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排序方式: 共有2108条查询结果,搜索用时 15 毫秒
991.
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994.
Takahito Kamada Masao Koda Mari Dezawa Reiko Anahara Yoshiro Toyama Katsunori Yoshinaga Masayuki Hashimoto Shuhei Koshizuka Yutaka Nishio Chikato Mannoji Akihiko Okawa Masashi Yamazaki 《Neuropathology》2011,31(1):48-58
The aim of this study was to evaluate whether transplantation of human bone marrow stromal cell‐derived Schwann cells (hBMSC‐SC) promotes functional recovery after contusive spinal cord injury of adult rats. Human bone marrow stromal cells (hBMSC) were cultured from bone marrow of adult human patients and induced into Schwann cells (hBMSC‐SC) in vitro. Schwann cell phenotype was confirmed by immunocytochemistry. Growth factors secreted from hBMSC‐SC were detected using cytokine antibody array. Immunosppressed rats were laminectomized and their spinal cords were contused using NYU impactor (10 g, 25 mm). Nine days after injury, a mixture of Matrigel and hBMSC‐SC (hBMSC‐SC group) was injected into the lesioned site. Five weeks after transplantation, cresyl‐violet staining revealed that the area of cystic cavity was smaller in the hBMSC‐SC group than that in the control group. Immunohistochemstry revealed that the number of anti‐growth‐associated protein‐43‐positive nerve fibers was significantly larger in the hBMSC‐SC group than that in the control group. At the same time, the number of tyrosine hydroxylase‐ or serotonin‐positive fibers was significantly larger at the lesion epicenter and caudal level in the hBMSC‐SC group than that in the control group. In electron microscopy, formation of peripheral‐type myelin was recognized near the lesion epicenter in the hBMSC‐SC group. Hind limb function recovered significantly in the hBMSC‐SC group compared with the control group. In conclusion, the functions of hBMSC‐SC are comparable to original Schwann cells in rat spinal cord injury models, and are thus potentially useful treatments for patients with spinal cord injury. 相似文献
995.
Keiichi Jingu Riwa KishimotoJun-Etsu Mizoe Azusa HasegawaHiroki Bessho Hiroshi TsujiTadashi Kamada Shogo YamadaHirohiko Tsujii 《Radiotherapy and oncology》2011,98(1):68-73
Background and purpose
To evaluate the potential of apparent diffusion coefficient (ADC) value before carbon ion radiotherapy (C-ion RT) for malignant mucosal melanoma (MMM) to predict prognosis.Materials and methods
We recruited 37 patients with MMM in the head and neck treated by C-ion RT with concomitant chemotherapy. Univariate and multivariate analyses of minimum ADC, mean ADC, tumor volume, age, PS, and gender were performed to identify prognostic factors.Results
The 3-year local control rate, distant metastasis-free survival rate and overall survival rate of all patients were 81.1%, 37.6% and 65.3%, respectively, with a median follow-up period of 19.0 months. In univariate analyses, lower minimum ADC (?0.6380 × 10−3 mm2/s) and lower mean ADC (?1.1523 × 10−3 mm2/s) were unfavorable prognostic factors for distant metastasis (p = 0.029 and p = 0.014, respectively), and lower minimum ADC was an unfavorable prognostic factor for overall survival (p = 0.019). However, there was no significant prognostic factor of local control including ADC value. In multivariate analyses, only minimum ADC was selected as a prognostic factor of distant metastasis-free survival and overall survival (p = 0.015 and p = 0.006, respectively).Conclusion
Minimum ADC can be a prognostic factor of MMM in the head and neck after C-ion RT. 相似文献996.
Nakamura H Masuko K Yudoh K Kato T Kamada T Kawahara T 《Rheumatology international》2007,27(3):213-218
The purpose of this study was to examine whether glucosamine has an antirheumatic effect in a randomized placebo-controlled
study.The subjects were 51 rheumatoid arthritis (RA) patients: 25 patients in the glucosamine group and 26 patients in the
placebo group. Glucosamine hydrochloride at a daily dose of 1,500 mg and placebo, respectively, were administered for 12 weeks
along with conventional medication.While significant improvement was not found in joint counts and in the rate of ACR20 responders,
the face scale and a visual analogue scale pain were significantly in favor of the glucosamine group. ESR and CRP levels did
not change, but serum MMP-3 levels decreased in the glucosamine group. Results of the patients’ self-evaluations and the physicians’
global evaluations indicated that the glucosamine treatment produced noticeable improvements in symptoms.Although glucosamine
administration had no antirheumatic effect evaluated by conventional measures, it seemed to have some symptomatic effects
on RA. 相似文献
997.
