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21.
22.
Background
Studies have found that deaf individuals have higher rates of psychiatric disorder than those who are hearing, while at the same time encountering difficulties in accessing mental health services. These factors might increase the risk of suicide. However, the burden of suicidal behaviour in deaf people is currently unknown. 相似文献23.
D. McDonald H. Deavall P. Moss† J. Steele† J. Thompson V. Turner 《Transfusion medicine (Oxford, England)》2006,16(S1):52-52
Over 20 years ago, the Birmingham Blood Centre established a facility for the cryopreservation of bone marrow (BM) for patients in the West Midlands suffering from haematopoietic disorders and for whom a bone marrow transplant was indicated. Today, the use of mobilised peripheral blood (PBSC) has overtaken bone marrow as the source of stem cells for transplantation and the numbers of patients benefitting and the diversity of conditions being treated has increased enormously. Allogeneic transplants, using stem cells from healthy donors, have become increasingly successful as a result of an improving understanding of the complexities of the HLA histocompatibility system. Additionally umbilical cord blood (HUC), which in the 1980s was recognised as a source of stem cells, can now be collected and used for transplantation. As scientific knowledge and the clinical management of patients has advanced, so too have laboratory methods for manipulating cell products to enrich or deplete certain cell populations (e.g. by CD34+cell selection) in order to minimise potentially fatal graft-versus-host disease (GVHD) or to eliminate tumour cells in the case of autologous patients. Donor lymphocytes (DLI) may also be collected and used to aid a graft-versus-leukaemia (GVL) effect. The laboratory is currently developing protocols for immunotherapy using virus-specific T cells which can be prepared and infused to combat potentially fatal CMV disease post-transplant. Clinical trials of vaccines employing tumour specific dendritic cells for treating patients with hepatocellular carcinoma (HCC) and metastatic melanoma (MM), which do not respond to conventional treatments, are also underway. The advances and expansion in the Stem Cell and Immunotherapy (SCI) service in Birmingham over the last 10 year period are reflected in the table below:
24.
This study provides additional information on the psychometric properties of the Sexual Aversion Scale (SAS). Results suggest a positive relationship between sexual aversion, generalized anxiety, and history of sexual victimization. Variables such as age and religiosity were unrelated to scores on the SAS, although females reported significantly more sexual anxiety than males. The factor structure of the SAS is described and suggests that sexual aversion is a multifaceted problem with at least three and possibly four different dimensions. 相似文献
25.
A. Piazzini M. P. Canevini P. Somenzi K. Turner R. Chifari R. Canger 《Neurological sciences》2006,27(5):340-344
Abstract The aim of the present paper was to describe some formative projects on work integration of patients with epilepsy and mild
cognitive deficits, so that similar initiatives may be promoted. The different phases of the formative projects were described:
the inclusion criteria, the selection of participants, the assessment instruments, the courses themselves and the final results
in terms of working experience. Thirteen participants were selected for each course. Patients were treated in different Lombardy
Epilepsy departments, which addressed them to the Epilepsy Center, S. Paolo Hospital, Milan, where the selection took place.
Seventy percent of the participants in the formative courses found a job in 1 year, even though most of the positions were
temporary. The work integration seemed to be mainly related to the level of intelligence and to verbal memory. We stress the
importance of organising similar courses in the future, in the context of wider networks. This will help more patients in
acquiring both economic and psychological autonomy from their families. 相似文献
26.
27.
A trend to market-driven health care in many parts of the world is focusing increasing attention on getting maximum value from available resources. Laboratories are not exempted. Well-informed clinical input has a potentially valuable role in any laboratory rationalization process. However, a communication difficulty exists in the sense that, although laboratory workers, commercial developers, regulatory bodies, etc., are thoroughly conditioned to using assay coefficient of variation as a general performance measure (for excellent reasons), this is not necessarily the most intuitive or informative scale from a clinician's perspective. Here we use routine clinical data from an immunoradiometric assay of thyrotropin to illustrate, first, a general approach to estimation and prediction of reproducibility, and second, an alternative summary that expresses the discriminatory power of an assay. This latter measure, our experience suggests, is more suited to the way clinicians perceive assays and assay results. The overall aim is improved clinician/laboratory communication. 相似文献
28.
Agents for prevention or treatment of osteoporosis must now be tested in a large animal species that exhibits bone remodeling.
Ovariectomized, nonhuman primates provide one such model, and they consistently develop osteopenia accompanied by high bone
turnover rates. The goal of this study was to further characterize this model, and particularly to determine the effect of
ovariectomy on bone strength in vertebrae and femoral necks. Longitudinal evaluations of spinal bone mass and serum markers
of bone turnover were performed in 19 sham-ovariectomized (SHAM) and 18 ovariectomized (OVX), domestically reared cynomolgus
monkeys, aged >9 years. OVX monkeys lost bone relative to both baseline values and SHAM controls. Serum markers of bone turnover
were increased by OVX. After 72 weeks, both vertebral bone compressive strength and femoral neck breaking strength were significantly
decreased in OVX animals compared with SHAM. Ovariectomized cynomolgus monkeys, like postmenopausal women, develop accelerated
bone loss, increased bone turnover, and reduced bone strength, and provide a suitable large animal model for efficacy studies
with agents for prevention or treatment of osteoporosis.
Received: 24 June 1996 / Accepted: 3 September 1996 相似文献
29.
Richard B Scott Ralph Gregory Joanna Wilson Sarah Banks Anna Turner Simon Parkin Nir Giladi Carol Joint Tipu Aziz 《Movement disorders》2003,18(5):539-550
Primary dystonia is a disorder of movement for which no consistent pathophysiology has been identified; in the absence of evidence to the contrary, it is assumed to be cognitively benign. We have studied a clinically heterogeneous group of 14 patients with primary dystonia on a battery of neuropsychological tests. Despite well-preserved speed of information processing, language, spatial, memory and general intellectual skills relative to normal controls, we have identified a constellation of attentional-executive cognitive deficits on the Cambridge Neuropsychological Test Automated Battery (CANTAB). Specifically, patients demonstrated significant difficulties negotiating the extra-dimensional set-shifting phase of the IED task. The implications of these findings for the pathophysiology of primary dystonia are discussed. This is, to the best of our knowledge, the first report of a significant cognitive deficit in patients with primary dystonia. 相似文献
30.