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41.
Diabetes is a metabolic disorder comprising of high glucose level in blood over a prolonged period in the body as it is not capable of using it properly. The severe complications associated with diabetes include diabetic ketoacidosis, nonketotic hypersmolar coma, cardiovascular disease, stroke, chronic renal failure, retinal damage and foot ulcers. There is a huge increase in the number of patients with diabetes globally and it is considered a major health problem worldwide. Early diagnosis of diabetes is helpful for treatment and reduces the chance of severe complications associated with it. Machine learning algorithms (such as ANN, SVM, Naive Bayes, PLS-DA and deep learning) and data mining techniques are used for detecting interesting patterns for diagnosing and treatment of disease. Current computational methods for diabetes diagnosis have some limitations and are not tested on different datasets or peoples from different countries which limits the practical use of prediction methods. This paper is an effort to summarize the majority of the literature concerned with machine learning and data mining techniques applied for the prediction of diabetes and associated challenges. This report would be helpful for better prediction of disease and improve in understanding the pattern of diabetes. Consequently, the report would be helpful for treatment and reduce risk of other complications of diabetes. 相似文献
42.
Anil Agarwal Tarun Suri Indereshwar Verma Shashi Kant Kumar Neeraj Gupta Abbas Shaharyar 《Indian Journal of Orthopaedics》2014,48(5):463-469
Background:
We retrospectively evaluated the pretreatment radiological presentation and the clinicoradiological outcome at the completion of 1 year chemotherapy in osteoarticular tuberculosis of hip in children to prognosticate correlation between them.Materials and Methods:
We retrospectively analyzed the clinical and plain radiographic findings in 27 patients with an age of 12 years or younger in whom hip tuberculosis was diagnosed and treated between 2006 and 2010. The diagnosis was based on histopathology in 14 and clinicoradiological basis in 13 patients. The pre and post treatment plain radiographs were evaluated according to Shanmugasundaram radiological classification and our observations regarding unclassified cases which were not fit in this classification were suggested. The functional outcome at the completion of chemotherapy was assessed using modified Moon''s criteria.Results:
The male female ratio was 11:16. The left hip was involved more frequently than the right (17:10). The average age was 7.37 years (range, 2-12 years). In the pretreatment radiographs, 9 hips were normal, 6 traveling, 4 dislocating, 1 protrusio acetabuli, 3 atrophic and 4 unclassified types (3 triradiate; 1 pseudarthrosis coxae). There were no Perthes and mortar pestle at the initial presentation. Posttreatment, the types changed to 9 normal, 3 Perthes, 1 protrusio acetabuli, 1 atrophic, 4 mortar pestle and 9 unclassified types (3 triradiate, 3 pseudarthrosis coxae and 3 ankylosed). There were 37% excellent, 18.5% good, 26% fair and 18.5% poor results. The prognosis was best with initial “triradiate” and normal types and worst with posttreatment atrophic and “ankylosed” types.Conclusions:
The Shanmugasundaram radiological types accurately predict prognosis only in normal types and “triradiate” pattern. The functional outcome is independent of radiological morphology of the hip in smaller children. 相似文献43.
ChandraMohan Ramasamy Biswajit Dubashi J. Sree Rekha Debdatta Basu Ankit Jain Tarun Kumar Dutta 《Indian journal of hematology & blood transfusion》2014,30(1):59-61
We report a case of hairy cell leukemia who improved after cladribine but succumbed to disseminated atypical mycobacterial infection 2 months after completing cladribine. 相似文献
44.
Dongjiang Chen Son B. Le Tarun E. Hutchinson Anda-Alexandra Calinescu Mathew Sebastian Dan Jin Tianyi Liu Ashley Ghiaseddin Maryam Rahman David D. Tran 《The Journal of clinical investigation》2022,132(8)
Tumor Treating Fields (TTFields), an approved therapy for glioblastoma (GBM) and malignant mesothelioma, employ noninvasive application of low-intensity, intermediate-frequency, alternating electric fields to disrupt the mitotic spindle, leading to chromosome missegregation and apoptosis. Emerging evidence suggests that TTFields may also induce inflammation. However, the mechanism underlying this property and whether it can be harnessed therapeutically are unclear. Here, we report that TTFields induced focal disruption of the nuclear envelope, leading to cytosolic release of large micronuclei clusters that intensely recruited and activated 2 major DNA sensors — cyclic GMP-AMP synthase (cGAS) and absent in melanoma 2 (AIM2) — and their cognate cGAS/stimulator of interferon genes (STING) and AIM2/caspase 1 inflammasomes to produce proinflammatory cytokines, type 1 interferons (T1IFNs), and T1IFN-responsive genes. In syngeneic murine GBM models, TTFields-treated GBM cells induced antitumor memory immunity and a cure rate of 42% to 66% in a STING- and AIM2-dependent manner. Using single-cell and bulk RNA sequencing of peripheral blood mononuclear cells, we detected robust post-TTFields activation of adaptive immunity in patients with GBM via a T1IFN-based trajectory and identified a gene panel signature of TTFields effects on T cell activation and clonal expansion. Collectively, these studies defined a therapeutic strategy using TTFields as cancer immunotherapy in GBM and potentially other solid tumors. 相似文献
45.
