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991.
992.
Neutrophilic panniculitis with vasculitis in a melanoma patient treated with vemurafenib: a case report and its management 下载免费PDF全文
993.
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Takashi Ueguchi Yuko Tanaka Seiki Hamada Risa Kawamoto Yuji Ogata Mitsuhiro Matsumoto Hironobu Nakamura Takeshi Johkoh 《Magnetic resonance in medical sciences》2006,5(3):147-150
Air microbubbles have been investigated recently at high magnetic field strength (2 Tesla or greater) as potential MR susceptibility contrast agents. We used a phantom to measure their susceptibility at 1.5 T to clarify their usefulness for this purpose. The phantom, filled with fresh Levovist suspension at 4 different doses (67 to 125 mg/mL), was continuously scanned with a gradient-echo technique at a temporal resolution of 10 s. The transverse relaxation increase (R2*) by microbubbles demonstrated a time course of exponential decay at each dose (time-constant, 39 to 57 s). The dependency of R2* on microbubble volume fraction was linear, with a slope of 89 s-1 per percentage microbubble volume fraction. Our study represents the first step towards applying microbubbles as susceptibility contrast agents at 1.5 T. 相似文献
996.
Masanori Nakanishi Yoshiki Demura Nobuyuki Kosaka Satoshi Nishikawa Takeshi Ishizaki 《European journal of radiology》2010,73(3):545-550
Background
To diagnose sputum smear-negative pulmonary tuberculosis (PTB) is difficult and the ability of high-resolution computed tomography (HRCT) for diagnosing PTB has remained unclear in the sputum smear-negative setting. We retrospectively investigated whether or not this imaging modality can predict risk for sputum smear-negative PTB.Methods
We used HRCT to examine the findings of 116 patients with suspected PTB despite negative sputum smears for acid-fast bacilli (AFB). We investigated their clinical features and HRCT-findings to predict the risk for PTB by multivariate analysis and a combination of HRCT findings by stepwise regression analysis. We then designed provisional HRCT diagnostic criteria based on these results to rank the risk of PTB and blinded observers assessed the validity and reliability of these criteria.Results
A positive tuberculin skin test alone among clinical laboratory findings was significantly associated with an increase of risk of PTB. Multivariate regression analysis showed that large nodules, tree-in-bud appearance, lobular consolidation and the main lesion being located in S1, S2, and S6 were significantly associated with an increased risk of PTB. Stepwise regression analysis showed that coexistence of the above 4 factors was most significantly associated with an increase in the risk for PTB. Ranking of the results using our HRCT diagnostic criteria by blinded observers revealed good utility and agreement for predicting PTB risk.Conclusions
Even in the sputum smear-negative setting, HRCT can predict the risk of PTB with good reproducibility and can select patients having a high probability of PTB. 相似文献997.
Indications for curative resection of advanced gallbladder cancer with hepatoduodenal ligament invasion 总被引:1,自引:0,他引:1
Endo I Shimada H Fujii Y Sugita M Masunari H Miura Y Tanaka K Misuta K Sekido H Togo S 《Journal of Hepato-Biliary-Pancreatic Surgery》2001,8(6):505-510
Abstract.
Purpose: Hepatoduodenal ligament invasion (HLI) is an inhibiting factor for the curative resection of advanced gallbladder cancer.
The aim of this study was to clarify the indications for surgical resection in patients with advanced gallbladder cancer with
and without HLI by analyzing outcomes.
Methods: The subjects were 58 patients with advanced gallbladder cancer who underwent aggressive resection, and 20 nonresected patients
diagnosed as haring HLI. The presence of stromal cancerous infiltration at six sites in the hepatoduodenal ligament was investigated.
The extent of cancer spread was classified into two grades by the number of sites where cancer cells detected: low grade,
one or two invasion sites; high grade, three or more sites.
Results: Pancreatoduodenectomy, vascular reconstruction, and extensive hepatectomy were frequently performed in the patients with
HLI. The cumulative 5-year-survival rate of the HLI patients was 10.9%, significantly worse than that of the resected patients
without HLI (46.6%; P < 0.01). Patients with paraaortic lymph node metastasis died within 1 year. The cumulative 5-year-survival rate after curative
resection was 38.1%, significantly better than that after noncurative resection (0%; P < 0.05). The survival was significantly worse in patients with high-grade invasion than in these with low-grade invasion
(P < 0.05), being equivalent to that in the nonresection patients. Of four factors, operative curability, hepatic lobectomy,
HLI grade, and paraaortic lymph node metastasis, the HLI grade and hepatic lobectomy were considered to be significant prognostic
factors by Cox's multivariate analysis (backward stepwise method).
Conclusions: Aggressive surgical resection for curative purposes should be limited to patients with low-grade HLI and metastasis-negative
paraaortic lymph nodes.
Received: January 9, 2001 / Accepted: May 11, 2001 相似文献
998.
Hiroaki Shiba Yuichi Ishida Shigeki Wakiyama Tomonori Iida Michinori Matsumoto Taro Sakamoto Ryusuke Ito Takeshi Gocho Kenei Furukawa Yuki Fujiwara Shoichi Hirohara Takeyuki Misawa Katsuhiko Yanaga 《Journal of gastrointestinal surgery》2009,13(9):1636-1642
Background In perioperative management of hepatic resection for hepatocellular carcinoma, excessive blood loss and blood transfusion
greatly influence postoperative complications and prognosis of the patients. We evaluated the influence of blood products
use on postoperative recurrence and prognosis of patients with hepatocellular carcinoma.
Methods The subjects were 66 patients who underwent elective hepatic resection for hepatocellular carcinoma without concomitant microwave
or radiofrequency ablation therapy nor other malignancies between January 2001 and June 2006. We retrospectively investigated
the influence of the use of blood products including red cell concentration and fresh frozen plasma on recurrence of hepatocellular
carcinoma and overall survival.
Results In multivariate analysis, the dose of blood products transfusion was a significant predictor of disease-free and overall survival.
Both disease-free and overall survival rates of those who were given blood products were significantly worse than those who
did not receive. On the other hand, in univariate analysis of disease-free and overall survival after hepatic resection and
clinical variables, the amount of blood loss was not a significant predictor of recurrence or death.
Conclusion Transfusion of blood products is associated with increased recurrence rate and worse survival after elective hepatic resection
for patients with hepatocellular carcinoma. 相似文献
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1000.
Ikeda T Kabasima A Ueda N Yonemura Y Ninomiya M Nogami M Fujii K Mashino K Tashiro H Sakata H 《Surgery today》2012,42(1):41-45