全文获取类型
收费全文 | 1314篇 |
免费 | 64篇 |
国内免费 | 7篇 |
专业分类
耳鼻咽喉 | 2篇 |
儿科学 | 21篇 |
妇产科学 | 37篇 |
基础医学 | 105篇 |
口腔科学 | 17篇 |
临床医学 | 65篇 |
内科学 | 386篇 |
皮肤病学 | 8篇 |
神经病学 | 64篇 |
特种医学 | 126篇 |
外科学 | 258篇 |
综合类 | 9篇 |
预防医学 | 17篇 |
眼科学 | 6篇 |
药学 | 42篇 |
中国医学 | 1篇 |
肿瘤学 | 221篇 |
出版年
2023年 | 11篇 |
2022年 | 12篇 |
2021年 | 24篇 |
2020年 | 12篇 |
2019年 | 13篇 |
2018年 | 22篇 |
2017年 | 21篇 |
2016年 | 17篇 |
2015年 | 23篇 |
2014年 | 45篇 |
2013年 | 38篇 |
2012年 | 76篇 |
2011年 | 61篇 |
2010年 | 33篇 |
2009年 | 34篇 |
2008年 | 44篇 |
2007年 | 44篇 |
2006年 | 53篇 |
2005年 | 63篇 |
2004年 | 58篇 |
2003年 | 33篇 |
2002年 | 33篇 |
2001年 | 50篇 |
2000年 | 46篇 |
1999年 | 58篇 |
1998年 | 19篇 |
1997年 | 21篇 |
1996年 | 17篇 |
1995年 | 12篇 |
1994年 | 9篇 |
1993年 | 13篇 |
1992年 | 53篇 |
1991年 | 39篇 |
1990年 | 40篇 |
1989年 | 31篇 |
1988年 | 32篇 |
1987年 | 27篇 |
1986年 | 23篇 |
1985年 | 20篇 |
1984年 | 7篇 |
1983年 | 16篇 |
1982年 | 5篇 |
1981年 | 8篇 |
1979年 | 8篇 |
1977年 | 7篇 |
1976年 | 6篇 |
1974年 | 8篇 |
1973年 | 7篇 |
1967年 | 5篇 |
1966年 | 4篇 |
排序方式: 共有1385条查询结果,搜索用时 15 毫秒
31.
32.
33.
Clinical outcomes of a novel therapeutic vaccine with Tax peptide‐pulsed dendritic cells for adult T cell leukaemia/lymphoma in a pilot study 下载免费PDF全文
Youko Suehiro Atsuhiko Hasegawa Tadafumi Iino Amane Sasada Nobukazu Watanabe Masao Matsuoka Ayako Takamori Ryuji Tanosaki Atae Utsunomiya Ilseung Choi Tetsuya Fukuda Osamu Miura Shigeo Takaishi Takanori Teshima Koichi Akashi Mari Kannagi Naokuni Uike Jun Okamura 《British journal of haematology》2015,169(3):356-367
Adult T cell leukaemia/lymphoma (ATL) is a human T cell leukaemia virus type‐I (HTLV‐I)‐infected T cell malignancy with poor prognosis. We herein developed a novel therapeutic vaccine designed to augment an HTLV‐I Tax‐specific cytotoxic T lymphocyte (CTL) response that has been implicated in anti‐ATL effects, and conducted a pilot study to investigate its safety and efficacy. Three previously treated ATL patients, classified as intermediate‐ to high‐risk, were subcutaneously administered with the vaccine, consisting of autologous dendritic cells (DCs) pulsed with Tax peptides corresponding to the CTL epitopes. In all patients, the performance status improved after vaccination without severe adverse events, and Tax‐specific CTL responses were observed with peaks at 16–20 weeks. Two patients achieved partial remission in the first 8 weeks, one of whom later achieved complete remission, maintaining their remission status without any additional chemotherapy 24 and 19 months after vaccination, respectively. The third patient, whose tumour cells lacked the ability to express Tax at biopsy, obtained stable disease in the first 8 weeks and later developed slowly progressive disease although additional therapy was not required for 14 months. The clinical outcomes of this pilot study indicate that the Tax peptide‐pulsed DC vaccine is a safe and promising immunotherapy for ATL. 相似文献
34.
