全文获取类型
收费全文 | 1335篇 |
免费 | 91篇 |
国内免费 | 7篇 |
专业分类
耳鼻咽喉 | 10篇 |
儿科学 | 68篇 |
妇产科学 | 18篇 |
基础医学 | 120篇 |
口腔科学 | 50篇 |
临床医学 | 182篇 |
内科学 | 260篇 |
皮肤病学 | 26篇 |
神经病学 | 41篇 |
特种医学 | 249篇 |
外科学 | 189篇 |
综合类 | 22篇 |
一般理论 | 1篇 |
预防医学 | 48篇 |
眼科学 | 43篇 |
药学 | 44篇 |
中国医学 | 12篇 |
肿瘤学 | 50篇 |
出版年
2023年 | 8篇 |
2021年 | 14篇 |
2020年 | 9篇 |
2019年 | 13篇 |
2018年 | 32篇 |
2017年 | 17篇 |
2016年 | 25篇 |
2015年 | 31篇 |
2014年 | 40篇 |
2013年 | 43篇 |
2012年 | 36篇 |
2011年 | 38篇 |
2010年 | 48篇 |
2009年 | 72篇 |
2008年 | 56篇 |
2007年 | 44篇 |
2006年 | 53篇 |
2005年 | 32篇 |
2004年 | 27篇 |
2003年 | 35篇 |
2002年 | 32篇 |
2001年 | 20篇 |
2000年 | 17篇 |
1999年 | 19篇 |
1998年 | 52篇 |
1997年 | 53篇 |
1996年 | 64篇 |
1995年 | 48篇 |
1994年 | 43篇 |
1993年 | 47篇 |
1992年 | 14篇 |
1991年 | 7篇 |
1990年 | 15篇 |
1989年 | 35篇 |
1988年 | 31篇 |
1987年 | 35篇 |
1986年 | 34篇 |
1985年 | 26篇 |
1984年 | 15篇 |
1983年 | 10篇 |
1982年 | 25篇 |
1981年 | 17篇 |
1980年 | 8篇 |
1978年 | 7篇 |
1977年 | 12篇 |
1976年 | 11篇 |
1975年 | 14篇 |
1974年 | 5篇 |
1969年 | 6篇 |
1968年 | 6篇 |
排序方式: 共有1433条查询结果,搜索用时 15 毫秒
11.
Transcaval extension of the thymoma to the right atrium has very rarely been reported, and cardiopulmonary bypass is recommended for successful resection. An invasive thymoma with intravascular invasion of the superior vena cava, and the left innominate vein extending into the right atrium was presented. Intra-atrial extension was resected through a transient external shunt from the inferior vena cava to the main pulmonary artery. We discussed the feasibility of this surgical technique and possible advantages of cardiopulmonary bypass avoidance. 相似文献
12.
MR Danzig RA Ghandour P Chang AA Wagner PM Pierorazio ME Allaf JM McKiernan 《Urologic oncology》2017,35(3):116
Purpose
We compared renal function outcomes among patients in the surveillance and intervention arms of the DISSRM registry.Materials and methods
Patients were grouped into chronic kidney disease stages by estimated glomerular filtration rate range. Cases were considered up staged if a more advanced chronic kidney disease stage was entered during followup. Chronic kidney disease up staging-free survival was compared among groups using Kaplan-Meier analysis and paired comparisons log rank tests. Multivariate Cox regression identified independent predictors of chronic kidney disease up staging-free survival.Results
A total of 162 patients met the study inclusion criteria, with 68 in the surveillance arm, 65 undergoing partial nephrectomy, 15 undergoing radical nephrectomy, and 14 undergoing cryoablation. Median tumor size was 2.2 cm. Mean estimated glomerular filtration rate change was significantly larger for radical nephrectomy vs. surveillance (?9.2 vs. ?0.5 ml/min/1.73 m2) and for radical vs. partial nephrectomy (?9.2 vs. ?1.9 ml/min/1.73 m2) (P = 0.001). No other groups differed significantly. On Kaplan-Meier analysis, patients undergoing radical nephrectomy had significantly worse chronic kidney disease up staging-free survival vs. those treated with partial nephrectomy (P = 0.029), surveillance (P = 0.007), and cryoablation (P = 0.019). No other groups differed significantly. On multivariate analysis, radical nephrectomy independently predicted poor chronic kidney disease up staging-free survival (odds ratio vs. surveillance 30.6, P = 0.001). Neither partial nephrectomy (P = 0.985) nor cryoablation (P = 0.976) predicted poor chronic kidney disease up staging-free survival relative to surveillance.Conclusions
Patients in the surveillance arm had superior estimated glomerular filtration rate preservation compared to those in the radical nephrectomy but not the partial nephrectomy arm. In certain patients with small renal masses, surveillance and partial nephrectomy may offer comparable renal functional outcomes. This could be partly attributable to a modest estimated glomerular filtration rate decrease associated with surveillance itself. A thorough understanding of the renal functional impacts of treatment modalities is critical in the management of small renal masses. 相似文献13.
