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61.
Rohrmann S Becker N Linseisen J Nieters A Rüdiger T Raaschou-Nielsen O Tjønneland A Johnsen HE Overvad K Kaaks R Bergmann MM Boeing H Benetou V Psaltopoulou T Trichopoulou A Masala G Mattiello A Krogh V Tumino R van Gils CH Peeters PH Bueno-de-Mesquita HB Ros MM Lund E Ardanaz E Chirlaque MD Jakszyn P Larrañaga N Losada A Martínez-García C Agren A Hallmans G Berglund G Manjer J Allen NE Key TJ Bingham S Khaw KT Slimani N Ferrari P Boffetta P Norat T Vineis P Riboli E 《Cancer causes & control : CCC》2007,18(5):537-549
Introduction Lymphomas are a heterogeneous group of malignant diseases of cells of the immune system. The best-established risk factors
are related to dys-regulation of immune function, and evidence suggests that factors such as dietary or lifestyle habits may
be involved in the etiology.
Material and methods In the European Prospective Investigation into Cancer and Nutrition (EPIC), 849 lymphoma cases were identified in a median
follow-up period of 6.4 years. Fruit and vegetable consumption was estimated from validated dietary questionnaires. Cox proportional
hazard models were used to examine the association between fruit and vegetable intake with the risk of lymphomas overall and
subentities.
Results There was no overall association between total fruit and vegetable consumption and risk of lymphoma [hazard ratio (HR) = 0.95,
95% confidence interval (CI) 0.78–1.15 comparing highest with lowest quartile]. However, the risk of diffuse large B-cell
lymphomas (DLBCL) tended to be lower in participants with a high intake of total vegetables (HR = 0.49, 95% CI 0.23–1.02).
Conclusion In this large prospective study, an inverse associations between fruit and vegetable consumption and risk of lymphomas overall
could not be confirmed. Associations with lymphoma subentities such as DLBCL warrant further investigation.
The work described in this article was carried out with the financial support of: Europe Against Cancer Program of the European
Commission (SANCO); Deutsche Krebshilfe, Deutsches Krebsforschungszentrum, German Federal Ministry of Education and Research;
Danish Cancer Society; Health Research Fund (FIS) of the Spanish Ministry of Health, Spanish Regional Governments of Andalucia,
Asturia, Basque Country, Murcia and Navarra; the ISCIII Network RCESP (C03/09), Spain; Cancer Research UK; Medical Research
Council, United Kingdom; Stroke Association, United Kingdom; British Heart Foundation; Department of Health, United Kingdom;
Food Standards Agency, United Kingdom; Wellcome Trust, United Kingdom; Greek Ministry of Health; Greek Ministry of Education;
Italian Association for Research on Cancer (AIRC); Italian National Research Council, Fondazione-Istituto Banco Napoli, Italy;
Compagnia di San Paolo; Dutch Ministry of Public Health, Welfare and Sports; World Cancer Research Fund; Swedish Cancer Society;
Swedish Scientific Council; Regional Government of Sk?ne, Sweden; Norwegian Cancer Society; Research Council of Norway; French
League against Cancer (LNCC); National Institute for Health and Medical Research (INSERM), France; Mutuelle Générale de l’Education
Nationale (MGEN), France; 3M Co, France; Gustave Roussy Institute (IGR), France; and General Councils of France. 相似文献
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Cust AE Allen NE Rinaldi S Dossus L Friedenreich C Olsen A Tjønneland A Overvad K Clavel-Chapelon F Boutron-Ruault MC Linseisen J Chang-Claude J Boeing H Schulz M Benetou V Trichopoulou A Trichopoulos D Palli D Berrino F Tumino R Mattiello A Vineis P Quirós JR Agudo A Sánchez MJ Larrañaga N Navarro C Ardanaz E Bueno-de-Mesquita HB Peeters PH van Gils CH Bingham S Khaw KT Key T Slimani N Riboli E Kaaks R 《International journal of cancer. Journal international du cancer》2007,120(12):2656-2664
