全文获取类型
收费全文 | 1688篇 |
免费 | 116篇 |
国内免费 | 6篇 |
专业分类
耳鼻咽喉 | 11篇 |
儿科学 | 46篇 |
妇产科学 | 18篇 |
基础医学 | 263篇 |
口腔科学 | 28篇 |
临床医学 | 178篇 |
内科学 | 343篇 |
皮肤病学 | 20篇 |
神经病学 | 134篇 |
特种医学 | 66篇 |
外科学 | 221篇 |
综合类 | 16篇 |
一般理论 | 2篇 |
预防医学 | 159篇 |
眼科学 | 56篇 |
药学 | 92篇 |
肿瘤学 | 157篇 |
出版年
2023年 | 14篇 |
2022年 | 16篇 |
2021年 | 24篇 |
2020年 | 37篇 |
2019年 | 48篇 |
2018年 | 47篇 |
2017年 | 44篇 |
2016年 | 42篇 |
2015年 | 39篇 |
2014年 | 69篇 |
2013年 | 91篇 |
2012年 | 120篇 |
2011年 | 125篇 |
2010年 | 60篇 |
2009年 | 72篇 |
2008年 | 112篇 |
2007年 | 106篇 |
2006年 | 106篇 |
2005年 | 127篇 |
2004年 | 88篇 |
2003年 | 66篇 |
2002年 | 89篇 |
2001年 | 11篇 |
2000年 | 8篇 |
1999年 | 8篇 |
1998年 | 14篇 |
1997年 | 8篇 |
1996年 | 19篇 |
1995年 | 15篇 |
1994年 | 9篇 |
1993年 | 11篇 |
1992年 | 10篇 |
1991年 | 10篇 |
1990年 | 6篇 |
1989年 | 8篇 |
1988年 | 9篇 |
1987年 | 11篇 |
1986年 | 6篇 |
1985年 | 6篇 |
1984年 | 11篇 |
1983年 | 13篇 |
1982年 | 7篇 |
1980年 | 4篇 |
1979年 | 4篇 |
1977年 | 5篇 |
1976年 | 5篇 |
1972年 | 7篇 |
1967年 | 3篇 |
1965年 | 4篇 |
1937年 | 5篇 |
排序方式: 共有1810条查询结果,搜索用时 15 毫秒
31.
Torben H?iland Hansen Mette Laursen Erik Christensen Helge Worning 《Journal of gastrointestinal cancer》1995,18(3):235-239
Summary The relationship between chronic pancreatitis (CP) and extrapancreatic cancer has been debated in the recent years. In prospective
studies, it has been found that pancreatic cancer develops in 0–5% of patients with chronic pancreatitis. Many papers describe
an increased relative risk for developing extrapancreatic cancer in patients suffering from chronic pancreatitis. In this
study including 181 patients with CP, we found 14 patients with extrapancreatic cancer (three of these had two different types
of cancer). No patient had pancreatic cancer. It was found that the respiratory airways and upper gastrointestinal tract were
the dominating locations (five and four cases, respectively), but also genital and hemolymphopoietic cancers were represented
(four and two cases, respectively). Two patients had metastatic cancer with unknown primary tumor. The patients with cancer
tended to be older than those without cancer. The patients with CP had a 2.43 times greater risk of developing cancer than
the general Danish population (age and sex standardized comparison). The relatively large number of cancers in the upper gastrointestinal
tract and respiratory airways suggest that tobacco and alcohol may be responsible, as these organs have the highest exposure
to these compounds, which are well known carcinogens. 相似文献
32.
Juul AB Wetterslev J Kofoed-Enevoldsen A Callesen T Jensen G Gluud C;Diabetic Postoperative Mortality Morbidity group 《American heart journal》2004,147(4):677-683
Background
Recent trials suggest that perioperative β-blockade reduces the risk of cardiac events in patients with a risk of myocardial ischemia who are undergoing noncardiac surgery. Patients with diabetes mellitus are at a high-risk for postoperative cardiac morbidity and mortality. They may, therefore, benefit from perioperative β-blockade.Methods
The Diabetic Postoperative Mortality and Morbidity (DIPOM) trial is an investigator-initiated and -controlled, centrally randomized, double-blind, placebo-controlled, multicenter trial. We compared the effect of metoprolol with placebo on mortality and cardiovascular morbidity rates in patients with diabetes mellitus who were β-blocker naive, ≥40 years old, and undergoing noncardiac surgery. The study drug was given during hospitalization for a maximum of 7 days beginning the evening before surgery. The primary outcome measure is the composite of all-cause mortality, acute myocardial infarction, unstable angina, or congestive heart failure leading to hospitalization or discovered or aggravated during hospitalization. Follow-up involves re-examination of patients at 6 months and collection of mortality and morbidity data via linkage to public databases. The study was powered on the basis of an estimated 30% 1-year event rate in the placebo arm and a 33% relative risk reduction in the metoprolol arm. The median follow-up period was 18 months.Results
Enrollment started in July 2000 and ended in June 2002. A total of 921 patients were randomized, and 54% of these patients had known cardiac disease, hypertension, or both.Conclusion
The results of this study may have implications for reduction of perioperative and postoperative risk in patients with diabetes mellitus who are undergoing major noncardiac surgery. 相似文献33.
34.
35.
