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991.
Yuji Arai Shuji Nakagawa Tetsuo Higuchi Atsuo Inoue Kuniaki Honjo Hiroaki Inoue Kazuya Ikoma Keiichiro Ueshima Takumi Ikeda Hiroyoshi Fujiwara Toshikazu Kubo 《Knee surgery, sports traumatology, arthroscopy》2017,25(8):2330-2336
Purpose
Medial patellofemoral ligament (MPFL) reconstruction has become a common form of treatment for recurrent patellar dislocation. This study was performed using open-MRI to compare the length change pattern of MPFL in patients with a history of patellar dislocation to that in healthy subjects.Methods
The subjects comprised 10 knees of 8 males and 13 knees of 12 females with a history of one or more patellar dislocations. The length of the MPFL was measured using open-MRI in both the leg-extended position and knee-flexed positions to analyse the length change pattern.Results
The average MPFL lengths were 58.6 ± 6.5 mm and 52.0 ± 4.6 mm for males and females in the extended knee position, respectively. The length change pattern of the MPFL showed slight variation up to a flexion angle of 30° and a clear decrease above 30°. This pattern differed from that of normal MPFL. In terms of morphology, the fibre bundle of the damaged MPFL followed a convex course towards the side of the patellofemoral joint surface at a knee flexion angle of 60°, whereas that of the normal MPFL followed a straight course.Conclusion
The in vivo damaged MPFL length change pattern was specific and differed distinctly from that of normal MPFL. The results of the present study suggested that MPFL fibres with a history of patellar dislocation lack sufficient tension at knee flexion angles of 0°–60°. However, further studies are needed to obtain a better understanding of cases with a patellar dislocation or postsurgical cases of MPFL reconstruction.Level of evidence
III.992.
Ryosuke Ikeguchi Manabu Nankaku Rie Yamawaki Hiroki Tanaka Ryota Hamada Takumi Kawano Masanobu Murao Gakuto Kitamura Tatsuya Sato Toru Nishikawa Takashi Noguchi Shinichi Kuriyama Akio Sakamoto Shuichi Matsuda 《Medicine》2021,100(37)
The purpose of this study is to investigate the predictive factors of home discharge for rehabilitation patients with cancer bone metastasis.Cancer patients with bone metastasis who underwent rehabilitation between April 2014 and March 2017 were retrospectively enrolled. Data on discharge destination were collected from medical records as outcomes. Multiple regression analyses were carried out to investigate the predictive factors of home discharge.Ninety-eight patients (mean age: 68.6 years, 42 females and 56 males) were included. Fifty patients were discharged home, 38 patients were discharged to other facilities, and 10 patients died. There were no skeletal-related events among these patients during their hospital stay. The receiver-operating curve for the predictive factors for home discharge of the Barthel Index at admission, Eastern Cooperative Oncology Group Performance Status at admission, and number of immediate family members living at home were 60 points (area under the curve [AUC] = 0.74, sensitivity = 0.6400, 1-specificity = 0.2766), 2 score (AUC = 0.65, sensitivity = 0.5400, 1-specificity = 0.2222), and 1 family member (AUC = 0.65, sensitivity = 0.9592, 1-specificity = 0.7222), respectively.In order to plan for cancer patients with bone metastasis to be discharged home, it is important to take into consideration the patients’ Barthel Index and Performance Status at the time of hospital admission and the number of immediate family members living at home. 相似文献
993.
Background We postulated that hair shafts preserve amplifiable messenger RNAs (mRNAs) and that these mRNAs could be utilized to characterize phenotypic differences in hairs at the gene expression level. Objectives This study aimed to prove the presence of amplifiable mRNAs in the hair shaft and then to utilize them to characterize black and white hairs at the gene expression level. Methods RNAs were extracted from black and white scalp hair shafts and amplified by quantitative real‐time polymerase chain reaction (qRT‐PCR). Microarray analysis was performed using T7 RNA polymerase‐amplified mRNAs derived from the hair shaft to examine the gene expression profiles of black and white hairs. Results We showed that hair shaft RNAs contained trace amounts of mRNAs and concluded that the acellular hair shaft contained mRNAs usable for microarray analysis. We termed the mRNA “fossil mRNA” (fmRNA) in this study. Totals of 10 and 2% of the detected genes were expressed at levels more than two‐fold higher in black and white hairs compared with white and black hairs, respectively. We selected five genes and examined their expression levels in five donors by qRT‐PCR. Among them, only hypothetical protein (L1H3 region) human was found to be expressed at 2.69 ± 1.81 (relative ratio) in black hairs. Conclusions We demonstrated that the scalp hair shaft conserves fmRNAs which are probably remnants that have been expressed during hair differentiation. Consequently, fmRNA is expected to be a useful source of information for the study of phenotypic changes in hairs at the molecular level. 相似文献
994.
