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111.
Scanning electron microscopic study on the lingual papillae of the Japanese insectivora 总被引:1,自引:0,他引:1
S Kobayashi S Arai S Tomo T Shimoda A Shimamura H Yamada 《Okajimas folia anatomica Japonica》1989,65(6):413-427
The tongue and lingual papillae of the Japanese Insectivora, the Shinto shrew (Sorex caecuiens saevus), the long-clawed shrew (S. unguiculatus), the dsinezumi shrew (Crocidura dsinezumi dsinezumi) and the Japanese water shrew (Chimarrogale himalyica platycephala), were observed by scanning electron microscope. The tongue of these animals had two vallate papillae. In two species of the Sorex a papilla in the vallate papilla was surrounded by two separated trenches, but in the other species it was surrounded by only a continuous trench and a clear vallum. The fungiform papillae in the Sorex were less developed than those of the other species. In the Sorex and Crocidura, there was no filiform papilla on the lingual apex. These genera, however, have papillary projections in the margin of the lingual apex. The results of this investigation suggest that the Sorex and Crocidura indicate an ancient form of the mammalian tongue. These characters, furthermore, were compared among seven species in six genera added three species observed by Kobayashi et al. (1983) to this study. 相似文献
112.
113.
Ohta F Takagi T Sato H Ignarro LJ 《Proceedings of the National Academy of Sciences of the United States of America》2007,104(4):1407-1411
The objective of this work was to evaluate the influence of exogenous L-arginine on the capillary blood flow of peripheral tissues of normotensive subjects. Rats were anesthetized with sodium pentobarbital, and the blood flow of femoral, dorsal, and ventral skin and gastrocnemius and soleus muscle was measured by laser Doppler flow and microsphere methods to compare the blood flow before and after the L-arginine infusion. L-arginine lowered the mean blood pressure in a dose-dependent manner, but a statistically significant reduction in mean blood pressure was detected only at a high dose of 500 mg/kg of body weight. The significant blood flow increment was detected after the L-arginine infusion at doses of 50 and 150 mg/kg without causing hypotension. Nicardipine, a calcium channel blocker, also increased the skin blood flow, but the blood flow increment and blood pressure fall were comparable. A significant increment in microperfusion was detected in gastrocnemius, soleus muscle, and ventral skin compared with control group by the microsphere method. No adverse effects were observed during L-arginine and microsphere infusion. The present work indicates that l-arginine infusion increases muscle capillary blood flow in rats that are not performing exercise. Supplementation with l-arginine might provide additional blood flow at rest and during exercise and result in the improvement of muscle performance and exercise capacity. 相似文献
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115.
Association Between Staphylococcus aureus Bacteremia and Hospital Mortality in Hemodialysis Patients With Bloodstream Infection: A Multicenter Cohort From Japanese Tertiary Care Centers 下载免费PDF全文
Takahiro Imaizumi Takeshi Hasegawa Atsushi Nomura Sho Sasaki Hiroki Nishiwaki Takaya Ozeki Hideaki Shimizu Shun Minatoguchi Taishi Yamakawa Masahiko Yazawa Daisuke Uchida Hiroo Kawarazaki Masahito Miyamoto Tomo Suzuki Ken'ichiro Koitabashi Masahide Furusho Yoshiro Fujita 《Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy》2017,21(4):354-360
Multiple studies have shown that Staphylococcus aureus bacteremia (SAB) has been a major cause of death in hemodialysis patients. We examined whether SAB is a risk for mortality among chronic hemodialysis patients in Japan where the standard vascular access is arteriovenous fistula (AVF). This was a multicenter, retrospective study of maintenance hemodialysis patients with bloodstream infection (BSI) from 2011 to 2013 at tertiary care centers in Japan. The endpoint was hospital mortality. Our cohort contained 32 SAB cases (14 MRSA and 18 MSSA) and 42 non‐SAB cases. Hospital mortality was higher among SAB cases than non‐SAB cases (46.9% vs. 23.8%, P = 0.038). In patients with BSI, SAB was significantly associated with hospital mortality after adjustment for potential confounders, including type of vascular access (OR 3.26). S. aureus was the leading cause of BSI and hospital mortality among this cohort. Therefore, initial empiric treatment should cover for S. aureus. 相似文献
116.
