全文获取类型
收费全文 | 6007篇 |
免费 | 369篇 |
国内免费 | 66篇 |
专业分类
耳鼻咽喉 | 64篇 |
儿科学 | 159篇 |
妇产科学 | 63篇 |
基础医学 | 808篇 |
口腔科学 | 73篇 |
临床医学 | 347篇 |
内科学 | 1698篇 |
皮肤病学 | 122篇 |
神经病学 | 431篇 |
特种医学 | 229篇 |
外科学 | 1101篇 |
综合类 | 19篇 |
预防医学 | 168篇 |
眼科学 | 90篇 |
药学 | 292篇 |
中国医学 | 3篇 |
肿瘤学 | 775篇 |
出版年
2023年 | 37篇 |
2022年 | 99篇 |
2021年 | 214篇 |
2020年 | 119篇 |
2019年 | 153篇 |
2018年 | 214篇 |
2017年 | 158篇 |
2016年 | 198篇 |
2015年 | 201篇 |
2014年 | 245篇 |
2013年 | 288篇 |
2012年 | 488篇 |
2011年 | 452篇 |
2010年 | 286篇 |
2009年 | 230篇 |
2008年 | 357篇 |
2007年 | 306篇 |
2006年 | 336篇 |
2005年 | 323篇 |
2004年 | 307篇 |
2003年 | 322篇 |
2002年 | 289篇 |
2001年 | 55篇 |
2000年 | 35篇 |
1999年 | 61篇 |
1998年 | 92篇 |
1997年 | 86篇 |
1996年 | 78篇 |
1995年 | 60篇 |
1994年 | 29篇 |
1993年 | 49篇 |
1992年 | 39篇 |
1991年 | 35篇 |
1990年 | 22篇 |
1989年 | 14篇 |
1988年 | 12篇 |
1987年 | 11篇 |
1986年 | 12篇 |
1985年 | 14篇 |
1984年 | 9篇 |
1983年 | 12篇 |
1982年 | 12篇 |
1981年 | 10篇 |
1980年 | 8篇 |
1978年 | 7篇 |
1975年 | 4篇 |
1957年 | 8篇 |
1956年 | 8篇 |
1955年 | 10篇 |
1954年 | 8篇 |
排序方式: 共有6442条查询结果,搜索用时 672 毫秒
51.
52.
Naoki Nakano Seiji Kubo Yutaka Sato Koji Takayama Kiyonori Mizuno Ryosuke Kuroda Tomoyuki Matsumoto 《Indian Journal of Orthopaedics》2021,55(4):948
BackgroundMany factors have been reported to affect postoperative range of knee flexion after total knee arthroplasty (TKA); however, no study has reported the impact of preoperative range of motion of the hip to the postoperative flexion angle of the knee thus far.MethodsOf 38 consecutive patients who underwent posterior-stabilized TKA, we assessed 21 patients after excluding 17 patients who met exclusion criteria. The range of motion of the knee and the hip, age, body-mass index, serum albumin level, HbA1c, Kellgren–Lawrence grade, knee extension strength and radiological femorotibial angle as well as postoperative knee flexion angle at three months were evaluated. The preoperative data and the knee flexion angle at three months after TKA were compared using Spearman''s rank correlation coefficient.ResultsKnee flexion angle at three months after TKA was positively correlated with preoperative flexion (ρ = 0.616, p = 0.007) and external rotation angle (ρ = 0.576, p = 0.012) of the hip as well as preoperative knee flexion angle (ρ = 0.797, p = 0.001). There were no correlations between postoperative knee flexion angle and other preoperative data.ConclusionsPatients with restricted flexion and/or external rotation of the hip may have contractures of Gluteus maximus, Gluteus medius and Tensor fasciae latae, which can cause hypertension of iliotibial tract. It may cause decreased internal rotation of the tibia when the knee is flexed, which affects postoperative knee flexion angle, thus limited flexion and/or external rotation of the hip might restrict knee flexion angle following TKA. 相似文献
53.
