全文获取类型
收费全文 | 2214篇 |
免费 | 86篇 |
国内免费 | 13篇 |
专业分类
耳鼻咽喉 | 10篇 |
儿科学 | 20篇 |
妇产科学 | 33篇 |
基础医学 | 267篇 |
口腔科学 | 42篇 |
临床医学 | 168篇 |
内科学 | 491篇 |
皮肤病学 | 44篇 |
神经病学 | 107篇 |
特种医学 | 67篇 |
外科学 | 437篇 |
综合类 | 15篇 |
预防医学 | 64篇 |
眼科学 | 11篇 |
药学 | 185篇 |
中国医学 | 7篇 |
肿瘤学 | 345篇 |
出版年
2023年 | 14篇 |
2022年 | 18篇 |
2021年 | 36篇 |
2020年 | 14篇 |
2019年 | 33篇 |
2018年 | 40篇 |
2017年 | 33篇 |
2016年 | 23篇 |
2015年 | 29篇 |
2014年 | 34篇 |
2013年 | 50篇 |
2012年 | 118篇 |
2011年 | 142篇 |
2010年 | 83篇 |
2009年 | 45篇 |
2008年 | 133篇 |
2007年 | 122篇 |
2006年 | 142篇 |
2005年 | 138篇 |
2004年 | 134篇 |
2003年 | 116篇 |
2002年 | 121篇 |
2001年 | 67篇 |
2000年 | 75篇 |
1999年 | 69篇 |
1998年 | 33篇 |
1997年 | 23篇 |
1996年 | 16篇 |
1995年 | 17篇 |
1994年 | 20篇 |
1993年 | 16篇 |
1992年 | 37篇 |
1991年 | 43篇 |
1990年 | 27篇 |
1989年 | 36篇 |
1988年 | 31篇 |
1987年 | 23篇 |
1986年 | 20篇 |
1985年 | 18篇 |
1984年 | 15篇 |
1983年 | 17篇 |
1982年 | 6篇 |
1979年 | 6篇 |
1976年 | 7篇 |
1974年 | 6篇 |
1973年 | 5篇 |
1971年 | 5篇 |
1970年 | 8篇 |
1968年 | 14篇 |
1967年 | 8篇 |
排序方式: 共有2313条查询结果,搜索用时 0 毫秒
61.
Cardiac abnormalities seen in patients with subarachnoid hemorrhage (SAH) are considered to be a neurally mediated process rather than a manifestation of coronary artery disease. In patients with SAH, myocardial injury evidenced by troponin elevation appears to predict short and long-term outcomes independently of other conventional risk. Although incidence of electrocardiographic changes, arrhythmias and left ventricular systolic dysfunction do not independently predict the outcomes, monitoring these changes and optimizing hemodynamic status in high-grade SAH is crucial to ensure adequate cerebral perfusion and arterial oxygenation. Novel interventions that go beyond blood pressure control, prevention of re-bleeding, and aneurysm obliteration should target early physiologic derangements seen in the acute phase of SAH. The early resuscitation phase in SAH represents the greatest opportunity for impacting clinical outcome and is thus the most promising window of opportunity to demonstrate a benefit when investigating novel therapeutic strategies related to protection and modulation of cardiovascular function. Specific measures, such as the early use of beta-adrenergic antagonists, to prevent these cardiac abnormalities and ameliorate its impact on morbidity and mortality are yet to be established. 相似文献
62.
63.
Gerrit Frommeyer Sridharan Rajamani Fabian Grundmann Jörg Stypmann Nani Osada Günter Breithardt Luiz Belardinelli Lars Eckardt Peter Milberg 《Journal of cardiac failure》2012,18(12):939-949
BackgroundRanolazine inhibits late Na+ and K+ currents. Earlier studies have reported an antiarrhythmic effect. The aim of the present study was to understand whether ranolazine could still preserve its antiarrhythmic properties in the settings of chronic heart failure (CHF).Methods and ResultsIn 12 female rabbits, CHF was induced by 4 weeks of rapid ventricular pacing leading to a decrease in ejection fraction. Twelve rabbits underwent sham operation. Isolated hearts were Langendorff perfused and demonstrated a significant QT prolongation after induction of heart failure. Ranolazine caused a concentration-dependent (10 and 30 μmol/L) increase of action potential duration (APD90) in sham-operated and failing hearts. Eight endo- and epicardial monophasic action potentials revealed a nonsignificant increase in spatial and temporal dispersion of repolarization. The increase in APD90 was accompanied by a greater increase in refractory period, resulting in a significant increase in postrepolarization refractoriness in sham-operated (+29 ms and +55 ms; P < .01) and failing (+22 ms and +30 ms; P < .05) hearts. In control conditions, programmed ventricular stimulation and a burst pacing protocol led to ventricular fibrillation (VF) in 5 of the 12 sham-operated (6 episodes) and in 7 of the 12 failing (18 episodes) hearts. In the presence of ranolazine, VF was inducible in only 2 of 12 failing hearts (5 episodes). In the presence of low [K+], only 1 ranolazine-treated sham-operated heart developed early afterdepolarizations and ventricular tachyarrhythmias despite significant QT prolongation.ConclusionsRanolazine decreases inducibility of VF in the presence of a significant increase in postrepolarization refractoriness. This antiarrhythmic effect in the intact heart is preserved in CHF and is not associated with drug-induced proarrhythmia. 相似文献
64.
