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排序方式: 共有1327条查询结果,搜索用时 78 毫秒
81.
This research reports on the concentration of plasma cortisol and the results of an oral glucose tolerance test in 60 fertile women taking quinestrol for between 4 and 13 years. In these women, the mean plasma cortisol concentration was 27.72 +or- 1.05 mcg/100 ml, which was significantly higher than 19.76 +or- 0.86 mcg/100 mg in 20 cases with a history of taking shortacting oral contraceptives and 15.53 +or- 0.50 mcg/100 ml in the normal volunteers. There was no significant difference in mean blood glucose levels between the group taking quinestrol and the control group. The above results indicated that the effect of quinestrol on adrenal cortisol function may be through the negative feedback of t pituitary-adrenal cortex axis. As a result, the levels of plasma cortisol were increased. Small doses of quinestrol had no apparent effect on carbohydrate metabolism. 相似文献
82.
山苍子油乳剂的抗菌机制研究 总被引:1,自引:0,他引:1
应用电镜和同住素掺入试验,研究山苍子油乳剂抗金黄色葡萄球菌、绿脓杆菌和白色念珠菌的机制。结果表明:药物作用后,三种菌的细胞壁、细胞膜均受到不同程度的损害,胞浆内容物漏出;三种菌的DNA,RNA,蛋白质,细菌的股聚糖和白色念珠菌麦角固醇的合成均受到明显抑制。提示山苍子油乳剂是作用于细菌胞壁的肽聚糖和真菌胞壁的甘露聚糖、几丁质及胞膜的麦角固醇。 相似文献
83.
本文报告用浸泡法的以常用,消毒液、化学驱虫药、中药及食品等共21个品种体外处理蛲虫卵的结果。实验显示:蛲虫卵经次氯酸钠(1000ppm)、过氧乙酸(1%)等消毒液,南鹤虱、苦楝皮、公丁香、白头翁、露蜂房、五倍子等6种中药煎剂(≈1g/ml生药)及食物青皮大蒜鳞茎液(1:2)、小葱葱白液(1:2)处理后,与未经药物处理的对照虫卵孵出率相比,有非常显著的差异。值得进一步研究。 相似文献
84.
本研究的目的是探索高本底和对照两地区癌亡与环境诱变因素问的关系, 以进一步分析造成两地区癌症死亡率差异的原因和正确地估价高本底辐射在其中的作用。所研究的肝癌、胃癌和肺癌病仞高本底地区分别为64、28和17例, 对照地区分别为75, 36和13例。病例和对照数的比例肝癌为1:1, 胃癌和肺癌为l:2.研究的因素包括职业, 受教育程度, 经济收入、居住史和居住条件等一般社会经济状况, 农药使用, 吸烟、饮酒、饮食以及医用诊断x线照射情况等。 相似文献
85.
86.
We previously developed a preliminary 3-D QSAR model for the binding of 14 hydantoins to the neuronal voltage-gated sodium channel; this model was successful in designing an effective non-hydantoin ligand. To further understand structural features that result in optimum binding, here we synthesized a variety of compound classes and evaluated their binding affinities to the neuronal voltage-gated sodium channel using the [3H]-batrachotoxinin A 20-alpha-benzoate ([3H]BTX-B) binding assay. In order to understand the importance of the hydantoin ring for good sodium channel binding, related non-hydantoins such as hydroxy amides, oxazolidinediones, hydroxy acids, and amino acids were included. Two major conclusions were drawn: (1) The hydantoin ring is not critical for compounds with long alkyl side chains, but it is important for compounds with shorter side chains. (2) Relative to Khodorov's pharmacophore, which contains two hydrophobic regions, a third hydrophobic region may enhance binding to provide nanomolar inhibitors. 相似文献
87.
Cyclooxygenases in cancer: progress and perspective 总被引:20,自引:0,他引:20
Aspirin has been used to control pain and inflammation for over a century. Epidemiological studies first associated a decreased incidence of colorectal cancer with the long-term use of aspirin in the early 1980s. Near the same time the first reports showing regression of colorectal adenomas in response to the non-steroidal anti-inflammatory drug (NSAID) sulindac were reported. In subsequent years, the use of other NSAIDs, which inhibit cyclooxygenase (COX) enzymes, was linked to reduced cancer risk in multiple tissues including those of the breast, prostate, and lung. Together these studies resulted in the identification of a new cancer preventive and/or therapeutic target-COX enzymes, especially COX-2. Meanwhile, the overexpression of COX-2, and less consistently, the upstream and downstream enzymes of the prostaglandin synthesis pathway, was demonstrated in multiple cancer types and some pre-neoplastic lesions. Direct interactions of prostaglandins with their receptors through autocrine or paracrine pathways to enhance cellular survival or stimulate angiogenesis have been proposed as the molecular mechanisms underlying the pro-carcinogenic functions of COX-2. The rapid development of safe and effective inhibitors targeting individual COX enzymes not only dramatically improved our understanding of the function of COX-2, but also resulted in discovery of COX independent functions of NSAIDs, providing important hints for future drug design. Here we review the fundamental features of COX enzymes, especially as related to carcinogenesis, their expression and function in both animal tumor models and clinical cancers and the proposed mechanisms behind their roles in cancer. 相似文献
88.
