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101.
In contrast to the systolic blood pressure at the posterior tibial artery, the evaluation of pressure at the digital artery of the foot before and after exercise in patients with peripheral arterial disease is not well known. Twenty three patients with peripheral vascular disease were examined. The systolic pressure was measured by means of an ultrasound velocity detector at the brachial and posterior tibial artery. Digital artery pressure was determined with photoplethysmography. Pressures were measured before and within 5 and 10 minutes after a treadmill test. Ankle and toe index was calculated. At rest the toe index is lower than the ankle index and after a treadmill test the decrease in toe index occurs in parallel to the ankle index. 相似文献
102.
M G Van Luijtelaar F G Wouterlood J A Tonnaer H W Steinbusch 《Synapse (New York, N.Y.)》1991,8(3):162-168
Degeneration of neurons in the central nervous system is associated with morphological changes. Previous observations made at the light microscopical level indicated degeneration of serotonin-immunoreactive (IR) fibers in the aged rat brain. In this study, a comparison at the ultrastructural level was made between serotonin-IR normal thin and aberrant swollen varicose fibers in the caudate-putamen complex of the aged rat. Ultrastructural features such as the size and content of the thin varicose fibers resembled those in the caudate-putamen complex of the young rat as reported by others. The aberrant profiles were swollen, reaching a size of 6 microns. Their vesicles varied in size and were no longer uniformly round. Moreover, distorted mitochondria and membrane-filled vacuolelike structures were a common feature of the aberrant profiles. These changes are indicative of a degenerative process and give further evidence that, whereas many serotonergic fibers are preserved at high age, other serotonergic fibers are degenerating in the caudate-putamen complex of the aged rat. 相似文献
103.
1背景 育龄妇女常见慢性下腹痛,可造成身体损害、情绪忧伤及导致巨大的健康服务费用。美国在这方面的花费超过8亿8千万美元(Mathias 1996)。英国全国数据库的一般性诊治资料显示,慢性下腹痛发病率及流行率与偏头痛、背部痛、哮喘发病率相似(Zondervan 1999)。 相似文献
104.
Genotyping of Chlamydia trachomatis in Urine Specimens Will Facilitate Large Epidemiological Studies 总被引:4,自引:0,他引:4 下载免费PDF全文
Servaas A. Morr Robert Moes Irene Van Valkengoed Joan P. Boeke Jacques T. M. van Eijk Chris J. L. M. Meijer Adriaan J. C. Van den Brule 《Journal of clinical microbiology》1998,36(10):3077-3078
The serovars of Chlamydia trachomatis-positive urine specimens (n = 81; as detected by PCR and ligase chain reaction) were successfully analyzed in 94% of cases by omp1 PCR-based RFLP analysis. The use of urine specimens and this simple and sensitive typing method will greatly facilitate epidemiological studies of C. trachomatis serovar distribution in asymptomatic C. trachomatis infections in both females and males. 相似文献
105.
Male subfertility induced by acute scrotal heating affects embryo quality in normal female mice 总被引:5,自引:0,他引:5
Jannes P; Spiessens C; Van der Auwera I; D'Hooghe T; Verhoeven G; Vanderschueren D 《Human reproduction (Oxford, England)》1998,13(2):372-375
The aim of this experiment was to design a suitable mouse model for male
subfertility in which to study the effect of decreased sperm quality on
embryo quality in vivo and in vitro. To achieve male subfertility, testes
of adult male mice were immersed in water at either 42 degrees C (heated)
or 33 degrees C (controls) during 20 min. Twenty-eight days after
treatment, all heat stressed males showed a significant decrease in
relative testis weight [384.7 mg in controls (286.7-460.6) versus 323 mg in
stress heated groups (117.9-405.6); P < 0.001], sperm concentration
[3.75 x 10(6)/ml (2.75-7.25) versus 1.00 x 10(6)/ml (0-4.00); P < 0.001]
and progressive sperm motility [57.5% (48.0-79.0) versus 42.5% (14.0-66.0);
P < 0.001]. Moreover, after mating to heat exposed males, not only the
number of pregnant females (20/22 versus 18/30) but also the weight of
their embryos [275.4 mg (78.7-339.4) versus 261.8 mg (68.1-339.0); P <
0.001] was significantly lower at 14.5 days post coitum when compared to
controls. Neither the number of resorption sites nor the number of viable
embryos per pregnant female was significantly different between groups.