Yasunari Ikuta Tomoyuki Nakasa Junichi Sumii Akinori Nekomoto Nobuo Adachi 《The Journal of foot and ankle surgery》2021,60(2):396-398
Recent reports have described midterm natural courses of osteochondral lesion of the talus (OLT) and lack of progression of ankle osteoarthritis (OA) in adult patients. The relationship between the OLT managed with nonoperative treatment and development of OA in children remains unknown. We report the long-term course of medial OLT in a 12-year-old female who was treated nonoperatively for 10 years. Radiographically, no osteoarthritic changes were observed at the first examination. She initially returned to her basketball club after nonoperative treatment. Although daily activities were not restricted, limitation of recreational activities began to appear at 4 years of follow-up. Subsequently, plain radiographs revealed bone absorption around the osteochondral fragment and osteophyte formation at the medial gutter, then ankle OA was advanced at the final follow-up. 相似文献
54.
Nishida Hayato Fukuhara Hiroki Nawano Takaaki Kanno Hidenori Yagi Mayu Yamagishi Atsushi Sakurai Toshihiko Naito Sei Kato Tomoyuki Kudo Kosuke Ichikawa Kazunobu Tsuchiya Norihiko 《Clinical and experimental nephrology》2021,25(12):1346-1353
Clinical and Experimental Nephrology - Arteriovenous fistula (AVF) is the most preferred vascular access for hemodialysis patients, and early failure of AVF is one of the most avoidable... 相似文献
55.
Yuko Kaneyasu Hisaya Fujiwara Tetsuo Nishimura Hideyuki Sakurai Tomoko Kazumoto Hitoshi Ikushima Takashi Uno Sunao Tokumaru Yoko Harima Hiromichi Gomi Takafumi Toita Midori Kita Shin-ei Noda Takeo Takahashi Shingo Kato Ayako Ohkawa Akiko Tozawa-Ono Hiroki Ushijima Yoko Hasumi Yasuyuki Hirashima Yuzuru Niibe Tomio Nakagawa Tomoyuki Akita Junko Tanaka Tatsuya Ohno the Working Group of the Gynecological Tumor Committee of the Japanese Radiation Oncology Study Group 《Journal of radiation research》2021,62(2):269
This study aimed to research the post-treatment quality of life (QOL) between radiotherapy (RT)- and operation (OP)-treated early cervical cancer survivors, using separate questionnaires for physicians and patients. We administered an observational questionnaire to patients aged 20–70 years old with Stages IB1–IIB cervical cancer who had undergone RT or OP and without recurrence as outpatients for ≥6 months after treatment. We divided 100 registered patients equally into two treatment groups (n = 50 each). The average age was 53 and 44 years in the RT and OP groups, respectively. The RT group included 34 and 66% Stage I and II patients, respectively, whereas the OP group included 66 and 34% Stage I and II patients, respectively. The OP group included 58% of patients with postoperative RT. Combination chemotherapy was performed in 84 and 48% of patients in the RT and OP groups, respectively. On the physicians’ questionnaire, we observed significant differences in bone marrow suppression (RT) and leg edema (OP). On the patients’ questionnaire, significantly more patients had dysuria and leg edema in the OP group than in the RT group, and severe (Score 4–5) leg edema was significantly higher in the post-operative RT group than in the OP only group. The frequency of sexual intercourse decreased after treatment in both groups. On the patients’ questionnaire, there were no significant differences between the two groups regarding sexual activity. These findings are useful to patients and physicians for shared decision-making in treatment choices. The guidance of everyday life and health information including sexual life after treatment is important. 相似文献
56.
An examination of the relationship of the self-rating sleep score to polygraphic sleep parameters was conducted. The self-rating
sleep questionnaire, OSA, includes five sleep quality factors: sleepiness (Fl), sleep maintenance without interruption (F2),
worry about daily life or poor emotional condition (F3), integrated or perceived sleep feeling (F4) and sleep initiation or
induction (F5). Polygraphic sleep parameters including each sleep stage in minutes were used. If intercorrelation coefficients
exceeded 0.8, only one of the related parameters was selected for multivariate analysis. Twelve male students slept a total
of 88 nights, among which the first night was not included, in an experimental room. When absolute values of Spearman’s rank
correlation coefficient of not less than 0.4 were tentatively selected, the following pairs were extracted: F2 score and S1
(-0.423) or S3+S4 (0.409), F5 score and sleep latency (-0.439). Deeper sleep was closely associated with sleep maintenance
without interruption. Agreement between self-rating and a polygraphic sleep parameter was recognized between the F5 score
and sleep latency. Each OSA factor score was predicted by other polygraphic sleep parameters using multiple regression analysis.
