全文获取类型
收费全文 | 1110篇 |
免费 | 74篇 |
国内免费 | 5篇 |
专业分类
耳鼻咽喉 | 9篇 |
儿科学 | 21篇 |
妇产科学 | 6篇 |
基础医学 | 120篇 |
口腔科学 | 4篇 |
临床医学 | 145篇 |
内科学 | 391篇 |
皮肤病学 | 7篇 |
神经病学 | 150篇 |
特种医学 | 45篇 |
外科学 | 100篇 |
综合类 | 9篇 |
预防医学 | 106篇 |
眼科学 | 1篇 |
药学 | 43篇 |
肿瘤学 | 32篇 |
出版年
2024年 | 2篇 |
2023年 | 10篇 |
2022年 | 10篇 |
2021年 | 33篇 |
2020年 | 25篇 |
2019年 | 30篇 |
2018年 | 35篇 |
2017年 | 22篇 |
2016年 | 22篇 |
2015年 | 25篇 |
2014年 | 40篇 |
2013年 | 44篇 |
2012年 | 82篇 |
2011年 | 81篇 |
2010年 | 37篇 |
2009年 | 34篇 |
2008年 | 75篇 |
2007年 | 72篇 |
2006年 | 57篇 |
2005年 | 52篇 |
2004年 | 41篇 |
2003年 | 30篇 |
2002年 | 37篇 |
2001年 | 33篇 |
2000年 | 23篇 |
1999年 | 39篇 |
1998年 | 5篇 |
1997年 | 7篇 |
1996年 | 16篇 |
1995年 | 5篇 |
1994年 | 13篇 |
1993年 | 6篇 |
1992年 | 22篇 |
1991年 | 16篇 |
1990年 | 16篇 |
1989年 | 14篇 |
1988年 | 15篇 |
1987年 | 10篇 |
1986年 | 8篇 |
1985年 | 11篇 |
1984年 | 11篇 |
1983年 | 3篇 |
1982年 | 4篇 |
1979年 | 2篇 |
1975年 | 2篇 |
1974年 | 2篇 |
1973年 | 2篇 |
1971年 | 1篇 |
1970年 | 2篇 |
1969年 | 1篇 |
排序方式: 共有1189条查询结果,搜索用时 31 毫秒
11.
Arthur J. Kievit Rutger C.I. van Geenen P. Paul F.M. Kuijer Thijs M.J. Pahlplatz Leendert Blankevoort Matthias U. Schafroth 《The Journal of arthroplasty》2014
The number of patients receiving a TKA during working life is increasing but little is known about the impact of TKA on patients’ reintegration into the workplace. In this cross-sectional survey it was found that 173 of 480 responders worked within 2 years prior to surgery. Sixty-three percent of the working patients stopped within two weeks prior to surgery and 102 patients returned within 6 months. One third never returned to work. Activities that most improved were operating foot pedals, operating vehicles, standing and walking on level terrain. Activities that least improved were kneeling, crouching and clambering. Fifty patients scored 5 or less on the Work Ability Index. Thirty patients were dissatisfied. TKA significantly, but unequally, reduces difficulties in carrying out knee-burdening work activities. 相似文献
12.
13.
14.
15.
16.
