全文获取类型
收费全文 | 4662篇 |
免费 | 233篇 |
国内免费 | 9篇 |
专业分类
耳鼻咽喉 | 59篇 |
儿科学 | 304篇 |
妇产科学 | 135篇 |
基础医学 | 576篇 |
口腔科学 | 105篇 |
临床医学 | 333篇 |
内科学 | 1140篇 |
皮肤病学 | 97篇 |
神经病学 | 165篇 |
特种医学 | 102篇 |
外科学 | 696篇 |
综合类 | 188篇 |
一般理论 | 1篇 |
预防医学 | 219篇 |
眼科学 | 196篇 |
药学 | 296篇 |
1篇 | |
中国医学 | 16篇 |
肿瘤学 | 275篇 |
出版年
2024年 | 12篇 |
2023年 | 34篇 |
2022年 | 85篇 |
2021年 | 176篇 |
2020年 | 81篇 |
2019年 | 128篇 |
2018年 | 159篇 |
2017年 | 109篇 |
2016年 | 124篇 |
2015年 | 141篇 |
2014年 | 180篇 |
2013年 | 221篇 |
2012年 | 350篇 |
2011年 | 349篇 |
2010年 | 194篇 |
2009年 | 154篇 |
2008年 | 251篇 |
2007年 | 265篇 |
2006年 | 197篇 |
2005年 | 177篇 |
2004年 | 172篇 |
2003年 | 152篇 |
2002年 | 138篇 |
2001年 | 92篇 |
2000年 | 99篇 |
1999年 | 82篇 |
1998年 | 37篇 |
1997年 | 21篇 |
1996年 | 13篇 |
1994年 | 21篇 |
1993年 | 14篇 |
1992年 | 61篇 |
1991年 | 66篇 |
1990年 | 52篇 |
1989年 | 64篇 |
1988年 | 36篇 |
1987年 | 41篇 |
1986年 | 33篇 |
1985年 | 36篇 |
1984年 | 16篇 |
1983年 | 24篇 |
1982年 | 21篇 |
1980年 | 12篇 |
1979年 | 25篇 |
1977年 | 12篇 |
1976年 | 22篇 |
1973年 | 16篇 |
1969年 | 13篇 |
1968年 | 13篇 |
1966年 | 14篇 |
排序方式: 共有4904条查询结果,搜索用时 15 毫秒
11.
K K Sethi N Pandit M Bhargava J C Mohan R Arora M Khalilullah 《Indian heart journal》1992,44(3):145-149
The long term performance of various pacing leads in use for at least one year is reported from one centre. Between January 1975 and December 1990, 1056 cardiac pacing leads were implanted in 881 patients (mean age 57 +/- 13 years). Eight hundred and three leads were silicone insulated (SI) and 253 leads were polyurethane insulated (PUI). Leads from different manufacturers were used (Medtronic, CPI, Telectronics). The average duration of follow up was 56.6 +/- 77 months (range 12-221 months) for SI and 47.1 +/- 24 months (range 12-99 months) for PUI leads. Overall lead failure occurred more often in the PUI group (n = 46, 18.2%) compared to SI group (n = 93, 11.3%, p < 0.025). Majority of lead failures occurred in the first 36 months after implantation. In particular, Medtronic models 6971, 6972 (urethane) and 6901 (silicone) showed higher rate of complications (25.5%, 26.3% and 44.5% respectively). 相似文献
12.
13.
Anand N Arora S Clowes M 《世界核心医学期刊文摘》2006,2(5):21-22
目的:前瞻性研究青光眼术中应用丝裂霉素C(MMC)对于结膜滤过泡高危因素如无血管化、经结膜的渗漏(TCO)和滤过泡裂孔的影响。方法:一位观察者对进行了青光眼手术联合MMC的125例连续患者的125只眼进行为期2年的前瞻性研究,这些患者最初都成功地建立了滤过通道。巩膜瓣切开前将MMC置于该区,多数患者MMC0.2g/L持续2min。青光眼手术包括小梁切除术、深巩膜切除术和联合手术。将干燥的荧光素试纸置于滤过泡的无血管区,以观察房水外流[点渗漏(PL)或未流出(TCO)]。 相似文献
14.
