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排序方式: 共有204条查询结果,搜索用时 15 毫秒
51.
SE Gargosky KF Wilson PJ Fielder MA Vaccarello FB Diamond RC Baxter AL Rosenbloom J Guevara-Aguirre RG Rosenfeld 《Acta paediatrica (Oslo, Norway : 1992)》1994,83(S399):159-162
The molecular distribution of insulin-like growth factor I (IGF-I) and IGF-II among the IGF binding proteins (IGFBPs) was studied before and during IGF-I therapy in Ecuadorean adults with growth hormone receptor deficiency (GHRD). Of the total circulating IGF-I and IGF-II, 70% was carried by the 150 kDa complex in normal subjects, while in patients with GHRD, 50% of serum IGF-I, but only 30–35% of serum IGF-II, was measured within the 150 kDa IGFBP-3 region. Administration of IGF-I altered the concentration of IGF-I and IGF-II, although the percentage of total IGF measured within each IGFBP region was not affected, as the increase in IGF-I and the decrease in IGF-II were proportional. Similarly, serum concentrations of IGFBP-3 and the acid-labile subunit, measured by radioimmunoassay, were unaltered. Thus, administration of IGF-I to patients with GHRD was unable to correct the aberrant distribution of IGFs among the IGFBPs. 相似文献
52.
Abstract: A preterm infant developed bilateral tension pneumothoraces and extensive vascular air embolism 6 h after being commenced on nasal continuous positive airway pressure (CPAP). Neonatal clinicians should be aware that catastrophic vascular air embolism could occur in infants receiving nasal CPAP, a modality of respiratory support conventionally considered non-invasive and 'safe'. 相似文献
53.
C M?lgaard BL Thomsen A Prentice TJ Cole KF Michaelsen 《Archives of disease in childhood》1997,76(1):9-15
Data from healthy children are needed to evaluate bone mineralisation during childhood. Whole body bone mineral content (BMC) and bone area were examined by dual energy x ray absorptiometry (Hologic 1000/W) in healthy girls (n = 201) and boys (n = 142) aged 5-19 years. Centile curves for bone area for age, BMC for age, bone area for height, and BMC for bone area were constructed using the LMS method. Bone mineral density calculated as BMC/bone area is not useful in children as it is significantly influenced by bone size. Instead, it is proposed that bone mineralisation is assessed in three steps: height for age, bone area for height, and BMC for bone area. These three steps correspond to three different causes of reduced bone mass: short bones, narrow bones, and light bones. 相似文献
54.
55.
Thirty children below the age of 12 with chronic renal failure (CRF) were studied. In 21 patients (70%) the renal failure was secondary to congenital or familial aetiology. Obstructive uropathy (53.3%), mostly due to posterior urethral valves (40%), comprised the majority of cases. Four cases (13.3%) were secondary to reflux nephropathy. It is concluded that the majority of cases of CRF in the state of Qatar are secondary to potentially treatable or preventable conditions. Use of antenatal ultrasonography combined with aggressive management of obstruction and urine infection may help reduce morbidity and mortality. 相似文献
56.
Montgomery Rice V; Limback SD; Roby KF; Terranova PF 《Human reproduction (Oxford, England)》1998,13(5):1285-1291
This study determined effects of follicle stimulating hormone (FSH) alone
and in combination with tumour necrosis factor (TNF), on granulosa cells
from small (5-10 mm diameter) and large (>10-25 mm) follicles during
follicular and luteal phases of the cycle and during periods of acyclicity.
Granulosa cells were collected from ovaries of premenopausal women
undergoing oophorectomy. The cells were cultured with human FSH (2 ng/ml)
and testosterone (1 microM) in the presence or absence of human TNF-alpha
(20 ng/ml). Media were removed at 48 and 96 h after culture and
progesterone, oestradiol and cAMP in media were measured by
radioimmunoassays. FSH stimulated the accumulation of oestradiol from
granulosa cells of small follicles during the follicular and luteal phases
but not during acyclicity; and TNF reduced oestradiol accumulation in the
presence of FSH. Interestingly, in granulosa cells from small follicles,
progesterone and cAMP secretion increased in response to FSH and neither
was affected by TNF. Thus, TNF specifically inhibited the conversion of
testosterone to oestradiol in granulosa cells from small follicles. FSH
stimulated oestradiol production by granulosa cells of large follicles
obtained only during the follicular phase of the cycle and TNF inhibited
the FSH-induced oestradiol secretion. Granulosa cells obtained from large
follicles during the luteal phase and during acyclicity did not accumulate
oestradiol in response to FSH. However, FSH increased progesterone and cAMP
secretion by granulosa cells obtained from large follicles during the
follicular and luteal phases. During the luteal phase alone, TNF in
combination with FSH increased progesterone accumulation above that of FSH
alone. FSH did not increase progesterone, oestradiol or cAMP secretion by
granulosa cells obtained from large follicles during acyclicity. Thus, FSH
increases progesterone, oestradiol and cAMP secretion by granulosa cells of
small follicles during the follicular and luteal phases and TNF appears to
inhibit FSH-induced oestradiol secretion specifically in those cells. In
large follicles, FSH- stimulated granulosa cell secretion of oestradiol is
limited to the follicular phase and this effect can be inhibited by TNF. In
addition, when granulosa cells of large follicles do not increase
oestradiol secretion in response to FSH, TNF stimulates progesterone
secretion.
