全文获取类型
收费全文 | 4667篇 |
免费 | 308篇 |
国内免费 | 15篇 |
专业分类
耳鼻咽喉 | 74篇 |
儿科学 | 128篇 |
妇产科学 | 69篇 |
基础医学 | 671篇 |
口腔科学 | 644篇 |
临床医学 | 351篇 |
内科学 | 921篇 |
皮肤病学 | 86篇 |
神经病学 | 410篇 |
特种医学 | 75篇 |
外科学 | 443篇 |
综合类 | 19篇 |
预防医学 | 489篇 |
眼科学 | 91篇 |
药学 | 372篇 |
中国医学 | 54篇 |
肿瘤学 | 93篇 |
出版年
2023年 | 63篇 |
2022年 | 118篇 |
2021年 | 247篇 |
2020年 | 153篇 |
2019年 | 184篇 |
2018年 | 215篇 |
2017年 | 138篇 |
2016年 | 171篇 |
2015年 | 197篇 |
2014年 | 246篇 |
2013年 | 270篇 |
2012年 | 388篇 |
2011年 | 418篇 |
2010年 | 223篇 |
2009年 | 175篇 |
2008年 | 275篇 |
2007年 | 242篇 |
2006年 | 191篇 |
2005年 | 173篇 |
2004年 | 102篇 |
2003年 | 112篇 |
2002年 | 133篇 |
2001年 | 70篇 |
2000年 | 57篇 |
1999年 | 55篇 |
1998年 | 26篇 |
1997年 | 10篇 |
1996年 | 15篇 |
1995年 | 9篇 |
1994年 | 18篇 |
1993年 | 8篇 |
1992年 | 35篇 |
1991年 | 31篇 |
1990年 | 17篇 |
1989年 | 9篇 |
1988年 | 13篇 |
1987年 | 15篇 |
1986年 | 10篇 |
1985年 | 10篇 |
1984年 | 15篇 |
1983年 | 12篇 |
1981年 | 7篇 |
1978年 | 10篇 |
1977年 | 7篇 |
1976年 | 8篇 |
1973年 | 7篇 |
1972年 | 9篇 |
1971年 | 9篇 |
1970年 | 10篇 |
1969年 | 8篇 |
排序方式: 共有4990条查询结果,搜索用时 855 毫秒
111.
Gabriela Lopes Santos Thiago Luiz Russo Angela Nieuwenhuys Davide Monari Kaat Desloovere 《Archives of physical medicine and rehabilitation》2018,99(3):501-511.e4
Objective
To compare sitting posture and movement strategies between chronic hemiparetic and healthy subjects while performing a drinking task, using statistical parametric mapping (SPM) and feature analysis.Design
Cross-sectional study.Setting
A university physical therapy department.Participants
Participants (N=26) consisted of chronic hemiparetic (n=13) and healthy individuals (n=13) matched for sex and age.Interventions
Not applicable.Main Outcome Measures
The drinking task was divided into phases: reaching, transporting the glass to mouth, transporting the glass to table, and returning to initial position. An SPM 2-sample t test was used to compare the entire kinematic waveforms of different joint angles (trunk, scapulothoracic, humerothoracic, elbow). Joint angles at the beginning and end of the motion, movement time, peak velocity timing, trajectory deviation, normalized integrated jerk, and range of motion were extracted from the motion data. Group differences for these parameters were analyzed using independent t tests.Results
At the static posture and beginning of the reaching phase, patients showed a shoulder position more deviated from the midline and externally rotated with increased scapula protraction, medial rotation, anterior tilting, trunk anterior flexion and inclination to the paretic side. Altered spatiotemporal variables throughout the task were found in all phases, except for the returning phase. Patients returned to a similar posture as the task onset, except for the scapula, which was normalized after the reaching phase.Conclusions
Chronic hemiparetic subjects showed more deviations in the proximal joints during seated posture and reaching. However, the scapular movement drew nearer to the healthy individuals' patterns after the first phase, showing an interesting point to consider in rehabilitation programs. 相似文献112.
