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D Popov M Hasu N Ghinea N Simionescu M Simionescu 《Journal of molecular and cellular cardiology》1992,24(9):989-1002
We investigated whether cardiomyocytes express specific albumin binding proteins (ABP) which may function in the dissociation of fatty acids from their non-covalent complexes with albumin. The experiments were performed on rat neonatal cardiomyocytes (freshly isolated and up to 3 days in culture) and on an enriched sarcolemmal fraction isolated from adult rabbit ventricular myocardium. Three types of experiments were conducted: (a) identification of ABP on electroblots of cardiomyocytes and sarcolemmal extracts reacted with [125I]-bovine serum albumin ([125I]Alb); (b) kinetic assays of [125I]Alb interaction with cardiomyocytes (at 37 degrees C), and with a sarcolemmal fraction (at 4 degrees C); (c) affinity isolation of ABP from solubilized radioiodinated sarcolemmal proteins interacted with an albumin-agarose matrix. The investigation showed that: first, two pairs of polypeptides (ABP of M(r) 18 and 31 kDa) in either cardiomyocytes or sarcolemmal fraction reacted on electroblots with [125I]Alb; second, the binding of the latter to cardiomyocytes was saturable and competed by unlabeled albumin: 50 microM albumin reduced by approximately 90% the binding of radiolabeled albumin. The sarcolemmal fraction bound [125I]Alb with a Kd of 3.66 x 10(-7) M. Thirdly, among the sarcolemmal proteins retained by the albumin-agarose matrix (18 and 31 kDa), the most prominent was the lower band (approximately 16 kDa) of the 18 kDa pair of ABP. The observations revealed that albumin interacts with relatively high affinity with specific binding sites on cardiomyocyte sarcolemma. This interaction may be a recognition step for subsequent fatty acid dissociation and translocation. 相似文献
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The authors assessed the efficacy of the prevention of frequently or continuously relapsing supraventricular (7 cases) and ventricular (8 cases) tachycardia as well as ventricular fibrillation (16 patients) with the help of overdrive pacing. In 28 out of 31 patients (90.3%) the therapy was successful in preventing arrhythmia relapses including patients with the syndrome of an increased QT interval. Overdrive pacing of the atria was more effective as compared to that of the ventricles (93% versus 71.4%). The effective frequency of overdrive pacing of the atria was 40.5% lower as against ventricular stimulation. The suppression of ectopic rhythm was achieved by increasing the heart rate on the average from 82.4 +/- 5.9 to 108.7 +/- 10.4 per minute. The administration of antiarrhythmic drugs made it possible to decrease significantly the frequency of electric impulses. 相似文献
35.
Diabetic mice (6 weeks duration) were studied to assess the interaction of advanced glycation endproduct-modifed albumin
(AGE-Alb) with micro- and macrovascular endothelium, and to evaluate the alterations induced in the ultrastructure of the
lung, kidney, and aorta. [125I]-AGE-Alb and AGE-Alb-Au were perfused in situ in the vasculature; the total uptake was quantitated by spectrometry, and
the endothelial pathways of AGE-Alb-Au and the morphological alterations of the vascular beds were examined by electron microscopy.
The results showed that [125I]-AGE-Alb (0.567 μM) was taken up specifically and saturably by all organs studied, and particularly by the lung. AGE-Alb-Au
endocytosis and transcytosis occurred in the pulmonary and aortic endothelia, and were enhanced in diabetic animals. Also
in diabetic animals, AGE-Alb-Au was detected throughout the kidney glomerular basement membrane (GBM) and within open filtration
slits of podocytes, suggesting altered barrier function. The structural modifications progressed, and at the end of the experimental
period, in the lung ∼28% of the capillaries and ∼25% of the alveoli became compressed or even collapsed, due to the hyperplasia
of extracellular matrix and interstitial connective tissue. The presence of adherent intravascular macrophages suggests the
development of an inflammatory immune process. The structural modifications observed in kidney glomeruli included thickening
(∼30%) of the GBM and the disappearance of diaphragms between the cellular processes of podocytes. The aortic endothelium
displayed luminal foldings, increased number (2.8-fold) of Weibel-Palade bodies, and proliferation of basal lamina. Together,
the results show that in diabetes there is enhanced vascular uptake of AGE-Alb and significant pathomorphological changes
of micro- and macrovessels.
Received: 28 June 1996 / Accepted in revised form: 8 May 1997 相似文献
36.
Dobrivoje Martinov Veljko Popov Zoran Ignjatov Robert D. Harris 《Journal of digital imaging》2013,26(2):209-216
Evolution of communication systems, especially internet-based technologies, has probably affected Radiology more than any other medical specialty. Tremendous increase in internet bandwidth has enabled a true revolution in image transmission and easy remote viewing of the static images and real-time video stream. Previous reports of real-time telesonography, such as the ones developed for emergency situations and humanitarian work, rely on high compressions of images utilized by remote sonologist to guide and supervise the unexperienced examiner. We believe that remote sonology could be also utilized in teleultrasound exam of infant hip. We tested feasibility of a low-cost teleultrasound system for infant hip and performed data analysis on the transmitted and original images. Transmission of data was accomplished with Remote Ultrasound (RU), a software package specifically designed for teleultrasound transmission through limited internet bandwidth. While image analysis of image pairs revealed statistically significant loss of information, panel evaluation failed to recognize any clinical difference between the original saved and transmitted still images. 相似文献
37.
Koda Samantha A. Subramaniam Kuttichantran Pouder Deborah B. Yanong Roy P. Frasca Salvatore Popov Vsevolod L. Waltzek Thomas B. 《Virus genes》2021,57(5):448-452
Virus Genes - The genus Megalocytivirus includes viruses known to cause significant disease in aquacultured fish stocks. Herein, we report the complete genome sequences of two megalocytiviruses... 相似文献
38.
Nuno Rocha Patrícia V. Mendonça Joana P. Mendes Pedro N. Simões Anatoliy V. Popov Tamaz Guliashvili Arménio C. Serra Jorge F. J. Coelho 《Macromolecular chemistry and physics.》2013,214(1):76-84
The synthesis of polystyrene (PS) by atom transfer radical polymerization using the Fe(0)/CuBr2 catalytic system in dimethylformamide is reported. The effects of temperature, ligand, initiator structure, and monomer to solvent ratio on the polymerization kinetics are evaluated. PS with high molecular weight, low polydispersity, and telechelic structure are achieved and successfully used for further reinitiation or the copper(I)‐catalyzed Huisgen 1,3‐dipolar cycloaddition click reaction between alkyne‐ and azide‐terminated PS. For the first time, suitable styrene polymerization rates are achieved using this cost‐effective and environmentally attractive catalytic system. This method can be very useful in macromolecular engineering to afford PS‐based materials with well‐controlled structure. 相似文献
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