica Amdi 《Early child development and care》1990,58(1):31-43
Every child despite his individual differences and uniqueness is to be considered of equal worth. He should therefore be entitled to equal social, economic, civil and political rights, so that he may fully realise his inherent potential and share equally in life (Gill, 1979).
Obviously, these values are rooted in the humanistic philosophy of any nation's declaration of independence. In accordance with these value premises therefore “any act of commission or ommission by individuals, institutions or the society as a whole, and any conditions which deprive children of equal rights and liberties and interfere with their optimal development, constitutes by definition abuse or neglectful acts or conditions” (Gill, 1979).
Child abuse is a significant contemporary community problem. Although children have been maltreated throughout history, our community has been silent in defence of abused children. Child abuse is not a phenomenon of the 20th Century nor is it unique to our society and culture alone. It has occurred throughout the recorded history of man. The future of any nation depends on its children and their capabilities. For this reason, they must be given a full chance. 相似文献
Obviously, these values are rooted in the humanistic philosophy of any nation's declaration of independence. In accordance with these value premises therefore “any act of commission or ommission by individuals, institutions or the society as a whole, and any conditions which deprive children of equal rights and liberties and interfere with their optimal development, constitutes by definition abuse or neglectful acts or conditions” (Gill, 1979).
Child abuse is a significant contemporary community problem. Although children have been maltreated throughout history, our community has been silent in defence of abused children. Child abuse is not a phenomenon of the 20th Century nor is it unique to our society and culture alone. It has occurred throughout the recorded history of man. The future of any nation depends on its children and their capabilities. For this reason, they must be given a full chance. 相似文献
13.
Positive predictive value of maximal posterior joint-line tenderness in diagnosing meniscal pathology: a pilot study 下载免费PDF全文
Veronica M.R. Wadey Nicholas G.H. Mohtadi Robert C. Bray Cyril B. Frank 《Canadian journal of surgery》2007,50(2):96-100
OBJECTIVE: The purpose of this prospective study was to determine the positive predictive value (PPV) of the point of maximal posterior joint line tenderness (JLT), as a clinical sign, to diagnose underlying meniscal tears. METHODS: We conducted a prospective study of patients requiring arthroscopic surgery, who consecutively presented to the University of Calgary's Sport Medicine Centre. The femurotibial joint line was palpated for the point of maximal tenderness. We recorded the data on the arthroscopy report. A second examiner (orthopedic sport medicine surgical fellow or sport medicine physician) performed the same protocol. An arthroscopist documented the site of pathology as detected by arthroscopy. RESULTS: We found a PPV of 60.0% and a negative predictive value of 62.5%, suggesting that maximal posterior JLT may be predictive of meniscal pathology. The sensitivity and specificity were 84.6% and 31.2%, respectively (p = 0.155), with Fisher's exact test. The kappa score assessed interobserver reliability and was good at 0.48. Patients with maximal posterior JLT but no meniscal pathology did have other confounding pathology and patients with no maximal posterior JLT who had meniscal pathology usually had confounding knee pathology. CONCLUSIONS: We found a PPV of 60.0% of maximal posterior JLT and meniscal pathology located at the same anatomical site on arthroscopic examination. 相似文献
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Expression of CDX2 and MUC2 in Barrett's mucosa 总被引:3,自引:0,他引:3
Steininger H Pfofe DA Müller H Haag-Sunjic G Fratianu V 《Pathology, research and practice》2005,201(8-9):573-577
Barrett's mucosa is a risk factor for esophageal adenocarcinoma and should be detected at an early stage. It is defined by the presence of columnar epithelium with goblet cells in the lower esophagus, but histologic diagnosis can be uncertain in the absence of distinct goblet cells. We investigated 55 biopsies from 48 patients with endoscopically plain Barrett's esophagus and performed immunohistochemistry for CDX2 and MUC2. In addition, alcian blue (pH 2,5)/PAS staining was done. In histologically unequivocal Barrett's mucosa, nuclear expression of CDX2 in goblet cells and many columnar cells, as well as cytoplasmic positivity for MUC2 in goblet cells, could be observed. Alcian blue (pH 2,5)/PAS stained acidic mucins in goblet cells and in some non-goblet columnar cells. In six cases, no definite Barrett's mucosa was present, and no expression of MUC2 could be observed. In these biopsies, there was granular cytoplasmic and/or focal nuclear staining for CDX2 in non-goblet columnar epithelial cells, indicating their intestinal differentiation. We suggest that this peculiar mucosa is the precursor of unequivocal Barrett's mucosa and would designate it early Barrett's mucosa. Alcian blue for acidic mucins is inconsistent in this epithelium and does not reliably indicate early intestinal differentiation. 相似文献
17.