M Herz V Arora B N Campaigne H E Scholtz M A Potgieter W Mollentze 《Suid-Afrikaanse tydskrif vir geneeskunde》2003,93(3):219-223
OBJECTIVE: To compare the effects of Humalog Mix25 (Humalog Mix75/25 in the USA) (Mix25) and human insulin 30/70 (30/70) on the 24-hour inpatient plasma glucose (PG) profile in patients with type 2 diabetes mellitus (T2DM). DESIGN: A randomised, open-label, 8-week crossover study. Study insulins were injected twice daily, 5 minutes before breakfast and dinner. SETTING: Four-week outpatient (dose-adjustment) treatment phase, and 3-day inpatient (test) phase. PATIENTS: Twenty-five insulin-treated patients with T2DM (ages 40-66 years), mean (+/- standard error of the mean) (SEM) HbA1c 7.7% +/- 0.23%, and body mass index (BMI) 29.3 +/- 0.83 kg/m2. OUTCOME MEASURES: 24-hour PG profiles, PG excursions after meals, PG area under the curve (AUC), and 30-day hypoglycaemia rate. RESULTS: The 2-hour PG excursions following breakfast (5.5 +/- 0.34 v. 7.2 +/- 0.34 mmol/l, p = 0.002) and dinner (2.4 +/- 0.27 v. 3.4 +/- 0.27 mmol/l, p = 0.018) were smaller with Mix25 than with 30/70. PG AUC between breakfast and lunch was smaller with Mix25 than with 30/70 (77.6 +/- 3.8 v. 89.5 +/- 4.3 mmol/h/ml, p = 0.001). PG AUC between lunch and dinner, dinner and bedtime, and bedtime and breakfast did not differ between treatments. Pre-meal and nocturnal PG were comparable. The postprandial insulin requirement for lunch meals was supplied equally by the two insulin treatments. The thirty-day hypoglycaemia rate was low (Mix25 0.049 +/- 0.018 v. 30/70 0.100 +/- 0.018 episodes/patient/30 days, p = 0.586) for both treatments. CONCLUSION: In patients with T2DM, Mix25 improved the 24-hour PG profile with lower postprandial PG excursions than with human insulin 30/70. 相似文献
15.
Geoffrey P. J. Mullan Christos Georgalas Asit Arora Anthony Narula 《European archives of oto-rhino-laryngology》2007,264(6):685-688
Tracheal rupture represents a rare but serious complication of intubation. We discuss a case of a major post-intubation rupture.
After investigation with CT scan tracheoscopy and bronchoscopy a low tracheostomy was formed protecting the rupture from pressure
changes associated with ventilation. The patient was managed with minimal surgical intervention, low tracheostomy with antibiotic
cover and monitoring in the intensive care unit for 24 h before being woken and moved to a ward after 48 h. The patient made
a full and uncomplicated recovery and was discharged 2 weeks after the original injury. Most of the literature on the subject
is made up of review of case reports that conclude management of such a major tear must be with surgical repair. This however
confers significant morbidity and an associated high mortality. We suggest an alternative management protocol. 相似文献
16.
R. S. Arora J. Mercer M. Thornley K. Tylee J. E. Wraith 《Journal of inherited metabolic disease》2007,30(5):821
Summary We describe a cohort of 14 Hurler–Scheie patients homozygous for the p.Leu490Pro missense mutation in the α-l-iduronidase gene. Now based in the UK, they are all of Pakistani/Kashmiri descent; 64% were female; 11/14 (79%) had a sibling
or cousin with MPS I and the parents are consanguineous in all cases. The median age at diagnosis was 1.8 years (range from
antenatal diagnosis to 16.5 years). Twelve were on ERT with recombinant human α-l-iduronidase (IDUA; Laronidase, Genzyme) for a median duration of 22.5 months (range 2–71 months) and median age at commencement
of ERT was 8.6 years (range 0.4–23.1 years). There was clear improvement in the size of liver and spleen as well as reduction
in urine glycosaminoglycans (GAGs). The mean (range) urine GAG levels in mg/mmol creatinine were 63.4 (28.9–105.6), 28.3 (10.9–41.4),
22.8 (12.1–43.1), 15.7 (9.2–24.8) and 16.3 (10.1–21.0) at commencement, 3 months post ERT, 6 months post ERT, 12 months post
ERT and 24 months post ERT, respectively. Effects on growth were not clear as there does not seem to be an obvious trend of
increase or decrease in height after commencement of ERT and this seems to be the case regardless of the age at which ERT
was started.
Electronic Supplementary Material The online version of this article (doi:) contains supplementary material, which is available to authorized users.
Online citation: JIMD Short Report #059 (2007) Online 相似文献
17.
18.
