全文获取类型
收费全文 | 914篇 |
免费 | 72篇 |
国内免费 | 5篇 |
专业分类
耳鼻咽喉 | 9篇 |
儿科学 | 71篇 |
妇产科学 | 22篇 |
基础医学 | 76篇 |
口腔科学 | 32篇 |
临床医学 | 89篇 |
内科学 | 259篇 |
皮肤病学 | 90篇 |
神经病学 | 47篇 |
特种医学 | 91篇 |
外科学 | 50篇 |
综合类 | 18篇 |
预防医学 | 32篇 |
眼科学 | 3篇 |
药学 | 43篇 |
中国医学 | 1篇 |
肿瘤学 | 58篇 |
出版年
2023年 | 5篇 |
2022年 | 10篇 |
2021年 | 11篇 |
2020年 | 10篇 |
2019年 | 15篇 |
2018年 | 15篇 |
2017年 | 7篇 |
2016年 | 11篇 |
2015年 | 21篇 |
2014年 | 31篇 |
2013年 | 38篇 |
2012年 | 37篇 |
2011年 | 36篇 |
2010年 | 52篇 |
2009年 | 41篇 |
2008年 | 43篇 |
2007年 | 41篇 |
2006年 | 25篇 |
2005年 | 29篇 |
2004年 | 23篇 |
2003年 | 24篇 |
2002年 | 14篇 |
2001年 | 9篇 |
2000年 | 18篇 |
1999年 | 14篇 |
1998年 | 34篇 |
1997年 | 38篇 |
1996年 | 37篇 |
1995年 | 31篇 |
1994年 | 22篇 |
1993年 | 20篇 |
1992年 | 12篇 |
1991年 | 11篇 |
1990年 | 14篇 |
1989年 | 22篇 |
1988年 | 23篇 |
1987年 | 21篇 |
1986年 | 13篇 |
1985年 | 20篇 |
1984年 | 10篇 |
1983年 | 10篇 |
1982年 | 12篇 |
1981年 | 13篇 |
1980年 | 5篇 |
1979年 | 5篇 |
1978年 | 4篇 |
1977年 | 6篇 |
1976年 | 6篇 |
1968年 | 4篇 |
1965年 | 3篇 |
排序方式: 共有991条查询结果,搜索用时 31 毫秒
21.
Breast cancer is the most common cause of cancer death in women in this country. Until recently, the traditional treatment has been radical surgery with or without radiation therapy for patients with primary breast cancer, and palliative endocrine therapy followed by chemotherapy for patients with advanced disease. These treatments have met with limited effectiveness in terms of eradicating the disease. Studies in the past decade have given cause for optimism for breast cancer patients. Adjuvant systemic therapy after local treatment appears promising for certain subsets of patients with primary breast cancer. The development of estrogen receptor assays has markedly changed our approach to the disease and improved patient care. Estrogen receptor is an important prognostic factor and is useful in planning appropriate therapy for patients with primary breast cancer as well as those with advanced disease. Further research is urgently needed to improve the dismal survival of certain women with this common malignancy. 相似文献
22.
23.
Alberto Bedogni Stefano Fedele Giorgio Bedogni Matteo Scoletta Gianfranco Favia Giuseppe Colella Alessandro Agrillo Giordana Bettini Olga Di Fede Giacomo Oteri Vittorio Fusco Mario Gabriele Livia Ottolenghi Stefano Valsecchi Stephen Porter Massimo Petruzzi Paolo Arduino Salvatore D’Amato Claudio Ungari Pok-Lam Fung Polly Giorgia Saia Giuseppina Campisi 《The British journal of oral & maxillofacial surgery》2014
Management of osteonecrosis of the jaw associated with antiresorptive agents is challenging, and outcomes are unpredictable. The severity of disease is the main guide to management, and can help to predict prognosis. Most available staging systems for osteonecrosis, including the widely-used American Association of Oral and Maxillofacial Surgeons (AAOMS) system, classify severity on the basis of clinical and radiographic findings. However, clinical inspection and radiography are limited in their ability to identify the extent of necrotic bone disease compared with computed tomography (CT). We have organised a large multicentre retrospective study (known as MISSION) to investigate the agreement between the AAOMS staging system and the extent of osteonecrosis of the jaw (focal compared with diffuse involvement of bone) as detected on CT. We studied 799 patients with detailed clinical phenotyping who had CT images taken. Features of diffuse bone disease were identified on CT within all AAOMS stages (20%, 8%, 48%, and 24% of patients in stages 0, 1, 2, and 3, respectively). Of the patients classified as stage 0, 110/192 (57%) had diffuse disease on CT, and about 1 in 3 with CT evidence of diffuse bone disease was misclassified by the AAOMS system as having stages 0 and 1 osteonecrosis. In addition, more than a third of patients with AAOMS stage 2 (142/405, 35%) had focal bone disease on CT. We conclude that the AAOMS staging system does not correctly identify the extent of bony disease in patients with osteonecrosis of the jaw. 相似文献
24.
