全文获取类型
收费全文 | 7125篇 |
免费 | 335篇 |
国内免费 | 76篇 |
专业分类
耳鼻咽喉 | 28篇 |
儿科学 | 141篇 |
妇产科学 | 133篇 |
基础医学 | 1073篇 |
口腔科学 | 147篇 |
临床医学 | 426篇 |
内科学 | 1747篇 |
皮肤病学 | 252篇 |
神经病学 | 600篇 |
特种医学 | 252篇 |
外科学 | 1073篇 |
综合类 | 23篇 |
预防医学 | 179篇 |
眼科学 | 73篇 |
药学 | 515篇 |
中国医学 | 18篇 |
肿瘤学 | 856篇 |
出版年
2023年 | 29篇 |
2022年 | 93篇 |
2021年 | 148篇 |
2020年 | 76篇 |
2019年 | 102篇 |
2018年 | 149篇 |
2017年 | 158篇 |
2016年 | 170篇 |
2015年 | 170篇 |
2014年 | 242篇 |
2013年 | 279篇 |
2012年 | 468篇 |
2011年 | 518篇 |
2010年 | 305篇 |
2009年 | 243篇 |
2008年 | 425篇 |
2007年 | 501篇 |
2006年 | 490篇 |
2005年 | 488篇 |
2004年 | 479篇 |
2003年 | 501篇 |
2002年 | 473篇 |
2001年 | 70篇 |
2000年 | 54篇 |
1999年 | 87篇 |
1998年 | 123篇 |
1997年 | 81篇 |
1996年 | 69篇 |
1995年 | 73篇 |
1994年 | 65篇 |
1993年 | 53篇 |
1992年 | 42篇 |
1991年 | 39篇 |
1990年 | 38篇 |
1989年 | 41篇 |
1988年 | 20篇 |
1987年 | 23篇 |
1986年 | 10篇 |
1985年 | 14篇 |
1984年 | 13篇 |
1983年 | 7篇 |
1982年 | 20篇 |
1981年 | 9篇 |
1980年 | 12篇 |
1979年 | 13篇 |
1978年 | 8篇 |
1977年 | 7篇 |
1976年 | 6篇 |
1973年 | 7篇 |
1969年 | 5篇 |
排序方式: 共有7536条查询结果,搜索用时 15 毫秒
101.
Jain Divyanu Oda Tomoaki Kawai Kenta Horikoshi Yoshimasa Matsumoto Masako Narumi Megumi Kohmura-Kobayashi Yukiko Furuta-Isomura Naomi Yaguchi Chizuko Uchida Toshiyuki Suzuki Kazunao Kanayama Naohiro Itoh Hiroaki Tamura Naoaki 《Journal of thrombosis and thrombolysis》2022,53(1):208-212
Journal of Thrombosis and Thrombolysis - Pulmonary thromboembolism (PTE) is one of the leading causes of maternal mortality. We previously reported that possible contamination of amniotic fluid... 相似文献
102.
Suzuki Yutaka Mori Toshiyuki Momose Hirokazu Matsuki Ryota Kogure Masaharu Abe Nobutsugu Isayama Hiroyuki Tazuma Susumu Tanaka Atsushi Takikawa Hajime Sakamoto Yoshihiro 《Journal of gastroenterology》2022,57(5):387-395
Journal of Gastroenterology - Predictive factors for intrahepatic cholangiocarcinoma in long-term follow-up of hepatolithiasis are unknown. We thus conducted a cohort study to investigate the... 相似文献
103.
Okusaka Takuji Ikeda Kenji Kudo Masatoshi Finn Richard Qin Shukui Han Kwang-Hyub Cheng Ann-Lii Piscaglia Fabio Kobayashi Masahiro Sung Max Chen Minshan Wyrwicz Lucjan Yoon Jung-Hwan Ren Zhenggang Mody Kalgi Dutcus Corina Tamai Toshiyuki Ren Min Hayato Seiichi Kumada Hiromitsu 《Journal of gastroenterology》2021,56(6):570-580
Journal of Gastroenterology - REFLECT was an open-label, phase 3 study comparing the efficacy and safety of lenvatinib versus sorafenib in patients with unresectable hepatocellular carcinoma... 相似文献
104.