OBJECTIVE: We investigated the correlation of age and intraocular pressure (IOP) with visual field damage in patients with normal-tension glaucoma (NTG) and asymmetric visual field defects. METHODS: A total of 88 NTG patients (176 eyes) were investigated. Patients in whom visual field defects were more severe in the eye with higher IOP than in the fellow eye were grouped as IOP-visual field-concordant patients, and the others as IOP-visual field-discordant patients. Mean 24-hour IOP was used as an indicator of IOP, and mean deviation (MD) as an indicator of visual field defects. Patients were also compared by age tertile. RESULTS: The IOP-visual field-concordant group comprised 53 of the 88 patients (60.2%), among whom the >70-years tertile had significantly greater absolute values for MD asymmetry. In contrast, no significant differences in asymmetry by age tertile were seen in the IOP-visual field-discordant group. CONCLUSION: Elevated IOP is a cause of visual field defects in many NTG patients. Among IOP-visual field-concordant patients, particular attention is required to visual field changes in the eyes of patients with higher IOP. 相似文献
995.
Nobukazu Fujimoto Kenichi Gemba Atsushi Yao Shinji Ozaki Katsuichiro Ono Sae Wada Yasuhiro Fujii Yoshifumi Namba Takumi Kishimoto 《Journal of infection and chemotherapy》2010,16(1):53-55
Tuberculosis is a leading cause of mortality due to an infectious agent worldwide. It often affects multiple organs by hematogenous
spread of Mycobacterium tuberculosis, but knee-joint involvement is extremely rare, comprising approximately 0.1% of all forms of tuberculosis. We present a case
of tuberculous pleuritis with knee-joint involvement. Cytological and biochemical analysis of the pleural fluid and a biopsy
specimen of the cervical lymph node indicated tuberculosis, but a definitive diagnosis was not given. A confirmed diagnosis
was finally obtained through PCR analysis of the synovial fluid. Tuberculosis should be included in the differential diagnosis
in patients with persistent pain and swelling of the knee. PCR analysis of the synovial fluid is a quick and useful method
for the diagnosis. 相似文献
996.
Takemura Y Kishimoto T Takigawa T Kojima S Wang BL Sakano N Wang DH Takaki J Nishide T Ishikawa K Ogino K 《Acta medica Okayama》2008,62(2):75-82
To decrease the incidence of pneumoconiosis, we examined dust protective mask performance and its relation to pulmonary function as well as the effects of worker education on the proper wearing of masks. One hundred and seventy-eight workers from 15 factories subject to dust exposure participated in this study. All participants were interviewed to obtain relevant personal information and underwent both a mask leakage and a pulmonary function test. The mask leakage was expressed as a percentage, with under 10% leakage indicating that the dust protective mask worked efficiently. In addition, 23 workers from 2 factories were educated on how to wear masks properly. The average mask leakage was 24.3%, and 58% of workers wore ineffective masks. Though pulmonary function was almost normal, the percent vital capacity (%VC) tended to be lower depending on the mask leakage. Mask education, which was very easy and took only a short time, dramatically decreased average mask leakage from 32.1% to 10.5% (p0.001). Educating workers to wear masks properly might prevent the worsening of pulmonary function in response to dust exposure. Appropriate mask fitness by education could be useful in preventing the development of pneumoconiosis. 相似文献
997.
Takumi Shiraishi Terukazu Nakamura Kazuya Mikami Natsuki Takaha Akihiro Kawauchi Tsuneharu Miki 《International journal of clinical oncology / Japan Society of Clinical Oncology》2009,14(5):436-441
Background
We investigated the efficacy and toxicity of a regimen consisting of paclitaxel and gemcitabine plus nedaplatin, a derivative of cisplatin (TGN) in patients with heavily pretreated cisplatin-refractory germ cell tumors (GCTs). 相似文献998.
