全文获取类型
收费全文 | 5895篇 |
免费 | 463篇 |
国内免费 | 29篇 |
专业分类
耳鼻咽喉 | 24篇 |
儿科学 | 211篇 |
妇产科学 | 102篇 |
基础医学 | 842篇 |
口腔科学 | 64篇 |
临床医学 | 667篇 |
内科学 | 1370篇 |
皮肤病学 | 92篇 |
神经病学 | 562篇 |
特种医学 | 149篇 |
外科学 | 697篇 |
综合类 | 55篇 |
一般理论 | 1篇 |
预防医学 | 620篇 |
眼科学 | 88篇 |
药学 | 487篇 |
中国医学 | 18篇 |
肿瘤学 | 338篇 |
出版年
2024年 | 6篇 |
2023年 | 85篇 |
2022年 | 99篇 |
2021年 | 254篇 |
2020年 | 160篇 |
2019年 | 220篇 |
2018年 | 222篇 |
2017年 | 161篇 |
2016年 | 196篇 |
2015年 | 206篇 |
2014年 | 244篇 |
2013年 | 317篇 |
2012年 | 461篇 |
2011年 | 502篇 |
2010年 | 256篇 |
2009年 | 226篇 |
2008年 | 404篇 |
2007年 | 360篇 |
2006年 | 404篇 |
2005年 | 351篇 |
2004年 | 308篇 |
2003年 | 282篇 |
2002年 | 200篇 |
2001年 | 43篇 |
2000年 | 33篇 |
1999年 | 50篇 |
1998年 | 44篇 |
1997年 | 35篇 |
1996年 | 23篇 |
1995年 | 39篇 |
1994年 | 17篇 |
1993年 | 12篇 |
1992年 | 24篇 |
1991年 | 15篇 |
1990年 | 14篇 |
1989年 | 18篇 |
1988年 | 6篇 |
1987年 | 9篇 |
1986年 | 4篇 |
1985年 | 9篇 |
1984年 | 8篇 |
1983年 | 12篇 |
1982年 | 8篇 |
1979年 | 4篇 |
1976年 | 3篇 |
1972年 | 3篇 |
1970年 | 4篇 |
1968年 | 2篇 |
1967年 | 3篇 |
1966年 | 2篇 |
排序方式: 共有6387条查询结果,搜索用时 46 毫秒
81.
82.
Wageh M Awara Alaa E El-Sisi Magda E El-Sayad Ahmed E Goda 《Pharmacological research》2004,50(5):487-498
The potential anti-tumour activity of non-steroidal anti-inflammatory drugs (NSAIDS) has been previously discussed. This study was undertaken to assess the possible anti-tumour activity of the cyclooxygenase-2 (COX-2) inhibitor; celecoxib in an animal model of mammary carcinoma; the solid Ehrlich carcinoma (SEC). The possibility that celecoxib may modulate the anti-tumour activity of doxorubicin on the SEC was also studied. Some of the possible mechanisms underlying such modulation were investigated. The anti-tumour activity of celecoxib (25 mg kg(-1)), diclofenac (12.5 mg kg(-1)) and doxorubicin (2 mg kg(-1)) either alone or in combination were investigated on SEC in vivo through the assessment of tumour growth delay (TGD) and tumour volume (TV), changes in tumour DNA content and nitric oxide (NO) levels, immunohistochemical staining of the tumour suppressor gene product; p53 histopathological examination and determination of apoptotic index of SEC. In addition, the influence of these drugs on the DNA fragmentation pattern of Ehrlich carcinoma cells (ECC) was studied. It was found that both celecoxib and diclofenac lack the anti-tumour activity on SEC. In addition there was a significant increase in doxorubicin anti-tumour activity when administered in combination with celecoxib. Moreover, it was found that both celecoxib and diclofenac have the potential to inhibit the function of P-glycoprotein (P-gp) in ECC using rhodamine uptake and efflux assays. Therefore, the current study suggested the chemosensitizing potential of celecoxib in the SEC animal model of mammary tumour, which could be explained in part on the basis of inhibition of P-gp function, with possible enhancement of doxorubicin anti-tumour activity. 相似文献
83.
84.
85.
Sinikka Pelkonen Susanne B. Lindahl P?ivi Suomala Jari Karhukorpi Sakari Vuorinen Irma Koivula Tia V?is?nen Jaana Pentik?inen Tiina Autio Tamara Tuuminen 《Emerging infectious diseases》2013,19(7):1041-1048
Streptococcus equi subspecies zooepidemicus (S. zooepidemicus) is a zoonotic pathogen for persons in contact with horses. In horses, S. zooepidemicus is an opportunistic pathogen, but human infections associated with S. zooepidemicus are often severe. Within 6 months in 2011, 3 unrelated cases of severe, disseminated S. zooepidemicus infection occurred in men working with horses in eastern Finland. To clarify the pathogen’s epidemiology, we describe the clinical features of the infection in 3 patients and compare the S. zooepidemicus isolates from the human cases with S. zooepidemicus isolates from horses. The isolates were analyzed by using pulsed-field gel electrophoresis, multilocus sequence typing, and sequencing of the szP gene. Molecular typing methods showed that human and equine isolates were identical or closely related. These results emphasize that S. zooepidemicus transmitted from horses can lead to severe infections in humans. As leisure and professional equine sports continue to grow, this infection should be recognized as an emerging zoonosis. 相似文献
86.
