全文获取类型
收费全文 | 2170篇 |
免费 | 125篇 |
国内免费 | 21篇 |
专业分类
耳鼻咽喉 | 22篇 |
儿科学 | 40篇 |
妇产科学 | 41篇 |
基础医学 | 177篇 |
口腔科学 | 91篇 |
临床医学 | 155篇 |
内科学 | 413篇 |
皮肤病学 | 71篇 |
神经病学 | 104篇 |
特种医学 | 110篇 |
外科学 | 463篇 |
综合类 | 35篇 |
一般理论 | 5篇 |
预防医学 | 254篇 |
眼科学 | 51篇 |
药学 | 151篇 |
中国医学 | 8篇 |
肿瘤学 | 125篇 |
出版年
2024年 | 4篇 |
2023年 | 27篇 |
2022年 | 52篇 |
2021年 | 111篇 |
2020年 | 78篇 |
2019年 | 86篇 |
2018年 | 116篇 |
2017年 | 64篇 |
2016年 | 73篇 |
2015年 | 85篇 |
2014年 | 97篇 |
2013年 | 134篇 |
2012年 | 172篇 |
2011年 | 182篇 |
2010年 | 118篇 |
2009年 | 71篇 |
2008年 | 139篇 |
2007年 | 126篇 |
2006年 | 135篇 |
2005年 | 113篇 |
2004年 | 99篇 |
2003年 | 69篇 |
2002年 | 56篇 |
2001年 | 14篇 |
2000年 | 12篇 |
1999年 | 19篇 |
1998年 | 21篇 |
1997年 | 7篇 |
1996年 | 4篇 |
1995年 | 5篇 |
1994年 | 2篇 |
1993年 | 1篇 |
1992年 | 1篇 |
1991年 | 3篇 |
1990年 | 2篇 |
1988年 | 1篇 |
1987年 | 1篇 |
1986年 | 2篇 |
1984年 | 2篇 |
1983年 | 1篇 |
1981年 | 2篇 |
1980年 | 3篇 |
1979年 | 1篇 |
1978年 | 1篇 |
1977年 | 1篇 |
1976年 | 1篇 |
1975年 | 1篇 |
1960年 | 1篇 |
排序方式: 共有2316条查询结果,搜索用时 208 毫秒
21.
PURPOSE: The purpose of the present study was to test the hypothesis that talkers previously classified by Y.-C. Tsao and G. Weismer (1997) as habitually fast versus habitually slow would show differences in the way they manipulated articulation rate across the rate continuum. METHOD: Thirty talkers previously classified by Tsao and Weismer (1997) as having habitually slow (n = 15; 7 males, 8 females) and habitually fast (n = 15; 8 males, 7 females) articulation rates produced a single sentence at 7 different rates, using a magnitude production paradigm. Hence, the participants were not randomly assigned to conditions. RESULTS: Quadratic regression functions relating measured to intended articulation rates were all statistically significant, and most important, there were significant differences between the slow and fast groups in the y intercepts of the functions, for both males and females. CONCLUSIONS: This study provides a constructive replication of Tsao and Weismer (1997), showing a difference between slow and fast talkers with a new set of speech materials and in a new task. The findings appear to be consistent with a biological basis for intertalker rate differences. 相似文献
22.
23.
24.
25.
26.
27.
Systemic sclerosis (SSc) is a heterogeneous condition characterized by the deposition of excess collagen in skin and internal organs due to vasculopathy, immune activation, low grade inflammation, and fibrosis. Progressive diffuse cutaneous SSc with organ involvement has a poor prognosis. The employment of autologous hematopoietic stem cell transplantation (HSCT) as a means to escalate immunosuppressive therapy has resulted in rapid and sustained improvement of skin thickening and functional ability, stabilization of major organ function with some improvement of vital capacity in pilot studies, registry analyses, and the phase II ASSIST trial. Results from the phase III ASTIS trial corroborate these findings and show long-term survival benefit of HSCT. The ASTIS and SCOT trials will determine whether the benefits of HSCT outweigh the risks of serious adverse events including treatment-related mortality of around 6–10 % and potential long-term complications. Better patient selection and safer transplant regimens may improve the outcome of HSCT for SSc. 相似文献
28.
High rate of A2142G point mutation associated with clarithromycin resistance among Iranian Helicobacter pylori clinical isolates 下载免费PDF全文
Reza Khashei Mahintaj Dara Abdollah Bazargani Kamran Bagheri Lankarani Alireza Taghavi Maryam Moeini Behzad Dehghani Maryam Sohrabi 《APMIS : acta pathologica, microbiologica, et immunologica Scandinavica》2016,124(9):787-793
This study aimed to investigate the clarithromycin resistance and its associated molecular mechanisms among Helicobacter pylori isolates from dyspeptic patients in Shiraz, Iran. From January to May 2014, 100 H. pylori strains were isolated from patients with gastroduodenal disorders. The resistance to clarithromycin was quantitatively evaluated, using Epsilometer (E‐test) method. Polymerase chain reaction‐restriction fragment length polymorphism (PCR‐RFLP) was performed on all the isolates to detect A2143G and A2142G mutations in 23S rRNA gene. The H. pylori isolation rate was found to be 31.4%. E‐test showed that 20% of isolates were resistant to clarithromycin (MIC ≥ 1 mg/L). MIC of clarithromycin ranged between 0.016 and 24 mg/L. Findings of PCR‐RFLP showed that the A2142G was the most (90%) frequently point mutation, followed by the A2143G (10%). No statistically significant difference was found between H. pylori clarithromycin resistance point mutations and patients’ gender or age. To the best of our knowledge, this is the first report of high frequency of A2142G point mutation in Iran and probably in other regions of the world. Considering the increasing trend of H. pylori resistance to clarithromycin due to these mutations, it is crucial to investigate the new therapeutic approaches against H. pylori infection. 相似文献
29.