Alpha-methylacyl-CoA racemase as an androgen-independent growth modifier in prostate cancer 总被引:11,自引:0,他引:11
Zha S Ferdinandusse S Denis S Wanders RJ Ewing CM Luo J De Marzo AM Isaacs WB 《Cancer research》2003,63(21):7365-7376
Alpha-methylacyl-CoA racemase (AMACR) is an enzyme involved in beta-oxidation of branched-chain fatty acids and bile acid intermediates. Recent work has identified AMACR as a new diagnostic marker for prostate cancer (PCa). The data from the present study suggest that AMACR is also functionally important for the growth of PCa cells. Overexpressed AMACR from both clinical tissues and PCa cell lines is wild type by sequence analysis and functionally active by enzymatic assay. Correspondingly, enzyme activity of AMACR increases approximately 4-fold in PCa in comparison with adjacent normal prostate. Small interference RNA (siRNA) against AMACR, but not the control inverted siRNA, reduced the expression of AMACR and significantly impaired proliferation of the androgen-responsive PCa cell line LAPC-4. No effect was observed in HeLaS3 cells, which express AMACR at a low level. Cell cycle analyses revealed a G(2)-M cell cycle arrest in LAPC-4 cells treated with siRNA compared with mock treatment or control inverted siRNA. Expression of a siRNA-resistant form of AMACR in LAPC-4 cells protects the cells from growth arrest after AMACR-specific siRNA treatment. Data from Western blotting and luciferase-based reporter assays suggest that the function and expression of AMACR are independent of androgen receptor-mediated signaling. Moreover, simultaneous inhibition of both the AMACR pathway by siRNA and androgen signaling by means of androgen withdrawal or antiandrogen suppressed the growth of LAPC-4 cells to a greater extent than either treatment alone. Taken together, these data suggest that AMACR is essential for optimal growth of PCa cells in vitro and that this enzyme has the potential to be a complementary target with androgen ablation in PCa treatment. 相似文献
89.
目的:了解湖州市食品中单增李斯特菌、肠出血性大肠埃希菌、沙门菌、金黄色葡萄球菌、副溶血性弧菌、空肠弯曲菌的污染状况,为食物中毒监测提供科学依据。方法:按国标方法,对6类食品进行单增李斯特菌、肠出血性大肠埃希菌、沙门菌、金黄色葡萄球菌、副溶血性弧菌和空肠弯曲菌分离、生化及血清型鉴定。结果:192份样品中共检出致病菌28株,总检出率为14.6%。其中单增李斯特菌检出10株,检出率为5.2%;沙门菌检出12株,检出率为6.3%;副溶血性弧菌检出6株,检出率为3.1%;未检出金黄色葡萄球菌、肠出血性大肠埃希菌、空肠弯曲菌。结论:湖州市食品中存在食源性致病菌的污染,其中生肉制品和水产品受到的污染最为严重,卫生监督部门应加强对生肉制品和水产品的监督管理,防止食源性疾病的发生。 相似文献
90.
抗生育中草药的抗HIV研究现状和展望 总被引:1,自引:0,他引:1
近年来,抗HIV药物的研究有了很大的发展,目前美国食品及药品管理局(FDA)已经批准了至少29种用于治疗HIV感染的抗病毒药物,主要包括3大类:核苷类逆转录酶抑制剂(NRTIs),非核苷类逆转录酶抑制剂(NNRTIs)及蛋白酶抑制剂(PIs),它们通过抑制HIV病毒的逆转录酶和蛋白酶发挥抗HIV活性。然而,目前HIV对临床使用的上述抗HIV药物均产生耐药性,因此围绕耐药性问题进行了大量的分子机制研究。与此同时,抗HIV天然药物因其专一性、毒副反应少、方便有效等原因得到了越来越多的重视和研究,包括生物碱类、香豆素类、黄酮类、木脂素类和酚类等化合物。研究发现,在天然药物中,有很多抗生育中草药同时具有抗HIV活性,由于抗生育与抗HIV在免疫机制、基因表达、信号转导和促进细胞凋亡方面的机理具有一定的相关性,同时艾滋病又是一种性传播疾病,因此抗生育与抗HIV结合可能成为临床基础研究的新热点。 相似文献