全文获取类型
收费全文 | 11989篇 |
免费 | 547篇 |
国内免费 | 116篇 |
专业分类
耳鼻咽喉 | 184篇 |
儿科学 | 252篇 |
妇产科学 | 236篇 |
基础医学 | 1659篇 |
口腔科学 | 266篇 |
临床医学 | 676篇 |
内科学 | 3192篇 |
皮肤病学 | 174篇 |
神经病学 | 981篇 |
特种医学 | 583篇 |
外国民族医学 | 1篇 |
外科学 | 1632篇 |
综合类 | 78篇 |
一般理论 | 4篇 |
预防医学 | 400篇 |
眼科学 | 205篇 |
药学 | 930篇 |
中国医学 | 24篇 |
肿瘤学 | 1175篇 |
出版年
2023年 | 54篇 |
2022年 | 72篇 |
2021年 | 194篇 |
2020年 | 115篇 |
2019年 | 159篇 |
2018年 | 210篇 |
2017年 | 158篇 |
2016年 | 233篇 |
2015年 | 239篇 |
2014年 | 314篇 |
2013年 | 429篇 |
2012年 | 615篇 |
2011年 | 696篇 |
2010年 | 417篇 |
2009年 | 349篇 |
2008年 | 638篇 |
2007年 | 690篇 |
2006年 | 737篇 |
2005年 | 686篇 |
2004年 | 689篇 |
2003年 | 705篇 |
2002年 | 732篇 |
2001年 | 240篇 |
2000年 | 257篇 |
1999年 | 251篇 |
1998年 | 186篇 |
1997年 | 146篇 |
1996年 | 112篇 |
1995年 | 111篇 |
1994年 | 94篇 |
1993年 | 123篇 |
1992年 | 222篇 |
1991年 | 185篇 |
1990年 | 170篇 |
1989年 | 182篇 |
1988年 | 148篇 |
1987年 | 120篇 |
1986年 | 131篇 |
1985年 | 114篇 |
1984年 | 79篇 |
1983年 | 87篇 |
1982年 | 46篇 |
1981年 | 39篇 |
1980年 | 41篇 |
1979年 | 43篇 |
1978年 | 32篇 |
1977年 | 36篇 |
1974年 | 31篇 |
1973年 | 28篇 |
1966年 | 29篇 |
排序方式: 共有10000条查询结果,搜索用时 78 毫秒
51.
HTLV-I uveitis: a distinct clinical entity caused by HTLV-I. 总被引:16,自引:0,他引:16
M Mochizuki T Watanabe K Yamaguchi K Takatsuki K Yoshimura M Shirao S Nakashima S Mori S Araki N Miyata 《Japanese journal of cancer research》1992,83(3):236-239
Seroepidemiological, clinical and virological studies were carried out in an HTLV-I endemic area to find out if HTLV-I caused an intraocular inflammatory disorder, uveitis. The seroprevalence in patients with uveitis without defined etiologies (62/175, 35.4%) was significantly higher than that in patients with non-uveitic ocular diseases (42/261, 16.1%) or in patients with uveitis with defined etiologies (8/78, 10.3%). Moreover, the seroprevalence in young adults (20-49 years) with uveitis without defined etiologies was 30/67 (44.8%), whereas it was only 10/107 (9.3%) in the other two groups. The uveitis in HTLV-I carriers was characterized clinically by a moderate inflammation of the vitreous body accompanied by a mild iritis and retinal vasculitis. The proviral DNA of HTLV-I was detected by polymerase chain reaction from the inflammatory cells in the anterior chamber in 9 out of 9 seropositive patients with the uveitis, but not in any of the tested patients with other types of uveitis. These data, thus, indicate that HTLV-I causes a specific type of intraocular inflammation, uveitis. 相似文献
52.
Tsutomu Sugimoto Toshiki Takahashi Kiyoshige Inui Takashi Minowa Takao Watanabe Yasuhisa Shimazaki 《The Japanese Journal of Thoracic and Cardiovascular Surgery》2003,51(10):524-527
Ductus arteriosus aneurysm is rare in adults and preoperative diagnosis has not been usually done. We report 2 cases of adult
type ductus arteriosus aneurysm. In both cases, 3D computed tomographic scanning showed a saccular aneurysm originating from
the distal aortic arch toward the left pulmonary artery, which had a notching in the orifice of the aortic side. They were
successfully treated surgically though one was a ruptured aneurysm to the left pulmonary artery. In these cases, 3D-CT scan
was of great value in the preoperative diagnosis of the ductus arteriosus aneurysm. 相似文献
53.
Akira Sezai Motomi Shiono Tatsuya Inoue Mitsumasa Hata Mitsuru Iida Tetsuya Niino Akira Saito Tsutomu Hattori Shinji Wakui Masao Soeda Nanao Negishi Yukiyasu Sezai 《Annals of thoracic and cardiovascular surgery》2004,10(3):191-194
The patient was a 48-year-old male who was diagnosed with unstable angina. He had worsening cardiogenic shock during coronary angiography. Emergency coronary artery bypass grafting (CABG) was performed. He had a methicillin-resistant Staphylococcus aureus (MRSA) mediastinitis on day 22 after CABG. Drains were placed in the anterior mediastinum, left thoracic cavity, and abscess cavity, and another drain was placed in the mediastinal space for continuous cleansing with povidone iodine, oxydol. For antibiotics, teicoplanin (TEIC) was administered intravenously and to the local site via the cleansing drain for about one month. No MRSA was detected by culture in discharges from the mediastinal drain. Inflammatory findings were improved, and the patient was discharged and resumed everyday life without recurrence of inflammation as of eight months. Although the number of cases of MRSA mediastinitis is small and accumulation of cases is necessary to investigate therapeutic methods and selection of antibiotics, our department will select closed continuous cleansing and TEIC for antibiotics as the first choice for MRSA mediastinitis, and accumulate cases to investigate its efficacy. 相似文献
54.
