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91.
The surgical techniques and clinical results of quadrantectomy as a form of breast-conserving surgery are described. A quadrantectomy is a breast-conserving technique including wide resection and tumorectomy. A quadrantectomy is designed to remove an anatomic segment of breast tissue (duct-lobular system). It has the advantage of greater surgical curability than other conserving techniques in cases with ductal spread, because breast cancer arising in the terminal duct often spreads in the duct-lobular system. However, quadrantectomy poses some cosmetic problems due to the large volume of breast tissue excised. Additionally, quadrantectomy has failed to show better results in local recurrence rates compared with wide resection. Therefore quadrantectomy should be limited to breast cancer with segmental and wide ductal spread. It is important to determine the surgical technique that compromises between local curability and cosmetic results for each patient with breast cancer. 相似文献
92.
Furuyama K Doi R Mori T Toyoda E Ito D Kami K Koizumi M Kida A Kawaguchi Y Fujimoto K 《World journal of surgery》2006,30(2):219-226
93.
Phosphodiesterase III inhibitor attenuates rat sinusoidal obstruction syndrome through inhibition of platelet aggregation in Disse's space 下载免费PDF全文
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Kozo Yoshikawa Mitsuo Shimada Hidenori Miyamoto Jun Higashijima Tomohiko Miyatani Masanori Nishioka Nobuhiro Kurita Takashi Iwata Hisanori Uehara 《Journal of gastroenterology》2009,44(11):1113-1117
Aim
The activation of Hedgehog signaling, which is critical to normal mammalian gastrointestinal development, is implicated in the development of various tumors, including colorectal cancer. In the pancreas, a precursor lesion overexpresses the Sonic hedgehog (Shh) when compared with normal tissue and cancer. The present study was designed to investigate Shh related protein expression in hyperplastic polyps and the adenoma-carcinoma sequence in the colon and rectum.Methods
Seventeen hyperplastic polyps, 24 adenomas of the colon, 69 adenocarcinomas (31 well-differentiated, 38 moderately-differentiated), and 30 normal colon samples were used in the study. We checked the expression of Shh, both patched (Ptch) and smoothened (Smo), by immunohistochemistry and compared the expression rate of each group.Results
Almost all adenomas, 22 of 23 (96%), expressed Shh. In other groups, 4 of 17 hyperplastic polyps (24%), 7 of 31 well-differentiated adenocarcinomas (23%), 13 of 38 moderately-differentiated adenocarcinomas (34%) and none of the 30 normal samples expressed Shh. The rate of expression in Ptch and Smo gradually increased in accordance with tumor progression.Conclusion
This result indicates that Shh-related carcinogenesis and Shh expression may be a trigger for the adenoma-carcinoma sequence. This study suggests a potential therapeutic target of hedgehog blockade in carcinogenesis. 相似文献97.
Comparative genomic hybridization analysis for pancreatic cancer specimens obtained by endoscopic ultrasonography-guided fine-needle aspiration 总被引:1,自引:0,他引:1
Kitoh H Ryozawa S Harada T Kondoh S Furuya T Kawauchi S Oga A Okita K Sasaki K 《Journal of gastroenterology》2005,40(5):511-517
Background Comparative genomic hybridization (CGH) analysis of pancreatic cancer has been done exclusively for surgical and autopsy specimens, because of the difficulty of tissue sampling without surgery. To overcome this difficulty, we applied CGH technology to cells obtained by endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA).Methods In the present study, we performed EUS-FNA for 17 patients with pancreatic cancer before surgery. Tumor cells were selected by microdissection. DNA was extracted from the cells and amplified by degenerate oligonucleotide-primed polymerase chain reaction (DOP-PCR). Then CGH was carried out.Results In the 15 patients with tubular adenocarcinoma, the most common loci of gains (including amplification) were 5p, 8q, and 20q (60% of the patients); and 1q, 7p, and 12p (27%). The most frequent losses were 17p (73%); 9p, 18q, and 19p (47%); and 8p (33%). These findings were similar to our previously reported data. Both of the patients with acinar cell carcinoma showed gains of 2q and 5p, and losses of 1p, 9p, 9q, 11p, 11q, 14q, 17p, 17q, and 18q.Conclusions The results of this study suggest that comprehensive genetic analysis is possible for EUS-FNA biopsy specimens, with a combination of microdissection and DOP-PCR. This analytical strategy will enable us to evaluate the biological characteristics of pancreatic cancer before treatment. 相似文献
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Haruna SAITO Kaori ICHIKAWA Tetsuo NOMIYAMA Nobuo TATSUMI Shinsuke WASHIZUKA Tokiji HANIHARA Naoji AMANO 《Psychogeriatrics》2008,8(1):12-18
Background: Patients with late‐life depression often exhibit cognitive deficits or disability. The relationship between late‐life depression and disability is an area of significance for geriatric psychiatry. The purpose of the present study was to investigate the association between changes in the severity of depression and activities of daily living (ADL) during treatment of late‐life depression. Methods: We examined the severity of depression, cognitive function and ADL among 70 subjects aged 65 years or older with a history or a current episode of major depression. Examination with the Hamilton Depression Rating Scale (Ham‐D), the Mini‐Mental State Examination (MMSE), the Barthel Index (BI) and the Hyogo Activities of Daily Living Scale (HADLS) were performed twice at an interval of approximately 1 month. All patients were receiving drug therapy for their depression. Results: Participants presented with varied depressive severity on the Ham‐D and a slight cognitive deficit on the MMSE; approximately 60% had at least one problem on the HADLS. Between baseline and the follow‐up examination, significant improvements were noted in Ham‐D, MMSE and HADLS scores, but not the BI score. The correlations between the Ham‐D and ADL scores were significant at baseline and at the follow up examinations. In a multiple regression analysis, the difference in follow‐up and baseline scores on the Ham‐D contributed significantly to that of HADLS. Conclusions: The present study demonstrates that many patients with late‐life depression have some problems with ADL and that a substantial improvement in ADL occurs in association with temporal improvement of depressive severity among subjects with late‐life depression. 相似文献
100.
Yuji Shono Tomohiko Akahoshi Satomi Mezuki Kenta Momii Noriyuki Kaku Jun Maki Kentaro Tokuda Tetsuro Ago Takanari Kitazono Yoshihiko Maehara 《The American journal of emergency medicine》2017,35(12):1836-1838