Robert J. Lamberts Sergio Laranjo Stiliyan N. Kalitzin Demetrios N. Velis Isabel Rocha Josemir W. Sander Roland D. Thijs 《Epilepsia》2013,54(3):523-529
Purpose: Postictal generalized EEG suppression (PGES) seems to be a pathophysiologic hallmark in ictal recordings of sudden unexpected death in epilepsy (SUDEP). It has recently been suggested that presence and duration of PGES might be a predictor of SUDEP risk. Little is known about the etiology of PGES. Methods: We conducted a retrospective case–control study in 50 people with convulsive seizures (CS) recorded on digital video–electroencephalography (EEG). One CS per individual was reviewed for presence and duration of PGES by two independent observers: Preictal and postictal heart rate (HR) (1 min before seizure onset and 1, 3, 5, 15, and 30 min after seizure end) and frequency domain measures of heart rate variability (HRV), including the ratio of low frequency (LF) versus high frequency (HF) power, were analyzed. The relationship between PGES and periictal autonomic changes was evaluated, as well as its association with several clinical variables. Key Findings: Thirty‐seven individuals (74%) exhibited PGES and 13 (26%) did not. CS resulted in a significant increase of periictal HR and the LF/HF ratio. PGES was associated with neither periictal HR (mean HR difference between PGES+ and PGES? seizures: ?2 beats per minute [bpm], 95% confidence interval [CI] ?10 to +6 bpm) nor HRV change. There was no association between the duration of PGES and periictal HR change. People with PGES were more likely to be asleep before seizure onset (odds ratio [OR] 4.7, 95% CI 1.2–18.3) and had a higher age of onset of epilepsy (median age 15 vs. 4 years). Significance: PGES was not associated with substantial changes in measures of cardiac autonomic instability but was more prevalent in CS arising from sleep. 相似文献
17.
Li Y Boggia J Thijs L Hansen TW Kikuya M Björklund-Bodegård K Richart T Ohkubo T Kuznetsova T Torp-Pedersen C Lind L Ibsen H Imai Y Wang J Sandoya E O'brien E Staessen JA;International Database on Ambulatory Blood Pressure Monitoring in relation to Cardiovascular Outcomes Investigators 《Blood pressure monitoring》2008,13(3):145-147
The objective of this study was to investigate the prognostic significance of the ambulatory blood pressure (BP) during night and day and of the night-to-day BP ratio (NDR). We studied 7458 participants (mean age 56.8 years; 45.8% women) enrolled in the International Database on Ambulatory BP in relation to Cardiovascular Outcome. Using Cox models, we calculated hazard ratios (HR) adjusted for cohort and cardiovascular risk factors. Over 9.6 years (median), 983 deaths and 943 cardiovascular events occurred. Nighttime BP predicted mortality outcomes (HR, 1.18-1.24; P<0.01) independent of daytime BP. Conversely, daytime systolic (HR, 0.84; P<0.01) and diastolic BP (HR, 0.88; P<0.05) predicted only noncardiovascular mortality after adjustment for nighttime BP. Both daytime BP and nighttime BP consistently predicted all cardiovascular events (HR, 1.11-1.33; P<0.05) and stroke (HR, 1.21-1.47; P<0.01). Daytime BP lost its prognostic significance for cardiovascular events in patients on antihypertensive treatment. Adjusted for the 24-h BP, NDR predicted mortality (P<0.05), but not fatal combined with nonfatal events. Participants with systolic NDR of at least 1 compared with participants with normal NDR (> or = 0.80 to <0.90) were older, at higher risk of death, but died at higher age. The predictive accuracy of the daytime and nighttime BP and the NDR depended on the disease outcome under study. The increased mortality in patients with higher NDR probably indicates reverse causality. Our findings support recording the ambulatory BP during the whole day. 相似文献
18.
