全文获取类型
收费全文 | 1359842篇 |
免费 | 87554篇 |
国内免费 | 2788篇 |
专业分类
耳鼻咽喉 | 18459篇 |
儿科学 | 43555篇 |
妇产科学 | 37056篇 |
基础医学 | 208028篇 |
口腔科学 | 35902篇 |
临床医学 | 117972篇 |
内科学 | 264239篇 |
皮肤病学 | 29317篇 |
神经病学 | 100724篇 |
特种医学 | 53329篇 |
外国民族医学 | 381篇 |
外科学 | 209351篇 |
综合类 | 25891篇 |
现状与发展 | 2篇 |
一般理论 | 345篇 |
预防医学 | 99045篇 |
眼科学 | 30898篇 |
药学 | 99962篇 |
1篇 | |
中国医学 | 2781篇 |
肿瘤学 | 72946篇 |
出版年
2018年 | 14008篇 |
2017年 | 10657篇 |
2016年 | 11917篇 |
2015年 | 13410篇 |
2014年 | 18614篇 |
2013年 | 28334篇 |
2012年 | 39262篇 |
2011年 | 42592篇 |
2010年 | 25361篇 |
2009年 | 23459篇 |
2008年 | 39893篇 |
2007年 | 43012篇 |
2006年 | 42647篇 |
2005年 | 41585篇 |
2004年 | 40123篇 |
2003年 | 38690篇 |
2002年 | 37842篇 |
2001年 | 59951篇 |
2000年 | 61483篇 |
1999年 | 51802篇 |
1998年 | 14461篇 |
1997年 | 12875篇 |
1996年 | 12811篇 |
1995年 | 11982篇 |
1994年 | 11212篇 |
1993年 | 10691篇 |
1992年 | 40424篇 |
1991年 | 40532篇 |
1990年 | 40133篇 |
1989年 | 38842篇 |
1988年 | 35928篇 |
1987年 | 35522篇 |
1986年 | 33684篇 |
1985年 | 32227篇 |
1984年 | 24030篇 |
1983年 | 20486篇 |
1982年 | 11762篇 |
1979年 | 22485篇 |
1978年 | 15861篇 |
1977年 | 13199篇 |
1976年 | 13062篇 |
1975年 | 14872篇 |
1974年 | 17321篇 |
1973年 | 16572篇 |
1972年 | 15582篇 |
1971年 | 14591篇 |
1970年 | 13935篇 |
1969年 | 12995篇 |
1968年 | 12340篇 |
1967年 | 11230篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
61.
62.
Xiaoyan Lu Isabelle R. Miousse Sandra V. Pirela Jodene K. Moore Stepan Melnyk 《Nanotoxicology》2016,10(5):629-639
Evidence continues to grow on potential environmental health hazards associated with engineered nanomaterials (ENMs). While the geno- and cytotoxic effects of ENMs have been investigated, their potential to target the epigenome remains largely unknown. The aim of this study is two-fold: 1) determining whether or not industry relevant ENMs can affect the epigenome in vivo and 2) validating a recently developed in vitro epigenetic screening platform for inhaled ENMs. Laser printer-emitted engineered nanoparticles (PEPs) released from nano-enabled toners during consumer use and copper oxide (CuO) were chosen since these particles induced significant epigenetic changes in a recent in vitro companion study. In this study, the epigenetic alterations in lung tissue, alveolar macrophages and peripheral blood from intratracheally instilled mice were evaluated. The methylation of global DNA and transposable elements (TEs), the expression of the DNA methylation machinery and TEs, in addition to general toxicological effects in the lung were assessed. CuO exhibited higher cell-damaging potential to the lung, while PEPs showed a greater ability to target the epigenome. Alterations in the methylation status of global DNA and TEs, and expression of TEs and DNA machinery in mouse lung were observed after exposure to CuO and PEPs. Additionally, epigenetic changes were detected in the peripheral blood after PEPs exposure. Altogether, CuO and PEPs can induce epigenetic alterations in a mouse experimental model, which in turn confirms that the recently developed in vitro epigenetic platform using macrophage and epithelial cell lines can be successfully utilized in the epigenetic screening of ENMs. 相似文献
63.
