全文获取类型
收费全文 | 32514篇 |
免费 | 1649篇 |
国内免费 | 149篇 |
专业分类
耳鼻咽喉 | 416篇 |
儿科学 | 586篇 |
妇产科学 | 609篇 |
基础医学 | 4381篇 |
口腔科学 | 1176篇 |
临床医学 | 2559篇 |
内科学 | 7682篇 |
皮肤病学 | 804篇 |
神经病学 | 2425篇 |
特种医学 | 1285篇 |
外科学 | 5296篇 |
综合类 | 222篇 |
一般理论 | 2篇 |
预防医学 | 1022篇 |
眼科学 | 493篇 |
药学 | 2192篇 |
中国医学 | 46篇 |
肿瘤学 | 3116篇 |
出版年
2022年 | 290篇 |
2021年 | 632篇 |
2020年 | 292篇 |
2019年 | 438篇 |
2018年 | 617篇 |
2017年 | 427篇 |
2016年 | 479篇 |
2015年 | 567篇 |
2014年 | 754篇 |
2013年 | 827篇 |
2012年 | 1298篇 |
2011年 | 1405篇 |
2010年 | 767篇 |
2009年 | 722篇 |
2008年 | 1279篇 |
2007年 | 1328篇 |
2006年 | 1367篇 |
2005年 | 1405篇 |
2004年 | 1377篇 |
2003年 | 1310篇 |
2002年 | 1317篇 |
2001年 | 1220篇 |
2000年 | 1384篇 |
1999年 | 1201篇 |
1998年 | 396篇 |
1997年 | 286篇 |
1996年 | 306篇 |
1995年 | 280篇 |
1994年 | 244篇 |
1993年 | 229篇 |
1992年 | 797篇 |
1991年 | 754篇 |
1990年 | 678篇 |
1989年 | 697篇 |
1988年 | 680篇 |
1987年 | 664篇 |
1986年 | 675篇 |
1985年 | 594篇 |
1984年 | 428篇 |
1983年 | 350篇 |
1979年 | 339篇 |
1978年 | 233篇 |
1977年 | 206篇 |
1975年 | 198篇 |
1974年 | 227篇 |
1973年 | 207篇 |
1972年 | 199篇 |
1971年 | 209篇 |
1970年 | 203篇 |
1969年 | 225篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
991.
Thuy Lam Vo Manabu Kanazawa Khaing Myat Thu Mari Asami Daisuke Sato Shunsuke Minakuchi 《Journal of prosthodontic research》2019,63(4):428-433
PurposeThe study aimed to compare the mixing ability (MA), comminuting ability (CA), and maximum bite force (MBF) of single-implant overdentures (IODs) and clinically acceptable complete dentures (CDs) through a randomized crossover control trial.MethodsNew CDs were fabricated for 22 patients. One implant was inserted in the middle of the symphyseal region for each patient. The patients were randomly allocated into two groups: group IC received an IOD, whereas group CI received a CD, for 2 months; the treatments were interchanged for the next 2 months. The MA, CA, and MBF were evaluated with the old CDs, new CDs (at the end of CD treatment period), and IODs (at the end of IOD treatment period).ResultsThe MA, CA, and MBF of the IODs were significantly higher than those of the old and new CDs (p < 0.01). New CDs only showed a significant improvement in MA (p < 0.05), while there were no significant differences in CA and MBF between the old and new CDs.ConclusionsCompared with the CD, IOD is more effective in restoring the MA, CA, and MBF of edentulous mandibles. 相似文献
992.