Purpose To determine the demand and preferences of infertility patients for sex selection for nonmedical reasons, and to investigate
the relation between these choices and their demographic and socioeconomic characteristics.
Methods A cross-sectional, self-administered survey by mail was conducted at a University hospital-based fertility center of 1,350
consecutive women who presented for infertility care, to assess patient demand and preferences for sex selection.
Results Of respondents, 49% wanted to select the sex of their next child for no added cost. Of these patients, 56% had no living children
and 37% had children all of one sex. After adjustment for observed predictors of gender preference, we found a significant
preference for a female child among women who had only sons, had more living children, or were single. Nulliparous women did
not significantly prefer one sex over the other. Among parous women, those with only daughters significantly desired to select
a male child, whereas those with sons significantly desired to select a female child.
Conclusion There is significant demand among infertility patients for preimplantation sex selection, with a significant portion of this
demand coming from patients who do not have any children or have children all of one sex.
Presented in part at the American Society for Reproductive Medicine (ASRM) Annual Meeting, New Orleans, Louisiana, October
2006.
Financial support: none
Conflict of interest: none 相似文献
46.
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48.
Praveen Kumar P. Sunil kumar K. T. Kavya Nainita M. Sai Tarun A. Raghu Ramudu B. G. Deepika K. Pramoda A. Yasmeen C. 《Neurotoxicity research》2020,37(2):264-274
Neurotoxicity Research - Cerebral ischemia-reperfusion (C I/R) accelerates neuronal injury through the overproduction of reactive oxygen species due to mitochondrial dysfunction. Hesperidin has... 相似文献
49.
Sidharth Mehan Saloni Rahi Aarti Tiwari Tarun Kapoor Kajal Rajdev Ramit Sharma Himanshi Khera Sourabh Kosey Umesh Kukkar Rajesh Dudi 《中国神经再生研究》2020,(6):1140-1149
Neuronal mitochondrial dysfunction increases inflammatory mediators and leads to free radical generation and anti-oxidant enzymatic alterations,which are major neuropathological hallmarks responsible for autism.Mitochondrial dysfunction in autism is associated with decreased ATP levels due to reduced levels of cyclic adenosine monophosphate.Rat models of autism were established by intracerebroventricular injection of propionic acid.These rat models had memory dysfunction,decreased muscle coordination and gait imbalance.Biochemical estimation of propionic acid-treated rats showed changes in enzyme activity in neuronal mitochondrial electron transport chain complexes and increases in pro-inflammatory cytokines,oxidative stress and lipid biomarkers.Oral administration of 10,20 and 30 mg/kg adenylate cyclase activator forskolin for 15 days reversed these changes in a dose-dependent manner.These findings suggest that forskolin can alleviate neuronal mitochondrial dysfunction and improve neurological symptoms of rats with autism.This study was approved by the RITS/IAEC,SIRSA,HARYANA on March 3,2014(approval No.RITS/IAEC/2014/03/03). 相似文献
50.
Gill Louise Buchanan Alaide Chieffo Emanuele Meliga Roxana Mehran Seung-Jung Park Yoshinobu Onuma Piera Capranzano Marco Valgimigli Inga Narbute Raj R. Makkar Igor F. Palacios Young-Hak Kim Piotr P. Buszman Tarun Chakravarty Imad Sheiban Christoph Naber Ronan Margey Arvind Agnihotri Sebastiano Marra Davide Capodanno Victoria Allgar Martin B. Leon Jeffrey W. Moses Jean Fajadet Thierry Lefevre Marie-Claude Morice Andrejs Erglis Corrado Tamburino Ottavio Alfieri Patrick W. Serruys Antonio Colombo 《The American journal of cardiology》2014