全文获取类型
收费全文 | 584篇 |
免费 | 40篇 |
国内免费 | 13篇 |
专业分类
耳鼻咽喉 | 1篇 |
儿科学 | 33篇 |
妇产科学 | 13篇 |
基础医学 | 55篇 |
口腔科学 | 9篇 |
临床医学 | 47篇 |
内科学 | 133篇 |
皮肤病学 | 19篇 |
神经病学 | 13篇 |
特种医学 | 142篇 |
外科学 | 60篇 |
综合类 | 20篇 |
预防医学 | 32篇 |
眼科学 | 6篇 |
药学 | 23篇 |
肿瘤学 | 31篇 |
出版年
2021年 | 6篇 |
2018年 | 5篇 |
2017年 | 2篇 |
2016年 | 5篇 |
2015年 | 13篇 |
2014年 | 8篇 |
2013年 | 11篇 |
2012年 | 8篇 |
2011年 | 15篇 |
2010年 | 24篇 |
2009年 | 31篇 |
2008年 | 17篇 |
2007年 | 26篇 |
2006年 | 24篇 |
2005年 | 24篇 |
2004年 | 24篇 |
2003年 | 22篇 |
2002年 | 13篇 |
2001年 | 25篇 |
2000年 | 8篇 |
1999年 | 4篇 |
1998年 | 20篇 |
1997年 | 36篇 |
1996年 | 23篇 |
1995年 | 23篇 |
1994年 | 17篇 |
1993年 | 7篇 |
1992年 | 8篇 |
1991年 | 4篇 |
1990年 | 9篇 |
1989年 | 15篇 |
1988年 | 9篇 |
1987年 | 15篇 |
1986年 | 9篇 |
1985年 | 10篇 |
1984年 | 6篇 |
1983年 | 9篇 |
1982年 | 7篇 |
1981年 | 11篇 |
1980年 | 14篇 |
1979年 | 7篇 |
1978年 | 12篇 |
1977年 | 8篇 |
1976年 | 9篇 |
1975年 | 7篇 |
1974年 | 6篇 |
1973年 | 5篇 |
1972年 | 3篇 |
1971年 | 4篇 |
1970年 | 3篇 |
排序方式: 共有637条查询结果,搜索用时 0 毫秒
91.
92.
93.
94.
van Uden CJ Nieman FH Voss GB Wesseling G Winkens RA Crebolder HF 《BMC health services research》2005,5(1):27
Background
In recent years, Dutch general practitioner (GP) out-of-hours service has been reorganised into large-scale GP cooperatives. Until now little is known about GPs' experiences with working at these cooperatives for out-of-hours care. The purpose of this study is to gain insight into GPs' satisfaction with working at GP cooperatives for out-of-hours care in separated and integrated cooperatives. 相似文献95.
96.
97.
Habeos IG Psyrogiannis A Kyriazopoulou V Psilopanagiotou A Papavassiliou AG Vagenakis AG 《Hormones (Athens, Greece)》2003,2(1):55-60
Several authors have suggested a positive association between diabetes type 2 (DM2) and the C282Y and H63D mutations of the hereditary hemochromatosis gene but others have disputed it. There are also papers reporting an increased iron load in diabetes type 2 and a possible association with the pathogenesis of the disease. We therefore performed a study in 100 type 2 diabetics and 100 age and sex matched controls to assess the possibility that C282Y and H63D mutations constitute a risk factor for DM2 in Greece. We also evaluated the iron load in 500 diabetes type 2 patients and 423 age and sex matched controls. We did not find any differences in the allele frequencies of the above mutations between patients with diabetes type 2 and controls. The allele frequencies were estimated to be 0.0075 for the C282Y and 0.115 for the H63D mutation. Subjects with even one mutation (C282Y or H63D) had higher transferrin saturation compared to those with no such mutations. This seems to apply to both diabetics (49+/- 8,6 vs 44,5+/- 5,4, p<0,01) and controls (49,3+/- 7,3 vs 42,6+/- 3,3 p<0,01). Patients with DM2 had higher transferrin saturation compared to the general population. These differences were found among men (n=250, mean+/- SD 31,8+11 vs n=73, mean+/- SD 29,5+8, p=0,05) as well as among women (n=250, mean+/- SD 28.5+10 vs n=350, mean+/- SD 25.5+9.6, p=0.001). The DM2 patients had higher ferritin levels compared to controls. In conclusion, DM2 patients have increased iron load. The C282Y and H63D mutations contribute to increased iron load in both DM2 and controls. There was no difference in the frequency of C282Y and H63D alleles between DM2 and controls in the Hellenic population. 相似文献
98.
99.
Differential expression of CD11b/CD18 (Mo1) and myeloperoxidase genes during myeloid differentiation 总被引:6,自引:0,他引:6
During the course of differentiation of early human myeloid cells toward monocytes and granulocytes, cell surface expression of the cell adhesion molecule, CD11b/CD18 (Mo1) increases dramatically and expression of myeloperoxidase (MPO), a bacteriocidal enzyme, decreases markedly. Using the inducible promyelocytic cell line HL-60 as a model, we studied the mRNA expression of these genes. Differentiation of these cells along both a monocytic and a granulocytic pathway demonstrated that the mRNA levels of the two subunits of CD11b/CD18 increased in a pattern temporally and quantitatively similar to the increase in cell surface expression of this heterodimer. In contrast, the expression of MPO mRNA decreased in a temporal and quantitative pattern similar to the known decrease in MPO protein during differentiation, suggesting that regulation of these myeloid-specific proteins may occur at the level of mRNA expression. These findings have important implications with regard to the nature of the block in differentiation in acute nonlymphocytic leukemia and the regulation of myeloid gene expression. 相似文献
100.