相似文献
57.
Neurons in area V4 of the macaque are generally not selective for direction of motion, as judged from their response to directional stimuli presented after a baseline condition devoid of movement. We used motion adaptation to investigate whether stimulation history influences direction-of-motion selectivity. We found that classically nondirectional V4 neurons develop direction-of-motion selectivity after adaptation, an observation that underscores the dynamic nature of functional cortical architecture. 相似文献
58.
Siachalou EJ Kitsas IK Panoulas KJ Zadelis ET Saragiotis CD Tolias YA Hadjileontiadis LJ Panas SM 《Journal of medical systems》2005,29(6):633-646
This paper presents an intensive-care acquisition and signal processing integrated framework in the area of intensive care units. The framework includes nearly all monitored biosignals in the intensive care, along with metadata and processing results. It is structured on two basic applications, i.e., the acquisition and the database one, running in two different PCs that are connected through a local area network, facilitating real-time data exchange between them. The analytical rundown shows that the proposed framework is a serious effort to give a complete clinical condition of a patient and a form of a diagnostic analysis implement in the intensive care by taking in real-time processing. 相似文献
59.
Kleindienst A Tolias CM Corwin FD Müller C Marmarou A Fatouros P Bullock MR 《Journal of neurosurgery》2005,102(6):1115-1121
OBJECT: After traumatic brain injury (TBI), S100B protein is released by astrocytes. Furthermore, cerebrospinal fluid (CSF) and serum S100B levels have been correlated to outcome. Given that no data exist about the temporal profile of cerebral S100B levels following TBI and their correlation to serum levels, the authors examined whether proton magnetic resonance (MR) spectroscopy is capable of measuring S100B. METHODS: Results of in vitro proton MR spectroscopy experiments (2.35-tesla magnet, 25 G/cm, point-resolved spatially localized spectroscopy) revealed an Sl00B-specific peak at 4.5 ppm and confirmed a positive correlation between different S100B concentrations (10 nM-1 microM) and the area under the curve (AUC) for the S100B peak (r = 0.991, p < 0.001). Thereafter, proton MR spectroscopy was performed in male Sprague-Dawley rats (7 X 5 X 5-mm voxel in each hemisphere, TR 3000 msec, TE 30 msec, 256 acquisitions). Exogenously increased CSF S100B levels (approximately 200 ng/ml) through the intraventricular infusion of S100B increased the AUC of the S100B peak from 0.06 +/- 0.02 to 0.44 +/- 0.06 (p < 0.05), whereas serum S100B levels remained normal. Two hours after lateral fluid-percussion injury, serum S100B levels increased to 0.61 +/- 0.09 ng/ml (p < 0.01) and rapidly returned to normal levels, whereas the AUC of the S100B peak increased to 0.19 +/- 0.04 at 2 hours postinjury and 0.41 +/- 0.07 (p < 0.05) on Day 5 postinjury. CONCLUSIONS: Proton MR spectroscopy proves a strong correlation between the AUC of the S100B peak and S100B concentrations. Following experimental TBI, serum S100B levels increased for only a very short period, whereas cerebral S100B levels were increased up to Day 5 postinjury. Given that experimental data indicate that S100B is actively released following TBI, proton MR spectroscopy may represent a new tool to identify increased cerebral S100B levels in patients after injury, thus allowing its biological function to be better understood. 相似文献
60.
Acute spinal cord injury: MR imaging at 1.5 T 总被引:19,自引:0,他引:19
Kulkarni MV; McArdle CB; Kopanicky D; Miner M; Cotler HB; Lee KF; Harris JH 《Radiology》1987,164(3):837-843
Thirty-seven magnetic resonance (MR) imaging studies were performed with a 1.5-T magnet and surface coils in 27 patients with suspected spinal cord injuries. Imaging was performed 1 day to 6 weeks after injury. Cord abnormalities were seen with MR in 19 patients, while skeletal and/or ligamentous injuries were seen in 21 (78%). Three types of MR signal patterns were seen in association with cord injuries. Acute intraspinal hemorrhage was seen in five patients with cord injuries and demonstrated decreased signal intensity on T2-weighted images obtained within 24 hours of injury. Cord edema and contusion had high signal intensity on T2-weighted images and were observed in 12 cases with cord injury. Neurologic recovery, determined in 16 patients, was insignificant in patients with intraspinal hemorrhage; however, patients with cord edema or contusion recovered significant neurologic function. MR at 1.5 T is extremely useful in the diagnosis of acute cord injury and also demonstrates potential in predicting neurologic recovery. 相似文献