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91.
Naruhiro Ishida Noriko Odani‐Kawabata Atsushi Shimazaki Hideaki Hara 《Cardiovascular therapeutics》2006,24(1):1-10
Elevated intraocular pressure (IOP) is one of the most important risk factors for the development of glaucoma, which is a progressive optic neuropathy. Lowering IOP is currently the only therapeutic approach to the therapy of glaucoma. Since the use of pilocarpine eye drops for glaucoma treatment was reported in the late 1870s, academic researchers and pharmaceutical companies attempted to discover new drugs with more potent, prolonged, and safer IOP‐reducing effects. These persistent efforts finally paid off, and prostanoids with FP‐receptor agonist activity were found to be very potent IOP‐lowering agents. To date, three prostanoids (latanoprost, travoprost and bimatoprost) have been launched in many countries, and now a new FP‐receptor agonist, tafluprost, is entering clinical development. All of these prostanoids are superior to the β‐adrenoceptor antagonists in their IOP‐lowering efficacy, and no severe side effects have been reported in their long‐term clinical use. In addition, tafluprost may be expected to improve ocular blood flow. Hence, prostanoids currently occupy center stage among glaucoma medications. It cannot be denied that in terms of efficacy, safety, patient compliance, and medical economy prostanoids are currently the first‐line medicines among ocular antihypertensive drugs. 相似文献
92.
Osamu Toyoshima Toshihiro Nishizawa Kazuma Sekiba Tatsuya Matsuno Ryo Kondo Hidenobu Watanabe Hidekazu Suzuki Chizu Tanikawa Kazuhiko Koike Koichi Matsuda 《Journal of Clinical Biochemistry and Nutrition》2021,68(1):73
The risk allele of a single nucleotide polymorphism (SNP) rs2294008 in the Prostate stem cell antigen (PSCA) gene is strongly associated with gastric cancer. Although the Kyoto classification score is believed to be an indicator of gastric cancer risk, it lacks supporting genetic evidence. We investigated the effect of this risk allele of PSCA SNP on the Kyoto score. Participants without a history of gastric cancer or Helicobacter pylori (H. pylori) eradication underwent esophagogastroduodenoscopy, H. pylori evaluation, and SNP genotyping. The Kyoto score is the sum of scores obtained from endoscopy-based atrophy, intestinal metaplasia, enlarged folds, nodularity, and diffuse redness. The Kyoto score is novel in the light of scoring for gastritis. A total of 323 patients were enrolled (number of individuals with genotype CC: 52; CT: 140; TT: 131, average age: 50.1 years, male: 50.8%). The patient baseline characteristics including age, sex, body mass index, smoking, drinking, family history of gastric cancer, and H. pylori status had no association with PSCA SNP. The Kyoto score was higher in T (CT or TT genotype; risk allele) carriers than in CC carriers. Atrophy, enlarged folds, and diffuse redness scores were higher in T allele carriers (risk allele) than in CC genotype individuals. In multivariate analysis, the Kyoto score was independently associated with PSCA SNP (OR: 1.30, p = 0.012). Thus, the Kyoto score was associated with a genetic predisposition. 相似文献
93.
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95.
Efficacy of naftopidil for nocturia in male patients with lower urinary tract symptoms: Comparison of morning and evening dosing 下载免费PDF全文
96.
Assessment of occult pancreatobiliary reflux in patients with pancreaticobiliary disease by ERCP 总被引:5,自引:0,他引:5
Itokawa F Itoi T Nakamura K Sofuni A Kakimi K Moriyasu F Tsuchida A Aoki T 《Journal of gastroenterology》2004,39(10):988-994
Background The aim of this study was to evaluate the degree of occult pancreatobiliary reflux by measuring the biliary amylase levels in the common bile duct (CBDA) and gallbladder (GBA) at endoscopic retrograde cholangiopancreatography (ERCP).Methods Eligible patients included 86 consecutive cases of pancreaticobiliary disease with prospective implementation of bile collection during an ERCP procedure. Patients with pancreatobiliary maljunction (PBM) were excluded. Nineteen cases of eligible patients had simultaneous collection of gallbladder bile. Bile was further collected by cholecystectomy in 8 cases.Results Twenty-two cases (26%) revealed a CBDA level higher than serum amylase (high bile amylase level, HBA group) and 64 cases exhibited a CBDA level lower than serum (LBA group). The mean values of CBDA in the HBA and LBA groups were 5502IU/l and 29IU/l, respectively. The rate of HBA was significantly higher in patients who were elderly, had a dilated common bile duct, and those with choledocholithiasis (P < 0.05). Three cases (16%) showed a CBDA greater than twice the GBA. Eleven cases (58%) exhibited a GBA higher than the CBDA. The values of GBA obtained during ERCP and cholecystectomy were consistent.Conclusions These findings suggest that even non-PBM cases can exhibit occult pancreatobiliary reflux, which can thereby cause biliary disease. 相似文献
97.
