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111.
Federica Piani Isabella Melena Kalie L. Tommerdahl Natalie Nokoff Robert G. Nelson Meda E. Pavkov Daniël H. van Raalte David Z. Cherney Richard J. Johnson Kristen J. Nadeau Petter Bjornstad 《Journal of diabetes and its complications》2021,35(4):107841
Sexual dimorphism may play a key role in the pathogenesis of diabetic kidney disease (DKD) and explain differences observed in disease phenotypes, responses to interventions, and disease progression between men and women with diabetes. Therefore, omitting the consideration of sex as a biological factor may result in delayed diagnoses and suboptimal therapies. This review will summarize the effects of sexual dimorphism on putative metabolic and molecular mechanisms underlying DKD, and the potential implications of these differences on therapeutic interventions. To successfully implement precision medicine, we require a better understanding of sexual dimorphism in the pathophysiologic progression of DKD. Such insights can unveil sex-specific therapeutic targets that have the potential to maximize efficacy while minimizing adverse events. 相似文献
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Rui Yang Marc Weisshaar Federico Mele Ibtihal Benhsaien Karim Dorgham Jing Han Carys A. Croft Samuele Notarbartolo Jrmie Rosain Paul Bastard Anne Puel Bernhard Fleckenstein Laurie H. Glimcher James P. Di Santo Cindy S. Ma Guy Gorochov Aziz Bousfiha Laurent Abel Stuart G. Tangye Jean-Laurent Casanova Jacinta Bustamante Federica Sallusto 《The Journal of experimental medicine》2021,218(8)
We have described a child suffering from Mendelian susceptibility to mycobacterial disease (MSMD) due to autosomal recessive, complete T-bet deficiency, which impairs IFN-γ production by innate and innate-like adaptive, but not mycobacterial-reactive purely adaptive, lymphocytes. Here, we explore the persistent upper airway inflammation (UAI) and blood eosinophilia of this patient. Unlike wild-type (WT) T-bet, the mutant form of T-bet from this patient did not inhibit the production of Th2 cytokines, including IL-4, IL-5, IL-9, and IL-13, when overexpressed in T helper 2 (Th2) cells. Moreover, Herpesvirus saimiri–immortalized T cells from the patient produced abnormally large amounts of Th2 cytokines, and the patient had markedly high plasma IL-5 and IL-13 concentrations. Finally, the patient’s CD4+ αβ T cells produced most of the Th2 cytokines in response to chronic stimulation, regardless of their antigen specificities, a phenotype reversed by the expression of WT T-bet. T-bet deficiency thus underlies the excessive production of Th2 cytokines, particularly IL-5 and IL-13, by CD4+ αβ T cells, causing blood eosinophilia and UAI. The MSMD of this patient results from defective IFN-γ production by innate and innate-like adaptive lymphocytes, whereas the UAI and eosinophilia result from excessive Th2 cytokine production by adaptive CD4+ αβ T lymphocytes. 相似文献
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Daria Capece Daniel DAndrea Federica Begalli Laura Goracci Laura Tornatore James L. Alexander Alessandra Di Veroli Shi-Chi Leow Thamil S. Vaiyapuri James K. Ellis Daniela Verzella Jason Bennett Luca Savino Yue Ma James S. McKenzie Maria Luisa Doria Sam E. Mason Kern Rei Chng Hector C. Keun Gary Frost Vinay Tergaonkar Katarzyna Broniowska Walter Stunkel Zoltan Takats James M. Kinross Gabriele Cruciani Guido Franzoso 《The Journal of clinical investigation》2021,131(11)
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Floriana Campanile Gino Mongelli Dafne Bongiorno Chiara Adembri Milva Ballardini Marco Falcone Francesco Menichetti Antonella Repetto Carla Sabia Assunta Sartor Claudio Scarparo Carlo Tascini Mario Venditti Federica Zoppi Stefania Stefani 《Journal of clinical microbiology》2013,51(4):1256-1259
In order to assess the frequency of clinically relevant linezolid-resistant staphylococcal isolates, and the role of linezolid in maintaining and coselecting multiple resistance mechanisms (cfr, 23S rRNA, L3/L4 mutations), a prospective Italian study was performed from 2010 to 2011 to confirm the diffusion of three major multidrug-resistant clones (ST2, ST5, ST23). 相似文献
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Reza Ghasemi Antonino Grassadonia Nicola Tinari Enza Piccolo Clara Natoli Federica Tomao Stefano Iacobelli 《Medical hypotheses》2013
Metastasis is the leading cause of cancer death, yet it is mechanistically considered a very inefficient process suggesting the presence of some sort of (e.g. systemic) routes for fuelling the process. The pre-metastatic niche formation is described as one such metastasis promoting route. Now, the emerging potentials of tumor-derived microvesicles (TDMVs), not only in formulating the pre-metastatic niche, but also conferring neoplastic phenotypes onto normal cells, has integrated new concepts into the field. Here, we note as an ancillary proposition that, exerting functional disturbances in other sites, TDMVs (we have termed them metastasomes) may aid foundation of the secondary lesions via two seemingly interrelated models: (i) tumor-organ-training (TOTr), training a proper niche for the growth of the disseminated tumor cells; (ii) tumor-organ-targeting (TOTa), contribution to the propagation of the transformed phenotype via direct or indirect (TOTr-mediated disturbed stroma) transformation and/or heightened growth/survival states of the normal resident cells in the secondary organs. Respecting the high content of the RNA molecules (particularly microRNAs) identified in the secretory MVs, they may play crucial parts in such “malignant trait” spreading system. That is, the interactions between tumor tissue-specific RNA signatures, being transferred via metastasomes, and the cell-type/tissue-specific RNA stockrooms in other areas may settle a unique outcome in each organ. Thus, serving as tumor-organ matchmakers, the RNA molecules may also play substantial roles in the seeding and tropism of the process. 相似文献
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Gutschmidt Kristina Musumeci Olimpia Díaz-Manera Jordi Chien Yin-Hsiu Knop Karl Christian Wenninger Stephan Montagnese Federica Pugliese Alessia Tavilla Graziana Alonso-Pérez Jorge Hwu Paul Wuh-Liang Toscano Antonio Schoser Benedikt 《Journal of neurology》2021,268(7):2482-2492
Journal of Neurology - Pompe disease is one of the few neuromuscular diseases with an approved drug therapy, which has been available since 2006. Our study aimed to determine the real-world... 相似文献
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