Osada M Kaneko M Sakamoto M Endoh M Takigawa K Suzuki-Inoue K Inoue O Satoh K Enomoto N Yatomi Y Ozaki Y 《Clinical and applied thrombosis/hemostasis》2012,18(3):272-280
We retrospectively studied 89 patients with chronic hepatitis C virus (HCV) infection, including 50 chronic hepatitis (CH) cases, 18 liver cirrhosis (LC) cases, and 21 LC with hepatocellular carcinoma (LC + HCC) cases, with regard to various factors related with thrombocytopenia. The platelet count decreased with the stage advancement of liver diseases. Multiple regression analysis revealed that splenomegaly and von Willebrand factor (vWF) were explanatory variables that correlated with thrombocytopenia. Splenomegaly appears to be the most responsible factor, although there are a considerable number of thrombocytopenic cases without splenomegaly, suggesting other factors may also be responsible. The vWF level is inversely correlated with the platelet count. Soluble thrombomodulin, a marker of endothelial dysfunction, increases with the advancement of liver fibrosis. It is positively correlated with vWF and inversely with the platelet count. Our present results imply that vascular endothelial dysfunction is also involved in thrombocytopenia during chronic HCV infection. 相似文献
65.
Reconstruction method after pancreaticoduodenectomy. Idea to prevent serious complications 总被引:1,自引:0,他引:1
Pancreatic fistula after pancreaticoduodenectomy represents a critical trigger of potentially life-threatening complications and is also associated with markedly prolonged hospitalization. Many arguments have been proposed for the method to anastomosis the pancreatic stump with the gastrointestinal tract, such as invagination vs. duct-to-mucosa, Billroth I (Imanaga) vs. Billroth II (Whipple and/or Child) or pancreaticogastrostomy vs. pancreaticojejunostomy. Although the best method for dealing with the pancreatic stump after pancreaticoduodenectomy remains in question, recent reports described the invagination method to decrease the rate of pancreatic fistula significantly compared to the duct-to-mucosa anastomosis. In Billroth I reconstruction, more frequent anastomotic failure has been reported, and disadvantages of pancreaticogastrostomy have been identified, including an increased incidence of delayed gastric emptying and of pancreatic duct obstruction due to overgrowth by the gastric mucosa. We review recent several safety trials and methods of treating the pancreatic stump after pancreaticoduodenectomy, and demonstrate an operative procedure with its advantage of the novel reconstruction method due to our experiences. 相似文献
66.
67.
68.
Hiroshi Shinohara Kiyoshi Matsuo Yoshiroh Osada Tatsuya Kawamura Yohei Tanaka 《Journal of plastic surgery and hand surgery》2013,47(1):17-22
We have created a new way of reanimating the face, involving transposition of the masseter muscle combined with tensor fascia lata, and using the zygomatic arch as a trochlea to reconstruct the inferior facial paralysis. We used it on five patients who had facial palsy after excision of malignant parotid tumours. The wide skin defect that exposed the masseter muscle after total parotidectomy was reconstructed with a free flap. This method differs from those of other methods of transposing the masseter muscle in that force is applied at an upper lateral angle. Our method provided dynamic raising of the upper lip, the corner of the mouth, and the nasolabial fold in four patients. We consider it to be useful, particularly for prompt surgical reconstruction of facial palsy after total parotidectomy with a wide defect in the skin of the cheek. 相似文献
69.
70.
Identification and structure–activity relationship of purine derivatives as novel MTH1 inhibitors 下载免费PDF全文
Ashutosh Kumar Tatsuro Kawamura Makoto Kawatani Hiroyuki Osada Kam Y. J. Zhang 《Chemical biology & drug design》2017,89(6):862-869
The human mutT homolog‐1 (MTH1) protein prevents the incorporation of oxidized nucleotides such as 2‐OH‐dATP and 8‐oxo‐dGTP during DNA replication by hydrolyzing them into their corresponding monophosphates. It was found previously that cancer cells could tolerate oxidative stress due to this enzymatic activity of MTH1 and its inhibition could be a promising approach to treat several types of cancer. This finding has been challenged recently with increasing line of evidence suggesting that the cancer cell‐killing effects of MTH1 inhibitors may be related to their engagement of off‐targets. We have previously reported a few purine‐based MTH1 inhibitors that enabled us to elucidate the dispensability of MTH1 in cancer cell survival. Here, we provide a detailed process of the identification of purine‐based MTH1 inhibitors. Several new compounds with potency in the submicromolar range are disclosed. Furthermore, the structure–activity relationship and associated binding mode prediction using molecular docking have provided insights for the development of highly potent MTH1 inhibitors. 相似文献