Akihiro Yoshimoto Kazuo Kasahara Hideharu Kimura Toshiyuki Kita Masaki Fujimura Shinji Nakao 《Nihon Kokyūki Gakkai zasshi》2004,42(1):56-61
Gefitinib blocks epidermal growth factor receptor autophosphorylation and subsequently the signal transduction pathways implicated in proliferation, metastasis, invasion, and angiogenesis. Reported adverse reactions to gefitinib include liver injury that is not fully understood. Liver injury was observed in 5 (12.2%) of 41 patients with non-small cell lung cancer who received gefinitib monotherapy. Onset of liver injury was seen between 28 and 56 days after initiation of administration. Two patients had Grade 2 liver injury and 3 patients, Grade 3. In 4 patients, liver injury was temporary, lasting during a period of continuous gefitinib administration. In another patient, gefitinib was discontinued because of the onset of liver injury, which improved when gefitinib administration was restarted. Gefitinib is necessary in most patients whose lung cancer is refractory to cytotoxic chemotherapy, because no other treatment regimens are available at present. The rate of liver injury in cases treated with gefitinib is high, and so it is necessary to observe liver function carefully, but the liver injury due to this drug is often transient. However, the use of gefitinib in many cases appears to be a necessity. 相似文献
105.
Yoshihiro Nakatani Toshiyuki Kitazawa Masao Fujimoto Nobuhiro Tamura Masahito Uemura Junichi Yamao Hiroshi Fukui 《Alcoholism, clinical and experimental research》2004,28(S2):123S-128S
Background: It is suggested that endotoxin and proinflammatory cytokines play an important role in the development and progression of alcoholic liver disease. Recently, a prostaglandin receptor subtype EP4 agonist with cytoprotective effect has been developed. We examined the efficacy of an EP4 agonist ONO-AE1-437 on tumor necrosis factor-α (TNF-α) secretion of Kupffer cells, splenic macrophages, and alveolar macrophages in acute ethanol-loaded rats.
Methods: Kupffer cells, splenic macrophages, and alveolar macrophages were isolated from control and acute ethanol-loaded rats (5 mg/g body weight of ethanol, intraperitoneally). After the preculture in the medium that containing 0, 0.1, 1, 10, or 100 nmol/liter of ONO-AE1-437, TNF-α secretion of these cells stimulated by 100 ng/ml of endotoxin was determined for 3 hr.
Results: The amount of TNF-α secreted from alveolar macrophages was largest in both the control and the acute ethanol-loaded rats. Acute ethanol load enhances TNF-α secretion of splenic macrophages. The addition of ONO-AE1-437 significantly inhibited TNF-α secretion of Kupffer cells and splenic macrophages in both the control and the acute ethanol-loaded rats. Alveolar macrophages were less affected.
Conclusions: An EP4 agonist ONO-AE1-437 suppresses excess TNF-α secretion from macrophages and seems promising for future trial in patients with severe alcoholic hepatitis. 相似文献
Methods: Kupffer cells, splenic macrophages, and alveolar macrophages were isolated from control and acute ethanol-loaded rats (5 mg/g body weight of ethanol, intraperitoneally). After the preculture in the medium that containing 0, 0.1, 1, 10, or 100 nmol/liter of ONO-AE1-437, TNF-α secretion of these cells stimulated by 100 ng/ml of endotoxin was determined for 3 hr.
Results: The amount of TNF-α secreted from alveolar macrophages was largest in both the control and the acute ethanol-loaded rats. Acute ethanol load enhances TNF-α secretion of splenic macrophages. The addition of ONO-AE1-437 significantly inhibited TNF-α secretion of Kupffer cells and splenic macrophages in both the control and the acute ethanol-loaded rats. Alveolar macrophages were less affected.
Conclusions: An EP4 agonist ONO-AE1-437 suppresses excess TNF-α secretion from macrophages and seems promising for future trial in patients with severe alcoholic hepatitis. 相似文献
106.
