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141.
William S. Helton Ulrike Ossowski Sanna Malinen 《Experimental brain research. Experimentelle Hirnforschung. Expérimentation cérébrale》2013,226(3):357-362
The present study was designed to explore the relationships between post-disaster self-reports of depression, vigilance task performance, and frontal cerebral oxygenation. Forty participants (20 women) performed vigilance tasks following a magnitude 7.1 earthquake in Christchurch, New Zealand. In addition to performance, we measured self-reports of depression, anxiety, and stress anchored to the initial earthquake event, and frontal cerebral activity with functional near-infrared spectroscopy. Among the participants, one case may have been an outlier with extremely elevated levels of self-reported depressivity. Excluding the extreme case, there was a correlation between change in response time (response slowing) and depressivity. Including the case there was a correlation between depressivity and right hemisphere oxygenation. These results provide some support for a relationship between moderate depressivity and sustained attention difficulties. 相似文献
142.
Niki Antypa Raffaella Calati Daniel Souery Silvia Pellegrini Othman Sentissi Daniela Amital Ulrike Moser Stuart Montgomery Siegfried Kasper Joseph Zohar Diana De Ronchi Julien Mendlewicz Alessandro Serretti 《Journal of affective disorders》2013
Background
Social adjustment is impaired in depressed patients. The difficulty to adjust to social circumstances has been hypothesized to be one of the causes of depression, as well as a consequence of the disorder. Genetic variation in the serotonin transporter gene has been previously associated with social adjustment levels in patients with mood disorders.Methods
We investigated whether variations on the HTR1A (rs6295) and HTR2A (rs7997012) genes were associated with levels of social adjustment using the Social Adjustment Scale in two samples of depressed patients (total n=156).Results
Patients carrying the GG genotype of the HTR2A-rs7997012 showed better social adjustment in areas of work and family unit bonding.Limitations
These findings did not survive correction for multiple testing and should be interpreted with caution.Conclusion
Our finding is in line with previous observations that have associated the G allele of the HTR2A-rs7997012 with higher rate of antidepressant response. The HTR2A-rs7997012 is worthy of further investigation in studies examining factors that are related to depression course and outcome. 相似文献143.
PTSD can develop in the aftermath of traumatic incidents like combat, sexual abuse, or life threatening accidents. Unfortunately, there are still no biomarkers for this debilitating anxiety disorder in clinical use. Anyhow, there are numerous studies describing potential PTSD biomarkers, some of which might progress to the point of practical use in the future. Here, we outline and comment on some of the most prominent findings on potential imaging, psychological, endocrine, and molecular PTSD biomarkers and classify them into risk, disease, and therapy markers. Since for most of these potential PTSD markers a causal role in PTSD has been demonstrated or at least postulated, this review also gives an overview on the current state of research on PTSD pathobiology. 相似文献
144.
Alexander Seiler Annemarie Brandhofe Ren-Maxime Gracien Waltraud Pfeilschifter Elke Hattingen Ralf Deichmann Ulrike Nth Marlies Wagner 《Journal of cerebral blood flow and metabolism》2021,41(1):67
Leptomeningeal collateral supply is considered pivotal in steno-occlusive vasculopathy to prevent chronic microstructural ischaemic tissue damage. The aim of this study was to assess the alleged protective role of leptomeningeal collaterals in patients with unilateral high-grade steno-occlusive vasculopathy using quantitative (q)T2 mapping and perfusion-weighted imaging (PWI)-based collateral abundance. High-resolution qT2 was used to estimate microstructural damage of the segmented normal-appearing cortex. Volumetric abundance of collaterals was assessed based on PWI source data. The ratio relative cerebral blood flow/relative cerebral blood volume (rCBF/rCBV) as a surrogate of relative cerebral perfusion pressure (rCPP) was used to investigate the intravascular hemodynamic competency of pial collateral vessels and the hemodynamic state of brain parenchyma. Within the dependent vascular territory with increased cortical qT2 values (P = 0.0001) compared to the contralateral side, parenchymal rCPP was decreased (P = 0.0001) and correlated negatively with increase of qT2 (P < 0.05). Furthermore, volumetric abundance of adjacent leptomeningeal collaterals was significantly increased (P < 0.01) and negatively correlated with changes of parenchymal rCPP (P = 0.01). Microstructural cortical damage is closely related to restrictions of antegrade blood flow despite increased pial collateral vessel abundance. Therefore, increased leptomeningeal collateral supply cannot necessarily be regarded as a sign of effective compensation in patients with high-grade steno-occlusive vasculopathy. 相似文献
145.
