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排序方式: 共有497条查询结果,搜索用时 15 毫秒
71.
Satomi Koizumi Terumi Kamisawa Sawako Kuruma Taku Tabata Kazuro Chiba Susumu Iwasaki Go Kuwata Takashi Fujiwara Junko Fujiwara Takeo Arakawa Koichi Koizumi Kumiko Momma 《Journal of Korean medical science》2015,30(6):743-748
IgG4-related disease (IgG4-RD) is a potentially multiorgan disorder. In this study, clinical and serological features from 132 IgG4-RD patients were compared about organ correlations. Underlying pathologies comprised autoimmune pancreatitis (AIP) in 85 cases, IgG4-related sclerosing cholangitis (IgG4-SC) in 12, IgG4-related sialadenitis (IgG4-SIA) in 56, IgG4-related dacryoadenitis (IgG4-DAC) in 38, IgG4-related lymphadenopathy (IgG4-LYM) in 20, IgG4-related retroperitoneal fibrosis (IgG4-RF) in 19, IgG4-related kidney disease (IgG4-KD) in 6, IgG4-related pseudotumor (IgG4-PT) in 3. Sixty-five patients (49%) had multiple IgG4-RD (two affected organs in 36 patients, three in 19, four in 8, five in 1, and six in 1). Serum IgG4 levels were significantly higher with multiple lesions than with a single lesion (P<0.001). The proportion of association with other IgG4-RD was 42% in AIP, the lowest of all IgG4-RDs. Serum IgG4 level was lower in AIP than in other IgG4-RDs. Frequently associated IgG4-RDs were SIA (25%) and DAC (12%) for AIP; AIP (75%) for IgG4-SC; DAC (57%), AIP (38%) and LYM (27%) for IgG4-SIA; AIP (26%) and LYM (26%) for IgG4-DAC; SIA (75%), DAC (50%) and AIP (45%) for IgG4-LYM; SIA (58%), AIP (42%) and LYM (32%) for IgG4-RF; AIP (100%) and SIA (67%) for IgG4-KID; and DAC (67%) and SIA (67%) for IgG4-PT. Most associated IgG4-RD lesions were diagnosed simultaneously, but IgG4-SIA and IgG4-DAC were sometimes identified before other lesions. About half of IgG4-RD patients had multiple IgG4-RD lesions, and some associations were seen between specific organs.
Graphical Abstract
相似文献72.
Reliability of measurements of knee extensor muscle strength using a
pull-type hand-held dynamometer
Terumi Suzuki 《Journal of Physical Therapy Science》2015,27(3):967-971
[Purpose] The purpose of this study was to examine the intra-examiner and inter-examiner
reliabilities of measurements of knee extensor muscle strength using a pull-type hand-held
dynamometer (HHD). [Subjects] Fifty-four healthy adults (35 males; average age, 23 years)
participated in this study. [Methods] Knee extensor muscle strength of each leg was
measured three times using the HHD. To examine the intra- and inter-examiner
reliabilities, measurements were performed by two examiners, a physical therapist and a
physical therapy student. [Results] The intra-examiner reliabilities, ICC (1, 1) and ICC
(1, 3) ranged from 0.94–0.99. The inter-examiner reliabilities, ICC (2, 1) and ICC (3, 1)
ranged from 0.90–0.92 for the right leg, and 0.88−0.90 for the left leg. Neither constant
nor proportional errors were found by Bland-Altman analysis. [Conclusion] Intra-examiner
and inter-examiner reliabilities were acceptable, indicating that muscle strength can be
measured with the pull-type HHD without dependence on skill of measurement. Pain was not
caused by measurements with the pull-type HHD.Key words: Inter-examiner reliability, Intra-examiner reliability, Hand-held dynamometer 相似文献
73.
74.