New Xenograft Model of Multiple Myeloma and Efficacy of a Humanized Antibody Against Human Interleukin-6 Receptor 总被引:2,自引:2,他引:2
98.
Y Shimazaki Y Kawashima M Ogawa H Hirose K Miyamoto S Morimoto 《Japanese circulation journal》1985,49(7):679-684
With use of biplane cine-angiocardiograms, the measurements of right and left ventricular volume were determined in 11 children with transposition of the great arteries following Mustard's procedure. Right ventricular end-diastolic volume (RVEDV) ranged from 124 to 264 percent of the normal right ventricular volume with an average of 188 +/- 40 (SDM) percent, and left ventricular end-diastolic volume (LVEDV) ranged from 57 to 181 (122 +/- 43) percent of the normal (p less than 0.01, vs. RVEDV). Right ventricular ejection fraction (RVEF) ranged from 0.26 to 0.66 (0.42 +/- 0.11), and left ventricular ejection fraction (LVEF) ranged from 0.51 to 0.79 (0.66 +/- 0.09) (p less than 0.001, vs RVEF). Left ventriculography showed a deviation of the interventricular septum toward the left ventricle in patients with simple transposition of the great arteries not associated with left ventricular hypertension. The left to right ventricular systolic pressure ratio ranged from 0.22 to 1.02 (0.48 +/- 0.28), and the left to right ventricular end-diastolic volume ratio ranged from 0.43 to 1.00 (0.63 +/- 0.18). There was a high correlation between the left to right ventricular systolic pressure ratio and the left to right ventricular end-diastolic volume ration (r = 0.94, p less than 0.001). The left to right ventricular systolic pressure ratio also correlated well with the right ventricular ejection fraction (r = 0.90, p less than 0.001). Deviation of the interventricular septum was considered to result in a diminished ejection fraction of the right ventricle, in patients with simple transposition of the great arteries not associated with left ventricular hypertension, after Mustard's procedure. 相似文献
99.
Masahiro Horiuchi Junko Endo Shin Akatsuka Tatsuya Hasegawa Eriko Yamamoto Tadashi Uno Sachiko Kikuchi 《Journal of Physical Therapy Science》2015,27(12):3711-3716
[Purpose] Forest walking may be effective for human health, but little information is
available about effects of energy expenditure on blood pressure responses after forest
walking. The aim of this study was to investigate the relationship between the activity
energy expenditure and changes in blood pressure in individuals after forest walking.
[Subjects] The subjects were 54 middle-aged and elderly people. [Methods] All subjects
walked in the forest for approximately 90 min. Blood pressure, salivary amylase, and the
Profile of Mood States were evaluated before and after forest walking, and activity energy
expenditure was monitored throughout forest walking. Subjects were divided into two groups
according to mean arterial pressure changes: a responder group (>5% decreases) and a
nonresponder group (<5%). [Results] Forest walking significantly reduced the mean
arterial pressure and improved the Profile of Mood States in both groups. Activity energy
expenditure was related to changes in mean arterial pressure in the responder group, while
this relation was not observed in the nonresponder group. Differential activity energy
expenditure did not strongly affect improvement of the Profile of Mood States.
[Conclusion] Greater walking-related greater activity energy expenditure might be required
to accentuate physiological beneficial effects on in middle-aged and aged people.
Furthermore, the forest environment per se can attenuate psychological stress.Key words: Hypertension, Profile of Mood States, Responder and nonresponder 相似文献
100.
Basudha Shrestha Tatsuya Tada Tohru Miyoshi-Akiyama Kayo Shimada Hiroshi Ohara Teruo Kirikae Bharat M. Pokhrel 《Antimicrobial agents and chemotherapy》2015,59(9):5847-5850
A novel New Delhi metallo-β-lactamase, NDM-13, was identified in a carbapenem-resistant Escherichia coli clinical isolate obtained from the urine of a patient in Nepal. The enzymatic activity of NDM-13 against β-lactams was similar to that of NDM-1. However, NDM-13 displayed significantly higher kcat/Km ratios for cefotaxime. The genetic environment of blaNDM-13 was determined to be tnpA-IS30-blaNDM-13-bleMBL-trpF-dsbC-cutA-groES-groL, with blaNDM-13 located within the chromosome. 相似文献