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991.
992.
E A Cristofalo J A Dipietro K A Costigan P Nelson J Crino 《Journal of perinatology》2006,26(4):215-223
OBJECTIVES: To determine maternal responses to detection of a minor structural variant, the choroid plexus cyst (CPC), in their fetus on prenatal ultrasound. STUDY DESIGN: We interviewed 34 pregnant women with an isolated CPC detected on mid-pregnancy ultrasound about their objective experience at diagnosis, emotional response and subsequent reactions. Audiotaped, transcribed responses were evaluated by two independent raters and analyzed qualitatively and quantitatively. RESULTS: All women reported negative emotional responses including shock, distress, fear and decreased attachment, despite counseling by 82% of providers that the CPC was probably benign. Three women underwent amniocentesis purely for reassurance after CPC detection. Most (79%) sought information beyond what their physician provided, frequently on the internet. One half of women reported that intense negative responses were temporary. However, weeks after diagnosis, 62% continued to believe that the CPC presented some danger to their baby. CONCLUSIONS: Detection of CPC prenatally can evoke profound, negative maternal emotional responses despite accurate provider counseling. Practitioners should consider these responses when counseling parents about these and other structural variants of unclear functional significance. 相似文献
993.
994.
995.
996.
Gastric cancer still represents the second most common cause of gastrointestinal cancers in Germany. A disturbing issue is that at the time of diagnosis there are less than 15% of patients for whom a cure can be achieved. Nowadays, biological, histomorphological, molecular genetic and epidemiological data suggest that Helicobacter pylori eradication may lead to the prevention of gastric pre-neoplastic lesions and even gastric cancer. At present, eradication can be offered to selected patients and populations at increased risk, but more research is required before embarking on general and global H. pylori eradication for gastric cancer prevention. The main challenge is to determine how long mucosal abnormalities remain reversible and gastric cancer development can be halted. 相似文献
997.
K Campbell 《Leukemia》2005,19(9):1704-1705
998.
Im Hinblick auf die eindrucksvollen Remissionsraten, die in den letzten Jahren in der Therapie des Hodgkin-Lymphoms erzielt wurden, gewinnen die therapieinduzierten Spätkomplikationen einen immer größeren Stellenwert. In Abhängigkeit von Stadium und Risikofaktoren können nach der Primärtherapie mittlerweile Langzeitremissionen von über 80% erzielt werden. Demzufolge hat gerade das Überleben junger Patienten im reproduktiven Alter zugenommen, weshalb genaue Analysen therapieinduzierter Spätfolgen immer mehr in den Vordergrund treten. Zu den wichtigsten therapieinduzierten Akut- und Spättoxizitäten zählen Infertilität, kardiale, pulmonale oder thyroidale Funktionsstörungen und insbesondere Sekundärneoplasien, die zu einer signifikanten Mortalität beitragen. Außerdem kann ein noch lange Zeit nach der Therapie anhaltendes Fatiguesyndrom auftreten. Die Therapiestrategien aktueller klinischer Studien zielen daher insbesondere auf eine Reduktion von therapiebedingten Spätfolgen bei gleichzeitiger Beibehaltung der guten Tumorkontrolle. 相似文献
999.
G. B. Slepchenko L. S. Anisimova V. F. Slipchenko E. V. Mikheeva N. P. Pikula 《Pharmaceutical Chemistry Journal》2005,39(3):166-168
Rapid voltammetric procedures for the determination of water-soluble vitamins C, B1, and B2, fat-soluble vitamin E (α-tocopherol acetate), and quercetin in bioactive food additives have been developed. The systematic error (i.e., correctness) of the proposed procedures was evaluated using certified reference materials and the additive recovery tests, which gave the following limiting metrological characteristics: relative error, 25 %; reproducibility, 28 %; convergence, 22 %. The full analysis time (with sample preparation) did not exceed 2 hours. Voltammetric determinations under optimum conditions can be performed in the automated regime controlled by a computer according to the specially developed software.__________Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 39, No. 3, pp. 54 – 56, March, 2005. 相似文献
1000.
The influence of chronic administration of a dry cleared extract of Glycyrrhiza glabra (DCEG) containing flavonoids on the behavioral status and learning of intact and ovariectomized adult female rats has been
studied. The DCEG preparation was administered in low (0.5 mg/kg, i.p.) and high (5.0 mg/kg, i.p.) daily doses over a period
of 14 days and the results were evaluated on the passive avoidance situation model and in the open field test. It was established
that the chronic administration of DCEG in both low and high doses produced correction of the passive avoidance performance
in ovariectomized female rats. The administration of DCEG in a low dose also positively influenced the structure of purposeful
behavior of females with deficiency of estrogens.
__________
Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 39, No. 8, pp. 27 – 29, August, 2005. 相似文献