Maurizio Fava Michael E Thase Charles DeBattista Karl Doghramji Sanjay Arora Rod J Hughes 《Annals of clinical psychiatry》2007,19(3):153-159
BACKGROUND: Partial response, no response, or residual symptoms following antidepressant therapy is common in clinical psychiatry. This study evaluated modafinil in patients with major depressive disorder (MDD) who were partial responders to adequate selective serotonin reuptake inhibitor (SSRI) therapy and excessive sleepiness and fatigue. METHODS: This retrospective analysis pooled the data of patients (18-65 yrs) who participated in two randomized, double-blind, placebo-controlled studies of modafinil (6-week, flexible-dose study of 100-400 mg/day or 8-week, fixed-dose study of 200 mg/day) plus SSRI therapy. Patients (n=348) met criteria for several residual symptoms (Epworth Sleepiness Scale [ESS] score>or=10; 17-item Hamilton Depression Scale [HAM-D] score between 4 and 25; and Fatigue Severity Scale [FSS] score>or=4). RESULTS: Compared to placebo, modafinil augmentation rapidly (within 1 week) and significantly improved overall clinical condition (Clinical Global Impression-Improvement), wakefulness (ESS), depressive symptoms (17-item HAM-D), and fatigue (FSS) (p<.01 for all). At final visit, patients receiving modafinil augmentation experienced statistically significant improvements in overall clinical condition, wakefulness, and depressive symptoms. Modafinil was well tolerated in combination with SSRI. CONCLUSIONS: Results of this pooled analysis provide further evidence suggesting that modafinil is an effective and well-tolerated augmentation therapy for partial responders to SSRI therapy, particularly when patients continue to experience fatigue and excessive sleepiness. 相似文献
19.
P. Arora V. Kher P. K. Rai M. K. Singhal S. Gulati A. Gupta 《Pediatric nephrology (Berlin, Germany)》1997,11(2):153-155
Various factors were analyzed in 80 consecutive children under 16 years who had acute renal failure (ARF), for various prognostic
factors. Overall mortality was 42.5%, with significantly higher levels seen in hemolytic uremic syndrome (68%, P <0.05) and associated with cardiac surgery (90.9%, P <0.01). Anuria (67.6% vs. 43.5%, P <0.05), need for dialysis (85.3% vs. 56.5%, P <0.05), neurological complications (50% vs. 6.3%, P <0.01), and respiratory complications (35.2% vs. 2.1%, P <0.01) were significantly higher in nonsurvivors than survivors. Multiple regression analysis showed the presence of neurological
and respiratory complications to be poor prognostic factors.
Received May 2, 1995; received in revised form August 28, 1996; accepted September 13, 1996 相似文献
20.
G. Michael Taylor Thomas J. Neuhaus Vanita Shah Susannah Dillon T. Martin Barratt 《Pediatric nephrology (Berlin, Germany)》1997,11(4):404-410
Experimental studies have pointed to charge selectivity as an important determinant of glomerular permeability to macromolecules.
Loss of glomerular basement membrane (GBM) polyanion has been proposed as a cause of the selective proteinuria in minimal
change nephrotic syndrome (MCNS). However, the presence of less-anionic albumin in urine than plasma from MCNS and focal and
segmental glomerulosclerosis (FSGS) patients has been interpreted both as evidence for partial maintenance of charge selectivity
and for involvement of other pathogenic mechanisms. The exact role of charge selectivity in the pathogenesis of nephrotic
proteinuria remains controversial. We have examined the clearance of endogenous proteins of differing size and charge in children
with idiopathic nephrotic syndrome (NS). Chromatofocusing was used to determine the isoelectric points (pIs) of albumins in
paired plasma and urine samples from patients with FSGS (n = 6) and MCNS (n = 6). Charge selectivity was assessed by comparing the pIs of the fractions with the highest albumin concentration (modal
pI) in plasma and urine. The difference between the modal pIs was defined as the delta modal pI. Charge selectivity was also
assessed from the albumin/transferrin and IgG4/IgG1 clearance ratios; size selectivity from the IgG1/albumin and IgG1/transferrin
as well as the IgG4/albumin and IgG4/transferrin clearances. In children with FSGS, the mean (± SD) delta modal pI was – 0.05
± 0.16, and in MCNS – 0.05 ± 0.11. Neither value differed significantly from zero. The albumin/transferrin clearance ratio
showed no significant difference between FSGS and MCNS, but the IgG4/IgG1 clearance ratio was significantly higher in MCNS
(P<0.05). Size selectivity was significantly reduced in FSGS compared with MCNS (for IgG1/transferrin P<0.01 and for IgG1/albumin P<0.05). For IgG4/transferrin and IgG4/albumin, P was <0.05. In conclusion, there was no evidence for residual charge selectivity in idiopathic NS associated with either MCNS
or FSGS during nephrotic-range proteinuria. There was a significant loss of GBM size selectivity in children with FSGS with
heavy proteinuria compared with children with MCNS with heavy proteinuria.
Received August 7, 1996; received in revised form and accepted December 16, 1996 相似文献