998.
Kaplan FS Shen Q Lounev V Seemann P Groppe J Katagiri T Pignolo RJ Shore EM 《Journal of bone and mineral metabolism》2008,26(6):521-530
Metamorphosis, the transformation of one normal tissue or organ system into another, is a biological process rarely studied
in higher vertebrates or mammals, but exemplified pathologically by the extremely disabling autosomal dominant disorder fibrodysplasia
ossificans progressiva (FOP). The recurrent single nucleotide missense mutation in the gene encoding activin receptor IA/activin-like
kinase-2 (ACVR1/ALK2), a bone morphogenetic protein type I receptor that causes skeletal metamorphosis in all classically
affected individuals worldwide, is the first identified human metamorphogene. Physiological studies of this metamorphogene
are beginning to provide deep insight into a highly conserved signaling pathway that regulates tissue stability following
morphogenesis, and that when damaged at a highly specific locus (c.617G > A; R206H), and triggered by an inflammatory stimulus
permits the renegade metamorphosis of normal functioning connective tissue into a highly ramified skeleton of heterotopic
bone. A comprehensive understanding of the process of skeletal metamorphosis, as revealed by the rare condition FOP, will
lead to the development of more effective treatments for FOP and, possibly, for more common disorders of skeletal metamorphosis. 相似文献
999.
Two cases of children with Beckwith-Wiedemann syndrome are presented. This syndrome consists of various abnormalities, including
macroglossia, visceromegaly, omphalocele, and gigantism. These abnormalities frequently require operative correction during
the neonatal period. We anesthesiologists should make plans for difficult airway managements in patients with this syndrome.
Our two patients also showed larger sized tracheas than those estimated by their age and height. A cuffed tube, though still
controversial, has recently been used in children. We recommend using a cuffed tube in patients with this syndrome, because
the appropriate tracheal size may not be predictable, tracheal intubation might be difficult, and risks incurred during changing
of a tracheal tube should be avoided. 相似文献
1000.
Cardioprotective effect and mechanism of action of landiolol on the ischemic reperfused heart 总被引:1,自引:0,他引:1
Kimura-Kurosawa S Kanaya N Kamada N Hirata N Nakayama M Namiki A 《Journal of anesthesia》2007,21(4):480-489
Purpose The authors examined the cardioprotective effect of landiolol, an ultra short-acting, highly selective β1-blocker, and its
role in cardiac work, antioxidative effect, and sarcoplasmic reticulum (SR) function in hearts subjected to ischemia-reperfusion.
Methods Isolated guinea pig hearts were subjected to ischemia-reperfusion by stopping the perfusion for 45 min and reperfusing. Before
the ischemia, hearts were treated with landiolol (20, 100, or 500 μM) for 15 min (LAN group). In another set of experiments,
before ischemia, hearts were washed out for 15 min after treatment with landiolol (WO group). In other hearts, the tissue
concentration of malondialdehyde was measured after reperfusion. We also examined the phosphorylation of phospholamban at
Ser16 and Thr17residues to evaluate the SR function.
Results After 90 min of reperfusion, left ventricular pressure (LVP) was restored significantly in the LAN-500 μM group regardless
of heart rate. However, the improvement in recovery in LVP disappeared in the WO group. The tissue malondialdehyde levels
were decreased in the LAN group compared with those in the control group. In the control group, the phosphorylation of phospholamban
at Ser16 and Thr17 residues was markedly increased after reperfusion. Landiolol at 500 μM suppressed the increase of phosphorylation at Ser16 residues.
Conclusion The present study demonstrated that landiolol had a lipid peroxidation-reducing effect and suppressed the increase in phospholamban
phosphorylation at the Ser16 residue in hearts subjected to ischemia-reperfusion. These findings indicate that landiolol may have an anti-ischemic effect,
via an antioxidant effect and/or via preserving SR function during the ischemic period.
Presented in part at the annual meeting of the American Society of Anesthesiologists, Las Vegas, Nevada, October 23–27, 2004. 相似文献