Hiroshi Kimura Kenichi Tanaka Makoto Kanno Kimio Watanabe Yoshimitsu Hayashi Koichi Asahi Hodaka Suzuki Keiji Sato Michiaki Sakaue Hiroyuki Terawaki Masaaki Nakayama Toshio Miyata Tsuyoshi Watanabe 《Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy》2014,18(5):461-467
Tissue accumulation of advanced glycation end products (AGE) is thought to contribute to the progression of cardiovascular disease (CVD). Skin autofluorescence, a non‐invasive measure of AGE accumulation using autofluorescence of the skin under ultraviolet light, has been reported to be an independent predictor of mortality associated with CVD in Caucasian patients on chronic hemodialysis. The aim of this study was to assess the predictive value of skin autofluorescence on all‐cause and cardiovascular mortality in non‐Caucasian (Japanese) patients on chronic hemodialysis. Baseline skin autofluorescence was measured with an autofluorescence reader in 128 non‐Caucasian (Japanese) patients on chronic hemodialysis. All‐cause and cardiovascular mortality was monitored prospectively during a period of 6 years. During the follow‐up period, 42 of the 128 patients died; 19 of those patients died of CVD. Skin autofluorescence did not have a significant effect on all‐cause mortality. However, age, carotid artery intima‐media thickness (IMT), serum albumin, high‐sensitivity C‐reactive protein (hsCRP), skin autofluorescence and pre‐existing CVD were significantly correlated with cardiovascular mortality. Multivariate Cox regression analysis showed skin autofluorescence (adjusted hazard ratio [HR] 3.97; 95% confidence interval [CI]1.67–9.43), serum albumin (adjusted HR 0.05; 95% CI 0.01–0.32), and hsCRP (adjusted HR 1.55; 95% CI 1.18–2.05) to be independent predictors of cardiovascular mortality. The present study suggests that skin autofluorescence is an independent predictor of cardiovascular mortality in non‐Caucasian (Japanese) patients on chronic hemodialysis. 相似文献
993.
Susumu Ookawara Hiroya Sato Hisatoshi Takeda Kaoru Tabei 《Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy》2014,18(2):202-207
Colloid osmotic pressure (COP) is important in calculating vascular permeability during hemodialysis (HD). However, few reports have directly measured COP in HD patients. Therefore, the currently published formulas may not be clinically optimal for predicting COP for HD patients. Here, the study aims were (i) to directly measure COP in HD patients and compare the measured and predicted COP values using four previously reported formulas, and (ii) to develop a formula for approximating COP using clinical parameters. We obtained 212 measured COP values using an osmometer; the average value was 22.0 ± 0.2 mm Hg. The predicted COP based on the four different formulas was positively correlated with the measured COP (0.87 < r < 0.89), but was significantly overestimated compared to it (P < 0.001). We also performed a stepwise analysis using serum albumin and non‐albumin protein concentrations and obtained the following simple formula for COP approximation: COP (mm Hg) = ?7.91 + 5.64 × albumin (g/dL) + 3.00 × non‐albumin proteins (g/dL). A positive linear correlation was observed between the measured COP and approximated COP using this formula (r = 0.90, P < 0.001). We calculated the mean Kr (plasma‐refilling coefficient) as a marker for determining dry weight in HD patients using the measured COP and approximated COP. No differences were observed between the mean Kr derived from the measured and approximated COP. We report here significant differences between measured and predicted COP values, and have devised a simple formula for COP approximation in HD patients. 相似文献
994.
Akemi Tsutsui Yoshimi Bando Yasunori Sato Hidenori Miyake Seiko Sawada-Kitamura Hiroshi Shibata Yuko Kakuda Kenichi Harada Motoko Sasaki Yasuni Nakanuma 《Clinical journal of gastroenterology》2014,7(5):441-448
Biliary adenofibroma (BAF) is a rare, benign liver tumor. Herein, we report a case of BAF with histological features of imminent malignant changes. Ultrasound and CT revealed a solid 2.5-cm mass in the right liver lobe. The patient was asymptomatic and had no past medical history including liver disease. A general examination that included the abdomen and the laboratory data were normal. Because of the increase of its size, this tumor was surgically resected. Grossly, a 3.5-cm nodular mass abutted on the hepatic capsule was found, and its cut surface showed a well-circumscribed, whitish, and firm lesion that showed microcystic changes in the periphery and solid changes in the central parts. Histologically, the tumor showed a proliferation of tubulocystic structures embedded in a fibrous stroma. Microcysts were prevalent in the periphery, while tubular components with abundant fibrous stroma were in the central parts. The tubules were variably dilated and branched. This case closely resembled the previously reported cases of BAF, except that there were complicated papillary projections with fine fibrovascular cores in some of the microcysts and that the epithelial component in papillary projections showed dysplastic changes and increased cellular proliferative activities, implicating ominous features of imminent malignant changes. These dysplastic and papillary changes may be an intermediate lesion leading to malignancy, which have occasionally been reported in BAF. 相似文献
995.
