全文获取类型
收费全文 | 24040篇 |
免费 | 1508篇 |
国内免费 | 55篇 |
专业分类
耳鼻咽喉 | 399篇 |
儿科学 | 675篇 |
妇产科学 | 475篇 |
基础医学 | 3520篇 |
口腔科学 | 504篇 |
临床医学 | 2155篇 |
内科学 | 4569篇 |
皮肤病学 | 452篇 |
神经病学 | 2554篇 |
特种医学 | 1076篇 |
外国民族医学 | 12篇 |
外科学 | 3332篇 |
综合类 | 211篇 |
一般理论 | 11篇 |
预防医学 | 1837篇 |
眼科学 | 790篇 |
药学 | 1579篇 |
中国医学 | 46篇 |
肿瘤学 | 1406篇 |
出版年
2022年 | 225篇 |
2021年 | 429篇 |
2020年 | 274篇 |
2019年 | 340篇 |
2018年 | 407篇 |
2017年 | 335篇 |
2016年 | 403篇 |
2015年 | 475篇 |
2014年 | 598篇 |
2013年 | 825篇 |
2012年 | 1203篇 |
2011年 | 1222篇 |
2010年 | 675篇 |
2009年 | 638篇 |
2008年 | 1055篇 |
2007年 | 1099篇 |
2006年 | 1043篇 |
2005年 | 1037篇 |
2004年 | 950篇 |
2003年 | 861篇 |
2002年 | 868篇 |
2001年 | 712篇 |
2000年 | 721篇 |
1999年 | 637篇 |
1998年 | 264篇 |
1997年 | 248篇 |
1996年 | 206篇 |
1995年 | 171篇 |
1994年 | 152篇 |
1992年 | 415篇 |
1991年 | 431篇 |
1990年 | 414篇 |
1989年 | 373篇 |
1988年 | 389篇 |
1987年 | 341篇 |
1986年 | 343篇 |
1985年 | 304篇 |
1984年 | 241篇 |
1983年 | 180篇 |
1982年 | 135篇 |
1979年 | 224篇 |
1978年 | 165篇 |
1977年 | 164篇 |
1976年 | 149篇 |
1975年 | 153篇 |
1974年 | 176篇 |
1973年 | 145篇 |
1972年 | 146篇 |
1970年 | 135篇 |
1968年 | 136篇 |
排序方式: 共有10000条查询结果,搜索用时 14 毫秒
111.
Hellmuth-Alexander Meyer Isabelle Ahrens-Fath Anette Sommer Bernard Haendler 《Biomedicine & Pharmacotherapy》2004,58(1):10-16
Prostate adenocarcinoma is one of the most frequently diagnosed forms of cancer in the male population of the Western world. The pivotal role of androgen and its receptor in this disease has been abundantly documented and indeed, chemical castration and treatment with antiandrogens are now standard therapies. However, relapse is often observed after 18-24 months, due to the remarkable ability of prostate tumour cells to adapt to low or undetectable androgen levels. Amplification and mutations of the androgen receptor (AR) gene have been described as well as alterations in cofactor expression and crosstalk with other signalling pathways. Another recent line of research focused on the re-programming of gene expression taking place in prostate tumours. Global expression profiling of normal and cancerous prostate tissues led to the identification of tumour-distinctive patterns. Validation studies are currently underway to identify novel drug targets as well as diagnostic and outcome prediction markers. 相似文献
112.
Daniel N. Streblow Craig N. Kreklywich Patricia Smith Jordana L. Soule Christine Meyer Michael Yin Patrick Beisser Cornelis Vink Jay A. Nelson Susan L. Orloff 《American journal of transplantation》2005,5(3):436-442
Cytomegalovirus (CMV) infection accelerates transplant vascular sclerosis (TVS) and chronic rejection (CR) in both human and animal solid organ transplantation models. The host/viral mechanisms involved in this process are unclear. We examine the role of the rat CMV (RCMV)-encoded chemokine-receptor R33 in the development of TVS using a rat heart transplantation/CR model. F344 heart grafts were transplanted heterotopically into Lewis recipients. The ability of RCMV lacking the R33 gene (RCMV-Deltar33) to accelerate CR/TVS (neointimal index, NI) was compared to wild-type (WT) RCMV. Allograft recipients were infected with 1 x 10(5) pfu RCMV or RCMV-Deltar33 on postoperative day (POD) 1. Grafts from RCMV-Deltar33-infected recipients demonstrated an accelerated time to allograft CR compared to grafts from uninfected recipients (POD = 56 vs. 90), this was slower than that seen in grafts from WT-RCMV-infected recipients (POD = 45). Similarly, the degree of graft TVS formation at terminal rejection in RMCV-Deltar33 infected recipients was more severe than uninfected recipients (NI = 63 vs. 45), yet not as severe as in WT-RCMV infected recipients (NI = 83). In parallel, RCMV-Deltar33 failed to induce vascular smooth muscle cell (SMC) migration in vitro, whereas WT-RCMV induced substantial migration. The RCMV-encoded chemokine-receptor r33 is critical for RCMV-accelerated TVS/CR and vascular SMC migration. 相似文献
113.
