全文获取类型
收费全文 | 2727篇 |
免费 | 138篇 |
国内免费 | 16篇 |
专业分类
耳鼻咽喉 | 39篇 |
儿科学 | 65篇 |
妇产科学 | 48篇 |
基础医学 | 372篇 |
口腔科学 | 34篇 |
临床医学 | 207篇 |
内科学 | 627篇 |
皮肤病学 | 48篇 |
神经病学 | 161篇 |
特种医学 | 101篇 |
外科学 | 391篇 |
综合类 | 20篇 |
一般理论 | 1篇 |
预防医学 | 82篇 |
眼科学 | 108篇 |
药学 | 266篇 |
中国医学 | 3篇 |
肿瘤学 | 308篇 |
出版年
2023年 | 25篇 |
2022年 | 53篇 |
2021年 | 89篇 |
2020年 | 38篇 |
2019年 | 65篇 |
2018年 | 73篇 |
2017年 | 44篇 |
2016年 | 81篇 |
2015年 | 83篇 |
2014年 | 91篇 |
2013年 | 115篇 |
2012年 | 209篇 |
2011年 | 194篇 |
2010年 | 129篇 |
2009年 | 90篇 |
2008年 | 145篇 |
2007年 | 185篇 |
2006年 | 190篇 |
2005年 | 163篇 |
2004年 | 129篇 |
2003年 | 139篇 |
2002年 | 131篇 |
2001年 | 20篇 |
2000年 | 18篇 |
1999年 | 20篇 |
1998年 | 29篇 |
1997年 | 25篇 |
1996年 | 38篇 |
1995年 | 25篇 |
1994年 | 26篇 |
1993年 | 14篇 |
1992年 | 14篇 |
1991年 | 15篇 |
1990年 | 9篇 |
1989年 | 10篇 |
1988年 | 9篇 |
1986年 | 6篇 |
1985年 | 7篇 |
1984年 | 6篇 |
1980年 | 4篇 |
1979年 | 4篇 |
1978年 | 5篇 |
1977年 | 5篇 |
1975年 | 4篇 |
1959年 | 5篇 |
1958年 | 8篇 |
1957年 | 23篇 |
1956年 | 16篇 |
1955年 | 17篇 |
1954年 | 11篇 |
排序方式: 共有2881条查询结果,搜索用时 46 毫秒
101.
Jun Endo Satoshi Yamaguchi Masahito Saito Takashi Itabashi Kouji Kita Wataru Koizumi Yoshikuni Kawaguchi Tomomi Asaka Osamu Saegusa 《Journal of orthopaedic science》2013,18(2):250-255
Background
Preoperative traction for hip fractures is of no benefit in semi-urgent surgery. However, its efficacy has not been assessed in cases in which emergency surgery was not possible. We evaluated the efficacy of preoperative skin traction for hip fractures in a level II trauma center in Japan where many patients undergo delayed surgery.Methods
We undertook a randomized controlled trial. Eighty-one patients were randomized to be treated with skin traction (41 patients), or bed rest (40 patients). Preoperative pain was assessed by use of a visual analogue scale and the number of analgesics required. Fracture reduction was measured on the basis of leg-length and neck–shaft angle discrepancies on the radiograph on admission, a day before surgery, and after surgery.Results
The mean time from admission to surgery was 7.5 days. Pain decreased markedly on the day after admission in both the traction and no-traction groups. No significant difference was found during the preoperative waiting period between the groups in either pain score or number of analgesics taken. No significant difference was found in radiographic data either before or after surgery, and satisfactory reduction was achieved after surgery irrespective of the use of skin traction.Conclusions
In our single-institution prospective randomized controlled trial, preoperative skin traction for patients with hip fracture had no effect on pain relief before surgery or reduction of fracture displacement during surgery, irrespective of preoperative waiting time. 相似文献102.
103.
Jin Kohno Yoshiyuki Matsui Toshinari Yamasaki Noboru Shibasaki Tomomi Kamba Koji Yoshimura Shinji Sumiyoshi Yoshiki Mikami Osamu Ogawa 《International journal of urology》2013,20(9):938-941
Epithelioid angiomyolipoma has malignant potential; however, no effective therapy has been established for advanced cases. A 50‐year‐old woman with a history of right nephrectomy for epithelioid angiomyolipoma was referred to our institution. Computed tomography and magnetic resonance imaging showed multiple tumors in her lung, liver and pelvic cavity. The liver and pelvic tumor specimens obtained by needle biopsy confirmed the diagnosis of epithelioid angiomyolipoma recurrence. The patient was treated with everolimus (10 mg/day). Three months later, pulmonary lesions disappeared; liver and pelvic tumors significantly shrank in size, but the pelvic tumor gradually enlarged again. We carried out surgical resection of the residual liver and pelvic cavity tumors. Although the mammalian target of rapamycin inhibitor seems to be effective for treating epithelioid angiomyolipoma, its long‐term effects remain unknown. Thus, aggressive administration of a multidisciplinary treatment including molecular target therapy and surgical resection is required to improve the prognosis of epithelioid angiomyolipoma. 相似文献
104.