Synchronous pulmonary atypical adenomatous hyperplasia and metastatic osteosarcoma in a young female
Ken Kodama Masahiko Higashiyama Koji Takami Naozumi Higaki Kazuyuki Oda Nobuhito Araki 《The Japanese Journal of Thoracic and Cardiovascular Surgery》2004,52(7):357-359
A 17-year-old female underwent metastasectomy of three synchronous lesions in the bilateral lungs under the diagnosis of metastatic
osteosarcoma, however, one of them was found to be atypical adenomatous hyperplasia (AAH). Since AAH is very rare among young
people, a careful evaluation of high-resolution computed tomographic image is important in determining the operative indications
and procedures in patients with multiple metastatic tumors. 相似文献
55.
56.
Yoshito Matsui Tomoatsu Kimura Noriyuki Tsumaki Haruhiko Nakahara Nobuhito Araki Natsuo Yasui Takahiro Ochi 《Journal of orthopaedic science》1996,1(2):130-135
Recent DNA studies performed by several groups have detected mutations of the gene encoding fibroblast growth factor receptor
3 (FGFR3) in patients with achondroplasia-group disorders, including achondroplasia (ACH), hypochondroplasia (HCH), and thanatophoric
dysplasia (TD). For this study, we analyzed theFGFR3 gene in 31 Japanese patients with typical ACH, four with HCH, three with a condition intermediate between ACH and HCH (ACH/HCH-intermediate),
and one with TD. Of the 31 typical ACH patients, 29 showed a G1138 to A transition and the other two a G1138 to C transversion,
both resulting in a common Gly380Arg substitution in the transmembrane domain of FGFR3. The one TD and the four HCH patients
did not display any mutations in the transmembrane domain of FGFR3. Of the three ACH/HCH-intermediate cases, one patient showed
the Gly380Arg substitution and one did not, and further analysis of the second patient revealed the presence of Asn540Lys
substitution. The first patient was, therefore, genotypically diagnosed as ACH and the second as HCH. Peripheral blood leukocyte
DNA analysis in the remaining ACH/HCH-intermediate patient indicated an unequal ratio of mutant to normal PCR products, possibly
representing a somatic mosaic for the Gly380Arg mutation. Analysis of the common FGFR3 mutation thus appears to help in the
molecular diagnosis of patients with achondroplasia-group disorders. 相似文献
57.
Toshifumi Gabata Masumi Kadoya Osamu Matsui Masashi Yamashiro Tsutomu Takashima Donald G. Mitchell Yasutaka Nakamura Kazuo Takeuchi Yasuni Nakanuma 《Journal of magnetic resonance imaging : JMRI》1998,8(2):503-504
We reported a case of the biliary cystadenoma of the liver. The cystic mass had labulation and septation and showed marked hyperintensity on T1-weighted images and hypointensity on T2-weighted images; MR findings were very unusual for cystadenoma. The content of the cystic mass was jelly-like, thick mucinous fluid without intracystic hemorrhage. We concluded that these unusual signal intensities of the cyst were due to hyperproteinous mucinous fluid. 相似文献
58.
59.
Ryozo Oishi Yoshinori Itoh Tamotsu Fukuda Yasunori Araki Kiyomi Saeki 《Journal of neural transmission (Vienna, Austria : 1996)》1988,73(1):65-69
Summary The size of the neuronal and non-neuronal histamine pools in the brain of three different strains of rats was measured by assuming that the -fluoromethylhistidine-induced maximal decrement of histamine represents the size of the neuronal pool. Although the total histamine levels in the brain showed a considerable interstrain variation, no significant interstrain difference was observed in the neuronal histamine level. These results suggest that the size of the neuronal histamine pool in the brain is relatively stable, whereas the size of the non-neuronal histamine pool is variable. 相似文献
60.
Ryozo Oishi Masahiro Nishibori Yoshinori Itoh Kiyomi Saeki Tamotsu Fukuda Yasunori Araki 《Naunyn-Schmiedeberg's archives of pharmacology》1988,337(1):58-63
Summary The turnover of brain histamine was examined in mice implanted subcutaneously with a morphine pellet (50 mg free base). The numbers of naloxone-precipitated jumpings and body shakes were maximum 2 and 3 days after implantation, respectively. The brain tele-methylhistamine level significantly increased (50% to 115%) during 12 h3 days after implantation of a morphine pellet, whereas the histamine level remained unchanged. The accumulation of tele-methylhistamine by pargyline treatment was significantly enhanced when pargyline was administered 12 h after implantation, suggesting an enhancement of histamine turnover. However, a similar degree of the tele-methylhistamine accumulation was induced by pargyline during 1–5 days after implantation, as compared with the accumulation in the control mice implanted with a placebo pellet. In mice undergoing morphine withdrawal by either the removal of morphine pellet or the treatment with naloxone 3 days after implantation, the degree of the pargyline-induced telemethylhistamine accumulation or the (S)--fluoromethylhistidine (-FMH)-induced histamine decrease was similar to that observed in the placebo pellet-control mice. The numbers of naloxone-precipitated jumpings and body shakes occurring in mice 3 days after implantation were not significantly affected by any of l-histidine, -FMH or metoprine. These results suggest that turnover of histamine in the brain is enhanced by acute morphine treatment and returns to the normal rate in the stage of chronic treatment and remains unchanged during the state of withdrawal.
Send offprint requests to K. Saeki 相似文献