Effect of ultrasound exposure on sonicated microbubbles stability

The study of intlavenous myocedal coneest echocedo~ (IVMCE) is a hot topic in the Pursuit ofcoronap healt disease, and much achievement has beenmade in ash ultheound etwpment development and cont. .[if ~t agent improvement. Most colltrsst opllts such asMiunex, Ophson etc. are pIDduced by sonication, andcan be used as echogenic bacers of blood flow in WMCE.SOme studies have suggested, however, that the ndcrobubbles exposed to ultrasound are Open to mpture[']. Ihan effort to detendne the o…     

超声照射对声振微泡稳定性的影响

目的与方法造影剂微泡浓度、大小是影响心肌声学显影最重要因素。本研究采用２×２×４析因分析法分析不同超声照射条件对造影剂微泡浓度及直径的影响,即声波频率、能量以及照射时间对微泡浓度、大小的单独及交互作用。为临床行静脉心肌声学造影检查时选择适宜的超声照射条件提供参考。结果能量越大、照射时间越长,微泡破坏越多,平均直径越小：照射频率对微泡浓度影响不大,但影响微泡大小,频率越高,微泡越小。结论为减少超声照射对微泡的破坏,提高心肌声学造影效果,应尽可能选用低能量、低频率超声波,并减少不必要的照射时间。     

Introduction to infantile Tuina

Infantile Tuina is an important component of traditional Tuina therapy, whose unique treatment system was formed during the Ming and Qing Dynasties. Infantile Tuina is a treatment method performed on the children‘s body or acupoints by some Tuina techniques under the guidance of Chinese medical theory to treat their diseases. Infantile Tuina functions to unblock meridian     

2004年武汉地区医院用药状况分析

目的：了解2004年度武汉地区的用药状况.方法：根据HPDIS提供的资料,回顾性统计分析购药金额、用药频度、每日费用及年平均增长率.结果：本年度购药金额与去年相比增幅明显,购药金额列前20名药品用药频度呈上升趋势,日费用有所下降.结论：武汉地区医院用药呈现稳定、健康增长,药品市场具有良好发展空间.     

膝骨性关节炎关节液分析研究进展

由于关节疾病所引起关节液的改变最能直观体现关节内环境变化的程度，因此，可以推测对关节液一些特定的检测将对关节疾病的诊断，以及治疗效果的评价起到积极作用。骨性关节炎（Osteoarthritis，OA）是关节炎中最为常见的一种，叉名退行性骨关节炎，其主要病理变化是以退行性软骨的生化及代谢发生了显著的变化，以及关节软骨进行性变性和消失、关节边缘和软骨下骨质的反应性变化为病理特点的疾病。目前随着科技发展，检测手段多样化，关节液的检查越来越受到国内外学者重视。本文就近年来关节液成分改变与临床意义、关节液的检查方法以及相关方面进展综述如下。     

Changes of the peripheral blood endothelial progenitor cells in peritoneal dialysis patients and its impact factors

Objective To investigate the number and activities changes of peripheral blood endothelial progenitor cells (EPCs) in continuous ambulatory peritoneal dialysis (CAPD) patients, and explore the connection between EPCs' number and the levels of advanced glycosylation end products (AGEs), homocysteine (Hcy) and C-reactive protein (CRP). Methods Twenty-five CAPD patients and thirty healthy volunteers were involved. Total mononuclear cells (MNCs) were isolated from peripheral blood of patients. EPCs were characterized as adherent cells by double staining of FITC-UEA-1 and DiL-AcLDL binding, and were further demonstrated by positive cells of CD34, CD133 and KDR using flow cytometry. The abilities of cell proliferation, adhesion and migration were further observed by fluorescent microscope. The correlations between the CEPCs' number and the levels of AGEs, Hcy andCRP were analyzed. Results The number and activities including migration and adhesion of EPCs in CAPD group were significantly lower than control group (P＜0.05). The levels of serum AGEs, Hcy and CRP in CAPD patients were increased (all P＜0.05) and had negative correlation with EPCs' number. Conclusions The number and activities of EPCs decrease in patients with CAPD, and EPCs' number is negatively correlated to the levels ofAGEs, Hcy and CRP.     

Associations of IL-27 Polymorphisms and Serum IL-27p28 Levels With Osteosarcoma Risk

Interleukin (IL)-27 is a novel cytokine secreted by stimulation of antigen-presenting cells. No previous studies currently reported the role of IL-27 in the carcinogenesis of osteosarcoma. We aimed to investigate the association of IL-27 polymorphisms and serum IL-27p28 with osteosarcoma risk in a Chinese population.One hundred and sixty osteosarcoma patients and 250 health controls were selected. IL-27 gene -964 A/G, 2905 T/G, and 4730 T/C polymorphisms were determined by using polymerase chain reaction-restriction fragment length polymorphism. Enzyme-linked immunosorbent assay were used to detect serum IL-27p28 levels.The serum IL-27p28 levels were significantly lower in osteosarcoma patients compared with those in controls (P < 0.01). Serum IL-27p28 levels in stages III–IV were lower than those in stages I–II of osteosarcoma (P < 0.05); similar results were also found in patients with metastasis, that is, patients with metastasis have higher IL-27p28 levels than those without metastasis (P < 0.05). There were no associations between genotype and allele frequencies of IL-27 -964 A/G, 2905 T/G, 4730 T/C, and the risk of osteosarcoma (P > 0.05). Stratification analysis also failed to show the associations between -964 A/G, 2905 T/G, and 4730 T/C polymorphisms and the clinical stage and metastasis of osteosarcoma (P > 0.05). Three possible haplotypes (A^-964T²⁹⁰⁵T⁴⁷³⁰, G^-964T²⁹⁰⁵T⁴⁷³⁰, and G^-964G²⁹⁰⁵C⁴⁷³⁰) were identified, but no associations were found between them and the osteosarcoma risk (P > 0.05).This study indicates that the lower serum IL-27p28 levels may be associated with development and progression of osteosarcoma, but IL-27 gene -964 A/G, 2905 T/G, and 4730 T/C polymorphisms and their haplotypes are not associated with osteosarcoma risk.     

Preoperative Evaluation and Endovascular Procedure of Intraoperative Aneurysm Rupture During Thoracic Endovascular Aortic Repair

Thoracic aortic aneurysms are now routinely repaired with endovascular repair if anatomically feasible because of advantages in safety and recovery. However, intraoperative aneurysm rupture is a severe complication which may have an adverse effect on the outcome of treatment. Comprehensive preoperative assessment and considerate treatment are keys to success of endovascular aneurysm repair, especially during unexpected circumstances. Few cases have reported on intraoperative aortic rupture, which were successfully managed by endovascular treatment. Here, we present a rare case of an intraoperative aneurysm rupture during endovascular repair of thoracic aortic aneurysm with narrow neck and angulated aorta arch (coarctation-associated aneurysm), which was successfully treated using double access route approach and iliac limbs of infrarenal devices. Level 5.     

复发性脑胶质瘤的显微手术切除探讨

目的探讨复发性胶质瘤的手术特点。方法统计26例复发性胶质瘤的临床资料、病理特点、显微技术及术中超声应用,分析其手术治疗效果。结果复发性胶质瘤再次手术全切除率较高,无死亡病例,术后病理分级大多数较第1次手术提高,多数患者术后能明显改善症状,延长寿命。结论患者的生存时间与首次术后复发时间、肿瘤复发后的病理分级、肿瘤生长部位及形态学特点、患者的年龄及身体状况有关,精确的手术结合术后放疗、化疗,可提高生存时间与生活质量,有效降低病死率与致残率。