全文获取类型
收费全文 | 1406篇 |
免费 | 75篇 |
国内免费 | 9篇 |
专业分类
耳鼻咽喉 | 4篇 |
儿科学 | 58篇 |
妇产科学 | 17篇 |
基础医学 | 151篇 |
口腔科学 | 12篇 |
临床医学 | 114篇 |
内科学 | 397篇 |
皮肤病学 | 16篇 |
神经病学 | 150篇 |
特种医学 | 77篇 |
外科学 | 173篇 |
综合类 | 5篇 |
预防医学 | 47篇 |
眼科学 | 11篇 |
药学 | 75篇 |
中国医学 | 2篇 |
肿瘤学 | 181篇 |
出版年
2022年 | 11篇 |
2021年 | 26篇 |
2020年 | 15篇 |
2019年 | 18篇 |
2018年 | 31篇 |
2017年 | 25篇 |
2016年 | 19篇 |
2015年 | 26篇 |
2014年 | 49篇 |
2013年 | 40篇 |
2012年 | 63篇 |
2011年 | 75篇 |
2010年 | 52篇 |
2009年 | 42篇 |
2008年 | 63篇 |
2007年 | 56篇 |
2006年 | 65篇 |
2005年 | 77篇 |
2004年 | 76篇 |
2003年 | 54篇 |
2002年 | 54篇 |
2001年 | 48篇 |
2000年 | 62篇 |
1999年 | 50篇 |
1998年 | 15篇 |
1997年 | 8篇 |
1996年 | 14篇 |
1995年 | 14篇 |
1994年 | 7篇 |
1993年 | 6篇 |
1992年 | 40篇 |
1991年 | 28篇 |
1990年 | 25篇 |
1989年 | 29篇 |
1988年 | 26篇 |
1987年 | 27篇 |
1986年 | 19篇 |
1985年 | 16篇 |
1984年 | 12篇 |
1982年 | 6篇 |
1981年 | 6篇 |
1980年 | 7篇 |
1979年 | 13篇 |
1975年 | 7篇 |
1974年 | 7篇 |
1973年 | 7篇 |
1972年 | 7篇 |
1971年 | 5篇 |
1970年 | 6篇 |
1969年 | 5篇 |
排序方式: 共有1490条查询结果,搜索用时 15 毫秒
21.
Gaspare Palaia Alessandra Impellizzeri Gianluca Tenore Federico Caporali Paolo Visca Alessandro Del Vecchio Gabriella Galluccio Antonella Polimeni Umberto Romeo 《Clinical oral investigations》2020,24(8):2645-2652
The aim of this study was to evaluate, ex vivo, the histological effects of 445-nm diode laser (Eltech K-Laser srl, Treviso, Italy), during an oral soft ti 相似文献
22.
23.
24.
The RET gene encodes a single-pass transmembrane receptor tyrosine kinase. RET is the oncogene that causes papillary thyroid carcinoma and medullary thyroid carcinoma. The latter may arise as a component of multiple endocrine neoplasia type 2 syndromes; germline mutations in RET are responsible for multiple endocrine neoplasia type 2 inheritance. In this report we review data on the mechanisms leading to RET oncogenic conversion and on RET targeting as a strategy in thyroid cancer treatment. 相似文献
25.
Kao PC Vecchio JA Hyman NH West AB Blaszyk H 《Journal of clinical gastroenterology》2005,39(8):704-708
Idiopathic myointimal hyperplasia of mesenteric veins (IMHMV) is a rare and poorly understood disease that occurs in the rectosigmoid colon of predominantly young, previously healthy male patients. IMHMV typically requires segmental resection due to complications after a relatively protracted clinical course. This disease presents a challenging diagnostic dilemma for the clinician because it is initially often confused with chronic idiopathic inflammatory bowel disease. We report a case of IMHMV, illustrate endoscopic and histopathologic features, and review key characteristics of this rare entity. 相似文献
26.
G Mazzotta A Camerini G Scopinaro F Claudiani R Griffo P Bellotti R Lionetto C Vecchio 《European heart journal》1992,13(3):330-337
In 183 consecutive patients with recent, uncomplicated myocardial infarction, the following variables were associated with 4-year cardiac death: haemodynamic decompensation with exercise (P = 0.01), left ventricular ejection fraction at rest (P = 0.004) and at peak exercise (P = 0.003), persistent ST segment elevation at rest in the area of infarction = (P = 0.004), exercise-induced ST segment elevation (P = 0.02), and late aneurysmal evolution (P = 0.01). Exercise left ventricular ejection fraction was the sole variable selected by Cox regression analysis as an independent predictor of cardiac death. In 40 patients with ST segment elevation at rest, left ventricular ejection fraction was 42 +/- 17% at rest and 40 +/- 18% at peak exercise, versus 52 +/- 12% and 52 +/- 14% in the remaining patients (both P less than 0.01). Among these 40, 16 (all with anterior infarction) also had exercise-induced ST segment elevation; their ejection fraction was 32 +/- 13% at rest, 30 +/- 13% during exercise, versus 53 +/- 15% and 53 +/- 15% in 129 patients with no ST segment elevation either at rest, or during exercise (both P less than 0.01). The 4-year risk of death was 20% in the former 40 patients, 36% in the latter 16, while in the complete absence of ST segment elevation, such risk was 3%. All 14 patients with ST segment elevation only during exercise were alive after 4 years: their left ventricular ejection fraction was 47 +/- 12% at rest, 45 +/- 13% with exercise. ST segment elevation was associated with late aneurysmal evolution but not with exercise-induced ischaemia.(ABSTRACT TRUNCATED AT 250 WORDS) 相似文献
27.
