Operation Iraqi Freedom: The Landstuhl Regional Medical Center Experience

Landstuhl Regional Medical Center, Germany, the only American medical center in Europe, received approximately 80% of American military patients evacuated out of theater during the first 4 months of Operation Iraqi Freedom. 1236 patients arrived at Landstuhl Regional Medical Center from the beginning of Operation Iraqi Freedom until May 15, 2003, consisting of 256 battle casualties (20.7%), 510 injury patients (41.3%), and 470 disease patients (38.0%). Retrospective record reviews were done on all battle casualties, as well as all disease and injury patients with a musculoskeletal diagnosis. Of the battle casualty patients, 68.4% suffered an extremity injury--a percentage that is consistent with that from prior wars. 52.8% had a lower extremity injury and 21.5% had a foot or ankle injury. Additionally, of all disease and non-battle injury patients with a musculoskeletal diagnosis, 74.7% had an extremity complaint, 44.1% had a lower extremity diagnosis, and 23.2% had foot or ankle pathology. Of all 1236 patients evacuated during this period, 39.5% had extremity pathology, 25.8% had lower extremity pathology, and 12.4% had foot and ankle pathology in isolation or combined with other complaints. Extremity injuries, and specifically lower extremity injuries, continue to be the predominant wounding pattern found in surviving troops in modern warfare. Proper staffing and positioning of medical specialties involved in musculoskeletal trauma care is vital in ensuring proper casualty care in future conflicts.     

报道一孟加拉国少年患结外鼻形NK／T细胞淋巴瘤

自然杀伤（NK）细胞瘤是比较罕见的肿瘤。直到2001年世界卫生组织才对其分级进行了明确的说明。在过去10年间，免疫血液学的发展对NK细胞瘤的识别和分类有一定的帮助。结外鼻形NK／T细胞淋巴瘤是这类肿瘤中的一型。这些淋巴细胞表达细胞毒性T细胞或NK细胞表型，包括CD56和TIA-1。鼻形NK／T细胞淋巴瘤起源于皮肤等结外部位，并常与EB病毒感染相关。亚洲成人的感染最常见。文献报道中极少有儿童患病者，且只有5例患者出现皮肤受累。作者报道1例结外鼻型NK／T细胞瘤，患者为一孟加拉国少年，表现为肢端皮肤结节。     

Carcinoma coexisting with Manson's schistosomiasis

Summary The coexistence of extensive infestation bySchistosoma mansoni and adenocarcinoma of the rectum in a young native of Puerto Rico is described. No claim for causal relationship can be made on this isolated experience. Nevertheless, it is suggested that the link between inflammation and neoplasia, if such a link exists, is in the nature of hyperplastic polypoid granulomas resulting from an undefined stimulus acting in a susceptible tissue.Acknowledgment is made of the preparation of the photomicrographs at the direction of Dr. Robert C. Horn, Jr.     

Ectopic ACTH production in disseminated prostatic adenocarcinoma

The second fully documented case of ACTH-producing prostatic adenocarcinoma with elevated plasma and tissue levels of ACTH is presented. The distinguishing characteristics of ACTH-producing extrapituitary neoplasms and the various modes of therapy are discussed.     

异体手移植1例:美国路易斯威尔经验

背景 依据国际复合组织移植大会的交流经验和猪异体肢体移植研究成功经验,我们制定了一个人类异体手移植计划。方法 通过全面的移植术前评估和患者的同意,选择移植物大小、性别、皮肤弹性相配的一个58岁的尸体供者的左手移植到一个失去左手13年的男性受者。免疫抑制治疗包括Simulect(一种新型免疫抑制剂,为竞争性IL-2受体阻断剂)诱导治疗和普乐可复、骁悉、强的松龙的维持治疗。结果 供手的冷缺血时间为310分钟。无术中或术后并发症。移植物皮肤在第6、20、27周发生了中等程度的排斥反应。通过静注甲基强的松龙,局部使用普乐可复(FK506)和氯倍他索(Clobetasol)缓解。温度觉、痛觉、压力觉在一年时到达手和手指。在术后一年,患者可以使用左手进行许多假肢没有的功能,例如投掷垒球、翻报纸、写字和系鞋带。结论 利用新型免疫抑制剂获得了异体手移植的早期成功。     

Single Nucieotide Polymorphisms in a male infertility-related cene CatSper

Aim: To identify the single nucleotide polymorphisms (SNPs) of human CatSper gene, the mouse homologous gene product. Methods: A systematic screening of SNPs in coding regions and flanking intronic regions of human CatSper gene in a sample subset from 210 Chinese Han males by DNA sequencing was demonstrated. PCR single-strand conformation polymorphism (SSCP) analysis was used to determine the allele frequencies of the possible SNPs. Results: Three SNPs, including two novels, were identified and their allele frequencies determined in 210 males. These SNPs were assembled into large SNP database that permits the analysis of the genetic basis of different diseases.