全文获取类型
收费全文 | 2386篇 |
免费 | 108篇 |
国内免费 | 27篇 |
专业分类
耳鼻咽喉 | 22篇 |
儿科学 | 22篇 |
妇产科学 | 44篇 |
基础医学 | 281篇 |
口腔科学 | 68篇 |
临床医学 | 169篇 |
内科学 | 535篇 |
皮肤病学 | 11篇 |
神经病学 | 131篇 |
特种医学 | 153篇 |
外科学 | 459篇 |
综合类 | 5篇 |
预防医学 | 126篇 |
眼科学 | 54篇 |
药学 | 163篇 |
肿瘤学 | 278篇 |
出版年
2023年 | 32篇 |
2022年 | 61篇 |
2021年 | 86篇 |
2020年 | 40篇 |
2019年 | 71篇 |
2018年 | 71篇 |
2017年 | 44篇 |
2016年 | 62篇 |
2015年 | 69篇 |
2014年 | 57篇 |
2013年 | 102篇 |
2012年 | 129篇 |
2011年 | 146篇 |
2010年 | 62篇 |
2009年 | 65篇 |
2008年 | 124篇 |
2007年 | 121篇 |
2006年 | 105篇 |
2005年 | 130篇 |
2004年 | 86篇 |
2003年 | 124篇 |
2002年 | 120篇 |
2001年 | 56篇 |
2000年 | 66篇 |
1999年 | 62篇 |
1998年 | 24篇 |
1997年 | 14篇 |
1996年 | 22篇 |
1995年 | 18篇 |
1994年 | 10篇 |
1993年 | 14篇 |
1992年 | 30篇 |
1991年 | 29篇 |
1990年 | 36篇 |
1989年 | 30篇 |
1988年 | 34篇 |
1987年 | 26篇 |
1986年 | 19篇 |
1985年 | 13篇 |
1984年 | 10篇 |
1983年 | 10篇 |
1981年 | 8篇 |
1980年 | 8篇 |
1979年 | 11篇 |
1977年 | 9篇 |
1974年 | 6篇 |
1972年 | 4篇 |
1969年 | 6篇 |
1968年 | 5篇 |
1966年 | 11篇 |
排序方式: 共有2521条查询结果,搜索用时 15 毫秒
51.
52.
53.
54.
55.
56.
Takuma K Kamisawa T Gopalakrishna R Hara S Tabata T Inaba Y Egawa N Igarashi Y 《World journal of gastroenterology : WJG》2012,18(10):1015-1020
Autoimmune pancreatitis (AIP) is a newly described entity of pancreatitis in which the pathogenesis appears to involve autoimmune mechanisms. Based on histological and immunohistochemical examinations of various organs of AIP patients, AIP appears to be a pancreatic lesion reflecting a systemic "IgG4-related sclerosing disease". Clinically, AIP patients and patients with pancreatic cancer share many features, such as preponderance of elderly males, frequent initial symptom of painless jaundice, development of new-onset diabetes mellitus, and elevated levels of serum tumor markers. It is of uppermost importance not to misdiagnose AIP as pancreatic cancer. Since there is currently no diagnostic serological marker for AIP, and approach to the pancreas for histological examination is generally difficult, AIP is diagnosed using a combination of clinical, serological, morphological, and histopathological features. Findings suggesting AIP rather than pancreatic cancer include: fluctuating obstructive jaundice; elevated serum IgG4 levels; diffuse enlargement of the pancreas; delayed enhancement of the enlarged pancreas and presence of a capsule-like rim on dynamic computed tomography; low apparent diffusion coefficient values on diffusion-weighted magnetic resonance image; irregular narrowing of the main pancreatic duct on endoscopic retrograde cholangiopancreatography; less upstream dilatation of the main pancreatic duct on magnetic resonance cholangiopancreatography, presence of other organ involvement such as bilateral salivary gland swelling, retroperitoneal fibrosis and hilar or intrahepatic sclerosing cholangitis; negative work-up for malignancy including endoscopic ultrasound-guided fine needle aspiration; and steroid responsiveness. Since AIP responds dramatically to steroid therapy, accurate diagnosis of AIP can avoid unnecessary laparotomy or pancreatic resection. 相似文献
57.
