A study of the relationship between the delivery to cord clamping interval and the time of cord separation

A randomised controlled trial of 554 women was carried out to compare the effects of late and early umbilical cord clamping on the time of cord separation. In addition data were collected on maternal and neonatal outcomes. There were no significant differences between the two groups in the duration of cord adherence and neonatal and maternal outcomes. There appeared to be a higher rate of jaundice in the late clamped group which did not reach statistical significance. There was an unexpectedly higher rate of breast feeding at home in the late clamped group which did reach statistical significance. Overall the trial provides no clear evidence for the benefit of early cord clamping (the current policy as part of the active management of the third stage in the UK) on the outcomes considered.     

我国医院药学的形成与发展

本文通过对医院药学的形成与发展的讨论,旨在确立该学科(也可说领域)的学术技术内容,尽快形成一个完善的学科,以利推进临床药物治疗学的发展,推进医药科学的进步。     

均一吸收体中SPECT重建多解性的探讨

通过对重建图像噪声特性的分析，间接证明ＳＰＥＣＴ的解具有多样性。分别用ＴｒｅｔｉａｋＭｅｔｚ、Ｇｕｌｂｅｒｇ、富谷武浩等推导的３种等价重建方法和Ｂｅｌｉｎｉ等推导的重建方法，经计算机模拟重建衰减均匀分布的图像，先预置相同的重建图像的空间分辨率，再比较它们的噪声特性。两种方法重建图像的噪声分布：前者近图像边缘时增大，而后者减小，从而间接证明在假定均匀衰减条件下，ＳＰＥＣＴ的重建有多解性。     

吗啡受体显像剂7α-o-IA-DPN的合成

设计、合成了一种新的吗啡受体显像剂。选用吗啡拮抗剂特培洛啡（ｄｉｐｒｅｎｏｒｐｈｉｎｅ，ＤＰＮ），经乙酰化选择性保护苯环３位—ＯＨ，将乙烯锡烷作为弥补基引入ＤＰＮ分子７α支链淑醇基团位置，采用碘代锡烷标记法一步合成碘烷ＤＰＮ（７αｏｉｏｄｏａｌｙｌｄｉｐｒｅｎｏｒｐｈｉｎｅ，即７αｏＩＡＤＰＮ）。其标记率达９０％，比活度为８０ＴＢｑ／ｍｍｏｌ，放化纯度大于９５％。体外吗啡受体结合分析表明其具有很高的亲和力（Ｋｉ＝０．４ｎｍｏｌ／Ｌ）。结果表明：新合成的碘标记吗啡配体适合于ＳＰＥＣＴ活体吗啡受体显像研究。     

视交叉后损害的临床与图形视觉诱发电位分析

图形视觉诱发电位(P—VEP)是眼接受图形的刺激时,视路及大脑皮质枕区所产生的一系列电位变化。在视交叉后病变的诊断,病情估计及预后推测中有比较肯定的价值。 本文对17例视交叉后损害的病人进行分析。发现视交叉后病变以视皮质损害为主,表现为视物模糊,视力下降,视野改变。P—VEP检查的异常率与病变部位大小及病变性质有关。同时检查半视野刺激有助于提高阳性率。     

A longitudinal study of semen quality in pesticide spraying danish farmers

It was hypothesized that occupational exposure to pesticides during a spraying season causes changes in semen quality that might be detected in a longitudinal study. We analyzed the within-person changes in semen quality and reproductive hormones across a spraying season in groups of farmers using and not using pesticides. A total of 248 men collected two semen samples (participation rate: 32%). The median sperm concentration declined significantly from the first to the second sample in both groups, but there was no statistical difference in the decline between the two groups, unadjusted or adjusted. Only minor changes were found in sperm morphology, vitality, motility, sperm chromatin denaturation (SCSA), and reproductive hormones, and the differences in changes between the two groups were nonsignificant, or, in the opposite direction to the expected. There was no relation between the changes in sperm parameters in relation to pesticide exposure variables. In conclusion, use of pesticides by Danish farmers is not a likely cause of short-term effects on semen quality and reproductive hormones.     

抗蝮蛇毒磷酸二酯酶单克隆抗体的制备及鉴定

从蝮蛇毒中提取磷酸二酯酶,用此酶免疫BALB/c小鼠,取其脾细胞与小鼠骨髓瘤细胞Fo融合,以间接ELISA检测杂交瘤细胞培养上清液和小鼠腹水中的特异性抗体,其效价分别为1∶128和1∶51 200.抗原阻断试验结果表明,此抗体对蛇毒磷酸二酯酶具有特异性.该杂交瘤细胞株定为G_8,该株单抗属鼠IgG_(2a)亚型,经体外持续培养6个月,其分泌抗体性能稳定.     

莒县胃癌年龄别死亡率Gompertz曲线拟合的探讨

采用Gompertz曲线对莒县1986～1990年胃瘤年龄别死亡率进行了拟合检验,并与直线、指数曲线、二次抛物线进行了比较,以Gompertz曲线拟合比较理想。描绘了胃癌死亡率年龄分布的理论轨迹,为胃癌死亡预测提供了一种简便科学的方法。     

医疗纠纷的非诉讼解决方式-医疗纠纷ADR

由于在纠纷解决方面所表现出来的简便，经济，快捷，专业性及保密性强等优点，非诉讼纠纷解决方式（又可译为代替性纠纷解决方式）ADR（Alternative Dispute Resolution）逐渐成为许多国家和地区解决民事纠纷的一大趋势，我国现行医疗纠纷解决机制存在着较多的问题，有待于进一步的改善与完善，根据我国所面临的现实情况，将ADR引入医疗纠纷领域是一条快速，有效地解决医疗纠纷的途径，医疗纠纷的非诉讼纠纷解决方式主要包括仲裁，调解与和解，这3种纠纷解决方式各具特点，适用于不同情况下医疗纠纷的解决。