Also, the in-vitro fertilization rate of oocytes, fertilized by spermatozoa
collected from heat stressed males, was significantly lower (44.9%; P <
0.0001) when compared to controls (65.1%; P < 0.0001). In conclusion,
the results of this study suggest that male subfertility induced by acute
scrotal heating may result in impaired sperm quality, reduced embryo weight
in vivo and decreased fertilization rate in vitro.
相似文献
106.
107.
This report looks at outpatient treatment of nasopharyngeal inlet stenosis, a more commonly seen postoperative complication of uvulopalatopharyngoplasty (UPPP). It does not study the effectiveness of the UPPP for treatment of obstructive sleep apnea syndrome (OSAS). The authors evaluated six patients who had a UPPP for OSAS, all of whom developed stenosis in the nasopharyngeal inlet ranging from 14 mm to complete closure. Two patients had failed rotation flap repairs. The carbon dioxide laser was used to treat these patients in the office under a local anesthesia in a staged manner. We now have patients from 3 months to 12 months follow-up who have had stenosis treated successfully. We believe that the postoperative complication of nasopharyngeal inlet stenosis after UPPP can be treated in a safe and cost-effective manner in the office setting. 相似文献
108.
Ted Van Noord D. Scott Wright Be-Sheng Kuo 《Journal of pharmaceutical and biomedical analysis》1996,14(12):1709-1716
CAM 4515 and CAM 4750 are new nonpeptide tachykinin NK1 receptor antagonists with different lipophilicities. Two separate, simple, and sensitive HPLC methods for the quantitation of these two compounds in plasma and the evaluation of their oral bioavailability in rats were developed and validated. Extraction of CAM 4515 from plasma involved protein precipitation with acetonitrile, while that for CAM 4750 involved a one-step liquid-liquid extraction with methylene chloride. The analytes in extracts were chromatographed on a C18 column using two different separation buffers, 47% 0.02 M sodium citrate (pH 3.5)-53% acetonitrile for CAM 4515 and 59% 0.02 M potassium phosphate dibasic (pH 7.0)-41% acetonitrile for CAM 4750, and both compounds were detected by fluorescence (excitation 278 nm; emission 342 nm). Stability profiles of both drugs at −20°C or room temperature in plasma and in reconstituted buffers were good. The limit of quantitation for both drugs was 5 ng ml−1 with good linearity from 5 to 1000 ng ml−1 using 100–200 μl of plasma. Excellent precision (relative standard deviation < 8.3%) and accuracy (relative error ± 9.2%) were observed for both CAM 4515 and CAM 4750. Oral bioavailability studies were conducted for each compound in rats receiving a p.o. dose of 20 mg kg−1 and an i.v. dose of 5 mg kg−1. The absolute oral bioavailability of CAM 4750 (80%) was estimated to be 40-fold greater than that of CAM 4515 (2%). The experimental results suggest that incorporation of a pyridine group into the structural backbone may greatly improve bioavailability. 相似文献
109.
110.
Martin Klomp Peter M. Van den Bergh Frits J. H. Harinck 《Child & youth care forum》1997,26(5):343-355
In child and youth care in the Netherlands, systematic planning of treatment is more and more considered to be a condition
for effective and well founded treatment. Although workers are convinced of the benefits of treatment plans, treatment planning
is not yet a natural and integrated part of residential care. There are several pressure points. In this article a model of
treatment planning will be presented that contributes to an answer to these pressure points. The theoretical bases and the
practical implications of this model will be discussed. 相似文献