Dynamic brain connectivity is a better predictor of PTSD than static connectivity

Using resting‐state functional magnetic resonance imaging, we test the hypothesis that subjects with post‐traumatic stress disorder (PTSD) are characterized by reduced temporal variability of brain connectivity compared to matched healthy controls. Specifically, we test whether PTSD is characterized by elevated static connectivity, coupled with decreased temporal variability of those connections, with the latter providing greater sensitivity toward the pathology than the former. Static functional connectivity (FC; nondirectional zero‐lag correlation) and static effective connectivity (EC; directional time‐lagged relationships) were obtained over the entire brain using conventional models. Dynamic FC and dynamic EC were estimated by letting the conventional models to vary as a function of time. Statistical separation and discriminability of these metrics between the groups and their ability to accurately predict the diagnostic label of a novel subject were ascertained using separate support vector machine classifiers. Our findings support our hypothesis that PTSD subjects have stronger static connectivity, but reduced temporal variability of connectivity. Further, machine learning classification accuracy obtained with dynamic FC and dynamic EC was significantly higher than that obtained with static FC and static EC, respectively. Furthermore, results also indicate that the ease with which brain regions engage or disengage with other regions may be more sensitive to underlying pathology than the strength with which they are engaged. Future studies must examine whether this is true only in the case of PTSD or is a general organizing principle in the human brain. Hum Brain Mapp 38:4479–4496, 2017. © 2017 Wiley Periodicals, Inc.     

氧流量对异氟烷的消耗与摄取的影响

目的：探讨不同氧流量对异氟烷的消耗量和体内摄取的影响。方法：２４例异氟烷全身麻醉的病人，按新鲜氧流量不同随机分为３组。氧流量分别为２．０、１．０和０．３Ｌ·ｍｉｎ－１。以微量泵向呼吸环路吸入远端输入异氟烷，调节输入速度使肺泡异氟烷浓度维持在最低肺泡有效浓度的１１倍。监测异氟烷吸入及呼出体积分数，以吸呼体积分数差作为摄取指标，观察异氟烷的消耗量及体内摄取量的变化。结果：异氟烷的消耗量随氧流量的增大而明显增加；体内摄取量各组间差异无显著性。结论：在维持相同最低肺泡有效浓度时，异氟烷的消耗量随着新鲜氧流量的增加而增加；体内对异氟烷的摄取量与新鲜氧流量的大小无关     

吸收度线性组合法测定复方雷锁辛醇溶液的含量

本文报道了用吸收度线性组合法测定复方雷锁辛醇溶液的含量,通过微机优化组合波长并获得浓度计算模型。雷锁辛、苯酚和水杨酸的平均回收率分别为99.9%、100.5%和100。1%,相对标准差分别为0.64%、1.1%和0.42%。     

均匀设计方法在4,5-二氢咪唑制备工艺中的应用

本文应用均匀设计方法,对二氢咪唑的制备工艺进行了研究,最终使收率达到89％,产品纯度达99.5％以上。     

生脉颗粒中五味子醇甲药动学研究

目的研究生脉颗粒中木脂素类成分在人和小鼠体内药物代谢动力学规律。方法人口服生脉颗粒3.6g/次,小鼠灌胃给予生脉颗粒4.7g/kg,在不同的时间点采血样,用HPLC方法分析生脉颗粒和血浆样品中木脂素类成分,测定五味子醇甲浓度的经时变化,浓度-时间数据用3P97药代动力学软件进行分析,计算药动学参数。结果人和小鼠给予生脉颗粒后,血浆中检测到五味子醇甲及新的成分,后者推测为五味子醇甲的代谢物。五味子醇甲在小鼠和人体内药动学参数分别是:T1/2ka为0.03和0.04h,T1/2ke为0.88和0.86h,Vd为19.12和1.73L·kg-1,CL为15.06和1.46L·h-1·kg-1,Cmax为1.196和0.098mg·L-1,Tpeak为0.21和0.50h,AUC0-∞为1.096和0.137mg·h·L-1。结论生脉颗粒中五味子醇甲可吸收进入体内,其在体内吸收和消除速度均比较快,并可在体内转化成代谢产物,且符合线性动力学规律。     

老年股骨颈骨折的微创内固定治疗

目的 总结评价老年新鲜股骨颈骨折应用微创空心加压螺钉内固定治疗的临床疗效。方法对1998年1月至2005年1月收治的60岁以上182例新鲜股骨颈骨折微创空心加压螺钉内固定治疗进行回顾性分析。结果182例均顺利完成手术，切口无感染，随访11～60个月，平均25个月，无骨不连发生，股骨头坏死6例，功能优良率为87．1％，术后并发内科疾病17例。结论微创空心加压螺钉内固定治疗股骨颈骨折具有创伤小、方法简便、固定牢靠、并发症少、费用小等优点，是治疗老年股骨颈骨折的一种比较好的方法。     

Expression of p53 and p21 proteins in rat brain tissue after reperfusion following forebrain ischemia

CerebtDvaSCulax diseases were counted among themost cond causes Of death, 56. 6% ~ 80. 0% Of whichare ischeM cereb~ diseases. Even thO8e patients whO.:.s~ the diSeaSeS will sde motorial, linghstic or captive ~elae of the nervous system. It isthe~ of po siedcance to stody hm ce~ascular ~ by s~ in iSChelnic rat models.Despite that the total synthesis of the Proteins inbarn hsspe ~es tempoedly ac i.hellha[lj, the.~ty Of some Proteins['] as ac-2, c-fOS, heat shockPain etc may inchs, whOSe …     

全髋关节翻修术（48例50髋随诊分析）

目的评价人工全髋关节翻修术临床效果。方法自1984年1月～2006年4月,56例58髋行髋关节翻修术,男22例,女34例,年龄36～73岁,平均63岁。初次人工髋关节置换前诊断为股骨颈骨折28例,股骨头缺血坏死18例,髋关节发育不良骨关节炎9例,强直性脊柱炎1例。初次行股骨头置换术9例,其中骨水泥2例,生物型固定7例。全髋关节置换47例49髋。其中骨水泥30髋,生物型固定19髋。术后早期脱位2例,16髋因髋关节严重疼痛,45例47髋因无菌性松动行全关节翻修术。翻修手术中28髋行髋臼植骨,其中自体碎屑植骨17例18髋。自体碎骨屑加异体大块植骨10例。结果资料完整48例50髋获得随访,最长20年,最短4个月,平均随访时间为5年。经随访,患者髋关节基本无疼痛,X线片显示髋臼和股骨柄假体位置满意,无松动和感染征象,髋臼植骨后愈合良好。4例股骨柄假体正位X线片仅1区出现约1mm宽的透亮带,临床检查无松动迹象。Harris评分由术前的平均41.3分(10～70分)提高到术后的平均80.4分(55～97分)。结论全髋关节翻修手术的病例经随访,临床达到满意效果。