Kenji Nakamura Masayuki Sada Kenzo Setojima Hirofumi Yamamoto Toshiyuki Ueki Masumi Sada 《Journal of hepato-biliary-pancreatic sciences》1997,4(4):449-452
The purpose of this paper is to describe our recent experience in performing laparoscopic cholecystectomies of which we performed 1904, from January 1991 to May 1997, at our private hospital, mainly to treat cholecystolithiasis. The patients included 1563 with gallbladder stones (82.0%), 82 with cholecystocholedocholithiasis (4.3%), 104 with adenomyomatosis (5.5%), 132 with polyps (6.9%), and 23 with gallbladder cancer (1.3%). A difficult pericholecystic dissection led to conversion to open surgery in 61 patients. The average operation time was 63 min. Bile duct injury or cystic artery bleeding occurred in 3 patients with acute cholecystitis, and small intestine injury occurred in 1 patient, while bile leakage or a right subphrenic abscess occurred in 6 patients postoperatively. Although this series included 69 patients with previous upper abdominal surgery, 14 with liver cirrhosis, 267 with a nonvisualized gallbladder, and 148 with acute cholecystitis, the overall conversion rate was only 3.2% and morbidity only 0.5%. Although almost all patients with cholelithiasis are now considered potential candidates for a laparoscopic cholecystectomy, difficulties during cholecystectomy have been encountered in patients with acute cholecystitis. Surgeons should thus be fully prepared to convert to open surgery whenever difficulties are encountered, in order to avoid complication. 相似文献
107.
108.
Yoshisato Tanimoto Hirotaka Tashiro Toshiyuki Itamoto Naoyuki Toyota Toshihiko Kohashi Hironobu Amano Hideki Ohdan Kohei Ishiyama Akihiko Oshita Toshimasa Asahara 《Journal of hepato-biliary-pancreatic sciences》2008,15(2):228-231
Hepatic venous outflow obstruction is a relatively uncommon but important and devastating complication occurring after liver transplantation. Recently, right lateral sector liver grafts have sometimes been used in living-donor liver transplantation (LDLT), but, to our knowledge, early hepatic venous outflow obstruction has never been reported in right lateral sector LDLT. A 58-year-old woman was diagnosed with liver cirrhosis and hepatocellular carcinoma and underwent right lateral sector LDLT. Postoperatively, she developed liver dysfunction. Doppler ultrasound examination revealed flat waveforms and low-flow velocity in the right hepatic vein (RHV). A computed tomography (CT) scan revealed a ventrally distorted RHV due to hypertrophy of the liver graft. Hepatic venous obstruction was suspected and a hepatic venogram was performed. The venogram revealed stenosis of the RHV due to the distortion of the vein. We performed percutaneous transfemoral balloon dilatation, but this was not effective. We then inserted an expandable metallic stent (EMS) into the RHV. After the EMS placement, the condition of the patient improved. Venogram and CT data suggested that the obstruction of the RHV developed because of distortion of the RHV to the ventral side during liver regeneration. 相似文献
109.
为了研究血管平滑肌细胞是否表达极低密度脂蛋白受体mRNA,采用Northern blot分析法检测培养兔主动脉平滑肌细胞表达极低密度脂蛋白受体mRNA的情况。结果发现,培养兔主动脉平滑肌细胞可以表达极低密度脂蛋白受体mRNA;而且,细胞因子白细胞介素-1β能使表达增强约2倍。提示极低密度脂蛋白受体有可能参与动脉平滑肌细胞源性泡沫细胞;白细胞介素-1β上行调节平滑肌细胞表达极低密度脂蛋白受体mRNA 相似文献
110.
Yamashita K Miyoshi T Arai T Endo N Itoh H Makino K Mizugishi K Uchiyama T Sasada M 《Proceedings of the National Academy of Sciences of the United States of America》2008,105(44):16912-16917
Reactive oxygen species produced by phagocytosing neutrophils are essential for innate host defense against invading microbes. Previous observations revealed that antibody-catalyzed ozone formation by human neutrophils contributed to the killing of bacteria. In this study, we discovered that 4 amino acids themselves were able to catalyze the production of an oxidant with the chemical signature of ozone from singlet oxygen in the water-oxidation pathway, at comparable level to antibodies. The resultant oxidant with the chemical signature of ozone exhibited significant bactericidal activity in our distinct cell-free system and in human neutrophils. The results also suggest that an oxidant with the chemical signature of ozone produced by neutrophils might potentiate a host defense system, when the host is challenged by high doses of infectious agents. Our findings provide biological insights into the killing of bacteria by neutrophils. 相似文献