113.
Jean-François Timsit Mark Rupp Emilio Bouza Vineet Chopra Tarja Kärpänen Kevin Laupland Thiago Lisboa Leonard Mermel Olivier Mimoz Jean-Jacques Parienti Garyphalia Poulakou Bertrand Souweine Walter Zingg 《Intensive care medicine》2018,44(6):742-759
Intravascular catheters are inserted into almost all critically ill patients. This review provides up-to-date insight into available knowledge on epidemiology and diagnosis of complications of central vein and arterial catheters in ICU. It discusses the optimal therapy of catheter-related infections and thrombosis. Prevention of complications is a multidisciplinary task that combines both improvement of the process of care and introduction of new technologies. We emphasize the main component of the prevention strategies that should be used in critical care and propose areas of future investigation in this field. 相似文献
114.
Fernando G. Zampieri Theodore J. Iwashyna Elizabeth M. Viglianti Leandro U. Taniguchi William N. Viana Roberto Costa Thiago D. Corrêa Carlos Eduardo N. Moreira Marcelo O. Maia Giulliana M. Moralez Thiago Lisboa Marcus A. Ferez Carlos Eduardo F. Freitas Clayton B. de Carvalho Bruno F. Mazza Mariza F. A. Lima Grazielle V. Ramos Aline R. Silva Fernando A. Bozza Jorge. I. F. Salluh Marcio Soares for the ORCHESTRA Study Investigators 《Intensive care medicine》2018,44(9):1512-1520
Purpose
Frail patients are known to experience poor outcomes. Nevertheless, we know less about how frailty manifests itself in patients’ physiology during critical illness and how it affects resource use in intensive care units (ICU). We aimed to assess the association of frailty with short-term outcomes and organ support used by critically ill patients.Methods
Retrospective analysis of prospective collected data from 93 ICUs in Brazil from 2014 to 2015. We assessed frailty using the modified frailty index (MFI). The primary outcome was in-hospital mortality. Secondary outcomes were discharge home without need for nursing care, ICU and hospital length of stay (LOS), and utilization of ICU organ support and transfusion. We used mixed logistic regression and competing risk models accounting for relevant confounders in outcome analyses.Results
The analysis consisted of 129,680 eligible patients. There were 40,779 (31.4%) non-frail (MFI?=?0), 64,407 (49.7%) pre-frail (MFI?=?1–2) and 24,494 (18.9%) frail (MFI?≥?3) patients. After adjusted analysis, frailty was associated with higher in-hospital mortality (OR 2.42, 95% CI 1.89–3.08), particularly in patients admitted with lower SOFA scores. Frail patients were less likely to be discharged home (OR 0.36, 95% CI 0.54–0.79) and had higher hospital and ICU LOS than non-frail patients. Use of all forms of organ support (mechanical ventilation, non-invasive ventilation, vasopressors, dialysis and transfusions) were more common in frail patients and increased as MFI increased.Conclusions
Frailty, as assessed by MFI, was associated with several patient-centered endpoints including not only survival, but also ICU LOS and organ support.115.
Zeferino Demartini Jr. Fernando Liebert Luana Antunes Maranha Gatto Thiago Simiano Jung Carlos Rocha Jr. Alex Marques Borges Santos Gelson Luis Koppe 《Case reports in ophthalmology》2015,6(3):482-487
Unilateral carotid cavernous fistula presents with ipsilateral ocular findings. Bilateral presentation is only seen in bilateral fistulas, usually associated with indirect (dural) carotid cavernous fistulas. Direct carotid cavernous fistulas are an abnormal communication between the internal carotid artery and the cavernous sinus. They typically begin with a traumatic disruption in the artery wall into the cavernous sinus, presenting with a classic triad of unilateral pulsatile exophthalmos, cranial bruit and episcleral venous engorgement. We report the case of a 38-year-old male with traumatic right carotid cavernous sinus fistula and bilateral ocular presentation successfully treated by interventional neuroradiology.Key Words: Exophthalmos, Papilledema, Carotid artery injury, Carotid cavernous sinus fistula, Endovascular procedure, Therapeutic embolization 相似文献
116.
