全文获取类型
收费全文 | 7183篇 |
免费 | 446篇 |
国内免费 | 21篇 |
专业分类
耳鼻咽喉 | 32篇 |
儿科学 | 211篇 |
妇产科学 | 192篇 |
基础医学 | 1203篇 |
口腔科学 | 163篇 |
临床医学 | 665篇 |
内科学 | 1536篇 |
皮肤病学 | 287篇 |
神经病学 | 684篇 |
特种医学 | 210篇 |
外科学 | 599篇 |
综合类 | 45篇 |
一般理论 | 3篇 |
预防医学 | 679篇 |
眼科学 | 68篇 |
药学 | 510篇 |
中国医学 | 26篇 |
肿瘤学 | 537篇 |
出版年
2023年 | 60篇 |
2022年 | 92篇 |
2021年 | 159篇 |
2020年 | 165篇 |
2019年 | 207篇 |
2018年 | 216篇 |
2017年 | 165篇 |
2016年 | 201篇 |
2015年 | 231篇 |
2014年 | 288篇 |
2013年 | 367篇 |
2012年 | 557篇 |
2011年 | 554篇 |
2010年 | 319篇 |
2009年 | 265篇 |
2008年 | 460篇 |
2007年 | 481篇 |
2006年 | 463篇 |
2005年 | 431篇 |
2004年 | 359篇 |
2003年 | 349篇 |
2002年 | 301篇 |
2001年 | 82篇 |
2000年 | 62篇 |
1999年 | 56篇 |
1998年 | 63篇 |
1997年 | 48篇 |
1996年 | 45篇 |
1995年 | 36篇 |
1994年 | 28篇 |
1993年 | 25篇 |
1992年 | 32篇 |
1991年 | 35篇 |
1990年 | 34篇 |
1989年 | 22篇 |
1988年 | 26篇 |
1987年 | 21篇 |
1986年 | 28篇 |
1985年 | 24篇 |
1984年 | 12篇 |
1983年 | 14篇 |
1982年 | 22篇 |
1981年 | 21篇 |
1979年 | 13篇 |
1978年 | 16篇 |
1977年 | 14篇 |
1976年 | 15篇 |
1974年 | 13篇 |
1971年 | 14篇 |
1967年 | 11篇 |
排序方式: 共有7650条查询结果,搜索用时 0 毫秒
21.
22.
23.
Dual role of interleukin-4 (IL-4) in pulmonary paracoccidioidomycosis: endogenous IL-4 can induce protection or exacerbation of disease depending on the host genetic pattern 下载免费PDF全文
Arruda C Valente-Ferreira RC Pina A Kashino SS Fazioli RA Vaz CA Franco MF Keller AC Calich VL 《Infection and immunity》2004,72(7):3932-3940
Resistance to paracoccidioidomycosis, the most important endemic mycosis in Latin America, is thought to be primarily mediated by cellular immunity and the production of gamma interferon. To assess the role of interleukin-4 (IL-4), a Th2 cytokine, pulmonary paracoccidioidomycosis in IL-4-depleted susceptible (B10.A) and intermediate (C57BL/6) mice was studied. Two different protocols were used to neutralize endogenous IL-4 in B10.A mice: 1 mg of anti-IL-4 monoclonal antibody (MAb)/week and 8 mg 1 day before intratracheal infection with 10(6) Paracoccidioides brasiliensis yeast cells. Unexpectedly, both protocols enhanced pulmonary infection but did not alter the levels of pulmonary cytokines and specific antibodies. Since in a previous work it was verified that C57BL/6 mice genetically deficient in IL-4 were more resistant to P. brasiliensis infection, we also investigated the effect of IL-4 depletion in this mouse strain. Treatment with the MAb at 1 mg/week led to less severe pulmonary disease associated with impaired synthesis of Th2 cytokines in the lungs and liver of control C57BL/6 mice. Conversely, in IL-4-depleted C57BL/6 mice, increased levels of tumor necrosis factor alpha and IL-12 were found in the lungs and liver, respectively. In addition, higher levels of immunoglobulin G2a (IgG2a) and lower levels of IgG1 antibodies were produced by IL-4-depleted mice than by control mice. Lung pathologic findings were equivalent in IL-4-depleted and untreated B10.A mice. In IL-4-depleted C57BL/6 mice, however, smaller and well-organized granulomas replaced the more extensive lesions that developed in untreated mice. These results clearly showed that IL-4 can have a protective or a disease-promoting effect in pulmonary paracoccidioidomycosis depending on the genetic background of the host. 相似文献
24.
