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41.
Murai J 《Shinrigaku kenkyu : The Japanese journal of psychology》1999,70(5):421-426
The present study examined the effects of pleasantness expressed in verbal messages on their perceived deceptiveness. The hypothesis was that pleasant messages are perceived as less deceptive than neutral or unpleasant ones. To test the hypothesis, three types of messages were constructed: pleasant, neutral, and unpleasant. Sixty-seven university students answered the questionnaire in which they rated, on seven-point semantic differential scales, perceived deceptiveness in one of the three types of messages. The result indicated that the unpleasant messages were perceived as the most deceptive, while the pleasant ones the least deceptive. The computer program "GPOWER" was used in order to obtain appropriate sample size. 相似文献
42.
M Aiba H Iri H Suzuki K Kageyama T Kawai O Abe M Murai H Tazaki T Saruta 《Archives of pathology & laboratory medicine》1985,109(4):357-360
Pathologic study of a rare 11-deoxycorticosterone-producing adrenocortical tumor causing primary aldosteronismlike signs and symptoms, revealed several characteristic features as follows: (1) fairly large size with histologic features corresponding to those of benign zone glomerulosa-type aldosteronoma, (2) lack of spironolactone (S) bodies despite S administration, and (3) heavy mast cell infiltration. In order to explain this rare histology, the localization of mast cells in the adrenal glands and functioning adrenocortical tumors of 67 surgical specimens were investigated. The results of the study supported the view that detection of mast cells helps in the differentiation of mineralocorticoid-producing tumors from cortisol-producing ones, and that the observed mast cell infiltration was due, in part, to its production of 11-deoxycorticosterone. 相似文献
43.
44.
Yokomizo Y Murai Y Tanaka E Inokuchi H Kusukawa J Higashi H 《Neuroscience research》2005,51(4):463-474
The mesencephalic trigeminal nucleus (MesV) contains the somata of primary afferent neurons innervating masticatory muscle spindles and the periodontal membrane. MesV afferent somata are unique in receiving synaptic inputs. Intracellular recordings in coronal pontine slices from adult rats were made from MesV neurons identified by having Cs-sensitive inward rectification and pseudounipolar morphology. Stimuli near the MesV evoked either a cluster of action potentials superimposed on a postsynaptic potential (PSP) or an antidromic spike at resting membrane potential (RMP). Membrane hyperpolarization revealed that each cluster of action potentials consisted of an antidromic spike and a subsequent PSP. Evoked PSPs in slices and miniature postsynaptic currents (mPSCs) recorded using whole-cell patch in dissociated MesV neurons were resistant to glutamate antagonists and strychnine but were reversibly abolished by 40 microM bicuculline. Superfusion of 1-10 mM GABA decreased input resistance and depolarized the membrane. Reversal potentials for evoked PSPs and GABA-induced depolarizations were similar and close to that for mPSCs which matched the Cl- equilibrium potential. Thus activation of synapses on MesV somata evokes GABAergic PSPs that generate action potentials at RMP in the adult. These data also indicate that primary afferent MesV neurons can act as interneurons in the central control of mastication. 相似文献
45.
Shunji Muraoka Toshihiro Sato Tatsuro Takahashi Masakatsu Ando Akihisa Shimoda 《Pathology international》1985,35(4):933-944
A rare case of plasma cell granuloma of the lung in a 5-year-old girl showing extrapulmonal extension to the adjoining thoracic wall was reported. Intrapulmonal and thoracic wall granulomas revealed the same histopathologic features; proliferation of plasma cells and fibrous connective tissue. Although slightly atypical plasma cells were observed among many mature ones, immunohistochemical examination revealed polyclonal proliferation, confirming their inflammatory nature. Cellular components of fibrous connective tissue were identified as fibroblastic cells and myofibroblasts by electron microscopy. The present case and literature suggested the importance of the fact that "infiltrative" plasma cell granuloma had a tendency to occur in children. ACTA PATHOL. JPN. 35: 933–944, 1985. 相似文献
46.
47.
Effect of rectal administration of rebamipide on dextran sulfate sodium-induced colitis: Role of hepatocyte growth factor 总被引:1,自引:0,他引:1
R. Murai T. Kanbe T. Mukoyama T. Shimomura K. Hashiguchi Y. Yoshida H. Tsuchiya Y. Hoshikawa A. Kurimasa G. Shiota 《Inflammation research》2007,56(6):240-245
Objective and design: Since rebamipide is effective for the treatment of ulcerative colitis (UC), we examined the involvement of hepatocyte growth
factor (HGF) in the action of rebamipide.