Thure Filskov Overvad Flemming Skjøth Ida Ehlers Albertsen Torben Bjerregaard Larsen Mette Søgaard Gregory Y.H. Lip 《The American journal of medicine》2021,134(1):67-75.e5
BackgroundWe aimed to investigate whether history of venous thromboembolism should be considered a prognostic factor for future thromboembolic events in patients with atrial fibrillation.MethodsThis was a nationwide cohort study of patients with incident atrial fibrillation from 2000-2017, defined and characterized using Danish health registries. Cox regression analyses were used to calculate hazard ratios and 95% confidence intervals for the outcomes ischemic stroke or systemic embolism, and ischemic stroke, systemic embolism, or venous thromboembolism, according to history of venous thromboembolism. Analyses were adjusted for components of the CHA2DS2-VASc score and time-varying use of oral anticoagulation.ResultsThe study included 246,313 patients with incident atrial fibrillation, of which 6,516 (2.6%) had previous venous thromboembolism. Patients with previous venous thromboembolism carried an overall similar adjusted risk of ischemic stroke or systemic embolism compared with patients without previous venous thromboembolism (reference; hazard ratio 0.99; 95% confidence interval, 0.90-1.09). When analyzing a composite thromboembolic outcome of ischemic stroke, systemic embolism, or venous thromboembolism, patients with previous venous thromboembolism were at high-risk (hazard ratio 1.76; 95% confidence interval, 1.64-1.90). Similar conclusions were drawn when stratifying by venous thromboembolism subtype, and when restricting to patients with low CHA2DS2-VASc scores or the non-anticoagulated subset of the study population.ConclusionPatients with atrial fibrillation and previous venous thromboembolism carried similar risk of ischemic stroke or systemic embolism compared with patients with atrial fibrillation without previous venous thromboembolism. Nonetheless, patients with previous venous thromboembolism remain a high-risk population due to an excess risk of future venous thromboembolism. Patients and physicians should keep this excess thromboembolic risk in mind when weighing the expected risks and benefits of oral anticoagulation in patients with atrial fibrillation. 相似文献
36.
Background
Critically ill patients and their relatives have complex needs for support during their stay in the intensive care unit (ICU) and the post-ICU rehabilitation period. Diaries written by nurses have proven beneficial for patients and relatives, preventing post-traumatic stress, anxiety and depression and helping patients and families find meaning. Actively involving relatives in writing a diary for critically ill patients is a new approach to helping relatives and patients cope; however, research is limited.The aim of this study is to test the hypothesis that a diary written by a close relative of a critically ill patient will reduce the risk of developing symptoms of post-traumatic stress disorder (PTSD) in the patient and relatives at 3 months post-ICU. Furthermore, the aim is to explore the perceptions and use of the diary and describe the diary content and structure.Method
The intervention consists of a hard-cover notebook that will be given to a close relative to write a diary for the critically ill patient while in the ICU. Guidance will be offered by ICU nurses on how to author the diary. The effect of the intervention will be tested in a two-arm, single-blind, randomized controlled trial, which aims to include 100 patient/relative pairs in each group. The primary outcome studied is symptoms of post-traumatic stress (PTSS-14). Secondary outcomes are scores on anxiety and depression (HADS) and the Medical Outcomes Study Questionnaire Short Form 36 (SF-36). The narrative structure and content of the diary as well as its use will be explored in two qualitative studies.Discussion
The results of this study will inform ICU nurses about the effects, strengths and limitations of prompting relatives to author a diary for the patient. This will allow the diary intervention to be tailored to the individual needs of patients and relatives.Trial registration
NCT02357680. Registered September 3, 2015.37.
38.
Use of Ultrasound Contrast Agents in Relation to Percutaneous Interventional Procedures: A Systematic Review and Pictorial Essay
下载免费PDF全文
![点击此处可从《Journal of ultrasound in medicine》网站下载免费的PDF全文](/ch/ext_images/free.gif)
Christian Pállson Nolsøe MD PhD Alexander Bjørneboe Nolsøe MD Jeanett Klubien MD Hans‐Christian Pommergaard MD PhD Jacob Rosenberg MD DSc Maria Franca Meloni MD Torben Lorentzen MD PhD 《Journal of ultrasound in medicine》2018,37(6):1305-1324
The aim of this article is to provide an inventory of the use of contrast‐enhanced ultrasound (CEUS) in relation to percutaneous interventional procedures. The article is structured into a systematic literature review followed by a clinical part relating to percutaneous CEUS‐guided procedures. A literature search identified 3109 records. After abstract screening, 55 articles were analyzed and supplemented with pictorial material to explain the techniques. In conclusion, the best‐evidenced indications for CEUS‐guided interventions are biopsy and ablation of inconspicuous or B‐mode–invisible tumors, intraprocedural ablation control and follow‐up, as well as percutaneous transhepatic cholangiography and drainage procedures. 相似文献
39.
Klemen Dovc MD Michelle Van Name MD Barbara Jenko Bizjan PhD Ewa Rusak MD Claudia Piona MD Gul Yesiltepe-Mutlu MD Rosaline Mentink MD Giulio Frontino MD Maddalena Macedoni MD Sofia Helena Ferreira MD Joana Serra-Caetano MD Júlia Galhardo MD Julie Pelicand MD Francesca Silvestri MD Jennifer Sherr MD Agata Chobot MD Torben Biester MD for the ISPAD JENIOUS Group 《Diabetes, obesity & metabolism》2022,24(3):564-569