25.
Pre‐therapy inflammation and coagulation activation and long‐term CD4 count responses to the initiation of antiretroviral therapy 下载免费PDF全文
26.
27.
Vincenzo Duino Luigi Fiocca Giuseppe Musumeci Emilia D’Elia Mauro Gori Elisa Cerchierini Orazio Valsecchi Michele Senni 《Medicine》2015,94(20)
Functional mitral regurgitation (FMR) is frequent in patients with heart failure (HF). It develops as a consequence of left ventricle (LV) geometry alterations, causing imbalance between increased tethering forces and decreased closing forces exerted on the mitral valve apparatus during systole.FMR is known to change at rest and during effort, due to preload–afterload changes, myocardial ischemia, and/or LV dysfunction. Despite optimized medical therapy, an FMR can be responsible of shortness of breath limiting quality of life and decompensation. In this report, we present a case of dynamic FMR treated with MitraClip.MitraClip implantation is a successful and innovative opportunity for HF patients with FMR. 相似文献
28.
29.
Ghazzawi IM; Sarraf MG; Taher MR; Khalifa FA 《Human reproduction (Oxford, England)》1998,13(2):348-352
A prospective study was carried out to compare the fertilizing capability
and pregnancy outcome following intracytoplasmic sperm injection (ICSI)
using spermatozoa obtained from ejaculates, or surgically from epididymis
or seminiferous tubules. A total of 77 ICSI cycles (one per patient) was
included. In all, 28 patients had severe oligoasthenoteratozoospermia, 19
patients had obstructive azoospermia and 30 patients had non-obstructive
azoospermia. The main outcome measures were fertilization rate per injected
metaphase II oocyte and the clinical pregnancy rate per embryo transferred
back to the female recipients. In patients with severe
oligoasthenoteratozoospermia, the fertilization and pregnancy rates were 79
and 25 %. In patients with obstructive azoospermia, for whom epididymal
spermatozoa were used, these were 75 and 28%, and in the non-obstructive
group for which testicular spermatozoa were used for injection, they were
69 and 21% respectively. These rates were not significantly different in
the three groups (P = 0.85 and P = 0.14 respectively), suggesting that
spermatozoa from the ejaculates and epididymal or testicular biopsies are
able to fertilize equally by using ICSI. Live birth per embryo transfer was
significantly reduced in patients with non-obstructive azoospermia compared
to the other two groups. The high abortion rate (50%) in the group in which
testicular spermatozoa were used raises doubts about the developmental
competence of such embryos.
相似文献
30.
Holyoake TL; Freshney MG; McNair L; Parker AN; McKay PJ; Steward WP; Fitzsimons E; Graham GJ; Pragnell IB 《Blood》1996,87(11):4589-4595
The characterization of many cytokines involved in the control of hematopoiesis has led to intense investigation into their potential use in ex vivo culture to expand progenitor numbers. We have established the optimum ex vivo culture conditions that allow substantial amplification of transient engrafting murine stem cells and which, simultaneously, augment the ability to sustain serial bone marrow transplantation (BMT). Short-term incubation of unfractionated BM cells in liquid culture with stem cell factor (SCF) and interleukin-11 (IL- 11) produced a 50-fold amplification of clonogenic multipotential progenitors (CFU-A). Following such ex vivo expansion, substantially fewer cells were required to rescue lethally irradiated mice. When transplanted in cell doses above threshold for engraftment, BM cells expanded ex vivo resulted in significantly more rapid hematopoietic recovery. In a serial transplantation model, unmanipulated BM was only able to consistently sustain secondary BMT recipients, but BM expanded ex vivo has sustained quaternary BMT recipients that remain alive and well more than 140 days after 4th degree BMT. These results show augmentation of both short-term recovery posttransplant and the ability to serially transplant marrow by preincubation in culture with SCF and IL-11. 相似文献