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31.
32.
Nittaya Phanuphak Nipat Teeratakulpisarn Frits van Griensven Nitiya Chomchey Suteeraporn Pinyakorn James LK Fletcher Rapee Trichavaroj Supanit Pattanachaiwit Nelson Michael Praphan Phanuphak Jerome H Kim Jintanat Ananworanich 《Journal of the International AIDS Society》2015,18(1)
Introduction
HIV transmission risk is highest during acute HIV infection (AHI). We evaluated HIV RNA in the anogenital compartment in men who have sex with men (MSM) during AHI and compared time to undetectable HIV RNA after three-drug versus five-drug antiretroviral therapy (ART) to understand risk for onward HIV transmission.Methods
MSM with AHI (n=54) had blood, seminal plasma and anal lavage collected for HIV RNA at baseline, days 3 and 7, and weeks 2, 4, 12 and 24. Data were compared between AHI stages: 1 (fourth-generation antigen-antibody combo immunoassay [IA]–, third-generation IA–, n=15), 2 (fourth-generation IA+, third-generation IA–, n=9) and 3 (fourth-generation IA+, third-generation IA+, western blot–/indeterminate, n=30) by randomization to five-drug (tenofovir+emtricitabine+efavirenz+raltegravir+maraviroc, n=18) versus three-drug (tenofovir+emtricitabine+efavirenz, n=18) regimens.Results
Mean age was 29 years and mean duration since HIV exposure was 15.4 days. Mean baseline HIV RNA was 5.5 in blood, 3.9 in seminal plasma and 2.6 log10 copies/ml in anal lavage (p<0.001). Blood and seminal plasma HIV RNA were higher in AHI Stage 3 compared to Stage 1 (p<0.01). Median time from ART initiation to HIV RNA <50 copies/ml was 60 days in blood, 15 days in seminal plasma and three days in anal lavage. Compared with the three-drug ART, the five-drug ART had a shorter time to HIV RNA <1500 copies/ml in blood (15 vs. 29 days, p=0.005) and <50 copies/ml in seminal plasma (13 vs. 24 days, p=0.048).Conclusions
Among MSM with AHI, HIV RNA was highest in blood, followed by seminal plasma and anal lavage. ART rapidly reduced HIV RNA in all compartments, with regimen intensified by raltegravir and maraviroc showing faster HIV RNA reductions in blood and seminal plasma. 相似文献33.
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36.
Kerna I Kisand K Laitinen P Tamm AE Kumm J Lintrop M Tamm AO 《Rheumatology international》2012,32(2):519-523
ADAM12 (A disintegrin and metalloprotease) is one of the candidate genes demonstrating susceptibility to osteoarthritis. The purpose
of this study was to investigate the relationship between ADAM12-S protein and radiographic knee osteoarthritis (KOA) and
its correlation to several bone and cartilage biomarkers. The ADAM12-S protein was measured in 276 subjects (60% women, aged
32–60 years), including 181 individuals with and 95 without radiographic KOA features. The radiographs were obtained from
both tibiofemoral (TF) and patellofemoral (PF) joints. The serum levels of ADAM12-S protein were measured by DELFIA1/AutoDELFIA
research kit. The ADAM12-S protein was found in detectable ranges in 43 subjects (16 men), without statistical difference
between the two genders. In the whole group, the ADAM12-S was related to radiographic KOA grades in TF (P = 0.004) as well in PF joint (P = 0.003). We also found a correlation between ADAM12-S protein and osteophytes in TF and/or PF joints (P = 0.003). No correlations were found between serum levels of S-CTx-I (C-terminal cross-linked telopeptides of type I collagen)
or S-PINP (type I procollagen N-terminal propeptide) and ADAM12-S. Similarly, in the whole group, the ADAM12-S protein was
not correlated with U-CTx-II (urinary C-telopeptide fragments of type II collagen); however, in the female group, trend to
positive correlation between the investigated biomarkers (P = 0.019) was observed. The ADAM12-S protein could be elevated in some KOA cases, and this elevation correlates with the grades
of the disease, mostly owning to development of osteophytes. This finding suggests the possible involvement of the ADAM12-S
protein in the pathogenesis of KOA. 相似文献
37.
Indran Davagnanam MB BCh BAO BMedSci FRCR Graeme Holland Raj S. Dattani Alexander Tamm Shashivadan P. Hirani MSc PhD CPsychol Nicky Kolfschoten MD Lisa Strycharczuk Cathy Green John S. Thornton PhD Alex Wright MB FRCP Mark Edsell FRCA Neil D. Kitchen MD FRCS David J. Sharp PhD Timothy E. Ham PhD Andrew Murray DPhil Cameron J. Holloway FRACP D.Phil Kieran Clarke PhD Mike P.W. Grocott BSc MBBS MD FRCA FRCP FFICM Birmingham Medical Research Expeditionary Society Caudwell Xtreme Everest Research Group 《Annals of neurology》2013,73(3):381-389
38.