Gustavo Monteiro Escott Letícia Guimarães da Silveira Vitor da Agostim Cancelier Angélica Dall'Agnol Sandra Pinho Silveiro 《Journal of diabetes and its complications》2021,35(2):107774
Diabetes mellitus is the leading cause of end-stage renal disease, and uncontrolled hyperglycemia is directly related to the increased mortality in this setting. As kidney function decreases, it becomes more challenging to control blood glucose since the risk of hypoglycemia increases. Decreased appetite, changes in glycaemia homeostasis, along with reduced renal excretion of anti-hyperglycemic drugs tend to facilitate the occurrence of hypoglycemia, despite the paradoxical occurrence of insulin resistance in advanced kidney disease. Thus, in patients using insulin and/or oral anti-hyperglycemic agents, dynamic adjustments with drug dose reduction or drug switching are often necessary. Furthermore, in addition to consider these pharmacokinetics alterations, it is of utmost importance to choose drugs with proven cardio-renal benefits in this setting, such as sodium-glucose co-transporter 2 inhibitors and glucagon-like peptide 1 receptor agonists. In this review, we summarize the indications and contraindications, titration of doses and side effects of the available anti-hyperglycemic agents in the presence of advanced diabetic kidney disease (DKD) and dialysis, highlighting the risks and benefits of the different agents. Additionally, basic renal function assessment and monitoring of glycemic control in DKD will be evaluated in order to guide the use of drugs and define the glycemic targets to be achieved. 相似文献
117.
118.
Corrêa Hugo Luca Gadelha André Bonadias Dutra Maurílio Tiradentes Neves Rodrigo Vanerson Passos de Deus Lysleine Alves Moura Sting Ray Gouvêa Silva Victor Lopes Reis Andrea Lucena Honorato Fernando Souza de Araújo Thaís Branquinho de Barros Carolina Fonseca Moraes Milton Rocha Ferreira Carlos Ernesto Santos Prestes Jonato Rosa Thiago Santos 《Sport Sciences for Health》2022,18(2):357-365
Sport Sciences for Health - To investigate the hemodynamic responses, especially HPE following different resistance exercises RE protocols in young adult subjects. Eighty-nine men... 相似文献
119.
120.
S de A Nishioka P V Silveira 《The American journal of tropical medicine and hygiene》1992,47(6):805-810
The records of 292 patients who were admitted to a teaching hospital from 1984 to 1990 in Uberlandia in southeastern Brazil after being bitten by snakes of the genus Bothrops were retrospectively surveyed. The patients were from 42 municipalities in three states of Brazil. Most (42%) bites occurred between 4:00 PM and 10:00 PM. Fourteen percent of the bites occurred in the month of April. In 54 (18%) of the cases, the snakes were captured and identified as belonging to the following species: B. moojeni (29), B. neuwiedi (18), and Bothrops species (7). A diagnosis was made based on clinical findings in 238 (82%) cases. The lower limbs were the commonest site of bite (74%). The median time interval between bite and admission to the hospital was 3 hr. Fang marks were recorded in 58% of the cases and swelling was recorded in 82%. Clotting time was greater than 15 min in (142 of 264) 54% of the cases. A tourniquet was used on 44 cases. The mean +/- SD dose of specific antivenom used was 187.48 +/- 93.44 mg. The complications that occurred included abscess formation in 18% of the cases, necrosis in 16%, and renal failure in 5%. Amputation was performed in three (1%) cases. The case fatality rate was also 1% (three cases). When all cases were analyzed, the chi-square test for trend showed an increased susceptibility of renal failure with age (P < 0.04). Clotting time greater than 15 min was associated with the development of abscesses (P < 0.02).(ABSTRACT TRUNCATED AT 250 WORDS) 相似文献