Lugo-Reyes Saul Oswaldo Pastor Nina González-Serrano Edith Yamazaki-Nakashimada Marco Antonio Scheffler-Mendoza Selma Berron-Ruiz Laura Wakida Guillermo Nuñez-Nuñez Maria Enriqueta Macias-Robles Ana Paola Staines-Boone Aide Tamara Venegas-Montoya Edna Alaez-Verson Carmen Molina-Garay Carolina Flores-Lagunes Luis Leonardo Carrillo-Sanchez Karol Niemela Julie Rosenzweig Sergio D. Gaytan Paul Yañez Jorge A. Martinez-Duncker Ivan Notarangelo Luigi D. Espinosa-Padilla Sara Cruz-Munoz Mario Ernesto 《Journal of clinical immunology》2021,41(7):1708-1708
Journal of Clinical Immunology - A Correction to this paper has been published: https://doi.org/10.1007/s10875-021-01075-7 相似文献
87.
88.
Rajani Kanteti Tamara Mirzapoiazova Jacob J. Riehm Immanuel Dhanasingh Bolot Mambetsariev Jiale Wang 《Cancer biology & therapy》2018,19(4):316-327
The non-receptor cytoplasmic tyrosine kinase, Focal Adhesion Kinase (FAK) is known to play a key role in a variety of normal and cancer cellular functions such as survival, proliferation, migration and invasion. It is highly active and overexpressed in various cancers including Pancreatic Ductal Adenocarcinoma (PDAC) and Malignant Pleural Mesothelioma (MPM). Here, initially, we demonstrate that FAK is overexpressed in both PDAC and MPM cell lines. Then we analyze effects of two small molecule inhibitors PF-573228, and PF-431396, which are dual specificity inhibitors of FAK and proline rich tyrosine kinase 2 (PYK2), as well as VS-6063, another small molecule inhibitor that specifically inhibits FAK but not PYK2 for cell growth, motility and invasion of PDAC and MPM cell lines. Treatment with PF-573228, PF-431396 and VS-6063 cells resulted in a dose-dependent inhibition of growth and anchorage-independent colony formation in both cancer cell lines. Furthermore, these compounds suppressed the phosphorylation of FAK at its active site, Y397, and functionally induced significant apoptosis and cell cycle arrest in both cell lines. Using the ECIS (Electric cell-substrate impedance sensing) system, we found that treatment of both PF compounds suppressed adherence and migration of PDAC cells on fibronectin. Interestingly, 3D-tumor organoids derived from autochthonous KC (Kras;PdxCre) mice treated with PF-573228 revealed a significant decrease in tumor organoid size and increase in organoid cell death. Taken together, our results show that FAK is an important target for mesothelioma and pancreatic cancer therapy that merit further translational studies. 相似文献
89.
Peggy Papeleu Tamara Vanhaecke Greetje Elaut Mathieu Vinken Tom Henkens Sarah Snykers 《Critical reviews in toxicology》2013,43(4):363-378
Histone deacetylase (HDAC) inhibitors target key steps of tumor development: They inhibit proliferation, induce differentiation and/or apoptosis, and exhibit potent antimetastatic and antiangiogenic properties in transformed cells in vitro and in vivo. Preliminary studies in animal models have revealed a relatively high tumor selectivity of HDAC inhibitors, strenghtening their promising potential in cancer chemotherapy. Until now, preclinical in vitro research has almost exclusively been performed in cancer cell lines and oncogene-transformed cells. However, as cell proliferation and apoptosis are essential for normal tissue and organ homeostasis, it is important to investigate how HDAC inhibitors influence the regulation of and interplay between proliferation, differentiation, and apoptosis in primary cells as well. This review highlights the discrepancies in molecular events triggered by trichostatin A, the reference compound of hydroxamic acid-containing HDAC inhibitors, in hepatoma cells and primary hepatocytes (which are key targets for drug-induced toxicity). The implications of these differential outcomes in both cell types are discussed with respect to both toxicology and drug development. In view of the future use of HDAC inhibitors as cytostatic drugs, it is highly recommended to include both tumor cells and their healthy counterparts in preclinical developmental studies. Screening the toxicological properties of compounds early in their development process, using a battery of different cell types, will enable researchers to discard those compounds bearing undesirable adverse activity before entering into expensive clinical trials. This will not only reduce the risk for harmful exposure of patients but also save time and money. 相似文献
90.
Krystyna Piasecka Magdalena Marć Hasmik Hayrapetyan Tamara Sarkisian Bartosz Korczowski 《Pediatria polska》2012,87(3):311-313
Familial Mediterranean Fever (FMF) is a disease with an autosomal recessive inheritance affecting inhabitants of the Mediterranean Sea basin area. It is the most prevalent fever-inflammatory syndrome manifested by fever episodes, serositis and rash. The symptoms regress spontaneously and between recurrent attacks of fever the child is healthy. Amyloidosis is the most serious complication. A case of a 8 year-old boy, a son of Armenian immigrants, with recurrent pleuritis is presented. 相似文献