MT significantly contributed to the Fl, F3 and F4 scores. The number of stage shifts per night significantly contributed to
the Fl and F3 scores, and the number of sleep spindles significantly contributed to the F5 score. Though prediction of sleep
quality by polygraphic sleep parameters is limited, the association between concrete subjective and objective sleep parameters
was clarified as mentioned above, and their practical meaning was partially elucidated. 相似文献
57.
58.
Haemodynamic effects of the crude venom from nematocysts of the box-jellyfish Chiropsalmus quadrigatus (Habu-kurage) in anaesthetized rabbits. 总被引:1,自引:0,他引:1
Tomoyuki Koyama Katsuhiko Noguchi Toshihiro Matsuzaki Mayuko Sakanashi Junko Nakasone Kanako Miyagi Makiko Sakanashi Matao Sakanashi 《Toxicon》2003,41(5):621-631
Haemodynamic effects of saline-extracted venom from nematocysts isolated from tentacles of the box-jellyfish Chiropsalmus quadrigatus (Habu-kurage) were investigated. In anaesthetized rabbits, i.v. injections of the venom produced hypotension following a transient hypertension. Mean femoral arterial blood flow markedly decreased immediately after the injection and femoral vascular resistance increased. Left ventricular dP/dt remarkably decreased after a transient and small increase, and heart rate decreased. Left ventricular end-diastolic pressure markedly elevated. All of the above changes by 0.2-5 microg/kg of the venom expressed as the amount of protein were seen dose-dependently and occurred without tachyphylaxis. In five of seven animals received an injection of the venom at 10 microg/kg, irreversible cardiac arrest occurred. Changes produced by 1 or 2 microg/kg of the venom were significantly attenuated either by heating the venom at 40 degrees C for 10min or by pretreatment with diltiazem. These results indicate that the venom from Habu-kurage has both vasoconstrictor and cardiodepressive effects, and suggest that these thermolabile actions may be due partly to activation of voltage-dependent calcium channels and probably subsequent calcium-overload. 相似文献
59.
60.
Tetsuya Otani Motoki Iwasaki Seiichiro Yamamoto Tomotaka Sobue Tomoyuki Hanaoka Manami Inoue Shoichiro Tsugane 《Cancer epidemiology, biomarkers & prevention》2003,12(12):1492-1500
Few studies have examined the association of alcohol consumption and cigarette smoking with colorectal cancer in Asian populations whose genetic susceptibility to these factors are different from Western populations. We investigated this association and the joint effect of these factors, and estimated the population-attributable fraction to clarify the public health impact on a Japanese population, based on a prospective study. We analyzed the 10-year (cohort I) and 7-year (cohort II) follow-up data of the Japan Public Health Center-based prospective study on cancer and cardiovascular disease, derived from 90,004 (42,540 male and 47,464 female) middle-aged and elderly Japanese. We identified 716 (457 in men and 259 in women) newly diagnosed cases of colorectal cancer. Both alcohol consumption and smoking were clearly associated with colorectal cancer in men, after adjusting for age, family history of colorectal cancer, body mass index, and physical exercise. Regular heavy drinking of 150 g/week or more of ethanol showed a statistically significant increased risk compared with nondrinkers: relative risks (RRs) were 1.4 [95% confidence interval (CI), 1.1-1.9] for 150-299 g/week and 2.1 (95% CI, 1.6-2.7) for 300 g/week or more. On the contrary, regular ethanol consumption was not associated with colorectal cancer (RR, 0.7; 95% CI, 0.4-1.1) in women. In terms of smoking, the RRs were 1.4 (95% CI, 1.1-1.8) for current smokers and 1.3 (95% CI, 0.98-1.7) for ex-smokers compared with never-smokers in men. The risk of smoking in women was similar to that in men, although not statistically significant. The colorectal cancer risk with 300 g/week or more of ethanol in current smokers was estimated at 3.0 (95% CI, 1.8-5.1) compared with nondrinkers among nonsmokers in men. Colorectal cancer attributable to alcohol consumption or smoking was estimated to be 46%. In conclusion, approximately half of the colorectal cancer cases may be preventable by tobacco and alcohol controls in middle-aged and elderly Japanese men. 相似文献