Materials: Fifty-five and forty female Balb/c mice, respectively, were used in Exp. 1 and 2.
Treatment: 50 mg/kg/day rebamipide (Exp. 1) and 1 × 107 pfu pAxCAHGF (the CAG promoter-driving HGF gene in adenovirus vector) (Exp. 2) were intrarectally introduced after induction
of colitis by 4 % dextran sulfate sodium (DSS).
Methods: Therapeutic effects were assessed by cell proliferation and apoptosis.
Results: Rebamipide caused proliferation of epithelial cells at 10 days after treatment, and decreased apoptosis at 10, 14 and 21 days,
compared with controls. Expression of HGF was greatly increased in rebamipide-treated mice. pAxCAHGF caused cell proliferation
and apoptosis, which showed the same pattern as with rebamipide treatment.
Conclusions: Rectal administration of rebamipide is effective for DSS-induced colitis in association with induction of HGF.
Received 17 June 2006; returned for revision 23 August 2006; returned for final revision 29 October 2006; accepted by I. Ahnfelt-R?nne
14 December 2006 相似文献
48.
Liu Y Takahashi S Ogasawara H Seo HG Kawagoe M Hirasawa F Guo N Ueno Y Kameda T Sugiyama T 《Biomedical research (Tokyo, Japan)》2005,26(1):9-14
A novel substance, #675, found from an Streptomyces sp. SM675 culture medium, dose-dependently stimulates the proliferation of human functional liver cell 4 (FLC4). When FLC4 cells were incubated under conditions without fetal bovine serum (FBS), typical features of apoptotic cell death such as shrinkage and nuclear condensation appeared; high molecular weight (HMW) DNA fragments were found; and caspase-3 and poly (ADP-ribose) polymerase (PARP) proteins were cleaved. When FLC4 cells were incubated with #675 and without FBS, the cells grew healthy, no HMW DNA fragments were found, and caspase-3 and PARP cleavage weakened, suggesting that #675 protects FLC4 cells from apoptosis induced by FBS-deprivation. The quantitative reverse-transcribed polymerase chain reaction did not show differences in PARP or Bcl-2 mRNA expression in FLC4 cells incubated with or without #675, indicating other genes may be involved in this anti-apoptosis effect. These results show that #675 enhances FLC4 proliferation via an apoptosis-inhibition pathway, implying potential pharmacological and clinical applications. 相似文献
49.
VRK1 is a novel human putative serine/threonine kinase, and is located on chromosome 14 at band q32 where an autosomal recessive
congenital microphthalmia (CMIC) is mapped. We isolated a polymorphic dinucleotide CA repeat marker from a genomic clone containing
the human VRK1 gene. This polymorphism will be useful in genetic studies of disorders localized at the 14q32 region, such as CMIC.
Received: October 8, 1998 / Accepted: October 16, 1998 相似文献
50.
Antitumor immune response by CX3CL1 fractalkine gene transfer depends on both NK and T cells 总被引:6,自引:0,他引:6
Xin H Kikuchi T Andarini S Ohkouchi S Suzuki T Nukiwa T Huqun Hagiwara K Honjo T Saijo Y 《European journal of immunology》2005,35(5):1371-1380
The CX3C chemokine fractalkine (CX3CL1) exists as both a membrane-bound form promoting firm cell-cell adhesion and a soluble form chemoattracting leukocytes expressing its receptor CX3CR1. When adenoviral vector expressing mouse fractalkine (AdFKN) was transduced to the tumor cells, fractalkine was expressed as both membrane-bound form on the tumor cells and soluble form in the supernatant in vitro. Intratumoral injection of AdFKN (1 x 10(9)PFU/tumor) into C26 and B16F10 tumors resulted in marked reduction of tumor growth compared to control (C26: 86.5%, p<0.001; B16F10: 85.5%, p<0.001). Histological examination of tumor tissues revealed abundant infiltration of NK cells, dendritic cells, and CD8(+) T lymphocytes 3 and/or 6 days after treatment with AdFKN. Splenocytes from mice treated by AdFKN developed tumor-specific cytotoxic T cells, and thereby protected from rechallenging with parental tumor cells. Antitumor effects by AdFKN were completely abrogated in both NK cell-depleted mice and CD8(-/-) mice, and partially blocked in CD4(-/-) mice. These data indicated that fractalkine mediates antitumor effects by both NK cell-dependent and T cell-dependent mechanisms. This study suggests that fractalkine can be a suitable candidate for immunogene therapy of cancer because fractalkine induces both innate and adaptive immunity. 相似文献