H Kyuno T Uchida S Kobayasi T Saito T Sato M Muramoto S Shimura Y Shibata K Koshiba 《Nihon Hinyōkika Gakkai zasshi. The japanese journal of urology》1999,90(7):669-674
PURPOSE: To evaluate the treatment of grade 3 superficial (stage pTa and pT 1) transitional cell carcinoma (T.C.C.) of the urinary bladder, retrospective analysis was performed with special reference to tumor prognostic factors. MATERIALS AND METHODS: From July 1971 to september 1995, 51 cases with grade 3 superficial T.C.C. of the urinary bladder were treated. The survival rates and prognostic factors of these patient were analyzed. RESULTS: Five year survival rate of grade 3, superficial tumors was 92.3% and showed significantly better prognosis compared to patients with pT 2 and pT 3 tumors of grade 3 (p < 0.001). As a initial treatments, transurethral resection (TUR) was conducted in 45 patients (88%). Intravesical recurrence was observed in 20 of 45 patients (44%) and 12 of 20 patients (60%) were recurred within 1 year. Non-recurrent rates of the patients treated with TUR were 69.6% at 1 year, 58.8% at 3 year, 49.7% at 5 year, respectively. No significant differences were noted regarding factors of tumor size, figures and a number of tumor. Of the 51 patients, 10 (19.6%) progressed beyond stage T 2 and 6 died with the disease. Survival rates at 10 years follow up in patients with non-papillary and papillary tumor were 57.1% and 97.8%, respectively. CONCLUSION: These results suggested that TUR should be performed as a initial treatment for the patients with grade 3 superficial T.C.C. of the urinary bladder. However, non-papillary tumors should be considered of more intensive treatment like as radical cystectomy, adjuvant chemotherapy or irradiation. 相似文献
999.
Kazuhiro Iwai Koji Yamanaka Takumi Kamura Nagahiro Minato Ronald C. Conaway Joan W. Conaway Richard D. Klausner Arnim Pause 《Proceedings of the National Academy of Sciences of the United States of America》1999,96(22):12436-12441
Mutations of von Hippel-Lindau disease (VHL) tumor-suppressor gene product (pVHL) are found in patients with dominant inherited VHL syndrome and in the vast majority of sporadic clear cell renal carcinomas. The function of the pVHL protein has not been clarified. pVHL has been shown to form a complex with elongin B and elongin C (VBC) and with cullin (CUL)-2. In light of the structural analogy of VBC-CUL-2 to SKP1-CUL-1-F-box ubiquitin ligases, the ubiquitin ligase activity of VBC-CUL-2 was examined in this study. We show that VBC-CUL-2 exhibits ubiquitin ligase activity, and we identified UbcH5a, b, and c, but not CDC34, as the ubiquitin-conjugating enzymes of the VBC-CUL-2 ubiquitin ligase. The protein Rbx1/ROC1 enhances ligase activity of VBC-CUL-2 as it does in the SKP1-CUL-1-F-box protein ligase complex. We also found that pVHL associates with two proteins, p100 and p220, which migrate at a similar molecular weight as two major bands in the ubiquitination assay. Furthermore, naturally occurring pVHL missense mutations, including mutants capable of forming a complex with elongin B-elongin C-CUL-2, fail to associate with p100 and p220 and cannot exhibit the E3 ligase activity. These results suggest that pVHL might be the substrate recognition subunit of the VBC-CUL-2 E3 ligase. This is also, to our knowledge, the first example of a human tumor-suppressor protein being directly involved in the ubiquitin conjugation system which leads to the targeted degradation of substrate proteins. 相似文献
1000.
Makoto Urushibara Hiroshi Takayanagi Takako Koga Sunhwa Kim Miho Isobe Yasuyuki Morishita Takumi Nakagawa Monika Leffler Tatsuhiko Kodama Hisashi Kurosawa Tadatsugu Taniguchi 《Arthritis \u0026amp; Rheumatology》2004,50(3):794-804