Maekawa M Nagaoka T Taniguchi T Higashi H Sugimura H Sugano K Yonekawa H Satoh T Horii T Shirai N Takeshita A Kanno T 《Clinical chemistry》2004,50(8):1322-1327
BACKGROUND: We developed a rapid, precise, and accurate microarray-based method that uses a three-dimensional platform for detection of mutations. METHODS: We used the PamChip microarray to detect mutations in codons 12 and 13 of K-ras in 15 cell lines and 81 gastric or colorectal cancer tissues. Fluorescein isothiocyanate-labeled PCR products were analyzed with the microarray. We confirmed the microarray results with PCR-single-strand conformation polymorphism (SSCP) analysis and DNA sequencing. RESULTS: We could correctly identify wild-type, heterozygous, and homozygous mutant genotypes with the PamChip microarray in <3.5 h. The array data were consistent with those of PCR-SSCP analysis and DNA sequencing. All 15 cell lines and 80 of 81 clinical cancer specimens (98.8%; 95% confidence interval, 96.4-100%) were genotyped accurately with the microarray, a rate better than that of direct DNA sequencing (38.9%) or SSCP (93.8%). Only one clinical specimen was misdiagnosed as homozygous for the wild-type allele. Densitometric analysis of SSCP bands indicated that the content of the mutant allele in the specimen was approximately 16%. The PamChip microarray could detect mutant alleles representing more than 25% of the SSCP band proportions. Therefore, the limit for detection of mutant alleles by the PamChip microarray was estimated to be 16-25% of the total DNA. CONCLUSIONS: The PamChip microarray is a novel three-dimensional microarray system and can be used to analyze K-ras mutations quickly and accurately. The mutation detection rate was nearly 100% and was similar to that of PCR-SSCP together with sequencing analysis, but the microarray analysis was faster and easier. 相似文献
75.
Kubota Kensuke Kamisawa Terumi Okazaki Kazuichi Kawa Shigeyuki Hirano Kenji Hirooka Yoshiki Uchida Kazushige Shiomi Hideyuki Ohara Hirotaka Shimizu Kyoko Arakura Norikazu Kanno Atsushi Sakagami Junichi Itoi Takao Ito Tetsuhide Ueki Toshiharu Nishino Takayoshi Inui Kazuo Mizuno Nobumasa Yoshida Hitoshi Sugiyama Masanori Iwasaki Eisuke Irisawa Atshishi Shimosegawa Toru Takeyama Yoshifumi Chiba Tsutomu 《Journal of gastroenterology》2017,52(8):955-964
Journal of Gastroenterology - The effect of maintenance steroid treatment (MST) in reducing the risk of relapse in patients with autoimmune pancreatitis (AIP) remains under debate. The aim of this... 相似文献
76.
77.
78.
Takata N Mishima T Hisatsune C Nagai T Ebisui E Mikoshiba K Hirase H 《The Journal of neuroscience》2011,31(49):18155-18165
Global brain state dynamics regulate plasticity in local cortical circuits, but the underlying cellular and molecular mechanisms are unclear. Here, we demonstrate that astrocyte Ca(2+) signaling provides a critical bridge between cholinergic activation, associated with attention and vigilance states, and somatosensory plasticity in mouse barrel cortex in vivo. We investigated first whether a combined stimulation of mouse whiskers and the nucleus basalis of Meynert (NBM), the principal source of cholinergic innervation to the cortex, leads to enhanced whisker-evoked local field potential. This plasticity is dependent on muscarinic acetylcholine receptors (mAChR) and N-methyl-d-aspartic acid receptors (NMDARs). During the induction of this synaptic plasticity, we find that astrocytic [Ca(2+)](i) is pronouncedly elevated, which is blocked by mAChR antagonists. The elevation of astrocytic [Ca(2+)](i) is crucial in this type of synaptic plasticity, as the plasticity could not be induced in inositol-1,4,5-trisphosphate receptor type 2 knock-out (IP(3)R2-KO) mice, in which astrocytic [Ca(2+)](i) surges are diminished. Moreover, NBM stimulation led to a significant increase in the extracellular concentration of the NMDAR coagonist d-serine in wild-type mice when compared to IP(3)R2-KO mice. Finally, plasticity in IP(3)R2-KO mice could be rescued by externally supplying d-serine. Our data present coherent lines of in vivo evidence for astrocytic involvement in cortical plasticity. These findings suggest an unexpected role of astrocytes as a gate for cholinergic plasticity in the cortex. 相似文献
79.
80.
Kohwi-Shigematsu T Han HJ Russo J Kohwi Y 《Journal of the National Cancer Institute》2010,102(24):1879-80; author reply 1880-1