Gasowski J Staessen JA Celis H Fagard RH Thijs L Birkenhäger WH Bulpitt CJ Fletcher AE Arabidze GG de Leeuw P Dollery CT Duggan J Kawecka-Jaszcz K Leonetti G Nachev C Safar M Rodico JL Rosenfeld J Seux ML Tuomilehto J Webster J Yodfat Y 《Journal of human hypertension》1999,13(2):135-145
The Systolic Hypertension in Europe (Syst-Eur) trial proved that blood pressure (BP) lowering therapy starting with nitrendipine reduces the risk of cardiovascular complications in older (> or = 60 years) patients with isolated systolic hypertension (systolic BP > or = 160 mm Hg and diastolic BP < 95 mm Hg). After the completion of the Syst-Eur trial on 14 February 1997, 3506 consenting patients (93.0% of those eligible) were enrolled in phase 2 of the Syst-Eur trial. This open follow-up study aims to confirm the safety of long-term antihypertensive therapy based on a dihydropyridine. To lower the sitting systolic BP below 150 mm Hg (target BP), the first-line agent nitrendipine (10-40 mg/day) may be associated with enalapril (5-20 mg/day), hydrochlorothiazide (12.5-25 mg/day), both add-on study drugs, or if required any other antihypertensive agent. On 1 November 1998, 3248 patients were still being followed, 86 patients had proceeded to non-supervised follow-up, and 43 had died. The median follow-up in Syst-Eur 2 was 14.3 months. At the last available visit, systolic/diastolic BP in the patients formerly randomised to placebo (n = 1682) or active treatment (n = 1824), had decreased by 13.2/5.2 mm Hg and by 4.6/1.6 mm Hg, respectively, so that the between-group BP difference was 1.7 mm Hg systolic (95% Ci: 0.8 to 2.6 mm Hg; P < 0.001) and 0.9 mm Hg diastolic (95% Cl: 0.4 to 1.5 mm mm Hg; P < 0.001). At the beginning of Syst-Eur 2, the goal BP was reached by 25.4% and 50.6% of the former placebo and active-treatment groups; at the last visit these proportions were 55.9% and 63.1%, respectively. At that moment, 45.9% of the patients were on monotherapy with nitrendipine, 29.3% took nitrendipine in combination with other study drugs. Until the end of 2001, BP control of the Syst-Eur 2 patients will be further improved. Cardiovascular complications and adverse events, such as cancer or gastro-intestinal bleeding, will be monitored and validated by blinded experts. 相似文献
19.
Esmée A. Bakker Duck-chul Lee Xuemei Sui Thijs M.H. Eijsvogels Francisco B. Ortega I-Min Lee Carl J. Lavie Steven N. Blair 《Mayo Clinic proceedings. Mayo Clinic》2018,93(4):419-428
Objective
To examine the associations of resistance exercise, independent of and combined with aerobic exercise, with the risk of development of hypercholesterolemia in men.Patients and Methods
This study used data from the Aerobics Center Longitudinal Study, which is a cohort examining the associations of clinical and lifestyle factors with the development of chronic diseases and mortality. Participants received extensive preventive medical examinations at the Cooper Clinic in Dallas, Texas, between January 1, 1987, and December 31, 2006. A total of 7317 men aged 18 to 83 years (mean age, 46 years) without hypercholesterolemia at baseline were included. Frequency (times per week) and total amount (min/wk) of resistance and aerobic exercise were determined by self-report. Hypercholesterolemia was defined as a total cholesterol level of 240 mg/dL or higher or physician diagnosis.Results
During a median (interquartile range) follow-up of 4 (2 to 7) years, hypercholesterolemia developed in 1430 of the 7317 men (20%). Individuals meeting the resistance exercise guidelines (≥2 d/wk) had a 13% lower risk of development of hypercholesterolemia (hazard ratio [HR], 0.87; 95% CI, 0.76-0.99; P=.04) after adjustment for general characteristics, lifestyle factors, and aerobic exercise. In addition, less than 1 h/wk and 2 sessions per week of resistance exercise were associated with 32% and 31% lower risks of hypercholesterolemia (HR, 0.68; 95% CI, 0.54-0.86; P=.001; and HR, 0.69; 95% CI, 0.54-0.88; P=.003), respectively, compared with no resistance exercise. Higher levels of resistance exercise did not provide benefits. Meeting both resistance and aerobic exercise guidelines (≥500 metabolic equivalent task min/wk) lowered the risk of development of hypercholesterolemia by 21% (HR, 0.79; 95% CI, 0.68-0.91; P=.002). compared with meeting none of the guidelines.Conclusion
Compared with no resistance exercise, less than 1 h/wk of resistance exercise, independent of aerobic exercise, is associated with a significantly lower risk of development of hypercholesterolemia in men (P=.001). However, the lowest risk of hypercholesterolemia was found at 58 min/wk of resistance exercise. This finding suggests that resistance exercise should be encouraged to prevent hypercholesterolemia in men. However, future studies with a more rigorous analysis including major potential confounders (eg, diet, medications) are warranted. 相似文献20.