全文获取类型
收费全文 | 5137篇 |
免费 | 246篇 |
国内免费 | 6篇 |
专业分类
耳鼻咽喉 | 57篇 |
儿科学 | 522篇 |
妇产科学 | 106篇 |
基础医学 | 630篇 |
口腔科学 | 89篇 |
临床医学 | 307篇 |
内科学 | 1024篇 |
皮肤病学 | 123篇 |
神经病学 | 220篇 |
特种医学 | 84篇 |
外科学 | 620篇 |
综合类 | 105篇 |
预防医学 | 333篇 |
眼科学 | 229篇 |
药学 | 643篇 |
中国医学 | 34篇 |
肿瘤学 | 263篇 |
出版年
2022年 | 62篇 |
2021年 | 101篇 |
2020年 | 64篇 |
2019年 | 77篇 |
2018年 | 121篇 |
2017年 | 79篇 |
2016年 | 101篇 |
2015年 | 125篇 |
2014年 | 166篇 |
2013年 | 217篇 |
2012年 | 285篇 |
2011年 | 301篇 |
2010年 | 202篇 |
2009年 | 152篇 |
2008年 | 279篇 |
2007年 | 271篇 |
2006年 | 287篇 |
2005年 | 247篇 |
2004年 | 253篇 |
2003年 | 227篇 |
2002年 | 169篇 |
2001年 | 117篇 |
2000年 | 141篇 |
1999年 | 111篇 |
1998年 | 36篇 |
1997年 | 26篇 |
1996年 | 21篇 |
1994年 | 20篇 |
1993年 | 32篇 |
1992年 | 73篇 |
1991年 | 67篇 |
1990年 | 71篇 |
1989年 | 65篇 |
1988年 | 70篇 |
1987年 | 59篇 |
1986年 | 59篇 |
1985年 | 64篇 |
1984年 | 51篇 |
1983年 | 41篇 |
1980年 | 37篇 |
1979年 | 38篇 |
1978年 | 31篇 |
1977年 | 30篇 |
1975年 | 37篇 |
1974年 | 38篇 |
1973年 | 23篇 |
1972年 | 25篇 |
1971年 | 26篇 |
1970年 | 31篇 |
1969年 | 19篇 |
排序方式: 共有5389条查询结果,搜索用时 15 毫秒
51.
The distribution of cardiac output (c.o.) was measured by the radioactive microsphere method in rats at different time intervals after the implantation of carrageenanimpregnated sponges. The amount of blood distributed to the developing granulomata increased from day 5 after sponge implantation to day 7, but showed no further increase at day 10. A similar pattern in blood flow was observed in the skin covering the granulomata. Injection of PGE1 (100 ng) into the sponges led to an increase in blood flow, the magnitude of which became gradually larger between days 5 and 10. A similar, though less marked increase in sensitivity to PGE1 was observed in the skin covering the granulomata, PGE1 causing a significant increase in blood flow to the skin on day 10. These changes in sensitivity to exogenous PGE1 may be due to decreasing levels of endogenous PGE and/or maturation of the newly formed blood vessels in the granulation tissue. 相似文献
52.
Anuraag Shrivastav Shailly Varma Anurag Saxena John DeCoteau Rajendra K Sharma 《Journal of translational medicine》2007,5(1):58-6
Background
Colon cancer is the second leading cause of cancer deaths in the western world. If detected early, colorectal cancer is one of the most treatable forms of cancer. Unfortunately, very few people are screened. N-myristoyltransferase (NMT) catalyzes myristoylation of various proteins including oncoproteins. We have demonstrated earlier the alteration of NMT activity during the progression of colorectal cancer and established NMT as a putative therapeutic target for cancer. 相似文献53.
Escherichia coli Isolated from Domestic Animals Pathogenic for Gnotobiotic Piglets 总被引:1,自引:0,他引:1 下载免费PDF全文
Three strains of Escherichia coli isolated from infectious processes in a calf, a dog, and a cat were examined for their capacity to produce disease or death, or both, in newborn gnotobiotic piglets. The O groups represented by these particular strains of E. coli were O4: (canine origin), O6: (feline origin), and O39: (bovine origin). All three isolates upon oral administration proved to be pathogenic. Infection with the E. coli O4: (canine) or O39: (bovine) consistently produced signs of enteric coli-bacillosis and death in all 1- and 3-day-old piglets within 24 to 48 hr. The O6: (feline) isolate, on the other hand, produced a marked polyserositis and generally required 6 to 7 days to kill a piglet. Only the respective type of E. coli used in the particular trial was recovered from the diseased piglets. These findings suggest the possible role of domestic animals and household pets in the spread of potentially pathogenic E. coli to other species. 相似文献
54.