Hiroshi Ashida M.D. Yoshinao Kotoura M.D. Kazumitsu Takagi M.D. Yoshio Ishikawa M.D. Joji Utsunomiya M.D. 《The American journal of gastroenterology》1989,84(1):71-74
We report a case of severe hemolysis after distal splenorenal shunt. Hemolysis was suddenly recognized at the time splenorenal venous anastomosis was completed, and it continued on the operative day and the first postoperative day. After the shunt, the intraoperative splenic venous blood flow was approximately double its previous level, as measured by electromagnetic flowmeter. Angiographic partial splenic embolization was performed on the second postoperative day, and then hemolysis stopped suddenly. This suggested that hemolysis after distal splenorenal shunt was related to increased splenic blood flow and acceleration of erythrocyte destruction. 相似文献
35.
36.
37.
Cheng-Tse Wu Ahmed I. A. Soliman Toru Utsunomiya Takashi Ichii Hiroyuki Sugimura 《RSC advances》2019,9(55):32313
Formation of precise and high-resolution silica micropatterns on polymer substrates is of importance in surface structuring for flexible device fabrication of optics, microelectronic, and biotechnology. To achieve that, substrates modified with affinity-patterns serve as a strategy for site-selective deposition. In the present paper, vacuum ultraviolet (VUV) treatment is utilized to achieve spatially-controlled surface functionalization on a cyclo-olefin polymer (COP) substrate. An organosilane, 2,4,6,8-tetramethylcyclotetrasiloxane (TMCTS), preferentially deposits on the functionalized regions. Well-defined patterns of TMCTS are formed with a minimum feature of ∼500 nm. The secondary VUV/(O)-treatment converts TMCTS into SiOx, meanwhile etches the bare COP surface, forming patterned SiOx/COP microstructures with an average height of ∼150 nm. The resulting SiOx patterns retain a good copy of TMCTS patterns, which are also consistent with the patterns of photomask used in polymer affinity-patterning. The high quality SiOx patterns are of interests in microdevice fabrication, and the hydrophilicity contrast and adjustable heights reveal their potential application as a “stamp” for microcontact printing (μCP) techniques.Patterned surface treatment on a polymer substrate is carried out by 172 nm VUV through a photomask. TMCTS pattern formation is guided by the resulting affinity-pattern. The secondary VUV treatment converted TMCTS patterns into silica patterns. 相似文献
38.
Yoshihiko Hangai Hiroto Kamada Takao Utsunomiya Soichiro Kitahara Osamu Kuwazuru Nobuhiro Yoshikawa 《Materials》2014,7(3):2382-2394
Al foam has been used in a wide range of applications owing to its light weight, high energy absorption and high sound insulation. One of the promising processes for fabricating Al foam involves the use of a foamable precursor. In this study, ADC12 Al foams with porosities of 67%–78% were fabricated from Al alloy die castings without using a blowing agent by the friction stir processing route. The pore structure and tensile properties of the ADC12 foams were investigated and compared with those of commercially available ALPORAS. From X-ray computed tomography (X-ray CT) observations of the pore structure of ADC12 foams, it was found that they have smaller pores with a narrower distribution than those in ALPORAS. Tensile tests on the ADC12 foams indicated that as their porosity increased, the tensile strength and tensile strain decreased, with strong relation between the porosity, tensile strength, and tensile strain. ADC12 foams exhibited brittle fracture, whereas ALPORAS exhibited ductile fracture, which is due to the nature of the Al alloy used as the base material of the foams. By image-based finite element (FE) analysis using X-ray CT images corresponding to the tensile tests on ADC12 foams, it was shown that the fracture path of ADC12 foams observed in tensile tests and the regions of high stress obtained from FE analysis correspond to each other. Therefore, it is considered that the fracture behavior of ADC12 foams in relation to their pore structure distribution can be investigated by image-based FE analysis. 相似文献
39.
40.