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排序方式: 共有7139条查询结果,搜索用时 15 毫秒
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Carbonic anhydrase II is a tumor vessel endothelium-associated antigen targeted by dendritic cell therapy. 总被引:3,自引:0,他引:3
Kenta Yoshiura Takashi Nakaoka Toshihide Nishishita Katsuaki Sato Akifumi Yamamoto Shinji Shimada Toshiaki Saida Yutaka Kawakami Tsuneo A Takahashi Hiroyuki Fukuda Shinobu Imajoh-Ohmi Naoki Oyaizu Naohide Yamashita 《Clinical cancer research》2005,11(22):8201-8207
Tumor-associated antigens are promising candidates as target molecules for immunotherapy and a wide variety of tumor-associated antigens have been discovered through the presence of serum antibodies in cancer patients. We previously conducted dendritic cell therapy on 10 malignant melanoma patients and shrinkage or disappearance of metastatic tumors with massive necrosis occurred in two patients. In this study, we found a 29-kDa protein against which antibody was elicited by dendritic cell therapy in one of the two patients. Matrix-assisted laser desorption ionization-time of flight/mass spectrometry analysis of the protein isolated by two-dimensional electrophoresis combined with Western blots revealed that the 29-kDa protein was carbonic anhydrase II (CA-II). Immunohistochemistry of the tumors and normal tissues showed that CA-II was expressed in the tumor vessel but not in normal vessel endothelium. CA-II expression in tumor endothelium was observed as well in other cancers including esophageal, renal, and lung cancers. In an in vitro angiogenesis model, CA-II expression of normal human vein endothelial cells was significantly up-regulated when cells were cultured in the acidic and hypoxic conditions indicative of a tumor environment. These findings suggest that CA-II is a tumor vessel endothelium-associated antigen in melanoma and other cancers, and elicitation of serum anti-CA-II antibody by dendritic cell therapy may be associated with good clinical outcome including tumor reduction. 相似文献
103.
Toshiaki Watanabe Takamitsu Kanazawa Yoshihiro Kazama Junichiro Tanaka Toshiaki Tanaka Soichiro Ishihara Hirokazu Nagawa 《Journal of clinical oncology》2005,23(35):9031-2; author reply 9032-3
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Extraocular sebaceous carcinoma accompanied by invasive squamous cell carcinoma: The first case report and consideration of histogenesis 下载免费PDF全文
Toshiaki Kogame Shuichi Ohe Fumikazu Yamazaki Hiroyuki Okamoto Takahiro Kiyohara 《The Journal of dermatology》2018,45(4):501-504
A 61‐year‐old man presented with a dome‐shaped nodule, 1.2 cm in size, with a central crater covered by keratinous material near the left lateral malleolus. Histological findings demonstrated a basophilic circular cone in the center, surrounded and sharply demarcated by a broad eosinophilic area. The central conical mass was composed mainly of atypical basaloid cells intermingled with scattered atypical sebaceous cells with scalloped nuclei and microvesicular cytoplasms, suggesting sebaceous carcinoma. The peripheral area consisted of atypical keratinizing squamoid cells without sebaceous cells, suggesting invasive squamous cell carcinoma. Atypical sebaceous cells were positive for adipophilin. Atypical basaloid cells were positive for 34βE12 and CAM5.2. Peripheral squamoid cells were positive for 34βB4 and 34βE12 throughout, and were positive for LHP1 in the superficial layer. We herein describe the first case of extraocular sebaceous carcinoma accompanied by invasive squamous cell carcinoma, which might have arisen from biphasic differentiation of cancer stem cells. 相似文献
106.
Results of a 36‐year surveillance program for ulcerative colitis‐associated neoplasia in the Japanese population 下载免费PDF全文
Junko Kishikawa Keisuke Hata Shinsuke Kazama Hiroyuki Anzai Takahide Shinagawa Koji Murono Manabu Kaneko Kazuhito Sasaki Koji Yasuda Kensuke Otani Takeshi Nishikawa Toshiaki Tanaka Tomomichi Kiyomatsu Kazushige Kawai Hiroaki Nozawa Soichiro Ishihara Teppei Morikawa Masashi Fukayama Toshiaki Watanabe 《Digestive endoscopy》2018,30(2):236-244
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Analysis of possible structures of inducible skin‐associated lymphoid tissue in lupus erythematosus profundus 下载免费PDF全文
Toshiaki Kogame Ryosuke Yamashita Masahiro Hirata Tatsuki R. Kataoka Hisashi Kamido Chiyuki Ueshima Miho Matsui Takashi Nomura Kenji Kabashima 《The Journal of dermatology》2018,45(9):1117-1121
Lupus erythematosus profundus (LEP) is a variant of lupus erythematosus, involving the deep dermis and subcutaneous fat. LEP is characterized by the presence of lymphoid follicles (LF) and germinal centers (GC). However, it remains unknown whether these lymphoid structures correspond to the lymphoid tissues such as cutaneous tertiary lymphoid organs (TLO). Previously, we identified dynamically orchestrated cellular elements in murine contact dermatitis that resembled lymphoid structures, which we termed inducible skin‐associated lymphoid tissues (iSALT). We subsequently reported structures analogous to iSALT in human secondary syphilis, suggesting that iSALT can also exist in humans. Here, we studied ectopic lymphoid tissues in the lesions of LEP by immunohistochemistry and compared their characteristics with those of TLO. We demonstrated that LF of LEP were composed of B‐cell follicles intermingled with CXCL13‐expressing cells, distinct aggregations of T cells, and some blood vessels expressing peripheral node addressin. These findings indicate that LF of LEP can be considered as a type of iSALT. 相似文献
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