Yasuko Ishimoto Taizo Wada Yoriko Kasahara Yumi Kimura Eriko Fukutomi Wenling Chen Mayumi Hirosaki Masahiro Nakatsuka Michiko Fujisawa Ryota Sakamoto Masayuki Ishine Kiyohito Okumiya Kuniaki Otsuka Kozo Matsubayashi 《Geriatrics & Gerontology International》2012,12(4):659-666
Aim: The 21‐item Fall Risk Index (FRI‐21) has been used to detect elderly persons at risk for falls. The aim of this longitudinal study was to evaluate the FRI‐21 as a predictor of decline in basic activities of daily living (BADL) among Japanese community‐dwelling elderly persons independent of fall risk. Methods: The study population consisted of 518 elderly participants aged 65 years and older who were BADL independent at baseline in Tosa, Japan. We examined risk factors for BADL decline from 2008 to 2009 by multiple logistic regression analysis on the FRI‐21 and other functional status measures in all participants. We carried out the same analysis in selected participants who had no experience of falls to remove the effect of falls. Results: A total of 45 of 518 participants showed decline in BADL within 1 year. Multivariate logistic regression analysis showed that age (odds ratio [OR] 1.13, 95% confidence interval [CI] 1.05–1.20), FRI‐21 ≥ 10 (OR 3.81, 95% CI 1.49–9.27), intellectual activity dependence (OR 3.25, 95% CI 1.42–7.44) and history of osteoarthropathy (OR 3.17, 95% CI 1.40–7.21) were significant independent risk factors for BADL decline within 1 year. FRI‐21 ≥ 10 and intellectual activity dependence (≤3) remained significant predictors, even in selected non‐fallers. Conclusion: FRI‐21 ≥ 10 and intellectual activity dependence were significant predictive factors of BADL decline, regardless of fall experience, after adjustment for confounding variables. The FRI‐21 is a brief, useful tool not only for predicting falls, but also future decline in functional ability in community‐dwelling elderly persons. Geriatr Gerontol Int 2012; ??: ??–?? . 相似文献
58.
Junko?Inoue Jun?WadaEmail author Sanae?Teshigawara Kazuyuki?Hida Atsuko?Nakatsuka Yuji?Takatori Shoichirou?Kojo Shigeru?Akagi Kazushi?Nakao Nobuyuki?Miyatake John?F?McDonald Hirofumi?Makino 《BMC nephrology》2012,13(1):163
Background
Visceral adipose tissue-derived serine proteinase inhibitor (vaspin) is an adipokine identified in genetically obese rats that correlates with insulin resistance and obesity in humans. Recently, we found that 7% of the Japanese population with the minor allele sequence (A) of rs77060950 exhibit higher levels of serum vaspin. We therefore evaluated the serum vaspin levels in Japanese chronic hemodialysis patients.Methods
Healthy Japanese control volunteers (control; n?=?95, 49.9±6.91?years) and Japanese patients undergoing hemodialysis therapy (HD; n?=?138, 51.4±10.5?years) were enrolled in this study, and serum samples were subjected to the human vaspin RIA system.Results
The measurement of the serum vaspin levels demonstrated that a fraction of control subjects (n?=?5) and HD patients (n?=?11) exhibited much higher levels (> 10?ng/ml; VaspinHigh group), while the rest of the population exhibited lower levels (< 3?ng/ml; VaspinLow group). By comparing the patients in the VaspinLow group, the serum vaspin levels were found to be significantly higher in the control subjects (0.87±0.24?ng/ml) than in the HD patients (0.32±0.15?ng/ml) (p?<?0.0001). In the stepwise regression analyses, the serum creatinine and triglyceride levels were found to be independently and significantly associated with the vaspin concentrations in all subjects.Conclusions
The creatinine levels are negatively correlated with the serum vaspin levels and were significantly reduced in the Japanese HD patients in the VaspinLow group.59.
Takashi Nakatsuka Kiyonori Harii Hirotaka Asato Satoshi Ebihara Takashi Yoshizumi Masahisa Saikawa 《Journal of plastic surgery and hand surgery》2013,47(3):307-310
We reviewed 109 consecutive patients with cancer of the hypopharynx or cervical oesophagus who underwent free flap transfer for immediate reconstruction after total pharyngolaryngo-oesophag-ectomy. The free flaps used were either free jejunal (n = 70) or radial forearm flaps (n = 39). Significantly more fistulas (3/70 compared with 15/39, p < 0.0001) and strictures (6/64 compared with 13/33, p = 0.0008) developed in the radial forearm than the jejunal flap group. However, functional donor site morbidity was minimal and there were no cases of total flap necrosis in the forearm flap group. We consider that the free jejunal flap should be the first choice for total reconstruction of pharyngo-oesophageal defects. However, the forearm flap is suitable for elderly, high risk patients, because it is less invasive and has minimal donor site morbidity, which facilitates early recovery. 相似文献
60.
Gender differences in maximum voluntary lip-closing force during lip pursing in healthy young adults
Murakami M Adachi T Nakatsuka K Kato T Oishi M Masuda Y 《Journal of oral rehabilitation》2012,39(6):399-404
The objectives of this study were to quantitatively evaluate the gender differences in the lip-closing force (LCF) generated during pursing-like lip-closing movement using a multidirectional LCF measurement system in healthy young adults. In 40 healthy subjects (20 women, 20 men; median age = 26·5 years, range = 22-41 years), LCF was recorded in eight directions during the performance of a voluntary pursing-like lip-closing task in four measurement sessions. The correlations between the total sum of the forces generated in all eight directions [total LCF (TLCF)] and each directional LCF (DLCF) and those between opposing DLCF were statistically analysed. The TLCF obtained from the highly reproducible measurements acquired in the four different sessions was normally distributed in both genders. The TLCF in men was significantly greater than that in women. Among the eight pairs of opposing DLCF, seven pairs of opposing DLCF showed significant correlations in men, while five pairs were significantly correlated in women. In men, no significant difference was observed between opposing DLCF; however, three pairs of opposing DLCF were significantly different in women. The present results quantitatively indicate that there are gender differences in the magnitude and directional specificity of the LCF produced during pursing-like lip-closing movement in healthy young adults. 相似文献