55.
Increased glomerular angiotensin II binding in rats exposed to a maternal low protein diet in utero 总被引:2,自引:0,他引:2
In the rat, protein restriction during pregnancy increases offspring blood pressure by 20–30 mmHg. We have shown in an earlier study that this is associated with a reduction in nephron number and increased glomerular sensitivity to angiotensin II (Ang II) in vivo . Hence, we hypothesized that exposure to a maternal low-protein diet increases glomerular Ang II AT1 receptor expression and decreases AT2 receptor expression. To test this hypothesis, pregnant Wistar rats were fed isocalorific diets containing either 18% (control) or 9% (LP) protein from conception until birth. At 4 weeks of age, the kidneys of male offspring were harvested to measure cortical AT1 and AT2 receptor expression, 125 I-Ang II glomerular binding, tissue renin activity, tissue Ang II and plasma aldosterone concentrations. AT1 receptor expression was increased (62%) and AT2 expression was decreased (35%) in LP rats. Maximum 125 I-Ang II (125 I-Ang II) binding ( B max ) was increased in LP rats (control n = 9, 291.6 ± 27.4 versus LP n = 7, 445.7 ± 27.4 fmol (mg glomerular protein)−1 , P < 0.01), but affinity ( K D ) was not statistically different from controls (control 2.87 ± 0.85 versus LP 0.84 ± 0.20 pmol 125 I-Ang II, P = 0.059). Renal renin activity, tissue Ang II and plasma aldosterone concentrations did not differ between control and LP rats. Increased AT1 receptor expression in LP rat kidneys is consistent with greater haemodynamic sensitivity to Ang II in vivo . This may result in an inappropriate reduction in glomerular filtration rate, salt and water retention, and an increase in blood pressure. 相似文献
56.
BCA200 has been described as a 200,000 Mr monomeric cell surface glycoprotein associated with human breast cancer. Since the physical properties and cellular distribution of BCA200 resemble those of c-erbB-2, antibodies to BCA200 were tested for the ability to bind a recombinant protein containing the c-erbB-2 extracellular domain (erbB-2 ECD). Three antibodies to distinct epitopes of BCA200 reacted with erbB-2 ECD but not with a control protein expressed in a similar baculovirus lysate. Control myeloma proteins and antibodies to four other antigens did not react with erbB-2 ECD. A protein with the expected molecular weight for erbB-2 ECD was also immunoprecipitated by anti-BCA200 antibody 520C9. We conclude that BCA200 is another synonym for c-erbB-2. 相似文献
57.
58.
Teruya Cheryl Joshi Vandana Urada Darren Trabin Tom Iturrios-Fourzan Isabel Huang Yu-Chuang 《The journal of behavioral health services & research》2022,49(2):190-203
The Journal of Behavioral Health Services & Research - Statistical reliability of the Treatment Perceptions Survey (TPS) questionnaire was examined using data from 19 California counties. The... 相似文献
59.
60.
Shrikala Acharya Maninder Singh Setia Amol Palkar Dandu Chandra Sekar Reddy Padmaja Keskar Pramod Deoraj Mugundu Ramien Parthasarthy Padum Narayan Shobhini Rajan Alok Saxena 《The International journal of health planning and management》2021,36(1):71-82
A key recommendation of the National AIDS Control Programme‐IV of India was to develop new strategies for geo‐prioritization of the human immunodeficiency virus (HIV) epidemic. We conducted this study to categorize the districts in Maharashtra (India) based on a multidimensional framework for geo‐prioritization of services. Programmatic data on trends of HIV prevalence, coverage of marginalized populations and vulnerability factors were included. A composite indicator based on these was developed, and the cumulative score was calculated for each district. HIV prevalence among general population has declined steadily from 0.60% in 2007 to 0.33% in 2017. The programme coverage was stable but inadequate for men who have sex with men (MSM). The coverage for female sex workers (FSWs) was inadequate and reduced over time. Nine districts were categorized as high priority, 13 as moderate priority and 11 were classified as low‐priority districts based on burden and vulnerability for HIV. The high‐priority districts were Pune, Solapur and Yavatmal for FSW interventions and Pune, Thane and Latur for MSM interventions. This multidimensional indicator is based on existing programmatic data, dynamic and can be made state‐specific. It is useful to categorize and prioritize districts for allocation of resources and geo‐prioritization of services in resource limited settings. 相似文献