146.
Der Freie Zahnarzt - 相似文献
147.
Christoph Käcker Alexander Marx Katharina Mössinger Frederike Svehla Ulrike Schneider Pancras Cornelis Wilhelmus Hogendoorn Ole Steen Nielsen Stefan Küffer Christian Sauer Cyril Fisher Christian Hallermann Jörg Thomas Hartmann Jean‐Yves Blay Gunhild Mechtersheimer Peter Hohenberger Philipp Ströbel 《Genes, chromosomes & cancer》2013,52(1):93-98
Irradiation is a major causative factor among the small subgroup of sarcomas with a known etiology. The prognosis of radiation‐induced sarcomas (RIS) is significantly worse than that of their spontaneous counterparts. The most frequent histological subtypes include undifferentiated pleomorphic sarcomas, angiosarcomas, and leiomyosarcomas. A high frequency of MYC amplifications in radiation‐induced angiosarcomas, but not in primary angiosarcomas, has recently been described. To investigate whether MYC amplifications are also frequent in RIS other than angiosarcomas, we analyzed the MYC amplification status of 83 RIS and 192 sporadic sarcomas by fluorescence in situ hybridization. We found significantly higher numbers of MYC amplifications in RIS than in sporadic sarcomas (P < 0.0001), especially in angiosarcomas, undifferentiated pleomorphic sarcomas, and leiomyosarcomas. Angiosarcomas were special in that MYC amplifications were particularly frequent and always high level, while other RIS showed low‐level amplifications. We conclude that MYC amplifications are a frequent feature of RIS as a group and may contribute to the biology of these tumors. © 2012 Wiley Periodicals, Inc. 相似文献
148.
Feher Balazs Frommlet Florian Lettner Stefan Gruber Reinhard Nemeth Letizia Elisabeth Ulm Christian Kuchler Ulrike 《Clinical oral investigations》2021,25(11):6093-6099
Clinical Oral Investigations - With only limited information available on dimensional changes after jaw cyst surgery, postoperative cyst shrinkage remains largely unpredictable. We aimed to propose... 相似文献
149.
150.
Jinjiao Wang Todd B. Monroe Adam Simning Yeates Conwell Thomas V. Caprio Xueya Cai Helena Temkin-Greener Ulrike Muench Fang Yu Song Ge Yue Li 《Pain Management Nursing》2021,22(1):36-43
BackgroundPain is common yet under-studied among older Medicare home health (HH) patients with Alzheimer's disease and related dementias (ADRD).AimsExamine (1) the association between ADRD and severe pain in Medicare HH patients; and (2) the impact of severe pain and ADRD on unplanned facility admissions in this population.DesignAnalysis of the Outcome and Assessment Information Set (OASIS) and Medicare claims data.Settings/Participants6,153 patients ≥65 years receiving care from a nonprofit HH agency in 2017.MethodsStudy outcomes included presence of severe pain and time-to-event measures of unplanned facility admissions (hospital, nursing home, or rehabilitation facilities). ADRD was identified using ICD-10 diagnosis codes and cognitive impairment symptoms. Logistic regression and Cox proportional hazard models were used to examine, respectively, the association between ADRD and severe pain, and the independent and interaction effects of severe pain and ADRD on unplanned facility admission.ResultsPatients with ADRD (n = 1,525, 24.8%) were less likely to have recorded severe pain than others (16.4% vs. 23.6%, p < .001). Adjusting for demographics, comorbidities, mental and physical functional status, and use of HH services, having severe pain was related to a 35% increase (hazard ratio [HR] = 1.35, p = .002) in the risk of unplanned facility admission, but the increase in such risk was the same whether or not the patient had ADRD.ConclusionsHH patients with ADRD may have under-recognized pain. Severe pain is a significant independent predictor of unplanned facility admissions among HH patients. 相似文献