Clinicopathological features of the first Asian family having vocal cord and pharyngeal weakness with distal myopathy due to a MATR3 mutation 下载免费PDF全文
Satoshi Yamashita Akira Mori Yasuto Nishida Ryoichi Kurisaki Nozomu Tawara Tomo Nishikami Yohei Misumi Hidetsugu Ueyama Shigehiro Imamura Yujiro Higuchi Akihiro Hashiguchi Itsuro Higuchi Shinichi Morishita Jun Yoshimura Makoto Uchino Hiroshi Takashima Shoji Tsuji Yukio Ando 《Neuropathology and applied neurobiology》2015,41(3):391-398
117.
Jakub Sikora Shaalee Dworski E. Ellen Jones Mustafa A. Kamani Matthew C. Micsenyi Tomo Sawada Pauline Le Faouder Justine Bertrand-Michel Aude Dupuy Christopher K. Dunn Ingrid Cong Yang Xuan Josefina Casas Gemma Fabrias David R. Hampson Thierry Levade Richard R. Drake Jeffrey A. Medin Steven U. Walkley 《The American journal of pathology》2017,187(4):864-883
118.
Shibutani Takayuki Onoguchi Masahisa Kanno Takayuki Wakabayashi Hiroshi Hiromasa Tomo Kinuya Seigo 《Annals of nuclear medicine》2022,36(12):1031-1038
Annals of Nuclear Medicine - Myocardial phantom studies are widely used as a tool to accurately assess the physical phenomenon of dual-isotope simultaneous acquisition (DISA) in the small-animal... 相似文献
119.
Taiga Miyazaki Kiyoyasu Fukushima Kohji Hashiguchi Yuichi Inoue Tomo Mihara Toyomitsu Sawai Naofumi Suyama Tsutomu Kobayashi Akira Kondo Yuichi Fukuda Yosuke Harada Eisuke Sasaki Norihito Kaku Shotaro Ide Takahiro Takazono Tomomi Saijo Kosuke Kosai Yoshitomo Morinaga Hiroshi Mukae 《Journal of infection and chemotherapy》2019,25(9):702-707
Oral antibiotic therapy for patients with acute exacerbations of chronic obstructive pulmonary disease (COPD) usually involves an aminopenicillin with clavulanic acid, a macrolide, or a quinolone. To date, however, the clinical efficacy and safety of the oral cephalosporin cefditoren pivoxil has not been evaluated in Japanese patients with acute exacerbations of COPD. We conducted a prospective, multicenter, single arm, interventional study from January 2013 to March 2017 to determine the efficacy and safety of oral administration of 200 mg cefditoren pivoxil three times daily for 7 days in a cohort of 29 eligible patients from 15 hospitals. The mean age (SD) of participants was 73.1 (8.1) years and 28 had a smoking history (the mean [SD] of smoking index, 1426.7 [931.7]). The primary efficacy endpoint was clinical response (cure rate) at test of cure, which was set at 5–10 days after treatment ceased. Of the 23 patients finally analyzed, cure was achieved in 15 (65.2%), while 8 (34.8%) remained uncured. Previous experience of acute exacerbations significantly affected the cure rate: none of the three patients who had at least two prior exacerbations were cured, while 15 of the 20 patients with one or fewer prior exacerbations were cured (p = 0.032). The microbiological eradication rate was 88.9% at test of cure. During treatment, mild pneumonia was reported as an adverse event in one patient (3.4%) but resolved within 10 days of onset. We conclude that cefditoren pivoxil represents a viable alternative for antibiotic therapy in patients with few prior exacerbations. 相似文献
120.
Garret Christensen Holly N. Dentz Amy J. Pickering Tomoé Bourdier Benjamin F. Arnold John M. Colford Jr Clair Null 《The American journal of tropical medicine and hygiene》2015,92(2):437-447
In preparation for a larger trial, the Water, Sanitation, and Hygiene (WASH) Benefits pilot study enrolled 72 villages and 499 subjects in two closely related randomized trials of WASH interventions in rural western Kenya. Intervention households received hardware and promotion for one of the following: water treatment, sanitation and latrine improvements, handwashing with soap, or the combination of all three. Interventions were clustered by village. A follow-up survey was conducted 4 months after intervention delivery to assess uptake. Intervention households were significantly more likely than controls to have chlorinated stored water (36–60 percentage point increases), covers over latrine drop holes (55–75 percentage point increases), less stool visible on latrine floors (16–47 percentage point reductions), and a place for handwashing (71–85 percentage point increases) with soap available (49–66 percentage point increases). The high uptake in all arms shows that combined interventions can achieve high short-term adoption rates if well-designed. 相似文献