Clinical and patient‐reported outcomes of Chinese patients undergoing haemodialysis in hospital or in the community: A 1‐year longitudinal study
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39.
F. Hirsch J. C. Brokmann S. K. Beckers R. Rossaint M. Czaplik M. Tamm S. Bergrath 《Notfall & Rettungsmedizin》2016,19(5):373-379
Background
Treatment of acute coronary syndrome and stroke in a prehospital setting benefits from telemedical procedures. This study investigates the availability and performance of telemedical data transfer and audiocommunication of different providers in an urban ambulance service using a commercial system.Materials and methods
After approval of the local ethic committee, the monitor and defibrillation units of two emergency vehicles were equipped with subscriber identity module (SIM) cards from different providers. After initiation by a mobile call, data transmission of static (12-lead ECG) and dynamic (live vital) data from 120 ambulance calls where sent to a physician-staffed call center. The quality of data transfer and functionality were rated using a standardised (5-point scale) questionnaire.Results
Of 120 trouble-free mobile call data transfers initiated, 117 were included. Transmission of the live vital data were significantly different (p = 0.0327) in quality of live vital data transmission between Telekom (median 2.0; range 1–4, 1 = no technical interference and 4 = teleconsultation impossible [5 = no documentation]) and Vodafone 2.5. Overall, the quality of the live data transmission was acceptable in 83?% of the cases. For the 12-lead ECG, data transmission was possible in 89?% (n = 32, Telekom) and 88?% (n = 36, Vodafone) of all transmissions.Conclusion
The performance of static and dynamic telemedical data transmission in an urban area were significantly different for the two providers. Data transmission for telemedical use was possible in slightly less than 90?% of cases. Against the background that telemedical applications are being increasingly used, technical requirements to ensure availability and functionality in terms of patients safety are necessary.40.
Borger P Matsumoto H Boustany S Gencay MM Burgess JK King GG Black JL Tamm M Roth M 《The Journal of allergy and clinical immunology》2007,119(1):98-105
BACKGROUND: CCAAT/enhancer-binding proteins (C/EBPs) control cell proliferation; lack of C/EBPalpha correlates with increased proliferation of bronchial smooth muscle cells (BSMCs) of asthmatic patients. OBJECTIVE: We sought to assess disease-specific expression of C/EBPalpha, beta, delta, and epsilon and the effects of budesonide (10(-8) mol/L) and formoterol (10(-8) mol/L). METHODS: Expression and function of C/EBPalpha, beta, delta, and epsilon BSMCs of control subjects (n = 9), asthmatic patients (n = 12), and patients with chronic obstructive pulmonary disease (COPD; n = 10) were determined. RESULTS: The control group expressed C/EBPalpha, beta, delta, and epsilon, which were upregulated by serum (5%). Budesonide completely inhibited C/EBPalpha and beta expression; formoterol increased C/EBPalpha expression (2-fold). C/EBPdelta and epsilon expression were not affected by the drugs. The asthmatic group did not appropriately express C/EBPalpha. Basal levels of C/EBPbeta, delta, and epsilon were upregulated by serum (5%). Budesonide and formoterol increased C/EBPbeta levels (3.4-fold and 2.5-fold, respectively), leaving C/EBPalpha, delta, and epsilon levels unaffected. The COPD group normally expressed C/EBPalpha, beta, and epsilon, which were upregulated by serum treatment (5%). Basal levels of C/EBPdelta were downregulated by serum in 7 of 10 BSMC lines. Budesonide inhibited C/EBPalpha and beta expression, upregulated C/EBPdelta (3.2-fold), and had no effect on C/EBPepsilon. Formoterol upregulated C/EBPalpha expression (3-fold) but not the other C/EBPs. Protein analysis and electrophoretic mobility shift assay confirmed the disease-specific expression pattern of C/EBPalpha in asthmatic patients and C/EBPdelta in patients with COPD. CONCLUSIONS: The expression and regulation of C/EBPs in BSMCs of asthmatic patients and patients with COPD seems disease specific. Budesonide and formoterol modulate C/EBP expression in a drug- and disease-specific pattern. CLINICAL IMPLICATIONS: The data could provide a method to discriminate between asthma and COPD at an early disease stage. 相似文献