114.
Jeffrey H Meyer Alan A Wilson Nathalie Ginovart Sylvain Houle 《Neuropsychopharmacology》2007,61(11):1314; author reply 1314-1314; author reply 1315
115.
Prof. Dr. D. Hilfiker-Kleiner T. Selle E. Podewski G.P. Meyer H. Drexler 《Der Kardiologe》2009,3(2):137-145
Peripartum cardiomyopathy (PPCM) is a rare and potentially life-threatening heart disease of unknown etiology that is restricted to the last month of pregnancy and up to 6 months postpartum. The morphology similates that of idiopathic dilated cardiomyopathy with a rapid progression to end-stage heart failure and is associated with a high morbidity and mortality rate. PPCM is treated with standard therapy for heart failure in accordance with the current guidelines. New findings suggest that elevated oxidative stress in the postpartum phase promotes cleavage of the nursing hormone prolactin into a toxic 16-kDa fragment that affects microcirculation and cardiomyocyte metabolism. Thus prolactin blocking using bromocriptine as a more specific therapy option showed promising early clinical results and is currently being tested in larger randomized trials. Frequent symptoms such as general fatigue, dyspnea and dry cough are often misinterpreted as pregnancy-related disturbances, and diagnosis is therefore often late. Interdisciplinary management, early diagnosis and more disease-specific therapy options appear to promote cardiac recovery in PPCM patients. 相似文献
116.
Matthias Peltz Tian-Teng He Glenn A Adams Robert Y Chao Michael E Jessen Dan M Meyer 《The Journal of heart and lung transplantation》2005,24(7):896-903
BACKGROUND: Lungs harvested for transplantation are stored while inflated with oxygen, which can serve to support oxidative metabolism. However, strategies aimed at increasing graft metabolism during storage have received little attention. In this study, we added pyruvate to the preservation solution Perfadex and measured the effects on oxidative metabolism and reperfusion lung function. METHODS: Rat lungs were stored for 6 and 24 hours in low-potassium dextran solution at 10 degrees C containing either 5 mmol/liter uniformly carbon-13 (U-(13)C) labeled glucose (Perfadex), 32 mmol/liter 3-(13)C pyruvate (pyruvate), or both (combined). Oxidation of exogenous substrates was measured as the incorporation of (13)C into tricarboxylic acid cycle intermediates by magnetic resonance spectroscopy. Additional groups of lungs with each substrate modification were preserved for 6 or 24 hours and then reperfused. RESULTS: Enrichment of tricarboxylic acid cycle intermediates was low in the Perfadex group (9% at 6 hours and 32% at 24 hours of storage, respectively). In contrast, enrichment was significantly increased in both the pyruvate group (50% and 59%, respectively) and combined group (39% and 54%, respectively) compared with the Perfadex group (p<0.01). Graft function was excellent after 6-hour storage in all groups. All lungs stored for 24 hours exhibited inferior lung function, but oxygenation, pulmonary artery pressures, and airway pressures in the combined group were significantly improved compared with the Perfadex group (p<0.05). CONCLUSIONS: Preservation solution substrate composition influences graft metabolism during storage. The addition of pyruvate to Perfadex increases metabolism during storage and improves reperfusion lung function. 相似文献
117.
David Quarcoo Tanja C Fischer Nora Peckenschneider David A Groneberg Pia Welker 《Journal of occupational medicine and toxicology (London, England)》2009,4(1):8
Background
Neurotrophin 3 (NT-3) is a member of the neurotrophin family, a group of related proteins that are known to regulate neuro-immune interactions in allergic diseases. Their cellular sources and role in the recruitment of mast cell precursors in atopic dermatitis have not been characterized in detail so far. 相似文献118.
119.
The epidemiology of deaths from volatile substance abuse (VSA) in those under 18 years that occurred in the UK from 1981-90 is described. The analysis of deaths is based on a national register, which has information obtained from a regular survey of coroners, the Office of Population Censuses and Surveys, and a press clippings agency. Altogether 605 people under 18 died from VSA during this period. Seventy per cent of deaths occurred between the ages of 14 and 16. The largest number of deaths were attributed to butane gas lighter refills. There was a large north-south gradient in age specific mortality ratios (Scotland 180, south east England 87) and nearly four times as many deaths occurred in social class V compared with social class I. Deaths from VSA are an important and preventable cause of deaths in those under 18. Strategies aimed at prevention should include measures to reduce experimentation, intervention to reduce socioeconomic deprivation, and health education campaigns aimed at schools and parents. 相似文献
120.