Pulcrano M Camera L Pagano L Del Vecchio S Ferone D Bodei L Murgia A Pace L Storto G Paganelli G Colao A Salvatore M Lombardi G Biondi B 《Journal of endocrinological investigation》2008,31(4):352-359
The identification of patients with von Hippel-Lindau (VHL) disease dictates accurate genetic counseling of family members, whereas screening for early detection of visceral and neurological involvement is usually performed by a combination of radiological and nuclear medicine techniques such as ultrasonography or contrast-enhanced computed tomography of the upper abdomen, magnetic resonance imaging of the central nervous system and 131I-metaiodobenzylguanidine-scintigraphy. The role of 111-indium-diethylenetriaminepentaacetic acid [111In-DTPA0] octreotide scintigraphy in this clinical context has never been investigated. Here, we report imaging findings in a VHL patient and in 3 consecutive family members undergoing clinical and radiological screening that included [111In-DTPA0] octreotide scintigraphy in addition to the above-mentioned procedures. Somatostatin receptor expression was investigated in vitro by immunohistochemistry in pancreatic tumor sections. On the basis of in vivo and in vitro findings, octreotide long-acting release treatment followed by 90Y-1,4,7,10-Tetraazacyclododecane-N,N',N',N'-tetraacetic acid (DOTA0)-Tyr3-octreotide led to a lack of progression in this patient although this result is a possibility which needs to be proved by further investigation and longer follow-up. The results of this study suggest that [111In-DTPA0] octreotide scintigraphy may be helpful in the routine work-up of VHL patients for diagnostic and therapeutic purposes. 相似文献
28.
Cammarota G Martino A Pirozzi GA Cianci R Cremonini F Zuccalà G Cuoco L Ojetti V Montalto M Vecchio FM Gasbarrini A Gasbarrini G 《Gastrointestinal endoscopy》2004,60(5):732-738
BACKGROUND: New generation videoendoscopes potentially may visualize duodenal villi. This study compared endoscopic findings with this type of instrument to the histopathologic evaluation of duodenal villi. METHODS: A total of 191 patients underwent upper endoscopy for the purpose of obtaining duodenal biopsy specimens. The findings were assessed independently by 3 experienced observers by using a commercially available, high-resolution, high-magnifying (x2) videoendoscope. The duodenal villous profile was determined by endoscopic magnification and by endoscopic magnification after filling the duodenum with water. With both endoscopic magnification and endoscopic magnification after filling the duodenum with water, villous patterns were scored as the following: definitely present, partially present, or definitely absent. Villous patterns also were histopathologically scored as the following: normal, partial villous pattern, or total villous atrophy. RESULTS: Interobserver variability was excellent (kappa = 0.93). The concordance between either endoscopic magnification or endoscopic magnification after filling the duodenum with water and histology was 100% for presence/absence of villi. The sensitivity, the specificity, and the positive and negative predictive values of endoscopic magnification for detection of any villous abnormality were 95%, 99%, 95%, and 99%, respectively; the respective values of endoscopic magnification after filling the duodenum with water were 95%, 98%, 92%, and 99%. CONCLUSIONS: High-resolution magnifying upper endoscopy can reliably predict the presence or the absence of duodenal villi. 相似文献
29.
Complete remission of refractory anemia following a single high dose of cyclophosphamide 总被引:1,自引:0,他引:1
Ferrara F Copia C Annunziata M di Noto R Russo C Palmieri S Spasiano A del Vecchio L 《Annals of hematology》1999,78(2):87-88
We describe a case of stable complete remission in a patient with refractory anemia complicated by severe autoimmune hemolytic
anemia, achieved with a single high dose (4 g/m2) of cyclophosphamide (cyclo). Concomitantly, an effective mobilization of CD34-positive cells was induced. Other immunosuppressive
approaches including high-dose methylprednisolone, high-dose immunoglobulin, and cyclosporine had been ineffective. This finding
suggests that, in selected cases, an immunologic mechanism may mediate cytopenia in myelodysplastic syndromes (MDS). In addition,
it demonstrates that successful mobilization of peripheral blood stem cells can be induced with high-dose cyclo in MDS.
Received: September 14, 1998 / Accepted: October 9, 1998 相似文献
30.
Restrictive diastolic abnormalities identified by Doppler echocardiography in patients with thalassemia major 总被引:7,自引:0,他引:7
The consequences of transfusional iron overload on left ventricular diastolic filling have never been investigated systematically in patients with thalassemia major. In the present study, the pattern of left ventricular filling was assessed by Doppler echocardiography in 32 patients with thalassemia major (age, 17 +/- 5 years) who had not experienced symptoms of heart failure and had normal left ventricular systolic function. Data were compared with those obtained in 32 age-matched and sex-matched normal subjects. An abnormal Doppler pattern of left ventricular filling with increased flow velocity at mitral valve opening followed by an abrupt and premature decrease of flow velocity in early diastole was identified in the patients with thalassemia. Peak flow velocity in early diastole was increased in patients compared with controls (90 +/- 10 vs. 81 +/- 15 cm/sec; p less than 0.01), and rate of deceleration of flow velocity after the early diastolic peak and the ratio between the early and late (atrial) peaks of flow velocity were also increased (1,050 +/- 325 vs. 762 +/- 193 cm/sec2 and 2.7 +/- 0.7 vs. 2.2 +/- 0.5, respectively; p less than 0.001), whereas flow velocity deceleration time was reduced (97 +/- 22 vs. 119 +/- 19 msec; p less than 0.001). This Doppler pattern of diastolic filling is usually described as "restrictive" and reflects a decrease in left ventricular chamber compliance. A restrictive pattern of left ventricular filling was also identified in the subgroup of 16 study patients who had undergone optimal iron chelation therapy with deferoxamine.(ABSTRACT TRUNCATED AT 250 WORDS) 相似文献