异基因造血干细胞移植(hematopoieticcelltransplantation,HCT)后代谢综合征的发生主要由预处理导致的神经激素系统紊乱、血管内皮损伤、移植物的免疫和炎症作用以及继发的移植物抗宿主病及其治疗等引起。对代谢综合征及其组分(糖尿病、高血压、血脂紊乱等)的筛查可以尽早地调整治疗策略,控制危险因素的发生,进而降低远期的心血管疾病的发生率和致死率。为此,美国的研究人员回顾性分析了86例异基因HCT受者代谢综合征的发生情况,并与代谢综合征在普通人群中的流行情况进行比较。 相似文献
14.
Toker H, Akp?nar A, Ayd?n H, Poyraz O. Influence of smoking on interleukin‐1beta level, oxidant status and antioxidant status in gingival crevicular fluid from chronic periodontitis patients before and after periodontal treatment. J Periodont Res 2012; 47: 572–577. © 2012 John Wiley & Sons A/S Background and Objective: The aim of this study was to evaluate the impact of smoking on the relationship between interleukin‐1 (IL‐1β) and oxidation in patients with periodontitis and response to nonsurgical periodontal therapy. Material and Methods: Data were obtained from 30 patients with generalized chronic periodontitis (15 smokers and 15 nonsmokers) and from 10 periodontally healthy controls. IL‐1β level, total oxidant status (TOS) and total antioxidant status (TAS) were recorded in gingival crevicular fluid. Probing depth, clinical attachment level, gingival and plaque indices and bleeding on probing were also measured. The gingival crevicular fluid and clinical parameters were recorded at baseline and 6 wk after periodontal treatment. Results: The study showed statistically significant improvement of clinical parameters in both smokers and nonsmokers after periodontal treatment. Moreover, the baseline IL‐1β levels were significantly higher in smokers compared with nonsmokers (p < 0.05). After periodontal treatment, the IL‐1β levels were significantly reduced in both smokers and nonsmokers (p < 0.05). There were no significant differences in TOS and TAS between periodontitis patients and healthy controls at baseline and 6 wk after periodontal treatment. The level of IL‐1β in gingival crevicular fluid was positively correlated with TOS in both smokers and nonsmokers. Conclusions: Periodontal treatment improved the clinical parameters in both smokers and nonsmokers. The results confirm that periodontal therapy has an effect on IL‐1β levels in gingival crevicular fluid, but not on TOS and TAS. 相似文献
15.
16.
17.
Bin Li Yang Yang Alper Toker Bentong Yu Chang Hyun Kang Ghulam Abbas Harmik J. Soukiasian Hecheng Li Hiroyuki Daiko Hongjing Jiang Jianhua Fu Jun Yi Kemp Kernstine Marcello Migliore Michael Bouvet Sara Ricciardi Yin-Kai Chao Yong-Hee Kim Yun Wang Zhentao Yu Abbas E. Abbas Inderpal S. Sarkaria Zhigang Li Cooperative Group of International Expert Consensus on Robot-assisted Esophagectomy for Esophageal Cancer 《Journal of thoracic disease》2020,12(12):7387
18.
Aziz Homayouni Rad Haniyeh Rasouli Pirouzian Nevzat Konar Omer Said Toker Derya Genc Polat 《RSC advances》2019,9(51):29676
Sucrose-free milk chocolates containing different types of bulk (isomalt, xylitol and maltitol) and high intensity (Stevia) sweeteners were produced by using a ball mill. The main quality characteristics of the formulated chocolates were evaluated and compared with those of the conventional sample containing sucrose. The Casson model was the best fitting model for the rheological data. Casson viscosity and Casson yield stress were significantly affected by the type of bulking agent in chocolates formulated with xylitol (p < 0.05). However xylitol notably improved the overall acceptability according to the sensory analysis results. Chocolates containing the sucrose replacers demonstrated lower Tonset values and higher enthalpy than the control sample. Sucrose-free chocolates illustrated a higher degree of particle agglomeration. Bulk sweeteners meanwhile seem to have high potential for milk chocolate production with low calorie values by using the ball mill technique. Industrial applications: the production of sucrose-free chocolates with conventional methods requires a lot of time and energy. Recently, using alternative methods for chocolate production has been raising interest in many small industries. This study proposed a ball mill method for the preparation of sucrose-free milk chocolates with physiochemical properties almost ranging in the standard limit defined for chocolate. Although using the ball mill method presents a more cost-effective technique for chocolate production and provides shorter processing times for small chocolate industries, it seems to be less efficient in evaporating moisture than the conventional processing. Challenges are still ahead for upgrading this alternative technique to be efficient in evaporating more moisture during operation ending in a high quality product.Sucrose-free milk chocolates containing different types of bulk (isomalt, xylitol and maltitol) and high intensity (Stevia) sweeteners were produced by using a ball mill. 相似文献
19.