Exploratory behavior (GMA) and habituation rate (IH) were studied in an open-field situation in normal and adrenalectomized rats. Following this procedure the rats were subjected to passive avoidance learning (PA). Wide-spreading individual differences were observed in the exploratory behavior and the tendency of habituation of normal rats. As compared to the normal values, either the adrenalectomy which was performed 24 hr, 7 days and 28 days prior to the experiments or the ACTH and hydrocortisone treatment failed to modify the GMA and the IH significantly. An improvement of PA was found in the normal rats following ACTH and hydrocortisone treatment. In the adrenalectomized animals the hydrocortisone proved to be effective, whereas ACTH did not influence PA. No correlation was found between GMA, IH versus PA values and the influence of ACTH and hydrocortisone administration on these parameters. It is concluded that the direction of PA is unpredictable on the basis of the open-field test performed on R-Amsterdam strain of rats, and the effect of ACTH on passive avoidance learning is mediated through the adrenal glands. 相似文献
18.
Cova L Ratti A Volta M Fogh I Cardin V Corbo M Silani V 《Stem cells and development》2004,13(1):121-131
In the past few years research on stem cells has exploded as a tool to develop potential therapies to treat incurable neurodegenerative diseases. Stem cell transplantation has been effective in several animal models, but the underlying restorative mechanisms are still unknown. Several events such as cell fusion, neurotrophic factor release, endogenous stem cell proliferation, and transdifferentiation (adult cell acquisition of new unexpected identities) may explain therapeutic success, in addition to replacement of lost cells. This issue needs to be clarified further to maximize the potential for effective therapies. Preliminary stem transplantation trials have already been performed for some neurodegenerative diseases. There is no effective pharmacological treatment for amyotrophic lateral sclerosis, but recent preliminary data both in experimental and clinical settings have targeted it as an ideal candidate disease for the development of stem cell therapy in humans. This review summarizes recent advances gained in stem cell research applied to neurodegenerative diseases with a special emphasis to the criticisms put forward. 相似文献
19.
c-kit Expression in small cell carcinoma of the urinary bladder: prognostic and therapeutic implications. 总被引:3,自引:0,他引:3
Chong-Xian Pan Ximing J Yang Antonio Lopez-Beltran Gregory T MacLennan John N Eble Michael O Koch Timothy D Jones Haiqun Lin Kelly Nigro Veronica Papavero Maria Tretiakova Liang Cheng 《Modern pathology》2005,18(3):320-323
The prognosis for small cell carcinoma of the urinary bladder is poor, and strategies for improved therapy are needed. Targeted therapy against the c-kit proto-oncogene has been successful in the management of gastrointestinal stromal tumor. We investigated the expression of c-kit in 52 cases of small cell carcinoma of the urinary bladder. Specimens with more than 10% of cells demonstrating strong membrane staining were considered to have positive immunostaining for c-kit. c-kit expression was detected in 21 of 52 specimens from these patients. Among the 21 specimens, seven had less than 10% staining, and were considered to be negative. Nine had 11-50% staining, and five had more than 50% staining. Overall, 14 of 52 (27%) small cell carcinomas of the urinary bladder were positive for c-kit expression. During a median follow-up of 11 months, 60% of the patients died of bladder cancer. No association was found between c-kit expression and survival or other clinicopathologic parameters. Five-year cancer-specific survivals for c-kit-positive and c-kit-negative tumors were 9 and 15%, respectively (P=0.36). A significant proportion (27%) of small cell carcinomas of the urinary bladder expressed c-kit, suggesting that it may prove useful as a therapeutic target in small cell carcinoma of the urinary bladder. 相似文献
20.
Viollet L Zarhrate M Maystadt I Estournet-Mathiaut B Barois A Desguerre I Mayer M Chabrol B LeHeup B Cusin V Billette De Villemeur T Bonneau D Saugier-Veber P Touzery-De Villepin A Delaubier A Kaplan J Jeanpierre M Feingold J Munnich A 《European journal of human genetics : EJHG》2004,12(6):483-488
Chronic distal spinal muscular atrophy (Chronic DSMA, MIM (*)607088) is a rare autosomal recessive disorder characterized by a progressive motor weakness and muscular atrophy, predominating in the distal parts of the limbs. A form of Chronic DSMA gene has been previously mapped to chromosome 11q13 in the 10.3 cM interval defined by loci D11S1889 and D11S1321. By linkage analysis in 12 European Chronic DSMA families, we showed that a disease gene maps to chromosome 11q13.3 (Z(max)=6.66 at theta=0.00 at the DSM4 locus) and suggested that this condition is genetically homogeneous. Recombination events allowed us to reduce the genetic interval to a 2.6 cM region, telomeric to the IGHMBP2 gene, excluding this gene as the disease causing gene in Chronic DSMA. Moreover, partial linkage disequilibrium was found between three rare alleles at loci D11S1369, DSM4 and D11S4184 and the mutant chromosome in European patients. Analysis of the markers at these loci strongly suggests that most Chronic DSMA chromosomes are derived from a single ancestor. Refinement of the Chronic DSMA locus will hopefully allow to test candidate genes and lead to identification of the disease-causing mutations. 相似文献