Kouhei Nishikawa Norihito Soga Kenichiro Ishii Manabu Kato Yoichi Iwamoto Yasuhide Hori Michiru Etoh Takeshi Ohkawara Tomomi Yamada Katsunori Uchida Hideaki Kise Kiminobu Arima Masaaki Narita Taizo Shiraishi Yoshiki Sugimura 《Urologic oncology》2013,31(6):787-795
ObjectivesTo investigate the presence of manserin in human prostate cancers and to correlate manserin expression with pathologic outcomes and progression-free survival.MethodsEighty-seven patients with recent prostate cancer were classified into 4 groups based on Gleason score, and manserin immunohistochemistry was correlated with Gleason sum grade. To investigate the validity of manserin as a prognostic factor, the Cox proportional hazards regression model was performed on 48 patients in our cohort with T3 or T4 prostate cancer who were initially treated with androgen deprivation therapy.ResultsThe manserin-positive rates of patients with Gleason sums of 6, 7, 8, and ≥9 were 0%, 20.0%, 35.0%, and 48.1%, respectively. Manserin-positive rates were positively correlated with Gleason sums (P = 0.0001). Median times to cancer progression in groups with (n = 8) and without (n = 40) manserin expression were 8 months and 28 months, respectively (P = 0.01). Univariate Cox analysis revealed that manserin expression, clinical stage T4, and high Gleason sum were significantly associated with progression. Multivariate analysis revealed that only 2 factors, manserin expression (hazard ratio (HR) 4.99, P = 0.01) and clinical stage T4 (HR 4.77, P = 0.03), were independent risk factors for progression.ConclusionsThis is the first report of manserin expression in human prostate cancers. Manserin may serve as a marker of prostate cancer progression. 相似文献
105.
Yojiro Umezaki Ayano Katagiri Motoko Watanabe Miho Takenoshita Tomomi Sakuma Emi Sako Yusuke Sato Akira Toriihara Akihito Uezato Hitoshi Shibuya Toru Nishikawa Haruhiko Motomura Akira Toyofuku 《European archives of psychiatry and clinical neuroscience》2013,263(4):315-323
Oral cenesthopathy is a somatic delusion or hallucination involving the oral area and is categorized as a delusional disorder, somatic type. The pathophysiology of this intractable condition remains obscure. In this study, we clarified the pathophysiology of oral cenesthopathy by evaluating regional brain perfusion. We performed single photon emission computed tomography (SPECT) using 99mTc-ethylcysteinate dimer in 16 subjects (cenesthopathy:control = 8:8). The SPECT images were visually assessed qualitatively, and quantitative analyses were also performed using a three-dimensional stereotactic region-of-interest template. The visual assessment revealed a right > left perfusion asymmetry in broad areas of the brain among the patients. The quantitative analysis confirmed that the regional cerebral blood flow values on the right side were significantly larger than those on the left side for most areas of the brain in the patients. A comparison of the R/(R + L) ratios in both groups confirmed the significant brain perfusion asymmetry between the two sides in the callosomarginal, precentral, and temporal regions in the patients. Qualitative evaluation of the SPECT images revealed right > left brain perfusion asymmetry in broad regions of the brain. Moreover, the quantitative analyses confirmed the perfusion asymmetry between the two sides in the frontal and temporal areas. Those may provide the key for elucidation of the pathophysiology of oral cenesthopathy. 相似文献
106.
107.
108.
109.
Norihito Soga Takumi Kageyama Yuji Ogura Tomomi Yamada Norio Hayashi 《Current Urology》2016,9(1):31-35
Introduction
The efficacy of conversion from a luteinizing hormone-releasing hormone agonist to an antagonist was evaluated prospectively in patients with castration-resistant prostate cancer.Materials and Methods
From October 2012 to December 2014, 8 cases with a serum testosterone level ≥ 20 ng/dl during following androgen deprivation therapy were enrolled and received degarelix monthly. The primary end-pointgoal was to determine the effective prostate-specific antigen response rate. The secondary end-pointgoal was to assess the proportion of cases with a decrease in serum testosterone level to < 20 ng/ml.Results
One patient achieved a complete response, with a prostate-specific antigen level of 0.02 ng/ml at the nadirend of the study. The effective response rate was 25.0% (2/8), and the proportion of cases with prostate-specific antigen decline was 62.5% (5/8). In 5/8 cases (5/8, 62.5%), serum testosterone levels declined to < 20 ng/dl.Conclusion
Switching to a luteinizing hormone-releasing hormone antagonist in patients with testosterone levels ≥ 20 ng/dl may be an option in sequential androgen deprivation therapy for some patients.Key Words: Castration-resistant, Degarelix, Prostatic neoplasms, Luteinizing hormone-releasing hormone, Testosterone 相似文献110.
Diagnostic value of liquid‐based cytology with fine needle aspiration specimens for cervical lymphadenopathy
下载免费PDF全文
![点击此处可从《Diagnostic cytopathology》网站下载免费的PDF全文](/ch/ext_images/free.gif)