A case of bullous pemphigoid associated with psoriasis vulgaris showing Hailey–Hailey disease‐like histopathological changes in regenerated epidermis without genomic mutation in ATP2C1 or ATP2A2 gene 下载免费PDF全文
64.
F. Fruzzetti G. Palla A. Sbrana T. Simoncini M. R. Sessa 《Gynecological endocrinology》2020,36(10):938-940
AbstractObjective: To understand the origin of extremely high gonadotropin levels in a perimenopausal woman.Methods: A 52-year-old woman with a 2?months of amenorrhea followed spontaneous menstrual cycles recovery was referred to our outpatient clinic with elevated follicle-stimulating hormone (FSH, 483 mUI/ml), luteinizing hormone (LH, 475 mUI/ml) and prolactin (PRL, 173?ng/ml). She was known to take levosulpiride. The gonadotropin levels did not fit with the clinical features.Results: A gonadotroph tumor was ruled out. Further analysis confirmed constantly high FSH, LH and PRL levels. The measurements were repeated using different analytical platforms with different results. After serial dilutions, nonlinearity was present suggesting an immunoassay interference. After post-polyethylene glycol recovery, hormone levels appeared in the normal range. Anti-goat antibodies were recognized in the serum of the patient.Conclusions: This case report shows a case of falsely abnormal high gonadotropin and PRL levels in a woman during menopause transition. In the clinical practice the evaluation of gonadotropin profile is not recommended at this age, but the abnormal levels stimulated further evaluation. An interference in the assay due to anti-goat antibodies resulted in abnormally high level of FSH and LH. A strict collaboration between clinicians and the laboratory is needed, when laboratory findings do not correspond to clinical findings. 相似文献
65.
C. Dessinioti C.C. Zouboulis V. Bettoli D. Rigopoulos 《Journal of the European Academy of Dermatology and Venereology》2020,34(10):2229-2240
Guidelines and consensus on the management of patients with acne aim to give evidence-based, expert-group recommendations. This review compares current guidelines and consensus articles to provide a compilation of recommendations on the treatment of acne with oral isotretinoin. Ten common, relevant, clinical questions are addressed, based on published recommendations, including the indications of isotretinoin, the proposed daily dose, the cumulative isotretinoin dose and the laboratory monitoring needed. Recommendations on special considerations are also addressed, including the timing of procedures and the question of an association of depression or inflammatory bowel disease with isotretinoin. A major limitation is the use of different classification systems for acne across guidelines. The recommended daily dose ranges from 0.3 to 0.5 mg/kg in the European guidelines to up to 1 mg/kg in the US guidelines. A specific duration of treatment of at least 6 months is only recommended in the European guidelines. All guidelines report the need of strict pregnancy prevention measures. The European, French and US guidelines recommend to monitor for symptoms of depression. Important clinical questions that are inconsistently addressed in guidelines include the age indication, the recommendation for a cumulative dose, the timing of procedures, the association of isotretinoin with IBD, the recommendation for preventing acne flares and for appropriate laboratory monitoring. These topics should be clearly included in the recommendations of guidelines as they are often raised in everyday clinical practice. 相似文献
66.
67.
T. Wu L. G. Trahair M. J. Bound C. F. Deacon M. Horowitz C. K. Rayner K. L. Jones 《Diabetic medicine》2015,32(5):595-600
68.
Martin F. Shapiro 《Journal of general internal medicine》2015,30(10):1392-1393
69.
70.
Feasibility and Diagnostic Potential of Pulmonary Transit Time Measurement by Contrast Echocardiography: A Pilot Study 下载免费PDF全文