We conducted a case-control study nested within the European Prospective Investigation into Cancer and Nutrition, to examine the associations between prediagnostic serum concentrations of C-peptide, insulin-like growth factor binding protein (IGFBP)-1 and IGFBP-2, and endometrial cancer risk. Among pre- and post-menopausal women, who were not currently using exogenous hormones, 286 women developed incident endometrial cancer during an average 5.1 years follow-up. Using risk set sampling, 555 matched control subjects were selected. In conditional logistic regression models adjusted for matching factors only, endometrial cancer risk increased with increasing serum levels of C-peptide (relative risks (RR) for the top vs. bottom quartile = 2.13 [95% confidence interval (CI) 1.33-3.41], p(trend) = 0.001, and decreasing serum levels of IGFBP-2 (RR for the top vs. bottom quartile = 0.56 [95% CI 0.35-0.90], p(trend) = 0.03, but was not significantly associated with IGFBP-1 levels (RR for the top vs. bottom quartile = 0.76 [95% CI 0.47-1.21], p(trend) = 0.25). In BMI-adjusted models, only the C-peptide association remained marginally statistically significant (RR for the top vs. bottom quartile = 1.56 [95% CI 0.94-2.57], p(trend) = 0.05 for C-peptide; 0.84 [95% CI 0.50-1.40], p(trend) = 0.74 for IGFBP-2; and 1.08 [95% CI 0.65-1.78], p(trend) = 0.86 for IGFBP-1 levels). These associations were stronger among nonfasting women (< or =< or =6 hr since last meal; 63% of subjects) but were not evident among fasting women, although the interactions were not statistically significant. The C-peptide-risk association was substantially attenuated after adjustment for free estradiol in postmenopausal women (RR for the top vs. bottom quartile = 1.28 [95% CI 0.67-2.45], p(trend) = 0.42. Our results provide modest support to the hypothesis that hyperinsulinaemia is a risk factor for endometrial cancer. 相似文献
65.
Keenan HA Poznik GD Varo N Schneider J Almasy L Warram JH Duggirala R Schoenbeck U Krolewski AS Doria A 《Atherosclerosis》2008,196(2):863-870
ObjectiveIndividual propensity to chronic, low-grade inflammation—a determinant of atherosclerosis-is in part under the control of genetic factors. To identify genes involved in this modulation, we performed a 10 cM genome screen for linkage with plasma C-reactive protein in 38 extended families including 317 non-diabetic and 177 type 2 diabetic family members (2547 relative pairs).Methods and resultsIn a variance component analysis, heritability of CRP values was significant (h2 = 0.39, p < 0.0001). This effect was independent of BMI and was present in both diabetic (h2 = 0.42, p = 0.003) and non-diabetic (h2 = 0.34, p = 0.0015) relatives. The strongest evidence of linkage with CRP was on chromosome 5p15, where the LOD score reached genome-wide significance (LOD = 3.41, genome-wide p = 0.013). Both diabetic and non-diabetic family members contributed to linkage at this location. Smaller linkage peaks were detected on chromosomes 5q35 (LOD = 1.35) and 17p11 (LOD = 1.33). When the analysis was restricted to diabetic family members, another peak of moderate intensity (LOD = 2.17) was evident at 3p21.ConclusionsA major gene influencing CRP levels appears to be located on chromosome 5p15, with an effect that is independent of diabetes. Another gene on 3p21 may control CRP variation but only in the presence of a diabetic or insulin-resistant environment. 相似文献
66.
Cristina Pérez Julia González-Rincón Arantza Onaindia Carmen Almaráz Nuria García-Díaz Helena Pisonero Soraya Curiel-Olmo Sagrario Gómez Laura Cereceda Rebeca Madureira Mercedes Hospital Dolores Suárez-Massa José L. Rodriguez-Peralto Concepción Postigo Alicia Leon-Castillo Carmen González-Vela Nerea Martinez Pablo Ortiz-Romero Margarita Sánchez-Beato Miguel á. Piris José P. Vaqué 《Haematologica》2015,100(11):e450-e453
67.
Acute cellular rejection versus recurrent hepatitis C after liver transplantation: Clinical and pathological features driving a rational diagnostic approach
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