Mastella Giulio Darstein Lars Raufhake Carsten Schneider Vera Corletto Anna Buiatti Alessandra Mller Alexander Schuessler-Hahn Franziska Gondert Markus Gerdes Heiko Martens Eimo 《Zeitschrift fur Gesundheitswissenschaften》2022,30(1):5-10
Journal of Public Health - Offshore wind energy is a fast growing market. Accordingly, a correspondingly large number of employees are working at the wind farms. Owing to the harsh operating... 相似文献
25.
Charlotte V. Hobbs Jan Drobeniuc Theresa Kittle John Williams Paul Byers Panayampalli S. Satheshkumar Kengo Inagaki Meagan Stephenson Sara S. Kim Manish M. Patel Brendan Flannery CDC COVID- Response Team CDC COVID- Response Team Bailey Alston Shanna J. Bolcen Darbi Boulay Peter Browning Li Cronin Ebenezer David Tonya Hayden Han Li Travis Lim Panagiotis Maniatis Palak Patel Mathew Pauly Amanda Poe Lili Punkova Vera Semenova Evelene P. Steward-Clark Alexandra Tejada Briana Zellner 《MMWR. Morbidity and mortality weekly report》2021,70(9):312
26.
Alexandra Schneider-Chaabane David Boschert Sibylle Rau Diana Lorena Guevara Solarte Vera Bleicher Ali Al-Ahmad Karen Lienkamp 《Macromolecular chemistry and physics.》2023,224(5):2200323
Facially amphiphilic polymers carrying cationic and hydrophobic groups on the same repeat unit have shown promising antimicrobial activity and biocompatibility, yet they are prone to suffer from protein adhesion which may induce biofilm formation. To overcome this problem, poly(diitaconate)-based copolymers with cationic/hydrophobic and protein-repellent/charge-neutral repeat units are synthesized. The bioactivity profile of surface-attached polymer networks made from these copolymers depends on the ratio of the cationic and charge-neutral repeat units. In all cases, the protein adhesion is substantially reduced compared to purely cationic polymers. At a 50:50 ratio, the polymer coatings are partially protein-repellent and antimicrobial, yet slightly cell toxic. At an intermediate composition of 30:70, they are still antimicrobial and the cell compatibility is substantially improved. The long-term stability of these materials still has to be determined to judge their suitability for medical applications. 相似文献
27.
28.
Chromosome 11q13 markers and D-type cyclins in breast cancer 总被引:7,自引:0,他引:7
Gordon Peters Vera Fantl Rosalind Smith Sharon Brookes Clive Dickson 《Breast cancer research and treatment》1995,33(2):125-135
Summary One in six primary human breast cancers has DNA amplification centered on the cyclin D1 gene (CCND1) on chromosome 11q13. This genetic abnormality is preferentially associated with estrogen-receptor positive tumors and may define a sub-class of patients with an adverse prognosis. AlthoughCCND1 has the credentials of a cellular oncogene, being a target for chromosomal translocation and retroviral integration, the 11q13 amplicon encompasses several other markers andCCND1 is not the only candidate for the key gene on the amplified DNA. To assess their relative importance, we have constructed a physical map of the amplified DNA and compared the extent and frequency of amplification across the region. Since it is likely that the gene providing the selective force for amplification will be expressed at elevated levels, we have also examined expression of both RNA and protein. By these criteria, cyclin D1 remains the strongest candidate for the key oncogene on the amplicon and we are currently investigating the functional consequences of its over-expression.Presented by Gordon Peters at the 16th Annual San Antonio Breast Cancer Symposium, San Antonio TX, USA, November 4, 1993; Minisymposium on Molecular Genetics in Breast Cancer. 相似文献
29.
30.
James N. Ingle MD Carl G. Kardinal Vera J. Suman James E. Krook Alan K. Hatfield 《Investigational new drugs》1996,14(2):235-237
Summary Octreotide is a synthetic somatostatin analogue which has shown inhibitory activity against human breast cancer cells in culture. Ten patients with metastatic breast cancer and no prior hormonal therapy exposure received octreotide at 150 g subcutaneously thrice daily. No objective responses were observed and the median time to treatment failure was short at 57 days. 相似文献