Case series of 17 patients with cholangiocarcinoma among young adult workers of a printing company in Japan
下载免费PDF全文
![点击此处可从《Journal of hepato-biliary-pancreatic sciences》网站下载免费的PDF全文](/ch/ext_images/free.gif)
Shoji Kubo Yasuni Nakanuma Shigekazu Takemura Chikaharu Sakata Yorihisa Urata Akinori Nozawa Takayoshi Nishioka Masahiko Kinoshita Genya Hamano Hiroaki Terajima Gorou Tachiyama Yuji Matsumura Terumasa Yamada Hiromu Tanaka Shoji Nakamori Akira Arimoto Norifumi Kawada Masahiro Fujikawa Hiromitsu Fujishima Yasuhiko Sugawara Shogo Tanaka Hideyoshi Toyokawa Yuko Kuwae Masahiko Ohsawa Shinichiro Uehara Kyoko Kogawa Sato Tomoshige Hayashi Ginji Endo 《Journal of hepato-biliary-pancreatic sciences》2014,21(7):479-488
996.
Distinctive population of Gfap‐expressing neural progenitors arising around the dentate notch migrate and form the granule cell layer in the developing hippocampus
下载免费PDF全文
![点击此处可从《The Journal of comparative neurology》网站下载免费的PDF全文](/ch/ext_images/free.gif)
Tatsunori Seki Toru Sato Keiko Toda Noriko Osumi Tetsuya Imura Seiji Shioda 《The Journal of comparative neurology》2014,522(2):261-283
In the adult hippocampus, granule cells continue to be generated from astrocyte‐like progenitors expressing glial fibrillary acidic protein (GFAP) that differ from embryonic neocortical progenitors. However, during the embryonic period, dentate granule neurons and neocortical pyramidal neurons are derived from the ventricular zone (VZ) of the pallium. Our question is when do GFAP+ progenitors of granule neurons appear in the developing hippocampus during the embryonic period, and how do they form the granule cell layer. The present analysis using Gfap‐GFP transgenic mice shows that the GFP+ distinct cell population first appears in the VZ of the medial pallium at the dorsal edge of the fimbria on embryonic day 13.5. During the perinatal period, they form a migratory stream from the VZ to the developing dentate gyrus, and establish the germinal zones in the migratory stream, and the marginal and hilar regions in the developing dentate gyrus. GFP+ cells in these regions were positive for Sox2 and Ki67, but negative for BLBP. GFP+ cells with Neurogenin2 expression were largely distributed in the VZ, whereas GFP+ cells with Tbr2 and NeuroD expressions were seen in the migratory stream and developing dentate gyrus. Prox1‐expressing GFP+ cells were restricted to the developing dentate gyrus. These results suggest that distinctive Gfap‐expressing progenitors arising around the dentate notch form germinal regions in the migratory stream and the developing dentate gyrus where they differentiate into granule neurons, indicating that distinct astrocyte‐like neural progenitors continue to generate granule neurons, from the beginning of dentate development and throughout life. J. Comp. Neurol. 522:261–283, 2014. © 2013 Wiley Periodicals, Inc. 相似文献
997.
998.
999.
1000.
Yagihara N Sato A Iijima K Izumi D Furushima H Watanabe H Irie T Kaneko Y Kurabayashi M Chinushi M Satou M Aizawa Y 《Journal of electrocardiology》2012,45(1):36-42
We determined the prevalence of J waves in the electrocardiograms (ECG) of 120 patients with Wolff-Parkinson-White syndrome in comparison with J-wave prevalence in a control group of 1936 men and women with comparable demographic and ECG characteristics and with normal atrioventricular conduction. J waves were present only during manifest preexcitation in 22 of 120 patients (18.3%), disappearing after catheter ablation and suggesting that J waves were associated with the presence of preexcitation. J waves were present in 19 (15.8%) of 120 patients only after ablation, apparently having been masked by early depolarization of the preexcited myocardial region, and in 22 patients (18.3%), J waves were not altered significantly by preexcitation. Thus, the overall J-wave prevalence was 52.5% (63/120) and, excluding those apparently due to preexcitation, 34.8% (41/120), both substantially higher than the prevalence (11.5%) in the control group (P < .001 for both). The patients with J waves appearing only during preexcitation were younger, predominantly females. The presence of J waves after ablation was associated with a history of atrial fibrillation and shorter ventricular effective refractory period. It is concluded that the prevalence of J waves is high in patients with Wolff-Parkinson-White syndrome and is influenced by manifest preexcitation. 相似文献