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101.
102.
Nikpay M ?eda O Tremblay J Petrovich M Gaudet D Kotchen TA Cowley AW Hamet P 《Hypertension research》2012,35(6):585-591
Links between substance use habits, obesity, stress and the related cardiovascular outcomes can be, in part, because of loci with pleiotropic effects. To investigate this hypothesis, we performed genome-wide mapping in 119 multigenerational families from a population in the Saguenay-Lac-St-Jean region with a known founder effect using 58,000 single-nucleotide polymorphisms and 437 microsatellite markers to identify genetic components of the following factors: habitual alcohol, tobacco and coffee use; response to mental and physical stress; obesity-related traits; and heart rate (HR) and blood pressure (BP) measures. Habitual alcohol and/or tobacco users had attenuated HR responses to mental stress compared with non-users, whereas hypertensive individuals had stronger HR and systolic BP responses to mental stress and a higher obesity index than normotensives. Genetic mappings uncovered numerous shared genes among substance use, stress response, obesity and hemodynamic traits, including CAMK4, CNTN4, DLG2, FHIT, GRID2, ITPR2, NOVA1 and PRKCE, forming network of interacting proteins, sharing synaptic function and display higher and patterned expression profiles in brain-related tissues; moreover, pathway analysis of shared genes pointed to long-term potentiation. Subgroup genetic mappings uncovered additional shared synaptic genes, including CAMK4, CNTN5 and DNM3 (hypertension-specific); CNTN4, DNM3, FHIT and ITPR1 (sex-specific), having protein interactions with genes driven from general analysis. In summary, consistent with the observed phenotypic correlations, we found substantial overlap among genomic determinants of these traits in synapse, which supports the notion that the neural synapse may be a shared interface behind substance use, stress, obesity, HR, BP as well as the observed sex- and hypertension-specific genetic differences. 相似文献
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Daniel Skuk Marlyne Goulet Martin Paradis Jacques P. Tremblay 《Neuromuscular disorders : NMD》2013,23(2):155-159
A rhesus macaque with generalized muscle atrophy and musculotendinous contractures was detected in our research center. Muscle biopsies showed myofibers with rimmed vacuoles and eosinophilic hyaline inclusions, accumulations of CD8+ and CD4+ lymphocytes and expression of major histocompatibility complex class I in myofibers. Intracellular inclusions were positive to Congo red. Semithin sections and transmission electron microscopy showed autophagic vacuoles within myofibers and myonuclei with inclusions of filaments. These morphological observations conform with the diagnostic criteria of human sporadic inclusion body myositis. This is the first report of this myopathy in nonhuman primates. 相似文献
105.
Stéphane Prange MD PhD Elise Metereau PhD Audrey Maillet PhD Hélène Klinger MPsych Emmanuelle Schmitt MPsych Eugénie Lhommée MPsych Amélie Bichon MPsych Sophie Lancelot PharmPhD Sara Meoni MD PhD Emmanuel Broussolle MD PhD Anna Castrioto MD PhD Léon Tremblay PhD Paul Krack MD PhD Stéphane Thobois MD PhD 《Movement disorders》2022,37(6):1211-1221
106.
Vergunst Francis Chadi Nicholas Orri Massimiliano Brousseau-Paradis Camille Castellanos-Ryan Natalie Séguin Jean R. Vitaro Frank Nagin Daniel Tremblay Richard E. Côté Sylvana M. 《European child & adolescent psychiatry》2022,31(11):1729-1738
European Child & Adolescent Psychiatry - Substance abuse is a significant public health concern that disproportionately burdens males and low-income communities. This study examined (1)... 相似文献
107.
Arcand C Tremblay E Vannasing P Ouimet C Roy MS Fallaha N Lepore F Lassonde M McKerral M 《Experimental brain research. Experimentelle Hirnforschung. Expérimentation cérébrale》2007,180(2):263-272
There are important developmental changes occurring during infancy in visual cortical structures that underlie higher-order
perceptual abilities. Using high-density electrophysiological recording techniques, the present study aimed to examine the
development of visual mechanisms, during the first year of life, associated with texture segregation. Forty-two normal full
term infants were tested at 1, 3, 6 or 12 months of age. Visual-evoked potentials to low-level stimuli varying in orientation
(oriVEP) and higher-level textured stimuli (texVEP) were recorded from 128 scalp electrodes. Difference potentials were obtained
to extract the VEP component associated specifically with texture segregation (tsVEP). Results show a clear developmental
pattern regarding amplitude, latency and scalp distribution of tsVEP, which appears at around 3 months but does not reach
maturity by 12 months of age. A reduction in latency is particularly evident between 3 and 6 months, whereas amplitude shows
a gradual increase with a marked increment between 3 and 6 months for low-level orientation stimuli and between 6 and 12 months
for higher-level textured stimuli. These developmental patterns are attributed to neural maturational processes such as myelination
and synaptogenesis. The differential developmental rates can be explained by delayed maturational processes of brain regions
involved in more complex visual processing. 相似文献
108.
Léonard G Tremblay F 《Experimental brain research. Experimentelle Hirnforschung. Expérimentation cérébrale》2007,177(2):167-175
In the present report, we extent our previous findings (Clark et al. in Neuropsychologia 42:105–122, 2004) on corticomotor facilitation associated with covert (observation and imagery) and overt execution (action imitation) of
hand actions to better delineate the selectivity of the effect in the context of an object-oriented action. A second aim was
to examine whether the pattern of facilitation would be affected by age. Corticomotor facilitation was determined in two groups
of participants (young n = 21, 24 ± 2 years; old n = 19, 62 ± 6 years) by monitoring changes in the amplitude and latency of motor evoked potentials (MEPs) elicited in hand
muscles by transcranial magnetic stimulation. MEP responses were measured from both the first dorsal interosseous (FDI, task
selective muscle) and the abductor digiti minimi (ADM) of the right hand while participants attended to four different video
presentations. Each of four videos provided specific instructions for participants to either: (1) close their eyes and relax
(REST), (2) observe the action attentively (OBS), (3) close their eyes and mentally simulate the action (IMAG), or (4) imitate
the action (IMIT). The action depicted in the videos represented a male subject cutting a piece of material with scissors.
In the young group, the pattern of results revealed selective facilitation in the FDI in conditions involving either covert
(OBS and IMAG) or overt action execution (IMIT). In the ADM, only overt execution with action imitation was associated with
significant MEP facilitation. In the old group, a similar pattern of results was observed, although the modulation was less
selective than that seen in the young group. In fact, older individuals often exhibited concomitant facilitation in both the
FDI and ADM during either covert (OBS and IMAG conditions) or overt action execution (IMIT condition). Taken together, these
results further corroborate the notion that the corticomotor system is selectively active when actions are covertly executed
through internal simulation triggered by observation or by motor imagery, as proposed by Jeannerod (Neuroimage 14:S103–S109,
2001). With aging, the ability to produce corticomotor facilitation in association with covert action execution appears to be
largely preserved, although there seems to be a loss in selectivity. This lack of selectivity may, in turn, reflect age-related
alterations in the function of the corticospinal system, which may impair the ability to individuate finger movements either
in the covert or overt stage of action execution. 相似文献
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110.